• Parasites, Hosts and Diseases
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• v.60 no.1
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• pp.25-34
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• 2022

Alveolar echinococcosis (AE) caused by infection with E. multilocularis metacestode, represents one of the most fatal helminthic diseases. AE is principally manifested with infiltrative, proliferating hepatic mass, resembling primary hepatocellular carcinoma. Sometimes metastatic lesions are found in nearby or remote tissue. AE diagnosis largely depends on imaging studies, but atypical findings of imaging features frequently require differential diagnosis from other hepatic lesions. Serological tests may provide further evidence, while obtaining reliable AE materials is not easy. In this study, alternative antigens, specific to AE were identified by analyzing E. granulosus protoscolex proteins. An immunoblot analysis of E. granulosus protoscolex showed that a group of low-molecular-weight proteins in the range from 14 kDa to 16 kDa exhibited a sensitive and specific immune response to AE patient sera. Partial purification and proteomic analysis indicated that this protein group contained myosin, tubulin polymerization promoting protein, fatty-acid binding protein, uncharacterized DM9, heat shock protein 90 cochaperone tebp P-23, and antigen S. When the serological applicability of recombinant forms of these proteins was assessed using enzyme-linked immunosorbent assay, DM9 protein (rEgDM9) showed 90.1% sensitivity (73/81 sera tested) and 94.5% specificity (172/181 sera tested), respectively. rEgDM9 showed weak cross-reactions with patient sera from the transitional and chronic stages of cystic echinococcosis (3 to 5 stages). rEgDM9 would serve as a useful alternative antigen for serodiagnosis of both early- and advanced-stage AE cases.

• Structural Monitoring and Maintenance
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• v.10 no.1
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• pp.1-23
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• 2023

Various efforts have been made to reduce the weight of concrete slabs while preserving their flexural strength. This will result in reducing deflection and allows the utilization of longer spans. The top zone of the slab requires concrete to create the compression block for flexural strength, and the tension zone needs concrete to join with reinforcing for flexural strength. Also, the top and bottom slab faces must be linked to transmit stresses. Voided slab systems were and are still used to make long-span slab buildings lighter. Eight slab specimens of (1000^*1000 (1000^*1000 mm²) were cast and tested as two-way simply supported slabs in this research. The tested specimens consist of one solid slab and seven voided slabs with the following variables (type of slab solid and voided), thickness of slab (100 and 125 mm), presence of steel fibers (0% and 1%), and the number of GFRP layers). The voids in slabs were made using high-density polystyrene of dimensions (200^*200^*50 mm) with a central hole of dimensions (50^*50^*50 mm) at the ineffective concrete zones to give a reduction in weight by (34% to 38%). The slabs were tested as simply supported slabs under partial uniform loading. The results of specimens subjected to monotonic loading show that the combined strengthening by steel fibers and GFRP sheets of the concrete specimen (V-125-2GF-1%) shows the least deflection, deflection (4.6 mm), good ultimate loading capacity (192 MPa), large stiffness at cracking and at ultimate (57 and 41.74) respectively, more ductility (1.44), and high energy absorption (1344.83 kN.mm); so it's the best specimen that can be used as a voided slab under this type of loading.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.594-601
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• 2023

Objective: To demonstrate an improvement in metastatic cancer pain and a decrease in tumor size in a patient with non-small cell lung cancer. Method: A 53-year-old female patient diagnosed with metastatic non-small cell lung cancer in August 2022 underwent integrative cancer treatment (ICT) for two months to decrease the tumor size and improve back pain from bone metastasis. The patient underwent chemotherapy with ICT. Radiologic outcomes were assessed by chest, abdomen, and pelvis computed tomography based on the Response Evaluation Criteria in Solid Tumors (RECIST) protocol. Clinical outcomes were assessed using National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Eastern Cooperative Oncology Group (ECOG), and a numeric rating scale (NRS). Result: During the two months of treatment, the NRS scores for back pain were improved, and the ECOG score improved from grade 2 to 1. The size and metabolic activity of the primary lung tumor decreased and underwent partial remission based on RECIST. No serious side effects of grade 3 or higher were noted on the NCI-CTCAE test. Conclusion: This case suggests that ICT may have a therapeutic effect for cancer pain and a synergetic effect with chemotherapy for metastatic non-small cell lung cancer.

• Journal of Veterinary Science
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• v.24 no.5
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• pp.54.1-54.13
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• 2023

Background: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccines do not provide full cross-protection, mainly due to the virus genetic variability. Despite this, vaccines based on modified-live PRRSV (PRRSV-MLV) reduce the disease impact. Objectives: To assess the efficacy of two commercial vaccines-one based on PRRSV1 (PRRSV1-MLV) and another on PRRSV2 (PRRSV2-MLV)-against a Japanese PRRSV2 field strain. Methods: Two groups of three-week-old piglets were vaccinated (G1: PRRSV1-MLV; G2: PRRSV2-MLV) and two were kept as non-vaccinated (INF and CTRL). One month later, G1, G2, and INF were challenged with a PRRSV2 field strain. Results: After the challenge, clinical signs were only observed in INF. Moreover, the highest rectal temperatures and values for the area under the curve (AUC) were observed in INF. Regarding viral detection, both AUC and the proportion of positive samples in blood were higher in INF. In G1, viremic animals never reached 100%. At necropsy (21 d after the challenge), differences for titers among groups were only found in tonsils (G1 < G2 and INF). One animal (belonging to G1) was negative in all tissues. Regarding humoral responses, G1 and G2 seroconverted after vaccination, as detected in the corresponding enzyme-linked immunosorbent assay. Specific neutralizing antibodies (NA) against PRRSV1-MLV were already detected at 14 d after vaccination in G1, showing a significant booster after the challenge, while PRRSV2-MLV NA were detected in G2 at the end of the experiment. Conclusions: Despite genetic differences, PRRSV1-MLV has been demonstrated to confer partial protection against a Japanese PRRSV2 strain, at least as good as PRRSV2-MLV.

• Journal of Distribution Science
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• v.22 no.3
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• pp.33-47
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• 2024

Purpose: Most emerging-market countries are concerned about the technology boom, which is accompanied by an increase in revenue from online sales and services. This finding has been demonstrated during the COVID-19 pandemic; however, is this tendency continuing in the new normal, and what factors are driving the increase in consumer decisions? The purpose of this research is to investigate how the decision to utilize online services will be affected in the new normal as well as propose a new research approach in this field. Research Design, Methodology and Approach: By following a deductive research method associated with positivist philosophy, a survey in South Vietnam with 426 respondents using a convenience sampling method was conducted. The reliability of the measurement scales was examined by using the SPSS program. The SmartPLS programme was utilised to assess the measurement and structural models as well as test hypotheses by using partial least squares structural equation modelling. Results: According to the research findings, decision-making has been impacted by social influences, perceived usefulness, perceived ease of use, perceived trust, perceived price, and perceived convenience. Conclusions: The research results also bring significant contributions not only in practice in providing management implications but also in theory. The research model has also demonstrated the feasibility of employing the stimuli-organism-response framework and combining the theory of perceived risk with the technology acceptance model via the explanation of decision-making.

• Clinical Endoscopy
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• v.56 no.2
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• pp.194-202
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• 2023

Background/Aims: Endoscopic therapy for neoplastic Barrett's esophagus (BE) has become the standard of care over the past two decades. In clinical practice, we regularly encounter patients who fail to achieve complete squamous epithelialization of the esophagus. Although the therapeutic strategies in the individual stages of BE, dysplasia, and esophageal adenocarcinoma are well studied and largely standardized, the problem of inadequate healing after endoscopic therapy is only marginally considered. This study aimed to shed light on the variables influencing inadequate wound healing after endoscopic therapy and the effect of bile acid sequestrants (BAS) on healing. Methods: Retrospective analysis of endoscopically treated neoplastic BE in a single referral center. Results: In 12.1% out of 627 patients, insufficient healing was present 8 to 12 weeks after previous endoscopic therapy. The average follow-up duration was 38.8±18.4 months. Complete healing was achieved in 13 patients already after intensifying proton pump inhibitor therapy. Out of 48 patients under BAS, 29 patients (60.4%) showed complete healing. An additional eight patients (16.7%) improved, but only partial healing was achieved. Eleven (22.9%) patients showed no response to BAS augmented therapy. Conclusions: In cases of insufficient healing even under exhaustion of proton pump inhibitors, treatment with BAS can be an option as an ultimate healing attempt.

• Korean Journal of Radiology
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• v.21 no.12
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• pp.1383-1392
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• 2020

Objective: This study aimed to evaluate the efficacy and safety of ultrasound (US)-guided minimally invasive treatment in patients with parathyroid lesions. Materials and Methods: This study included 27 patients who had undergone US-guided radiofrequency ablation (RFA) or ethanol ablation (EA) for parathyroid lesions between January 2010 and 2018. RFA was performed in 19 patients with primary hyperparathyroidism (PHPT, n = 11) or secondary hyperparathyroidism (SHPT, n = 8), and EA was performed in eight patients with symptomatic nonfunctioning parathyroid cysts (SNPCs). Nodule size, volume, serum parathyroid hormone (PTH) and calcium levels were recorded before and after treatment. Complications were evaluated during and after treatment. Results: In patients with PHPT, significant reductions in size and volume were noted after RFA at 6- and 12-month follow-up (all, p < 0.05). Seven nodules nearly completely disappeared (residual volume < 0.1 mL); serum PTH and calcium levels were reduced to normal ranges (7/11, 63.6%). Four patients experienced partial reductions of serum PTH and calcium levels (4/11, 36.4%). In patients with SHPT, three experienced therapeutic response of serum PTH (3/8, 37.5%), while five showed persistent hyperparathyroidism (5/8, 62.5%) within 6 months after RFA. In patients with SNPCs, EA resulted in significant reductions in cyst size and volume (all, p < 0.05) at the last follow-up. A total of four complications (two transient hypocalcemia [RFA], one permanent [RFA], and one transient [EA] hoarseness) were observed. Conclusion: Minimally invasive treatments, such as RFA and EA, may serve as therapeutic alternatives for patients with PHPT or SNPCs; they may have limited usefulness in patients with SHPT.

• Earthquakes and Structures
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• v.26 no.3
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• pp.175-189
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• 2024

Aiming at studying the plastic hinge (PH) evolution regularities and failure mode of rocking wall moment frame (RWMF) structure in earthquakes, the whole-working history analysis of seismic performance state of RWMF structure based on co-operation performance and PH evolution was carried out. Building upon the theoretical analysis of the elastic internal forces and deformations of RWMF structures, nonlinear finite element analysis (FEA) methods were employed to perform both Pushover analysis and seismic response time history analysis under different seismic coefficients (δ). The relationships among PH occurrence ratios (R_ph), inter-story drifts and δ were established. Based on the plotted curve of the seismic performance states, evaluation limits for the R_ph and inter-story drifts were provided for different performance states of RWMF structures. The results indicate that the R_ph of RWMF structures exhibits a nonlinear evolution trend of "fast at first, then slow" with the increasing of δ. The general pattern is characterized by the initial development of beam hinges in the middle stories, followed by the development towards the top and bottom stories until the beam hinges are fully formed. Subsequently, the development of column hinges shifts from the bottom and top stories towards the middle stories of the structure, ultimately leading to the loss of seismic lateral capacity with a failure mode of partial beam yield, demonstrating a global yielding pattern. Moreover, the limits for the R_ph and inter-story drifts effectively evaluate the five different performance states of RWMF structures.

• Journal of Environmental Science International
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• v.33 no.3
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• pp.193-203
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• 2024

This study aims to determine the factors affecting the level of satisfaction with the Cell Broadcast Service (CBS) among citizens in Incheon. Partial least squares (PLS) regression, instead of multiple regression, was used for the analysis because it can solve multicollinearity and sample size issues. The analysis results are as follows: The factor with the greatest effect on satisfaction with CBS among Incheon citizens, was the elimination of redundancies (VIP=1.185). Therefore, local governments, government agencies, and public organizations must coordinate their ideas and collectively create guidelines to eliminate redundancies. The second most influential factor was the expansion in the broadcast medium from legal, institutional, and policy aspects (VIP=1.087). This is because differences in generation, age, gender, and personal characteristics were not considered. Therefore, it is necessary to devise a customized messaging tool through the expansion of broadcast media. The broadcast criteria of the legal, institutional, and policy perspectives comprised the third most influential factor, with a high VIP value of 1.053. Consequently, it is essential to devise a plan to avoid distributing unnecessary cell broadcast services, by establishing criteria for areas and sections, time, and the direct and indirect impact zones of a disaster. In the future, this study could be used as base data to develop policies, guidelines, and response measures for Incheon CBS. Given the lack of research on the diverse characteristics of each social class and the city traits of each region, and a lack of concrete empirical research on each factor, continuous and in-depth studies are required in the future.

• Nuclear Engineering and Technology
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• v.56 no.7
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• pp.2534-2544
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• 2024

This paper proposes a flooding safety system (FSS) and its operation strategy that can provide long-term safety and effective maintenance for modules of small modular reactor (SMR) and metal containment maintained at dried environment during normal operation. During hypothesized accidents, the FSS re-collects the evaporated steam into the common pool by the condenser installed above the common water pool and provides an emergency coolant for the cavities and auxiliary pools. This study suggested that the condensate re-collection strategy using the FSS can effectively delay the depletion of available water in response to the accidents. Without recollection, the achievable grace periods ranged from 44 to 1507 days for six-module and one-module accidents, respectively. However, with a full re-collection (ratio = 1.0), the time to total depletion of emergency coolant was estimated indefinite. Even with a partial re-collection ratio of 0.3, a grace period of 83.5 days could be ensured for a six-module transient. This study reported the effectiveness of condensate re-collection and the FSS as an innovative safety management strategy and system. Employing a condensate re-collection strategy with a high re-collection ratio can enhance the long-term safety and effective convenience of SMR operations and maintenance.