• 한국사회정책
• /
• v.24 no.2
• /
• pp.157-179
• /
• 2017

In Korea, 'spoon class discourse' has attracted public attention in the press and among young people, which reflects that mass awareness that the class status structure is clearly rooted in the society becomes widespread. Although income distribution has been improved since late 2000s, it is interesting that Korean people's subjective perception concerning class mobility and social justice has been worsemed. By using the survey data on people's perception of opportunity inequality, this study finds that Korean people have by and large negative subjective awareness regarding socio-economic opportunity inequality, magnitude of opportunity inequality, and achievement by efforts, and that the degree of the negative perception is greater in accordance with the people's subjective identification. The regression analysis reveals that the social status of respondents and their parents(-), experience of discrimination(+), age(-), and high education of college and above (+) have consistent effect over socio-economic opportunity inequality, magnitude of opportunity inequality, and achievement by efforts with statistical significance. More concretely, as people have lower subjective status identification at the time of parent generation and their own generation, as they have the experience of discriminatory misconduct, and as they are young and highly educated, they have negative or pessimistic perception regarding opportuinity inequality. In addition, it is revealed that the unemployed and non-regular workers have significantly negative perception on socio-economic opportunity inequality, magnitude of opportunity inequality, while negative perception on the magnitude of opportunity inequality and achievement by efforts is noticeable among high and middle income households.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.16 no.3
• /
• pp.1-12
• /
• 2021

In this paper, we study empirically examined the adventurous investments in corporate venture capital (CVC) firms' investment in the U.S. based corporate venture capital industry. Unlike existing studies focusing CVC firm's characteristics related to parent corporates and regarding CVC firm as a vehicle of corporate venturing, we identified CVC firm as an independent learning agent to adapt to dynamic environment and investigate their exploration and exploitation in investments based on organizational learning theory. Specifically, we investigate the market-environmental factors affecting CVC's adventurous investment in different sector rather than previously done. First, we examined competition intensity in CVC industry might be related to CVC firm's explorative investments. Second, CVC firm's investment experiences might affect as an inertia to invest on unexperienced sector. Finally, we investigated risk preference effect on CVC firm's venturing investments. The empirical data analyzed in the study contained a total of 85 U.S. based CVC firms and their 2,306 investments from 1996 until 2017. After conducting a GEE regression analysis and a Logit regression analysis, we found the significance and direction of our independent and moderating variables strongly supported all of our four hypotheses in a highly robust manner.

• Korean Journal of School Psychology
• /
• v.17 no.3
• /
• pp.243-261
• /
• 2020

Fear of missing out (FoMO) refers to the desire to stay continually connected with what others are doing because they are afraid of missing the flow or not being included. Although FoMO has been recently proposed as a widespread phenomenon within social media, there has been few empirical research by which mechanism FoMO leads to social networking service (SNS) addiction. Therefore, this study examined whether FoMO mediated the relationship between adolescents' attachment and SNS addiction proneness. A total of 517 middle and high school students participated in the study and completed self-report questionnaires. Results showed that FoMO partially mediated the relationship between adolescents' parental attachment and SNS addiction proneness, whereas the relationship between adolescents' peer attachment and SNS addiction proneness was fully mediated by FoMO. These results suggest that unstable attachment might contribute to SNS addiction through FoMO, especially in case of peer attachment. Lastly, we discussed theoretical and practical implications of this study and suggestions for future research.

• Journal of Service Research and Studies
• /
• v.11 no.2
• /
• pp.67-77
• /
• 2021

This study is a study on the methodology of establishing an innovation strategy centering on the customer experience, which is essential in order to transform the existing collection and preservation-centered mutual aid company service into a visitor-centered service. To this end, we conducted literature research on environmental changes in the funeral industry from the perspective of service science and the significance and value of customer experiences within them, good customer experiences and bad customer experiences from the perspective of customer experience management. A study was conducted to present and prove a specific model. The customer experience-oriented innovation strategy of the funeral industry means to search for various alternatives that can reach the target state from the present state, focusing on the customer, and select the most appropriate transformation plan among them. As an effect of application, it was found that it is a source of differentiation by generating positive emotions to customers, and that customer experience data is highly helpful in making important decisions for the actual resource input of the parent company. This innovation model was presented, and its value was firstly proved by analyzing the difference from the existing evaluation method. Finally, as a result of analyzing the causal relationship through regression analysis using the customer experience measurement procedure, customer experience diagnosis/evaluation, customer experience innovation strategy, and cooperative company's performance as variables, the relationship proved to be significant.

• 한국노년학
• /
• v.31 no.4
• /
• pp.1083-1101
• /
• 2011

The purpose of this study is to describe how the structural and functional features of social network change among widowed middle and older adults and to examine the effect of personal predictors of the social network change. Data was obtained from men and women between 45 to 98 years of age(N=118) who were bereaved by the death of their spouse since the first wave survey and participated in the second wave survey of the Korean Longitudinal Study of Ageing(KLoSA). The main findings are as follows: First, their social network after the bereavement was strengthened centered around children; for example, the number of adult children living in proximity to the parent, frequency of contact with children, and the financial and non-financial support from children generally increased. Second, the social network change pattern was categorized into four types such as "overall increased type," "children-centered increased type," "children/close relationship-centered increased type," and "stagnation type." Finally, the health condition of the widowed middle and older adults was a strong predictor of the social network change.

• Korean Journal of Culture and Social Issue
• /
• v.14 no.1_spc
• /
• pp.273-298
• /
• 2008

The purpose of this study is to explore a risk and a protective factors of adolescent runaway based on the previous researches. Runaway of adolescents is increasing, and it is longer and more habit gradually than past. The prevailance methods of runaway is no longer effects on the decrease of adolescent runaway. Now there is to accept adolescent runaway, and has to support the difficult life conditions and the emotional distress of adolescent post-runaway. This means that must be identify and treatment the protective factors having an buffering effect as well as the risk factors influencing on runaway. Although the worse factors related family are the highest risk factors of runaway, others factors including negative peer relation, a academic stress also an have significant influence on runaway. And the protective factors mediating the negative influence of risk factors are an monitoring and controlling of parent as authoritative rearing attitude, a social support, a positive coping strategies, a self-esteem, and a conventional peer group. Protective factors prevent from runaway behavior, as well as improve a resilience of adolescents in the poor environment. The tasks of follow study are to investigate empirically the mediating effects of the protective factors on the problem behavior of post-runaway and resilience of runaway adolescents based on the systematic research design.

• Journal of Ginseng Research
• /
• v.47 no.5
• /
• pp.662-671
• /
• 2023

Background: 20(S)-protopanaxadiol (PPD), a ginsenoside metabolite, has prominent benefits for the central nervous system, especially in improving learning and memory. However, its transcriptional targets in brain tissue remain unknown. Methods: In this study, we first used mass spectrometry-based drug affinity responsive target stability (DARTS) to identify the potential proteins of ginsenosides and intersected them with the transcription factor library. Second, the transcription factor PURA was confirmed as a target of PPD by biolayer interferometry (BLI) and molecular docking. Next, the effect of PPD on the transcriptional levels of target genes of PURA in brain tissues was determined by qRT-PCR. Finally, bioinformatics analysis was used to analyze the potential biological features of these target proteins. Results: The results showed three overlapping transcription factors between the proteomics of DARTS and transcription factor library. BLI analysis further showed that PPD had a higher direct interaction with PURA than parent ginsenosides. Subsequently, BLI kinetic analysis, molecular docking, and mutations in key amino acids of PURA indicated that PPD specifically bound to PURA. The results of qRT-PCR showed that PPD could increase the transcription levels of PURA target genes in brain. Finally, bioinformatics analysis showed that these target proteins were involved in learning and memory function. Conclusion: The above-mentioned findings indicate that PURA is a transcription target of PPD in brain, and PPD upregulate the transcription levels of target genes related to cognitive dysfunction by binding PURA, which could provide a chemical and biological basis for the study of treating cognitive impairment by targeting PURA.

• Journal of the Korean Society of Radiology
• /
• v.85 no.1
• /
• pp.3-23
• /
• 2024

Intervertebral disc herniation is frequently encountered in radiological practice. Sequestered disc herniation occurs when the disc material undergoes degeneration and completely loses continuity with the parent nucleus pulposus. Sequestered discs can reside within and outside the spinal canal, exerting a mass effect on adjacent structures, compressing nerve pathways, and eliciting a range of clinical symptoms. In particular, sequestered discs within the dura cannot be identified without durotomy. Therefore, precise preoperative localization is crucial for surgical planning. On MRI, the signal intensity of the sequestered disc may vary due to independent degeneration processes. Additionally, most sequestered disc fragments show varying degrees of peripheral enhancement depending on the degree of angiogenesis and granulation around the isolated tissue. In this article, we review various imaging findings and the location of the sequestered disc to provide patients with an accurate diagnosis and appropriate treatment direction.

• International Journal of Oncology
• /
• v.56 no.1
• /
• pp.368-378
• /
• 2020

Meridianin C is a marine natural product with anticancer activity. Several meridianin C derivatives (compounds 7a-j) were recently synthesized, and their inhibitory effects on pro-viral integration site for Moloney murine leukemia virus (PIM) kinases, as well as their antiproliferative effects on human leukemia cells, were reported. However, the anti-leukemic effects and mechanisms of action of meridianin C and its derivatives remain largely unknown. The aim of the present study was to investigate the effects of meridianin C and its derivatives on MV4-11 human acute myeloid leukemia cell growth. The parent compound meridianin C did not markedly affect the viability and survival of MV4-11 cells. By contrast, MV4-11 cell viability and survival were reduced by meridianin C derivatives, with compound 7a achieving the most prominent reduction. Compound 7a notably inhibited the expression and activity of PIM kinases, as evidenced by reduced B-cell lymphoma-2 (Bcl-2)-associated death promoter phosphorylation at Ser112. However, meridianin C also suppressed PIM kinase expression and activity, and the pan-PIM kinase inhibitor AZD1208 only slightly suppressed the survival of MV4-11 cells. Thus, the anti-survival effect of compound 7a on MV4-11 cells was unrelated to PIM kinase inhibition. Moreover, compound 7a induced apoptosis, caspase-9 and -3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, but did not affect death receptor (DR)-4 or DR-5 expression in MV4-11 cells. Compound 7a also induced the generation of cleaved Bcl-2, and the downregulation of myeloid cell leukemia (Mcl)-1 and X-linked inhibitor of apoptosis (XIAP) in MV4-11 cells. Furthermore, compound 7a increased eukaryotic initiation factor (eIF)-2α phosphorylation and decreased S6 phosphorylation, whereas GRP-78 expression was unaffected. Importantly, treatment with a pan-caspase inhibitor (z-VAD-fmk) significantly attenuated compound 7a-induced apoptosis, caspase-9 and -3 activation, PARP cleavage, generation of cleaved Bcl-2 and downregulation of Mcl-1 and XIAP in MV4-11 cells. Collectively, these findings demonstrated the strong anti-survival and pro-apoptotic effects of compound 7a on MV4-11 cells through regulation of caspase-9 and -3, Bcl-2, Mcl-1, XIAP, eIF-2α and S6 molecules.

• The Journal of Korean Academy of Sensory Integration
• /
• v.18 no.3
• /
• pp.14-26
• /
• 2020

Objective : The purpose of this study was to investigate the effect of therapeutic listening on task performance, auditory behavior problems, and attention in children with sensory modulation disorder. Methods : Sixteen children aged four to seven years who were classified as children with sensory modulation disorder were randomly assigned to either the experimental group (n = 8) or the control group (n = 8). From July 1 to October 18, 2017, both groups participated in sensory integration programs, while therapeutic listening training was administered only to the experimental group. Sensory integration therapy was conducted in two sessions per week for six weeks (12 sessions); each session consisted of 40 minutes of therapy and 10 minutes of parent education. Therapeutic listening was conducted in three thirty-minute sessions per week for six weeks (18 sessions). We used the Canadian Occupation Performance Measure (COPM) to evaluate changes in the participants' occupational performance between pre- and post-intervention. We used Fisher's Auditory Problems Checklist (FAPC) to observe changes in behavioral problems related to hearing. The Child Attention Scale for Teacher (CAST) was used to evaluate changes in attention. Results : No significant differences pre- and post-intervention between the two groups were observed. The participants' auditory behavioral problems improved significantly in the experimental group, but no significant difference was found between the two groups. There was no significant difference in attention between the two groups, but there was a significant difference between the two groups in the "adaptability" and "emotion" domains (p < .05). Conclusion : The results suggest that therapeutic listening training has a positive effect on reducing problematic behaviors related to hearing and improving the occupational performance of children with sensory modulation disorder. This study provides a basis for improving the sensory processing ability of children with sensory modulation disorder by applying listening training in the clinical field and at home.