• Archives of Pharmacal Research
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• v.26 no.5
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• pp.421-425
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• 2003

The aim of the present study was to evaluate the effects of two phospholipid permeation enhancers, lysophosphatidylcholine (LPC) and didecanoylphosphatidylcholine (DDPC), along with a fusidic acid derivative, sodium taurodihydrofusidate (STDHF) and ethanol (EtOH) on the buccal transport of propranolol hydrochloride (PPL) using an ex vivo buccal diffusion model. The permeation rate of [$^3 H$]PPL as measured by steady-state fluxes increased with increasing EtOH concentration. A significant flux enhancement (P＜0.05) was achieved by EtOH at 20 and 30 %v/v concentrations. At a 0.5 %w/v permeation enhancer concentration, the buccal permeation of [$^3 H$]PPL was significantly enhanced by all the enhancers studied (i.e., LPC, DDPC and STDHF) compared to the control (phosphate-buffered saline pH 7.4, PBS). LPC and DDPC displayed a greater degree of permeation enhancement compared with STDHF and EtOH-PBS mixtures with an enhancement ratio of 3.2 and 2.9 for LPC and DDPC, respectively compared with 2.0 and 1.5 for STDHF and EtOH:PBS 30:70 %v/v mixture, respectively. There was no significant difference between LPC and DDPC for the flux values and apparent permeability coefficients of [$^3$H]PPL. These results suggest that phospholipids are suitable as permeation enhancers for the buccal delivery of drugs.

• KSBB Journal
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• v.26 no.5
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• pp.433-438
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• 2011

These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.

• Korean Journal of Soil Science and Fertilizer
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• v.19 no.3
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• pp.251-268
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• 1986

Selecting a site for the safe disposal of radioactive waste requires the evaluation of a wide range of geologic, mineralogic, hydrologic, and physicochemical properties. Although highly diverse, these properties are in fact interrelated. Site requirements are also diverse because they are influenced by the nature of the radionuclides in the waste, for example, their half-lives, specific energy, and chemistry. A fundamental consideration in site selection is the mineralogy of the host rock, and one of the most ubiquitous mineral groups is clay minerals. Clays and clay minerals as in situ lithologic components and engineered barriers may playa significant role in retarding the migration of radionuclides. Their high sorptivity, longevity (stability), low permeability, and other physical factors should make them a very effective retainer of most radionuclides in nuclear wastes. There are, however, some unanswered questions. For example, how will their longevity and physicochemical properties be influenced by such factors as radionuclide concentration, radiation intensity, elevated temperatures, changes in redox condition, pH, and formation fluids for extended periods of time? Understanding of mechanisms affecting clay mineral-radionuclide interactions under prevailing geochemical conditions is important; however, the utilization of experimental geochemical information related to physicochemical properties of clays and clay-bearing materials with geohydrologic models presents a uniquely challenging problem in that many assessments have to be based on model predictions rather than on experiments. These are high-priority research investigations that need to be addressed before complete reliance for disposal area performance is made on clays and clay minerals.

• Journal of the Korean Society of Safety
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• v.34 no.4
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• pp.103-110
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• 2019

Underwater works are indispensable in the coastal and ocean engineering fields, and the reliance on manpower is higher than land works. Divers who work for a long time in a high-pressure underwater environment are always exposed to the risks of diving-related diseases. To prevent them, proper planning, operation, and management of diving by a supervisor with professional diving knowledge are required. This study provides the basic data for supervisors to plan, operate, and manage air diving for safe and efficient work in underwater construction sites. It is well-known that air diving simulations using the varying permeability model (VPM) require a longer decompression time as the water depth and the residence time in water increase. Therefore, it is crucial to have a proper surface interval through repetitive diving rather than single diving to improve the safety of the divers and the efficiency of underwater work. Furthermore, coastal and ocean engineers who manage and supervise underwater construction work must acquire expert knowledge on diving before they can plan, operate, and manage diving.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.6
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• pp.131-140
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• 2021

It is becoming more important to utilize reclaimed lands in South Korea, due to the increasing competition for its usage among different sectors. However, the high groundwater level and poor permeability are exposing them to deterioration by salinization. Salinization is difficult to predict because the pattern changes according to various characteristics of soil and groundwater. In this study, the capillary rising time was studied by the water content profile in the soil. The prediction equation of soil salinity was developed based on simulation result of the CHEMFLO model. to enable prediction considering various soil water content and groundwater level. The two terms constituting the equation showed the coefficients of determination of 0.9816 and 0.9824, respectively. Using the prediction equation of the study, the surface salinity can be easily predicted from the initial surface salinity and the salinity of the groundwater. In the future, more precise predictions will be possible with the results of studies on the hydraulic characteristics of various reclaimed soils, changes in water content profile by seasonal and climate events.

• Journal of the Korean Society of Visualization
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• v.19 no.1
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• pp.50-56
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• 2021

With the advances in recent nanotechnology, mass transport phenomena have been receiving large attention both in academic researches and industrial applications. Nonetheless, it is not clearly determined which parameters are dominant at nanoscale mass transport. Especially, membrane is a kind of technology that use a selective separation to secure fresh water. The development of great separation membrane and membrane-based separation system is an important way to solve existing water resource problems. In this study, glass fiber-based membranes which are treated by graphene oxide (GO), poly-styrene sulfonate (GOP) and sodium dodecyl sulfate (GPS) were fabricated. Mass transport parameters were investigated in terms of material-specific and structure-specific dominance. The 3D structural information of GO, GOP, and GPS was obtained by using synchrotron X-ray nano tomography. In addition, electrostatic characteristic and water absorption rate of the membranes were investigated. As a result, we calculated internal structural information using Tomadakis-Sotrichos model, and we found that manipulation of surface characteristics can improve spacer arm effect, which means enhancement of water permeability by control length of ligand and surface charge functionality of the membrane.

• Structural Engineering and Mechanics
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• v.83 no.1
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• pp.79-92
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• 2022

In this paper, the impact of a vernacular pozzolanic kaolinite mine on concrete alkali-silica reaction and strength has been evaluated. For making the samples, kaolinite powder with various levels has been used in the quality specification test of aggregates based on the ASTM C1260 standard in order to investigate the effect of kaolinite particles on reducing the reaction of the mortar bars. The compressive strength, X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM) experiments have been performed on concrete specimens. The obtained results show that addition of kaolinite powder to concrete will cause a pozzolanic reaction and decrease the permeability of concrete samples comparing to the reference concrete specimen. Further, various machine learning methods have been used to predict ASR-induced expansion per different amounts of kaolinite. In the process of modeling methods, optimal method is considered to have the lowest mean square error (MSE) simultaneous to having the highest correlation coefficient (R). Therefore, to evaluate the efficiency of the proposed model, the results of the support vector machine (SVM) method were compared with the decision tree method, regression analysis and neural network algorithm. The results of comparison of forecasting tools showed that support vector machines have outperformed the results of other methods. Therefore, the support vector machine method can be mentioned as an effective approach to predict ASR-induced expansion.

• Journal of the Korea Safety Management & Science
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• v.25 no.1
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• pp.23-29
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• 2023

Among the Additive Manufacturing (AM) technologies, the Binder-Jetting printing technology is a method of spraying an adhesive on the surface of powder and laminate layer by layer. Recently, this technique has become a major issue in the production of large casting products such as ship-building, custom vehicles and so on. In this study, we performed research to make actual mold castings and increase mechanical property by using special sand and water-based binders. For use as a mold, it has a strength of more than 3MPa and permeability. Various experiments were carried out to obtain suitable them. The major process parameters were binder jetting volume, binder types, layer thickness and heat treatment condition. As a result of this study, the binder drop quantity was measured to be about 60 pico-liter, layer thickness was 100㎛ and the heat treatment condition was measured about 1,000℃ and compressive strength were measured to be more than 5MPa. The optimum condition of this experiment was established through actual casting of aluminum. The equipment used in this study was a Freeforms T400 model (SFS Co., Ltd.), and the printing area of 420 * 300 * 250mm and resolution of 600dpi can be realized.

• Safety and Health at Work
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• v.14 no.1
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• pp.107-117
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• 2023

Background: Thermophysiological comfort in a cold environment is mainly ensured by clothing. However, the thermal performance and protective abilities of textile fabrics may be sensitive to extreme environmental conditions. This article evaluated the thermal insulation properties of three technical textile assemblies and determined the influence of environmental parameters (temperature, humidity, and wind speed) on their insulation capacity. Methods: Thermal insulation capacity and air permeability of the assemblies were determined experimentally. A sweating-guarded hotplate apparatus, commonly called the "skin model," based on International Organization for Standardization (ISO) 11092 standard and simulating the heat transfer from the body surface to the environment through clothing material, was adopted for the thermal resistance measurements. Results: It was found that the assemblies lost about 85% of their thermal insulation with increasing wind speed from 0 to 16 km/h. Under certain conditions, values approaching 1 clo have been measured. On the other hand, the results showed that temperature variation in the range (-40℃, 30℃), as well as humidity ratio changes (5 g/kg, 20 g/kg), had a limited influence on the thermal insulation of the studied assemblies. Conclusion: The present study showed that the most important variable impacting the thermal performance and protective abilities of textile fabrics is the wind speed, a parameter not taken into account by ISO 11092.

• Journal of the Korean GEO-environmental Society
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• v.13 no.5
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• pp.13-24
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• 2012

In this study, the in-situ model test has been conducted and used to estimate and analyze consolidation behavior of the ground by using the miniature test that reconstructs economically geotechnical behavior of in-situ full scale structure. To analogize the relation among effective stress, void ratio and coefficient of permeability at the self-weight consolidation stage, the low stress seepage consolidation test has been conducted and the involution function of constitutive equation had been obtained from the result of the curve fitted seepage consolidation test result. As a result of the numerical analysis that had been conducted on the representative section using a constitute equation, final settlement was similar with those of self-weight consolidation of the centrifugal model test. But, it was more or less smaller. It seems that these trends are caused by the difference between estimated values.