• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2235-2245
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• 2016

Ulcerative colitis (UC) results from colonic epithelial barrier defects and impaired mucosal immune responses. In this study, we aimed to investigate the modifying effects of a Spirogyra neglecta extract (SNE), a polysaccharide extract (PE) and a chloroform fraction (CF) on dextran sodium sulfate (DSS)-induced colitis in mice and to determine the mechanisms. To induce colitis, ICR mice received 3% DSS in their drinking water for 7 days. Seven days preceding the DSS treatment, oral administration of SNE, PE and CF at doses of 50, 25 and 0.25 mg/kg body weight (low dose), 200, 100 and 1 mg/kg body weight (high dose) and vehicle was started and continued for 14 days. Histologic findings showed that DSS-induced damage of colonic epithelial structure and inflammation was attenuated in mice pre-treated with SNE, PE and CF. Furthermore, SNE and PE significantly protected colonic epithelial cells from DSS-induced cell cycle arrest, while SNE, PE and CF significantly diminished apoptosis. Proteome analysis demonstrated that SNE and PE might ameliorate DSS-induced colitis by inducing antioxidant enzymes, restoring impaired mitochondria function, and regulating inflammatory cytokines, proliferation and apoptosis. These results suggest that SNE and PE could prevent DSS-induced colitis in ICR mice by protection against and/or aiding recovery from damage to the colonic epithelium, reducing ROS and maintaining normal mitochondrial function and apoptosis.

• Journal of Industrial Convergence
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• v.20 no.8
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• pp.69-75
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• 2022

In order to prevent traffic accidents for children who are vulnerable to traffic around elementary schools, a school zone in the children's protection zone is designated, and parking and stopping are prohibited in this area as the vehicle speed is less than 30km/h. However, Korea has a disgrace that the death rate of children from traffic accidents is the No. 1 among OECD countries. Against this backdrop, this study aims to contribute to preventing traffic accidents and raising awareness of driver safety by establishing an illegal parking and stopping system in the child protection zone due to various road conditions in the child protection zone. As a research method, a plan to build a parking and stopping prevention system was presented based on major preceding studies and literature investigation and analysis. Through the construction plan, effects such as preventing traffic accidents, inducing smart drivers to drive safely, strengthening pedestrian safety awareness, and inducing driver's awareness of safety can be expected.

• Conservation Science in Museum
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• v.29
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• pp.133-152
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• 2023

This study references preceding studies to examine the history of paint application techniques using various paints in the past, with the aim to contribute to the long-term preservation of large military cultural heritage assets situated outdoors. To this end, the study compared the findings of preceding research with the findings of an analysis conducted on a H-13 helicopter housed at the War Memorial of Korea. Upon collecting and analyzing samples from three grounded WWII aircraft from above-ground by preceding studies, it was confirmed from each sample that the various chemical properties of chrome ensured the effectiveness of the protective coating. The compound was first tested as a corrosion-inhibiting pigment in the early 1940s and proved its excellent moisture-resistant properties over the course of 80 years, despite the deterioration of the paint layer and long-term exposure to the natural environment. For this reason, it has been widely used as a corrosion inhibitor for aluminum alloys in the aviation industry. In other word, the most widely-used material for preventing corrosion was an organic primer containing chromate. In this study, based on the paint analysis of a H-13 helicopter operated in the Korean War, it was shown that the second layer, consisting of the primer, contains chromium oxide (Cr₂O₃). In addition, it was estimated that red lead tetraoxide (Pb₃O₄) was used for the vehicle. Analysis results and data from previous studies can help to confirm the continued effectiveness of corrosion prevention function provided by chromate. Meanwhile, the result of infrared spectroscopy analysis confirmed the use of alkyd resin. In the future, comparisons with a more diverse range of artifacts will allow the identification of changes in the manufacturing technology of paints used to protect alloys from corrosion.

• Korean Journal of Veterinary Research
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• v.32 no.1
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• pp.15-24
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• 1992

The effects of CC the ovulatory response, oocyte normality, ovarian steroidogenesis and subsequent embryo developmental potential were examined in PMSG-treated rats. On Days of 25~27 of age, immature female Sprague Dawley rats were treated with three different doses(0.05, 0.1 or 1.0mg /day) of clomiphene citrate or vehicle. The females subsequently received 4IU PMSG on Day 28 and/or 10IU hCG on Day 30, and were killed on Day 31. Some females given 0.1mg CC or vehicle with 4IU PMSG were then mated and killed on Days 2, 3, 4 and 5 of pregnancy. Compared to vehicle(control) group, by increasing the doses of CC, there were a significant decrease in the ovulatory response as judged by both the proportion of rats ovulating and the mean number of oocytes per rat and a marked reduction of ovarian weight. The increasing doses of CC substantially promoted the degeneration(%) of oocytes ovulating in a dose-dependent manner. The CC-mediated inhibitions of the ovulatory response and ovarian weight were oompletely overcome by a subsequent treatment of hCG. Increasing doses of CC resulted in a siginificant elevation of serum estradiol with the decreased levels of progesterone and androgens. The additive treatment with hCG was effective to reduce the elevation of estradiol and to increase the reduction of progesterone produced by high dose(1.0mg) of CC. The preimplantation embryos recovered from 0.1mg CC-treated pregnant rats demonstrated a progressive early loss from Day 3 of pregnancy with a significant increase in the percentage of degeneration during all periods examined, compared to controls. The rate of progressive embryo cleavage in the CC-treated rats were slower than that in controls from Day 3 of pregnancy. Additionally, the percentage of the cleaved embryos recovered from the CC-treated rats remained significantly lower consistently from Day 2 of pregnancy, compared to control regimen. These results demonstrate a possible mechanism of CC-mediated inhibition of ovulatory response in the rats which may include the attenuation or blockade of the endogenous secretion of gonadotropins and also suggest that its detrimental effects observed on oocyte normality and embryonic development may be caused by abnormal follicular steroidogenesis( especially elevated estradiol) preceding fertilization.

• Korean Security Journal
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• no.58
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• pp.35-58
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• 2019

Drone was originally developed for air force aircraft or missile exercise shooting targets, and is being considered as the entire unmanned aircraft to the public. The core concept of a drone can be divided into 'unmanned' and 'aircraft'. However, there are many questions about whether the Fourth Industrial Revolution, expressed as a convergence scientific innovation, is appropriate at a time when smart cities are proposed as a concept of new urban spatial formation, and the role of self-driving vehicles, including drones, is being emphasized within the new urban integrated transport system. In this study, the concept of the existing drones was analyzed for the development process, definitions in each country's laws, and the results of the preceding research to present a concept suitable for future society and a unified term. It is not desirable to define a drone for the purpose of a country, an institution, or an operating entity, depending on the circumstances of the era. It is more reasonable to find the concept of a drone based on human life than in the traditional way, and more reasonable considering the development of the drones in the future. Subsequent studies should be more detailed, more data and research results analyzed, and discussed areas that were not covered in this study. Based on this, research should also be conducted on a variety of topics, including legislation, preparation of operational regulations, and related industrial processes and regulations.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.57-64
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• 2020

The leading technologies of the ADAS (Advanced Driver Assist System) are ACC (Advanced Cruise Control), LKAS (Lane Keeping Assist System), and AEB (Autonomous Emergency Braking). LKAS is a system that uses cameras and infrared sensors to control steering and return to its running lane in the event of unintentional deviations. The actual test is performed for a safety evaluation and verification of the system. On the other hand, research on the system evaluation method is insufficient when an additional steering angle is applied. In this study, a model using Prescan was developed and simulated for the scenarios proposed in the preceding study. Comparative analyses of the simulation and the actual test were performed. As a result, the modeling validity was verified. A difference between the front wheels and the lane occurred due to the return velocity. The results revealed a maximum error of 0.56 m. The error occurred because the lateral velocity of the car was relatively small. On the other hand, the distance from wheels to the lanes displayed a tendency of approximately 0.5 m. This can be verified reliably.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.2
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• pp.56-62
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• 2010

The purpose of this study was to compare the difference of driving pattern between male and female drivers for a straight driving and unexpected situation using driving simulator and motion data. The participants included total 60 university students; 30 males aged 24.3$\pm$1.4 years and 30 females aged 23.2$\pm$1.9 years with 1~3 years of driving experience. The driving task required participants to keep the constant distance (20m, 25m or 30m) with preceding vehicle running at 55~65km/hr speed using driving simulator which was programed unexpected situation for two minutes. Simulator and motion data were acquired. The acquired data was divided in straight driving block for 40 second and unexpected situation block for 2 second. The coefficient of variation (CV) of lane keeping and jerk-cost (JC) function were analyzed for straight driving and unexpected situation blocks. The results show that CV was smaller in males than females for both straight and unexpected situation blocks (p < .05). JC was smaller in females than males for both straight and unexpected situation blocks. As the distance of vehicles become longer, JC was smaller for both male and female (p < .05).

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2D
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• pp.233-239
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• 2006

Most research for until at now link travel time were research for mean link travel time calculate or estimate which uses the average of the individual vehicle. however, the link travel time distribution is divided caused by with the impact factor which is various traffic condition, signal operation condition and the road conditional etc. preceding study result for link travel time distribution characteristic showed that the patterns of going through traffic were divided up to 2 in the link travel times. therefore, it will be more accurate to divide up the link travel time into the one involving delay and the other without delay, rather than using the average link travel time in terms of assessing the traffic situation. this study is it analyzed transit hour distribution characteristic and a cause using examine to the variables which give an effect at link travel time distribute using simulation program and determinate link travel time distribute ratio estimation model. to assess the distribution of the link travel times, this research develops the regression model and the fuzzy model. the variables that have high level of correlations in both estimation models are the rest time of green ball and the delay vehicles. these variables were used to construct the methods in the estimation models. The comparison of the two estimation models-fuzzy and regression model- showed that fuzzy model out-competed the regression model in terms of reliability and applicability.