• The Korea Journal of Herbology
• /
• v.31 no.5
• /
• pp.1-6
• /
• 2016

Objectives : Nardostachys jatamansi (NJ) is a medicinal herb that has been reported in various traditional systems of medicine for its use in antispasmodic, a digestive stimulant, skin diseases. Previous studies have already reported that NJ effectively protects against inflammation. However, the active compound in NJ is unknown. Therefore, in the present study, we analyzed effects of a compound, 8α-hydroxy pinoresinol (HP), isolated from NJ against lipopolysaccharide (LPS) induced inflammation in RAW 264.7 cells.Methods : To examine the anti-inflammatory effect of HP against LPS, intraperitoneally pre-treat the HP (100, 200, 500 and 1,000 nM) 1 h prior to LPS challenges. LPS was stimulated with 500 ng/ml in RAW 264.7 cells. To identify the anti-inflammatory effect of HP, we measured inflammatory mediators such as inducible nitric oxide synthase (iNOS) and its derivative nitric oxide (NO), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2). Also we evaluated molecular mechanisms including mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-κB) activation by western blot.Results : The HP inhibited production of inflammatory mediators, such as iNOS and its derivative NO, COX-2 and PGE2 in LPS- induced inflammationin RAW 264.7 cells. Additionally, HP also inhibited activation of p38 pathway signaling but not extracellularsignal-regulatedkinase (ERK), c-jun NH2-terminal kinase (JNK), and NF-κB.Conclusion : Our results suggest that HP has anti-inflammatory functions through the dephosphorylation of p38 and HP can provide beneficial strategy for prevention and therapy of inflammation.

• The Journal of Korean Medicine
• /
• v.21 no.3
• /
• pp.99-112
• /
• 2000

Objective: This study was conducted to suggest a proper administration system of the quality of herbal medicine. Methods: Related literature was carefully inspected and discussions among specialists in the field of herbal medicine's growth, production, circulation and administration were conducted. Results: 1. The administration of herbal medicine's quality should be done in each stage of its circulation; growing stage, harvesting stage, importing stage, production stage, quality examination stage, wrapping stage, circulating stage, and administration stage. 2. A safety standard should be established for items, parts and origins of each medicinal herb. A standard for the identification of forged products and objective standards for quality discrimination should also be established. 3. A national system for the training of herbal medicine quality administration personnel and herbal medicine discrimination personnel should be established. A data base of standardized product specimens should be established and a pharmacopoeia of herbal medicine should be published as a standard of quality administration in herbal medicine. 4. Research into the following preliminary areas should be conducted to investigate quality adminstration of herbal medicine: research related to herbal medicine's raw materials and herbal medicinal drugs; quality estimation of raw materials and drugs; quality administration in oriental medical hospitals; herbal medicine administration law; herbal medicine administration organization; herbal medicinal pharmacology; and policy-related research for the quality improvement of domestically grown medicinal herbs. Conclusion: For the proper administration of herbal medicine's quality, governmental support and intensive research among specialists should be done for the supply of good quality medicinal herbs and the improvement of the efficacy of herbal medicine.

• The Journal of Internal Korean Medicine
• /
• v.44 no.6
• /
• pp.1150-1175
• /
• 2023

Objectives: This study was conducted to examine the current status of traditional Korean medicine studies on chronic prostatitis in Korea, identify deficiencies, and suggest future medicine research methods to lay the foundation for traditional Korean medicine treatment. Methods: All domestic clinical research papers on the traditional Korean treatment of chronic prostatitis were selected from the literature published until October 2023 in three domestic databases. A total of 13 selected research data were classified into clinical research papers. Results: In clinical research papers, the basis for the diagnosis of cases was clinical symptoms through medical history listening and diagnosis through past visits to hospitals. The average treatment period was 7 weeks, and the duration of treatment was not significantly affected by the duration of the disease. The most widely used Korean medicine treatment intervention was herbal medicine. Conclusions: This study included all domestic clinical research papers on chronic prostatitis to identify research trends in the Korean oriental medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans.

• Archives of Pharmacal Research
• /
• v.26 no.7
• /
• pp.516-520
• /
• 2003

A reversed-phase high performance liquid chromatographic method was developed to determine the contents of psoralen and angelicin from some medicinal herbs. The optimum eluent for chromatography was 20 v/v% acetonitrile in water on a Zorbax 300SB $C_{18}$ column. The identification was carried out by comparing the retention time and mass spectra of the relevant peaks with their standards. The variation of the concentration of psoralen and angelicin was wide between different species. The seeds of Psoralea corylifolia showed the highest contents of psoralen (7.8 mg/g) and angelicin (2.3 mg/g) among the tested herbs.

• Culinary science and hospitality research
• /
• v.22 no.6
• /
• pp.14-23
• /
• 2016

This purpose of this study is to examine the antioxidant and antimicrobial activities of Persicaria hydropiper L. extract in 70% ethanol and in water, a medicinal herb, as an effort to examine the potential of medicinal herbs for development of antioxidants and natural preservative substitutes. The total poly-phenol content in the 70% ethanol extract and in the water extract were 19.88 mg/g and 7.46 mg/g, respectively. The DPPH radical scavenging activity was 90.99% and 64.98% in the 70% ethanol extract and water extract, in which 70% ethanol extract showed a higher activity. The antioxidant effect of Persicaria hydropiper L. extract appears to be very good and due to its excellent growth inhibitory effect on food-poisoning-causing microorganisms in the food, it is thought to be utilized as a potential natural preservative substitute in many areas.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.54 no.2
• /
• pp.198-202
• /
• 2009

The starch properties of two chinese yams were evaluated in this study. Amylose content ranged 13.5% to 19.3%. The swelling power of starches varied 10.98% to 11.43%. Water binding capacity in chinese yam starches ranged 93.46% to 107.21%, high WBC was observed in Ma 1. The onset temperature (To) of two chinese yam starches ranged 62.9 to $75.0^{\circ}C$, peak temperature (Tp) ranged 76.2 to $84.7^{\circ}C$. The PHI(peak height index) was about 4-fold higher in Anwon cultivar than in Ma 1 cultivar. SEM revealed that starches has a presence of large oval or spherical to small irregular-shape granules. Starch granule size ranged 15.23 to 15.52 ${\mu}m$, showing a typical C-type X-ray pattern.

• Journal of Korean Medical classics
• /
• v.21 no.3
• /
• pp.43-58
• /
• 2008

Wanghogo(王好古) is a prominent doctor in Geum-Won(金元) Dynasty. He is also the inheritor of Jangwonso(張元素) and Igo(李杲) in study, and studied "Hwangjenaegyeong(黃帝內經)", "Sanghallon(傷寒論)". So, he contributed to a later age. Although we have some researches of Wanghogo, but the researches in his books are insufficient as yet. More, the publication year of his books have some different views, so I tried to study this. By this study, We can understand that Wanghogo published "Uiruwonyung(醫壘元戎)" which is for exogenous febrile disease and miscellaneous diseases in general plan of twelve meridians in 1297, "Eumjeung-yangnye(陰證略例)" which is for harm and diagnosis and treatment of Eum syndromes of exogenous febrile disease in 1303, and "Tang-aekboncho(湯液本草)" which is for property and flavor and meridian tropism of Herb and five kind of flavor's tonification and reduction, the meaning of prescription, care of health by food, "Chasananji(此事難知)" which is for meridian, Jangbu(臟腑), pathology, pathogen, clinical distinction, medical care in 1308.

• Natural Product Sciences
• /
• v.20 no.1
• /
• pp.13-16
• /
• 2014

Five compounds were isolated from the stem of Zea mays. Based on spectral data, they were identified as 4-hydroxybenzaldehyde (1), N-trans-p-coumaryl tyramine (2), N-trans-ferulyl tryptamine (3), N-(p-coumaryl) serotonine (4), and N-(p-coumaryl)-tryptamine (5). All isolates were evaluated in vitro for their inhibitory activity on acetylcholinesterase. Among tested compounds, compounds 2 - 5 exhibited acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 125, 60.4, 183.5 and 53.3 ${\mu}M$, respectively. Compound 1 did not show acetylcholinesterase inhibitory activity in the present study.

• The Korean Journal of Pharmacology
• /
• v.5 no.2
• /
• pp.75-79
• /
• 1969

Aconitum Koreanum rhizoma has been applied in therapy from old in oriental medicine (Korean Hanbang), The action of the water and alcohol extracts of the rhizoma and root of Aconitum Koreanum R. Raymond, a common herb in Korea, on the isolated Frog heart and $LD_{50}$ were observed. The results of the studies were as follows: 1. The cardiac effect in the concentration of the extracts$(10^{-3})$ was increased and duratrin of action prolonged approximately 10 minutes, but in the extracts $(3{\times}10^{-3})blocked$. 2. The $LD_{50}$ of extracts were 722 mg/kg (water) and 151mg/kg (alcohol) intraperitoneally in mice.

• Toxicological Research
• /
• v.13 no.4
• /
• pp.349-352
• /
• 1997

Scopoliae rhizoma is a perennial herb which has a similar effect with atropine on the cardiovascular system. It is also known to have a seditive and anticonvulsant activity on the central nerve system. In order to evaluate an acute toxicity of Scopoliae rhizoma, the present study was performed after administration the Scopoliae rhizoma prepared by both decoctional and frozen dried extract through three different routes (oral; 5,000 mg/kg, intraperitoneal; 2,000 mg/kg, subcutaneous; 5,000 mg/kg) to the female ICR mice. In the group treated intraperitoneally with a frozen dried extract, abnormal clinical signs such as decreased activity, crouch, potosis and abnormal walking were observed for 40 rain after administration. With regard to WBC, decreased number of lymphocyte and increased number of monocyte and granulocyte were also observed in the animals received intraperitoneally with Scopoliae rhizoma extract. Taken together, what toxicity of Scopoliae rhizoma was shown differently depending on its type for administration may be resulted in the differency of administered dose. The results provided here support a pharmacological and toxicological consideration for its clinical use in the regard of oriental medicine.