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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity

생약 조성물, DTS20의 알코올 분해 및 항염증 효과

  • Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University) ;
  • Jo, Sun-Young (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Lee, Sue-Jung (Department of Food & Nutrition, Yuhan University) ;
  • Kim, Eun-Young (Department of Food & Nutrition, Yuhan University) ;
  • Shin, Kwang-Soon (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Suh, Hyung-Joo (Department of Food and Nutrition, Korea University)
  • Received : 2011.08.04
  • Accepted : 2011.10.11
  • Published : 2011.10.31
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Abstract

These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.

Keywords

References

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