• Radiation Oncology Journal
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• v.2 no.1
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• pp.59-69
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• 1984

Guidelines for the optimal management of patients with cervical cancerous nodes from an unknown primary site, has not been yet settled. However. radical treatment has been advocated employing either a surgery, or radiotherapy, or a combination of the two in relation to the location, stage and histologic features of the nodes in the neck. Of 43 patients who presented with 'Cervical metastases from an unknown primary' since 1971, $31.2\%$ survived 3 years after adequate management. Combined modality with surgery and radiation showed more favorable treatment results: in local control rate, 3 year survival rates and the subsequent appearances of the contralateral side of neck node through the retrospective analysis. In 11 cases, the primary tumors became apparent later, carcinoma of the hypopharynx, being the most frequent site, rather than the nasopharynx.

• Magazine of the Korean Society of Agricultural Engineers
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• v.43 no.5
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• pp.70-82
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• 2001

This study was conducted to derive the regional design rainfall by the regional frequency analysis based on the regionalization of the precipitation suggested by the first report of this project. Using the L-moment ratios and Kolmogorov-Smirnov test, the underlying regional probability distribution was identified to be the Generalized extreme value distribution among applied distributions. Regional and at-site parameters of the generalized extreme value distribution were estimated by the linear combination of the probability weighted moments, L-moment. The regional and at-site analysis for the design rainfall were tested by Monte Carlo simulation. Relative root-mean-square error(RRMSE), relative bias(RBIAS) and relative reduction(RR) in RRMSE were computed and compared with those resulting from at-site Monte Carlo simulation. All show that the regional analysis procedure can substantially reduce the RRMSE, RBIAS and RR in RRMSE in the prediction of design rainfall. Consequently, optimal design rainfalls following the legions and consecutive durations were derived by the regional frequency analysis.

• Journal of Environmental Science International
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• v.30 no.3
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• pp.289-293
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• 2021

This study was conducted to investigate the distribution of duck production in duck housing as a function of the breeding period. The items in duck production distribution included body weight, feed intake, feed conversion ratio, and average duck production. All data were based on eight cycles (June and December, 2017; February, June, August, September, and November, 2018; February, 2019) at Farm Site 1 through 7. The most optimal results in the duck production distribution were observed at Site 1 for weight gain, feed intake, and feed efficiency. This could be explained by the fact that Site 1 was well managed in environmental improvement and sustainability. Based on these data, selective alternatives to improve duck production in duck farms are recommended as follows: first, proper management and recording of litter used as a flooring material are required, and second, continuous management such as temperature, relative humidity and ventilation is needed. Lastly, it is necessary to change duck facilities by introducing environmental management techniques. Furthermore, efforts to improve the overall facilities and management of duck breeding farms through additional field studies are needed in the future.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.55 no.11
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• pp.532-537
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• 2006

Lightning induced faults accounts for more than 66% at the transmission lines of KEPCO. The lightning causes damages to power system equipments including transmission line, the blackout of electricity and the electro-magnetic interference. Because of this reason, we need the real time lightning information for the optimal operation of power system. And, it is required to obtain and accumulate the lightning current parameters for the insulation design. In 2005, KEPRI constructed a lightning detection network, the KLDNet (i.e. Kepco Lightning Detection & Information System) and launched a lightning information service for KEPCO customers. It is intended to provide data service on the operation of transmission lines and collect lightning-related data, which is the most important factor regulating power system design and operation. The new system will replace LPATS, the old detection system, which has been operating since 1995 and is rapidly failing in terms of both detection performance and location accuracy. The purpose of this paper is to explain the work performed and the results of that work in performing a site survey of several locations. The purpose of the site survey is to find locations acceptable for the installation of a lightning location receiver in support of a Lightning detection system(LDS). A restriction was placed on the surveyed locations, as they must belong to the Korea Electric Power Company. This requirement was made to facilitate the communication needs of the LDS network. Total of 15 sites were evaluated as possible LDS sensor sites. Some of the sites were rejected for physical reasons and therefore no electrical testing was performed. Of the 15 sites, total of 10 sites were considered acceptable and 5 sites were rejected for various reason. In this paper, we would like to explain the site survey and detection efficiency for LDS.

• Molecules and Cells
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• v.43 no.4
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• pp.350-359
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• 2020

Pathogenic aminoacyl-tRNA synthetases (ARSs) are attractive targets for anti-infective agents because their catalytic active sites are different from those of human ARSs. Mupirocin is a topical antibiotic that specifically inhibits bacterial isoleucyl-tRNA synthetase (IleRS), resulting in a block to protein synthesis. Previous studies on Thermus thermophilus IleRS indicated that mupirocin-resistance of eukaryotic IleRS is primarily due to differences in two amino acids, His581 and Leu583, in the active site. However, without a eukaryotic IleRS structure, the structural basis for mupirocin-resistance of eukaryotic IleRS remains elusive. Herein, we determined the crystal structure of Candida albicans IleRS complexed with Ile-AMP at 2.9 A resolution. The largest difference between eukaryotic and prokaryotic IleRS enzymes is closure of the active site pocket by Phe55 in the HIGH loop; Arg410 in the CP core loop; and the second Lys in the KMSKR loop. The Ile-AMP product is lodged in a closed active site, which may restrict its release and thereby enhance catalytic efficiency. The compact active site also prevents the optimal positioning of the 9-hydroxynonanoic acid of mupirocin and plays a critical role in resistance of eukaryotic IleRS to anti-infective agents.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.1
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• pp.52-66
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• 2009

The increase of rice productivity, the decrease of rice demand, aging farmers, and the market-opening of rice along with the domestic and international conditions changes have been led to the increase of the abandoned rice paddy fields. Such abandoned rice paddy fields have been left in many areas and most of them have become wetlands. The purpose of this study is methodology of selection to the wetland for development in the abandoned rice paddy fields along with surroundings. The selection of habitat suitability index assessment study to conservation and restoration was done through hydrology, wild animals habitation, wetland vegetation, outside disturbance, and natural purification capacity assessment. In addition, the same method was applied to assessment items and standards for both the restoration site selection and the type of restoration. Both assessment items and standards were applied to the sites, drawn on the maps, and overlayer for the comprehensive map, and then the wetland suitability index was applied to the suitable site. The development technique was applied to 10 sites near the Banwol Stream watershed in Gunpo, Gyeonggi province. The selection of conservation, restoration, and the optimal sites can lead to not only the biodiveristy increase in agricultural or semi natural areas but also to the establishment of ecological networks in national level.

• Bulletin of the Korean Chemical Society
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• v.30 no.6
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• pp.1360-1364
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• 2009

The bacterium Sphingomonas chungbukensis DJ77 produces the extracellular polysaccharide gellan in high yield. Gellan produced by this bacterium is widely used as a gelling agent, and the enzyme UDP-glucose pyrophosphorylase (UGP) is thought to play a key role in the gellan biosynthetic pathway. The UGP gene has been successfully cloned and over-expressed in E. coli. The expressed enzyme was purified with a molecular weight of approximately 32 kDa, as determined by a SDS-polyacrylamide gel, but the enzyme appears as ca. 63 kDa on a native gel, suggesting that the enzyme is present in a homodimer. Kinetic analysis of UDP-glucose for UGP indicates $K_m$ = 1.14 mM and $V_{max}$ = 10.09 mM/min/mg at pH 8.0, which was determined to be the optimal pH for UGP catalytic activity. Amino acid sequence alignment against other bacteria suggests that the UGP contains two conserved domains: An activator binding site and a glucose-1-phosphate binding site. Site-directed mutagenesis of Lys194, located within the glucose-1-phosphate binding site, indicates that substitution of the charge-reversible residue Asp for Lys194 dramatically impairs the UGP activity, supporting the hypothesis that Lys194 plays a critical role in the catalysis.

• Advances in Computational Design
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• v.4 no.2
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• pp.119-139
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• 2019

Planning and management building projects should tackle the coordination of works and the management of limited spaces, traffic and supplies. Activities cannot be performed without the resources available and resources cannot be used beyond the capacity of workplaces. Otherwise, workspace congestion will negatively affect the flow of works. Better on-site management allows for substantial productivity improvements and cost savings. The procurement system should be able to manage a wider variety of materials and products of the required quality in order to have less stock, in less time, using less space, with less investment and avoiding multiple storage stations. The objective of this paper is to demonstrate the advantages of using the Chronographic modeling, by combining spatiotemporal technical scheduling with the 4D simulations, the Last Planner System and the Takt-time when modeling the construction of building projects. This paper work toward the aforementioned goal by examining the impact that material flow has on site occupancy. The proposed spatiotemporal model promotes efficient site use, defines optimal site-occupancy and workforce-rotation rates, minimizes intermediate stocks, and ensures a suitable procurement process. This paper study the material flow on the site and consider horizontal and vertical paths, traffic flows and appropriate means of transportation to ensure fluidity and safety. This paper contributes to the existing body of knowledge by linking execution and supply to the spatial and temporal aspects. The methodology compare the performance and procurement processes for the proposed Chronographic model with the Gantt-Precedence diagram. Two examples are presented to demonstrate the benefits of the proposed model and to validate the related concepts. This validation is designed to test the model's graphical ability to simulate construction and procurement.

• Journal of the Korean association of regional geographers
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• v.3 no.1
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• pp.63-80
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• 1997

This study attempts to establish the criteria of site selection for establishing solid waste disposal facility, to determine optimal solid waste disposal sites with the criteria, and to examine the suitability of the selected sites. The Multi-Criteria Evaluation(MCE) module in Idrisi is used to determine optimal sites for solid waste disposal. The MCE combines the information from several criteria in interval and/or ratio scale to form a single index of evaluation without leveling down the data scale into ordinal scale. The summary of this study is as follows: First, the considerable criteria are selected through reviewing the literature and the availability of data: namely, percent of slope, fault lines, bedrock characteristics, major residential areas, reservoirs of water supply, rivers, inundated area, roads, and tourist resorts. Second, the criteria maps of nine factors have been developed. Each factor map is standardized and multiplies by its weight, and then the results are summed. After all of the factors have been incorporated, the resulting suitability map is multiplied by each of the constraint in turn to "zero out" unsuitable area. The unsuitable areas are discovered in urban district and its adjacencies, and mountain region as well as river, roads, resort area and their adjacency districts. Third, the potential sites for establishing waste disposal facilities are twenty five districts in Youngyang-gun. Five districts are located in Subi-myun Sinam-ri, nine districts in Chunggi-myun Haehwa-ri and Moojin-ri, and eleven districts in Sukbo-myun Posan-ri. The first highest score of suitability for waste disposal sites is shown at number eleven district in Chunggi-myun Moojin-ri and the second highest one is discovered at number twenty one district in Sukbo-myun Posan-ri that is followed by number nine district in Chunggi-myun Haehwa-ri, number seventeen and twenty three in Sukbo-myun Posan-ri, and number two in Subi-myun Sinam-ri. The first lowest score is found in number six district in Chunggi-myun Haehwa-ri, and the second lowest one is number five district in Subi-myun Sinam-ri. Finally, the Geographic Information System (GIS) helps to select optimal sites with more objectively and to minimize conflict in the determination of waste disposal sites. It is important to present several potential sites with objective criteria for establishing waste disposal facilities and to discover characteristics of each potential site as a result of that final sites of waste disposal are determined through considering thought of residents. This study has a limitation of criteria as a result of the restriction of availability of data such as underground water, soil texture and mineralogy, and thought of residents. To improve selection of optimal sites for a waste disposal facility, more wide rage of spatial and non-spatial data base should be constructed.

• Tuberculosis and Respiratory Diseases
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• v.41 no.1
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• pp.20-25
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• 1994

Background: Hemoptysis is a common clinical symptom, responsible for 11% of admission to the hospital chest service. Correct diagnosis, accurate localization of the bleeding source and proper management are imperative to reduce the risk of massive hemoptysis. We performed the study to define the optimal time of fiberoptic bronchoscopy in 63 patients with hemoptysis admitted to Kyung Hee University Hospital between Aug 1989 and Aug 1992. Methods: Retrospective analysis of medical records concerning the cause, amount, duration of hemoptysis and the timing of fiberoptic bronchoscopy in 63(M:F=36:27) patients. Results: 1) The main causes of hemoptysis were pulmonary tuberculosis(52.4%) bronchiectasis(27.0%) and lung cancer(11.1%). 2) The bleeding sites were localized in 26 patients(41.3%). 3) The rates of localization of bleeding site were not related to the amount and duration of hemoptysis. 4) The rates of localization of bleeding site were 61.8%(21/34) during hemoptysis, 18.2%(22) within 24hr after resolution of hemoptysis, 14.3%(1/7) thereafter. Conclusion : Early bronchoscopy, especially during hemoptysis may show higher rates of successful localization than delayed bronchoscopy.