• Nuclear Engineering and Technology
• /
• 제55권9호
• /
• pp.3150-3163
• /
• 2023

To improve the performance of blanket: maximizing the tritium breeding rate (TBR) for tritium self-sufficiency, and minimizing the Dose of backplate for radiation protection, most previous studies are based on manual corrections to adjust the blanket structure to achieve optimization design, but it is difficult to find an optimal structure and tends to be trapped by local optimizations as it involves multiphysics field design, which is also inefficient and time-consuming process. The artificial intelligence (AI) maybe is a potential method for the optimization design of the blanket. So, this paper aims to develop an intelligent optimization method based on an improved multi-objective NSGA-III algorithm and an adaptive BP neural network to solve these problems mentioned above. This method has been applied on optimizing the radial arrangement of a conceptual design of CFETR HCSB blanket. Finally, a series of optimal radial arrangements are obtained under the constraints that the temperature of each component of the blanket does not exceed the limit and the radial length remains unchanged, the efficiency of the blanket optimization design is significantly improved. This study will provide a clue and inspiration for the application of artificial intelligence technology in the optimization design of blanket.

• Nuclear Engineering and Technology
• /
• 제55권4호
• /
• pp.1382-1399
• /
• 2023

Pressure relief valve (PRV) is one of the important control valves used in nuclear power plants, and its sealing performance is crucial to ensure the safety and function of the entire pressure system. For the sealing performance improving purpose, an explicit function that accounts for all design parameters and can accurately describe the relationship between the multi-design parameters and the seal performance is essential, which is also the challenge of the valve seal design and/or optimization work. On this basis, a surrogate model-based design optimization is carried out in this paper. To obtain the basic data required by the surrogate model, both the Finite Element Model (FEM) and the Computational Fluid Dynamics (CFD) based numerical models were successively established, and thereby both the contact stresses of valve static sealing and dynamic impact (between valve disk and nozzle) could be predicted. With these basic data, the polynomial chaos expansion (PCE) surrogate model which can not only be used for inputs-outputs relationship construction, but also produce the sensitivity of different design parameters were developed. Based on the PCE surrogate model, a new design scheme was obtained after optimization, in which the valve sealing stress is increased by 24.42% while keeping the maximum impact stress lower than 90% of the material allowable stress. The result confirms the ability and feasibility of the method proposed in this paper, and should also be suitable for performance design optimizations of control valves with similar structures.

• Smart Structures and Systems
• /
• 제31권3호
• /
• pp.283-299
• /
• 2023

Structural stability of floating platforms has long since been a crucial issue in the field of marine engineering. Excessive motions would not only deteriorate the operating conditions but also seriously impact the safety, service life, and production efficiency. In recent decades, several control devices have been proposed to reduce unwanted motions, and an attractive one is the tuned heave plate (THP). However, the THP system may reduce or even lose its effectiveness when it is mistuned due to the shift of dominant wave frequency. In the present study, a novel adaptive tuned heave plate (ATHP) is proposed based on inerter by adjusting its inertance, which allows to overcome the limitation of the conventional THP and realize adaptations to the dominant wave frequencies in real time. Specifically, the analytical model of a representative semisubmersible platform (SSP) equipped with an ATHP is created, and the equations of motion are formulated accordingly. Two optimization strategies (i.e., J₁ and J₂ optimizations) are developed to determine the optimum design parameters of ATHP. The control effectiveness of the optimized ATHP is then examined in the frequency domain by comparing to those without control and controlled by the conventional THP. Moreover, parametric analyses are systematically performed to evaluate the influences of the pre-specified frequency ratio, damping ratio, heave plate sizes, peak periods and wave heights on the performance of ATHP. Furthermore, a Simulink model is also developed to examine the control performance of ATHP in the time domain. It is demonstrated that the proposed ATHP could adaptively adjust the optimum inertance-to-mass ratio by tracking the dominant wave frequencies in real time, and the proposed system shows better control performance than the conventional THP.

• Wind and Structures
• /
• 제37권4호
• /
• pp.303-314
• /
• 2023

In this study, two steady RANS turbulence models (SST k-ω and Realizable k-ε) and four unsteady turbulence models (URANS SST k-ω and Realizable k-ε, SST-SAS, and SST-IDDES) are evaluated with respect to their capacity to predict crosswind characteristics on high-speed trains (HSTs). All of the numerical simulations are compared with the wind tunnel values and LES results to ensure the accuracy of each turbulence model. Specifically, the surface pressure distributions, time-averaged aerodynamic coefficients, flow fields, and computational cost are studied to determine the suitability of different models. Results suggest that the predictions of the pressure distributions and aerodynamic forces obtained from the steady and transient RANS models are almost the same. In particular, both SAS and IDDES exhibits similar predictions with wind tunnel test and LES, therefore, the SAS model is considered an attractive alternative for IDDES or LES in the crosswind study of trains. In addition, if the computational cost needs to be significantly reduced, the RANS SST k-ω model is shown to provide relatively reasonable results for the surface pressures and aerodynamic forces. As a result, the RANS SST k-ω model might be the most appropriate option for the expensive aerodynamic optimizations of trains using machine learning (ML) techniques because it balances solution accuracy and resource consumption.

• Molecules and Cells
• /
• 제46권12호
• /
• pp.764-777
• /
• 2023

Recombinant immunotoxins (RITs) are fusion proteins consisting of a targeting domain linked to a toxin, offering a highly specific therapeutic strategy for cancer treatment. In this study, we engineered and characterized RITs aimed at mesothelin, a cell surface glycoprotein overexpressed in various malignancies. Through an extensive screening of a large nanobody library, four mesothelin-specific nanobodies were selected and genetically fused to a truncated Pseudomonas exotoxin (PE24B). Various optimizations, including the incorporation of furin cleavage sites, maltose-binding protein tags, and tobacco etch virus protease cleavage sites, were implemented to improve protein expression, solubility, and purification. The RITs were successfully overexpressed in Escherichia coli, achieving high solubility and purity post-purification. In vitro cytotoxicity assays on gastric carcinoma cell lines NCI-N87 and AGS revealed that Meso(Nb2)-PE24B demonstrated the highest cytotoxic efficacy, warranting further characterization. This RIT also displayed selective binding to human and monkey mesothelins but not to mouse mesothelin. The competitive binding assays between different RIT constructs revealed significant alterations in IC₅₀ values, emphasizing the importance of nanobody specificity. Finally, a modification in the endoplasmic reticulum retention signal at the C-terminus further augmented its cytotoxic activity. Our findings offer valuable insights into the design and optimization of RITs, showcasing the potential of Meso(Nb2)-PE24B as a promising therapeutic candidate for targeted cancer treatment.

• International Journal of Internet, Broadcasting and Communication
• /
• 제16권2호
• /
• pp.237-246
• /
• 2024

In recent years, the frequent occurrence of fire accidents in university libraries has posed significant threats to the safety of students' lives and property, alongside negative social impacts. Accurately analyzing the factors affecting evacuation during library fires and proposing optimized measures for safe evacuation is thus crucial. This paper utilizes a specific university library as a case study, simulating fire evacuation scenarios using the Pathfinder software, to assess and validate evacuation strategies and propose relevant optimizations. Pathfinder, developed by Thunderhead Engineering in the United States, is an intuitive and straightforward personnel emergency evacuation assessment system, offering advanced visualization interfaces and 3D animation effects. This study aims to construct evacuation models and perform simulation analysis for the selected university library using Pathfinder. The library's structural layout, people flow characteristics, and the nature of fire and smoke spread are considered in the analysis. Additionally, evacuation scenarios involving different fire outbreak locations and the status of emergency exits are examined. The findings underscore the importance of effective evacuation in fire situations, highlighting how environmental conditions, individual characteristics, and behavioral patterns significantly influence evacuation efficiency. Through these investigations, the study enhances understanding and optimization of evacuation strategies in fire scenarios, thereby improving safety and efficiency. The research not only provides concrete and practical guidelines for building design, management, and emergency response planning in libraries but also offers valuable insights for the design and management of effective evacuation systems in buildings, crucial for ensuring occupant safety and minimizing loss of life in potential hazard situations

• 한국조경학회지
• /
• 제48권5호
• /
• pp.16-27
• /
• 2020

본 연구는 서울시 도심 하천 중 국가하천인 중랑천을 대상으로 보전지역 설정 프로그램인 Marxan with zones 프로그램을 기반으로 한 하천 내 보전지역 설정 및 생태적 관리방안을 제시하였다. Marxan with zones 프로그램 적용은 유역권(planning unit) 설정, 맵핑지표(mapping index) 적용, 반복적인 분석을 위한 수치보정, 분석을 통한 시나리오 별 최적안 작성, 시나리오 별 민감도 분석, 시나리오 중 최적안 검토 및 선정 단계로 진행하였다. 중랑천 내 보전지역 설정 결과, 기존에 보전지역으로 지정 및 관리하고 있는 중랑천 상류 야생생물보호구역을 포함한 다수의 유역권과 중랑천 하류의 철새보호구역을 포함한 유역권이 핵심보전지역으로 설정되었다. 상류는 중랑천을 중심으로 수락산과 도봉산 등 산림이 인접하여 다수의 야생조류가 관찰되었다. 하류는 한강 합수부, 청계천 합수부 등 하천생태계가 인접하여 하천을 따라 이동하는 철새 도래지이다. 따라서 중랑천 상류와 하류는 유역권 내 도봉산, 수락산, 응봉산 등 산림생태계, 도심 내 녹지, 청계천 합수부, 한강 합수부 등 다양한 생태계와 연결되어 있어 보전지역 설정에 영향을 주었다. 본 연구는 보전지역 검증 시 Marxan with zones 프로그램을 통한 기존 보전지역 설정 및 평가를 검증하였고, 프로그램을 통해 핵심보전지역으로 도출된 유역권을 생태적으로 관리하기 위해 하천 내 관리방안과 유역권 관리방안으로 구분하여 제시하였다.

• 한국응용과학기술학회지
• /
• 제29권2호
• /
• pp.199-204
• /
• 2012

유기 박막 트랜지스터 (organic thin-film transistors; OTFTs)는 유기 반도체 그리고 디스플레이와 같은 분야에 그들의 잠재적인 응용 가능성 때문에 많은 주목을 받고 있다. 하지만 급격한 산화 혹은 낮은 전기 이동도와 같은 단점으로 인하여 n-형 물질은 p-형 물질에 비해서 상대적으로 많은 연구가 진행되지 못한 실정이다. 따라서 본 논문에서는 n-형 반도체 물질인 [6,6]-phenyl-C61-butyricacidmethylester (PCBM)과 Poly(4-vinylphenol) (PVP)을 유기 절연막으로 이용하여 o-dichlorobenzene, toluene and chloroform과 같은 다양한 유기 용매를 사용한 플라스틱 기판에 유기트랜지스터를 제작하였고 유기 용매가 ODCB 경우 전계 효과 이동도는 약 0.034 $cm^2/Vs$ 그리고 점멸비(on/off ratio)는 ${\sim}1.3{\times}10^5$ 으로 향상 되었다. 다양한 유기 용매의 휘발성에 따라서 PCBM TFT의 전기적 특성에 미치는 영향을 규명하였다.

• 한국산학기술학회논문지
• /
• 제17권11호
• /
• pp.635-639
• /
• 2016

초고주파 대역에서 사용하는 소자들은 기생성분으로 인하여 주파수가 증가함에 따라 이득이 감소한다. 이러한 특성을 보상하기 위해 전자전과 같은 광대역 시스템에서는 반대의 기울기를 갖는 선형 이득 등화기가 필요하다. 본 논문에서는 18~40GHz 대역에서 사용할 수 있는 선형 이득 등화기를 설계하고 제작하였다. 설계와 제작의 오차를 줄이기 위하여 회로설계와 모멘텀 설계를 진행하였다. 구현 주파수 대역 내에서 가능한 기생성분을 최소화하기 위해 thin film 공정을 사용하였으며, 박막저항의 길이에 의한 파장 변화를 최소화하기 위해 100 ohm/square의 sheet resistance로 설계하였다. 본 선형 이득 등화기는 직렬 마이크로스트립 라인에 사분의 일 파장을 갖는 공진기를 저항으로 결합하는 구조이다. 모두 3개의 1/4 파장의 Short 공진기를 사용하였다. 제작된 선형 이득 등화기는 40GHz에서 -5dB 이상의 손실을 가졌으며, 18 ~ 40 GHz 대역에서 6dB 기울기를 나타내었다. 제작된 이득 등화기를 전자전 수신기와 같은 광대역 MMIC들이 다단으로 연결된 장치 내부에 사용한다면 주파수가 증가에 따른 이득 평탄도 악화를 감소시킬 수 있을 것이다.

• 한국수자원학회:학술대회논문집
• /
• 한국수자원학회 2008년도 학술발표회 논문집
• /
• pp.500-504
• /
• 2008

The objective of this paper is to evaluate the feasibility of using an optimization model as a effective way to search conjunctive operation scheme to meet two conditions; one is to minimize the electric cost for pumping and another is to meet the water demand for satisfying customers. The feasibility is confirmed as comparing the best combinations of pumps between multi-regional water supply networks from multiple sources which are obtained through an optimization modeling and EPAnet modeling. KModsim model, a network optimization model, was used to determine conjunctive operation scheme in the pipe system. KModsim, based on Lagrangian Relaxation algorithm, is useful for modeling network system and obtaining simultaneously pump combination and water allocation with given input option such as energy unit cost supplying from a source into a consumer, operating pumping combination. This study develops the procedure of determining optimal conjunctive operation scheme with using KModsim model. As a study region, the water supplying systems of the Geojae-city in the Geongsang Namdo Province was selected and investigated. The EPAnet hydraulic simulation result(Ryu et al, 2007, KSWW) gave input data for optimization model; energy unit price(won/$m^3$), water service available area etc.. It was assured that the combination of pump operation through optimum conjunctive operation is to be optimum scheme to obtain the best economic water allocation with comparison to the hydraulic simulation result such as electric cost and pump combination cases. The results obtained through the study are as follows. First, It was found that a well-allocated water supply scheme, the best combination of pump operation through optimum joint operation, promises to save the electric cost and satisfy all operational goals such as stability and revenues during the period. Second, an application of KModSim, a network model, gave the amount of water allocation from each source to a consumer with consideration of economic supply. Finally, in a service area available to supply through conjunctive operation of existing inter-regional water supply networks within short distance, a conjunctive operation is useful for determining each transmission pipeline's service area and maximizing the effectiveness of optimizations in pumping operation time.