• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.507-516
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• 2004

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the commom disease in public health service. Although a variety of oriental presciptions in study POD(Polygala tenuifolia extracted from dichlorometan) have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that AP peptide divided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CT105, carboxy terminal 105 aminoacids peptide fragment of APP, may be an important factor causing neurotoxicity in AD. SK-N-SH cells expressed with CT105 exhibited remarkable apoptotic cell damage. Based on morphological observations by phase contrast microscope and NO formation in the culture media, the CT105-induced cell death was significantly inhibited by POD. In addition, AD is one of brain degeneration disease. So We studied on herbal medicine that have a relation of brain degeneration. From old times, In Oriental Medicine, PO water extract has been used for disease in relation to brain degeneration. We were examined by ROS formation, neurite outgrowth assay and DPPH scravage assay. Additionally, we investigated the association between the CT105 and neurite degeneration caused by CT105-induced apoptotic response in neurone cells. We studied on the regeneratory and inhibitory effects of anti-Alzheimer disease in pCT105-induced neuroblastoma cell lines by POD. Findings from our experiments have shown that POD inhibits the synthesis or activities of CT105, which has neurotoxityies and apoptotic activities in cell line. In addition, treatment of POD(>50 ㎍/㎖ for 12 hours) partially prevented CT(105)-induced cytotoxicity in SK-N-SH cell lines, and were inhibited by the treatment with its. POD(>50 ㎍/㎖ for 12 hours) repaired CT105-induced neurite outgrowth when SK-N-SH cell lines was transfected with CT105. As the result of this study, In POD group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. Decrease of memory induced by injection of scopolamin into rat was also attenuted by POD, based on passive avoidance test. Taken together, POD exhibited inhibition of CT105-induced apoptotic cell death. POD was found to reduce the activity of AchE and induced about the CA1 in rat hippocampus. Base on these findings, POD may be beneficial for the treatment of AD.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.5
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• pp.383-389
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• 2014

POD analysis has been done to investigate the internal flow characteristics using LES calculation results of hybrid rocket combustion chamber. The special emphasis was put on the change in the mode energy distribution caused by the installation of diaphragm compared to the baseline case. Also the comparison was made to investigate the effect of wall blowing on the changes in the mode energy between the regions near and far from the diaphragm. For baseline case, POD results clearly distinguish the primary mode containing most of flow energy from the rest of flow modes (2-9 mode) depicting small scale modes. Also, the increase in the energy of flow modes 2-5 is responsible for the formation of relatively large scale structures due to diaphragm. In addition, the comparison of mode energy distributions of flow fields with diaphragm shows similar patterns in both wall blowing and no blowing case. This implies that the local increase in regression rate just after the diaphragm is directly associated with the increase in energy distributions of 2-5 modes.

• Journal of Korean Biological Nursing Science
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• v.20 no.3
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• pp.177-186
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• 2018

Purpose: Increasing number of older adults are receiving cancer surgeries especially for gastrointestinal cancers, which brings forth attention to age-related postoperative complication prevention. Postoperative delirium (POD) is a common complication that rises after surgical procedures involving general anesthesia, largely in the elderly population. Due to its sudden onset and fluctuating symptoms, POD often goes underdiagnosed and undertreated even though it may lead to various adverse outcomes. POD in GI cancer surgical elderly patients is poorly understood in terms of prevalence, pathophysiology, assessment, treatment and nursing management. We aimed to identify available literature and investigate study results to broaden our understanding of geriatric GI cancer POD. Methods: The search process involved six databases to identify relevant studies abided by inclusion criteria. Results: Eleven studies were selected for this review. Geriatric POD is closely related to frailty and surgical complications. Frailty increases vulnerability to surgical stress and causes cerebral changes that affect stress-regulating neurotransmitter proportions, brain blood flow, vascular density, neuron cell life and intracellular signal transductions. These conditions of frailty result in increased risks of surgical complications such as blood loss, cardiovascular events and inflammation, which all may lead to the POD. Mini Metal State Examination (MMSE), Confusion Assessment Method (CAM) and Delirium Rating Scale-revised-98 (DRS-R-98) are recommended for POD assessment to identify high-risk patients. Conclusion: The POD prevalence ranged from 8.2% to 51.0%. The multifactorial causative mechanism suggests nurses to identify highrisk elderly GI-cancer surgical patients by reviewing patient-specific factors and surgery-specific factors.

• Journal of the Korean Society of Safety
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• v.21 no.4 s.76
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• pp.42-48
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• 2006

The strategies of maintenance and operation are usually established based on the number of flaws and their size distribution obtained from nondestructive inspection in order to preserve safety of the plant. But non destructive inspection results are different from the physical flaws which really exist in the equipments. In case of a single inspection, it is easy to estimate the number of physical flaws using the POD curve. However, we may be faced with some difficulties in obtaining the number of physical flaws from the periodic in-service non destructive inspection data. In this study a simple method for estimating the number of physical flaws from periodic in-service nondestructive inspection data was proposed. In order to obtain the flaw growth history, the flaw growth was simulated using the Monte Carlo method and the flaw size and the corresponding POD value were obtained for each flaw at each periodic inspection time. The flaw growth rate used in the simulation was statistically calculated from the in-service inspection data. By repeating the simulation numerous flaw growth data could be generated and the effective POD curve was obtained as a function of flaw size. From the effective POD curve the number of physical flaws was obtained. The usefulness and convenience of the proposed method was evaluated from several applications and satisfactory results were obtained.

• Wind and Structures
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• v.23 no.4
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• pp.367-383
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• 2016

The influence mechanism of mean value components, noted as $P_0$, on POD applications for complete random fields $P_C(t)$ and fluctuating random fields $P_F(t)$ are illustrated mathematically. The critical philosophy of the illustration is introduction of a new matrix, defined as the correlation function matrix of $P_0$, which connect the correlation function matrix of $P_C(t)$ and $P_F(t)$, and their POD results. Then, POD analyses for several different wind pressure fields were presented comparatively as validation. It's inevitable mathematically that the first eigenmode of $P_C(t)$ resembles the distribution of $P_0$ and the first eigenvalue of $P_C(t)$ is close to the energy of $P_0$, due to similarity of the correlation function matrixs of $P_C(t)$ and $P_0$. However, the viewpoint is not rigorous mathematically that the first mode represents the mean pressure and the following modes represent the fluctuating pressure when $P_C(t)$ are employed in POD application. When $P_C(t)$ are employed, POD results of all modes would be distorted by the mean value components, and it's impossible to identify $P_0$ and $P_F(t)$ separately. Consequently, characteristics of the fluctuating component, which is always the primary concern in wind pressure field analysis, can only be precisely identified with $P_0$ excluded in POD.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.4
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• pp.310-317
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• 2006

This study was conducted to investigate the influence of drought stress during the pod developing and seed filling stage on source-sink relationships of soybean (Glycine max). Drought treatments were imposed by withholding water at the full-pod stage, 19 days after flowering, and then limited watering was relieved at 15 days after the initiation of drought treatment. Soybean seed yield was reduced by 39% mainly due to decreased pod number under drought stress, but the 100-seed weight was relatively less reduced. In spite of the 15-day drought during the full-pod stage, soybean produced good seeds showing similar l00-seed weight, protein, starch and soluble sugar content to those from the well-watered. Although drought during the full-pod stage caused source limitations; i.e. accelerated leaf senescence and reduced leaf soluble sugars, it did not cause limitations of other source characteristics such as SGR and leaf starch level. This is because the reduction in size of sinks, such as pod and seed abortions compensated for source limitations, resulting in balanced source-sink as expressed by LAR and the ratio of leaf area to seed dry weight. Drought stress during the pod developing and seed filling stage did not disrupt the source-sink balance

• Journal of Life Science
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• v.10 no.1
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• pp.107-113
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• 2000

This study carried out to investigate activities of the superoxide dismutase(SOD), peroxidase(POD) and diterpene cyclase of rice plant treated by environmental stress conditions. The rice leaves of Ilpum was shown to have the most highest specific activity of POD. POD activity in the susceptible cv. Ilpum and Hwasung during the disease progress show a increase, while for a decreasing activity in the resistant cv. Dasan. SOD activity of rice plants treated by chitosan were increased as the treatment concentration increased. At the chitosan application, the SOD activity in the susceptible cv. Hwansung at the rice leaves 14days after treatment was higher in treatment than chitosan-untreated control. The activity of POD in the susceptible cv. Ilpum decreased as long as UV-B irradiation, while that in the resistant cv. Dasan increased. Futhermore, activity of that in Dasan were similar to as time on UV irradiation, Hwasung showed two times higher than untreated control at 40 minutes after UV-B exposure. The activity of diterpene cyclase in rice plants inoculated with Pyricularia oryzae has much higher tendency than UV-B irradiation. The activity of diterpene cyclase in the rice leaves gradually increased until 5 days after inoculation with Pyricularia oryzae.

• Wind and Structures
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• v.21 no.1
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• pp.63-84
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• 2015

The shape of a tall building has significant impact on wind force generation and wind-induced dynamic response. To study the effect of recessed cavities, wind excitations on a wind-tunnel model of an H-section tall building were compared with those on a square-section building model. Characteristics of the fluctuating wind pressures on the side faces of the two tall buildings and their role in the generation of crosswind forces on the buildings were investigated with the space-time statistical tool of proper orthogonal decomposition (POD). This paper also compares the use of different pressure data sets for POD analysis in situations where pressures on two different surfaces are responsible for the generation of a wind force. The first POD mode is found to dominate the generation of crosswind excitation on the buildings.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.6
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• pp.1193-1198
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• 2012

In this paper, we design and implement A4 sized, web-based POP(Print On Demand) system using multi-layer technique. We Propose the framework of POP system, which uses multi-layer technique, uses highly accessible web-service, produces template, enables a user to easily edit, and allows the user to instantly print edited files. This system will be widely used in web-based electronic publication and e-book.

• Journal of Electrical Engineering and Technology
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• v.10 no.2
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• pp.487-495
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• 2015

This paper proposes a new robust decentralized power oscillation dampers (POD) design of doubly-fed induction generator (DFIG) wind turbine for damping of low frequency electromechanical oscillations in an interconnected power system. The POD structure is based on the practical $2^{nd}$-order lead/lag compensator with single input. Without exact mathematical model, the inverse output multiplicative perturbation is applied to represent system uncertainties such as system parameters variation, various loading conditions etc. The parameters optimization of decentralized PODs is carried out so that the stabilizing performance and robust stability margin against system uncertainties are guaranteed. The improved firefly algorithm is applied to tune the optimal POD parameters automatically. Simulation study in two-area four-machine interconnected system shows that the proposed robust POD is much superior to the conventional POD in terms of stabilizing effect and robustness.