• Journal of Korean Neurosurgical Society
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• 제56권3호
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• pp.269-271
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• 2014

Spinal subdural hematoma is a rarely reported disease and spontaneous spinal subdural hematomas (SSDH) without underlying pathological changes are even rarer. The patients usually show typical symtoms such as back pain, quadriplegia, paraplegia or sensory change. But rarely, patients may show atypical symptoms such as hemiparesis and misdiagnosed to cerebrovascular accident. We recently experienced a case of SSDH, where the patient initially showed vague symptoms, such as the sudden onset of headache which we initially misdiagnosed as subarachnoid hemorrhage. In this case, the headache of patient improved but the neck pain persisted until hospital day 5. Therefre, we conducted the MRI of cervical spine and finally confirmed SSDH. The patient was managed conservatively and improved without recurrence. In this case report, we discuss the clinical features of SSDH with emphasis on the importance of an early diagnosis.

• 한국패류학회지
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• 제8권1호
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• pp.52-60
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• 1992

Clams were collected from mouth part of Mangeong Gang(river) of which heavy metals were heavily contaminated. Scapharca subcrenata, one of the clams, were fed to mice for 1-2 months with regular food stuffs. Eventhough difference of body weight was recognized between the experimental group and normal diat group, accumulation of heavy metals examined, cadmium was found 1.16 $\mu\textrm{g}$/gm in liver, 3.31 $\mu\textrm{g}$/gm in kidney and 0.21 $\mu\textrm{g}$/gm in blood of experimental group at 60th day, whereas 0.14 $\mu\textrm{g}$/gm, 0.35$\mu\textrm{g}$/gm and 0$\mu\textrm{g}$/gm respectively in normal diet group ate tje same period. No specific histo pathological finding was found in brain and kidney, although slighr fatty change and focal necrosis were found in liver tissues of the experimental group in second month.

• Childhood Kidney Diseases
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• 제23권1호
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• pp.1-6
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• 2019

Nephrotic syndrome (NS) is the most common glomerular disorder in childhood, and a vast majority of cases are idiopathic. The precise cause of this common childhood disease is not fully elucidated despite significant advancements in our understanding of podocyte biology. Idiopathic NS has been considered "a disorder of T-cell function" mediated by a circulating factor that alters podocyte function resulting in massive proteinuria since the last four decades. Several circulatory factors released from T-cells are considered to be involved in pathophysiology of NS; however, a single presumptive factor has not been defined yet. Extended evidence obtained by advances in the pathobiology of podocytes has implicated podocytes as critical regulator of glomerular protein filtration and podocytopathy. The candidate molecules as pathological mediators of steroid-dependent NS are CD80 (also known as B7-1), hemopexin, and angiopoietin-like 4. The "two-hit" hypothesis proposes that the expression of CD80 on podocytes and ineffective inhibition of podocyte CD80 due to regulatory T-cell dysfunction or impaired autoregulation by podocytes results in NS. Recent studies suggest that not only T cells but also other immune cells and podocytes are involved in the pathogenesis of MCNS.

• 대한치과의료관리학회지
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• 제6권1호
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• pp.1-10
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• 2018

Prior to the end of the 20th century, microorganism research was limited to culture and has since been revolutionized by genetic analysis. Microorganisms, including bacteria, can cause disease, but most of them are commensal microorganisms in our bodies. This knowledge changes the pathological approach to infectious diseases and lends to a new perspective on the effects of gut and oral microorganisms on disease and health. The oral cavity, particularly the periodontal pocket, is considered to be a reservoir of microbes that cause disease, and oral microbial control is becoming more important. In this review, I will examine the changes in the microbiological revolution and the meaning of oral healthcare management based on those changes.

• Journal of Medicine and Life Science
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• 제20권4호
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• pp.178-182
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• 2023

Aneurysmal venous dilatation is a frequent complication of arterio venous fistulas (AVFs) created for hemodialysis. Venous aneurysm rupture can lead to lethal hemorrhage. A 49-year-old male patient presented with a giant aneurysmal dilatation of his AVF 10 years after its creation. The patient had complaints of pulsating pain and discomfort due to swelling of the left forearm. We performed an aneurysm resection and revised the overlying dermal lesion through a brachial plexus block. Here, we describe the pathological features of the arterialized venous aneurysm compared to simple venous aneurysms.

• Applied Microscopy
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• 제5권1호
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• pp.9-19
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• 1975

고구마 위축병의 병원해부학적 변화상과 myco-plasma 병원상의 식물체내 이동 관계를 조사하여 경단분열조직에서의 조직학적 방어기작을 연구하고저 고구마 수원 147 호 (Ipomoea batatas (L.) Lamm. Suwon 147) 를 재료로 하여 광학 및 전자현미경으로서 조직관찰 및 무병주 생산을 위한 조직배양 실험을 하였다. Mycoplasma 의 감염경로의 조사를 위하여 나병주의 경단분열조직을 부위별로 조직배양을 하여서 mycoplasma의 상승한계를 측정하고 아울러 mycoplasma 의 세포내의 변화상과 이동상을 살핀 결과는 다음과 같다. 1. Mycoplasma 는 원시 및 제 l 기 분열조직을 포함한 경단에서는 존재하지 않음을 확인하였고 그 밑의 유관속 분화층에서는 존재하고 있으며 분화조직으로 갈수록 그의 크기가 커지고 미분화 조직에 갈수록 소형이며 미숙한 mycoplasma 가 존재함을 관찰하였다. 2. 경단분열조직속에 mycoplasma 가 존재하지 않는 것은 미숙 mycoplasma가 통과 할 수 있는 사역 및 원형질연락계와 같은 통과구조가 미분화되기 때문에 통과되지 못하는 것으로 인정된다. 3. 조직배양에서 경단 $1.0{\sim}1.5mm$ 부위를 배양하여 얻어진 식물은 이병되지 않았으며 경단 $2.0{\sim}3.0mm$ 부위의 것에서는 이병이 됨을 볼 수 있었다. 이것은 배양온도에서는 미숙한 mycoplasma 가 퇴화되며 소실된다는 사실을 알 수 있다.

• Biomolecules & Therapeutics
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• 제32권1호
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• pp.154-161
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• 2024

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive paralysis. L-Citrulline is a nonessential neutral amino acid produced by L-arginine via nitric oxide synthase (NOS). According to previous studies, the pathogenesis of ALS entails glutamate toxicity, oxidative stress, protein misfolding, and neurofilament disruption. In addition, L-citrulline prevents neuronal cell death in brain ischemia; therefore, we investigated the change in the transport of L-citrulline under various pathological conditions in a cell line model of ALS. We examined the uptake of [¹⁴C]L-citrulline in wild-type (hSOD1wt/WT) and mutant NSC-34/ SOD1^G93A (MT) cell lines. The cell viability was determined via MTT assay. A transport study was performed to determine the uptake of [¹⁴C]L-citrulline. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was performed to determine the expression levels of rat large neutral amino acid transported 1 (rLAT1) in ALS cell lines. Nitric oxide (NO) assay was performed using Griess reagent. L-Citrulline had a restorative effect on glutamate induced cell death, and increased [¹⁴C]L-citrulline uptake and mRNA levels of the large neutral amino acid transporter (LAT1) in the glutamate-treated ALS disease model (MT). NO levels increased significantly when MT cells were pretreated with glutamate for 24 h and restored by co-treatment with L-citrulline. Co-treatment of MT cells with L-arginine, an NO donor, increased NO levels. NSC-34 cells exposed to high glucose conditions showed a significant increase in [¹⁴C]L-citrulline uptake and LAT1 mRNA expression levels, which were restored to normal levels upon co-treatment with unlabeled L-citrulline. In contrast, exposure of the MT cell line to tumor necrosis factor alpha, lipopolysaccharides, and hypertonic condition decreased the uptake significantly which was restored to the normal level by co-treating with unlabeled L-citrulline. L-Citrulline can restore NO levels and cellular uptake in ALS-affected cells with glutamate cytotoxicity, pro-inflammatory cytokines, or other pathological states, suggesting that L-citrulline supplementation in ALS may play a key role in providing neuroprotection.

• Korean Journal of Radiology
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• 제24권5호
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• pp.384-394
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• 2023

Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT - pre-NCT)/pre-NCT Vbd × 100 (%). The stable, decreased, and increased groups were defined as -20% ≤ ΔVbd% ≤ 20%, ΔVbd% < -20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195-0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.

• 사상체질의학회지
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• 제24권1호
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• pp.1-12
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• 2012

1. Objective : The purpose of this study is to understand the origin, changes and composition of Soeumin's Bojungikgi-tang. 2. Methods : 1) Analyzed the context of the progressive transformation of soeumin's Bojungikgi-tang in related passages from "Donguibogam (東醫寶鑑)", "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午 本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)", "Dongmuyugo (東武遺稿)" 2) Examined the differences between the utilization of Soeumin's Bojungikgi-tang in pre-existing manuscripts according to pathological pattern and more specifically at a pathological stage. 3) Analyzed the total primary effect of the herbs as a prescriptive category, as well as the herbal properties of each component. 3. Results and Conclusions : 1) Originally Dongwon's Bojungikgi-tang was prescribed as a stomach & spleen organ tonifying medicine so it was easily applied and established as a prescription appropriate for Soeumin constitutional types with a weaker spleen organ. 2) From Gabobon(甲午本), Soeumin's Bojungikgi-tang was modified, excluding Bupleurum falcatum(柴胡), Cimicifuga heracleifolia (升麻) and substituting Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉) which are herbs appropriate for the Soeumin constitutional type. 3) In the Gabobon(甲午本), the Gegi-tang which has yang raising properties is included in the Soeumin's Bojungikgi-tang. In Sinchukbon(辛丑本), the Gegi-tang of the Soeumin's Bojungikgi-tang in the Gabobon was excluded and the Gegi-tang mutated into Hwangigyeji-tang. 4) In the Gabobon(甲午本), as the Soeumin's Bojungikgi-tang was prescribed for Soeumin disease regardless of favorable-unfavorable patterns and mild-severe patterns, the stage of the disease when to prescribe Soeumin's Bojungikgi-tang was not clarified. 5) As of the Sinchukbon(辛丑本) edition, as Soeumin's prescriptions have been obvious, the soeumin's Bojungikgi-tang was applied to Mang-yang disease with Hwangigyeji-tang and Seungyangikki-tang 6) As of the Sinchukbon(辛丑本) edition, the Soeumin's Bojungikgi-tang has been applied to parients having both exterior-heat Mang-yang disease and Greater-yin disease, at the same time. 7) As of the Sinchukbon(辛丑本) edition, finally, the Soeumin's Bojungikgi-tang formula has been established as gathering Qi and middle tonification with Panax ginseng(人蔘), Astragalus membranaceus(黃芪), keeping the spleen healthy with Artractylodes japonica(白朮), keeping the spleen strong with Angelica acutiloba(當歸), rooting the spleen with Citrus reticulata(陳皮), raising Yang and middle jiao with Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉), middle tonification with Glycyrrhiza glabra(甘草灸), Zingiber officinale(生薑), Zizyphus jujuba(大棗).

• 대한수의학회지
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• 제24권2호
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• pp.183-193
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• 1984

In this study lactating female rabbits and strains of coliforms previously isolated from the cases of acute and chronic mastitis in dairy cattle were employed. The pathological changes were observed on the mastitis experimentally induced with the coliform strains and the mamary glands after infusions of E. coli suspension together with dexamethasone, dextran iron or transferrin were grossly and microscopically observed. From the results reported, the following points are concluded. In the bacterial suspension-infused groups by E. coli, K. pneumoniae and Ent. aerogenes, respectively, the affected quarters of udder showed grossly swelling, hyperemia, hemorrhage, focal necrosis and firmness. The microscopic findings of early stage of the mastitis were appearance of large numbers of heterophils in the glandular lumina and ducts accompanied by degeneration, necrosis and desquamation of epithelial cells and also infiltration of heterophils, hemorrhage and edema in the interstitial tissue and destruction of alveoli. Later, proliferation of fibroblasts, plasma cells, lymphocytes, eosinophils and macrophages appeared in the glandular tissue and with these cells necrotic foci of glandular tissue were surrounded by highly proliferated connective tissue. In addition, granulomatous inflammatory changes could be observed in the glandular tissue from the 7th day after infusion. The difference of the inflammatory response among the groups did not recognized. In the groups infused with dexamethasone and E. coli suspension the inflammatory response was slighter at the inflammatory change with alveolar destruction and hemorrhage was more rapid and severer than E. coli alone. Also in the groups infused with dextran iron and E. coli suspension the inflammatory change was more rapid and severer than E. coli alone and the histological changes were not recognized in the groups infused with dextran iron alone. Reaction of the iron staining was diffusely strong positive within the glandular alveolar lumina in the groups of dextran iron alone, hut was slightly positive toward epithelial cells in the groups of dextran iron and E. coli infusion. In the group infused with transferrin and E. coli suspension, the inflammatory response was tighter, but the peroxidase activity of the heterophils in the glandular lumina was more or less stronger than E. coli alone.