• 대한인간공학회지
• /
• 제16권2호
• /
• pp.73-82
• /
• 1997

Daily exposure to constrained body postures and deviations from neutral postures over a long period may result in discomfort as well as pains and aches in the muscles, joints, tendons, and other soft tissues. Furthermore, it was known that poor body postures are a major cause of musculoskeletal disorders in industry. Therefore, in this study, comfort ranges of joint motions were obtained as a criterion for evaluating body postures and designing workplaces ergonomically, which were bases on subjects' perceived discomfort level estimated by magnitude estimation. Nineteen healthy male subjects participated in the laboratory study. They results showed that comfort ranges of joint motions occurred in the wrist, elbow, neck, and ankle were little less than their normal range of joint motions, but those in the back(L5/S1) and hip joint were much less than their normal ones. This fact implies that the back and jip movements are more stressful than the other joints movements. It is expected that comfort ranges of joint motions can be used as a valuable guideline when designing and evaluating workplaces.

• Journal of Genetic Medicine
• /
• 제13권2호
• /
• pp.89-94
• /
• 2016

Purpose: Molecular genetic analysis is the main approach used for prenatal diagnosis of hemophilia A and B. However, in certain cases, such analysis is uninformative. In such situations, direct measurement of fetal coagulation factor levels is still the best option, and it may be the only option in some cases. This study was conducted to determine the normal ranges of mid-trimester cord blood factor VIII (FVIII) and IX (FIX) in a Korean population. Materials and Methods: Twenty-six FVIII samples and 29 FIX samples were assayed in fetal cord blood acquired by ultrasound-guided cordocentesis. Sampling was conducted during gestational ages of 19-24 weeks. Results: The mean and standard deviations for FVIII and FIX activity were $45.5{\pm}30.5%$ and $19.9{\pm}12.2%$, respectively. Ranges for FVIII and FIX were 1.5-125.0% and 6.0-52.0%, respectively. Conclusion: Our study revealed the normal ranges and lowest level of factor VIII and factor IX in non-affected normal fetus by fetal cord blood sampling during the mid-trimester in a Korea population. The factor assay of the fetal cord blood is invasive but feasible and provides important basic data related to hemophilia.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 1996년도 춘계학술대회논문집; 부산수산대학교, 10 May 1996
• /
• pp.177-183
• /
• 1996

By utilizing the concept of normal modes, nonlinear dynamics is studied on pendulum dynamic absorber. When the spring mode loses the stability in undamped free system, a dynamic two-well potential is formed in Poincare map. A procedure is formulated to compute the forced responses associated with bifurcating mode and predict double saddle-loop phenomenon. It is found that quasiperiodic motion and stable periodic motion coexist in some parameter ranges, and only periodic motions or rotation of pendulum with chaotic fluctuation are observed in other ranges.

• 대한핵의학회지
• /
• 제2권1호
• /
• pp.27-41
• /
• 1968

The ferrokinetics and red cell life spans of the patients with chronic glomerulonephritis were investigated by the double tracing method using radioactive iron ($^{59}Fe$) and chromium ($^{51}Cr$). According to the serum NPN levels, the patients were subdivided into 3 groups: Group 1. 6 patients, had the levels below 40 mg/dl Group 2. 6 patients, had the levels between 41 mg/dl to 80 mg/dl Group 3. 10 patients, had the levels above 80 mg/dl The results were as follows: 1) Red blood cell-, hematocrit- and hemoglobin values were moderately reduced in patients with normal serum NPN levels, while markedly reduced in patients with elevated serum NPN levels. 2) The plasma volume was increased, while the red cell volume was decreased in patients with elevated serum NPN levels, hence, total blood volume was unchanged. 3) The serum iron level was slightly reduced h patients of groups 1 and 2, while was within the normal ranges in patients of group 3. 4) i) In patients with normal serum NPN levels, the plasma iron disappearance rate, red cell iron utilization rate, red cell iron turnover rate, daily red cell iron renewal rate, circulating red cell iron and red cell iron concentration were within the normal ranges, while the plasma iron turnover rate was slightly reduced. ii) In patients with elevated serum NPN levels, the plasma iron disappearance rate was delayed, while the plasma iron turnover rate was within the normal ranges. The red cell iron utilization rate, red cell iron turnover rate and circulating red cell iron were decreased and the period in which the red cell iron utilization rate reachd its peak was delayed in Group 3 patients. The daily red cell iron renewal rate and the red cell iron concentration were unchanged. iii) The mean red cell life span was within the normal ranges in patients with normal serum NPN levels, while was shortened in patients with elevated serum NPN levels.

• 한국임상수의학회지
• /
• 제17권1호
• /
• pp.219-224
• /
• 2000

This study was conducted to examine the prognosis of canine pyometra after surgical treatment in terms of their clinical indications, hematology and serum chemistry. A total of 20 bitches diagnosed as pyometra after physical examination was hospitalized at the Veterinary Medical Teaching Hospital, Seoul National University, during the period of 1998 to 1999. After examining all profiles, ovariohysterectomy was performed to treat pyometra. All bitches had clinical symptoms of general depression, polyuria/polydipsia, anorexia and abdominal distension. In hematologic profiles, 65% of bitches had higher level of leukocyte count compared with normal level, but RBC and PCV values maintained within the normal ranges in most pyometric bitches. In serum chemistry profiler, ALT and ALP values were increased over the normal range, and BUN and creatine values were higher than normal ranges only in 10(50%) and 3 bitches (15%), respectively. Survival rate after ovariohisterectomy was 90% (18/20), but bitches that had higher ALT, ALP, BUN, creatine and potassium than normal values were died after surgical treatment. The results of this clinical investigation show that the recovery of pyometric bitches after ovariohysterectomy can be prognosed by hematologic and serum profiles including ALT, ALP, BUN, creatinine and potassium.

• 한국수정란이식학회지
• /
• 제29권2호
• /
• pp.119-125
• /
• 2014

Although the majority of surviving pigs cloned by somatic cell nuclear transfer (SCNT) appear to be physiologically normal, there is a general lack of detailed hemato-physiologic studies for the period of early adulthood to substantiate this claim. In the present study, we investigated variation in blood chemistry and endocrinological parameters between mesenchymal stem cells (MSCs) derived from cloned and normal age-matched female and male miniature pigs. Cloned females and males showed normal ranges for complete blood count assessments. Biochemical assessments showed that ${\gamma}$-GGT, ALT and cholesterol levels of male and female clones were significantly (P<0.05 or P<0.01, respectively) higher than that of age-matched control miniature pigs. Variations in insulin and IGF-1 were higher in female clones than in male clones and controls. Thus, although female and male cloned miniature pigs may be physiologically similar to normal animals, or at least within normal ranges, a greater degree of physiological and endocrinological variation was found in cloned pigs. The above variation must be taken into account before considering cloned female or male miniature pigs for various biomedical applications.

• Journal of the Korean Statistical Society
• /
• 제30권4호
• /
• pp.667-678
• /
• 2001

The asymptotic behavior and distribution for quantiles estimators using ranked samples are introduced. Applications of quantiles estimation on finding the normal ranges (2.5% and 97.5% percentiles) and the median of some medical characteristics and on finding the Hodges-Lehmann estimate are discussed. The conclusion of this study is, whenever perfect ranking is possible, the relative efficiency of quantiles estimation using ranked samples relative to SRS is high. This may translates to large savings in cost and time. Also, this conclusion holds even if the ranking is not perfect. Computer simulation results are given and real data from lows 65+ study is used to illustrate the method.

• Earthquakes and Structures
• /
• 제24권1호
• /
• pp.53-64
• /
• 2023

Earth fissures with several kilometers will inevitably approach or cross the metro line, significantly threatening the safety of the underground structure in the earth fissure site. However, the influence of the earth fissure site's amplification effect on the metro station's dynamic response is still unclear. A representative earth fissure in Xi'an was taken as an example to establish a numerical model of a metro station in the earth fissure site. The dynamic response characteristics of the metro stations at different distances from the earth fissure under various seismic waves were calculated. The results show that the existence of the earth fissure significantly amplifies the dynamic response of the nearby underground structures. The responses of the axial force, shear force, bending moment, normal stress, horizontal displacement, inter-story drift, and relative slip of the metro station were all amplified within a specific influence range. The amplification effect increases with the seismic wave intensity. The amplification effect caused by the earth fissure has relatively weak impacts on the axial shear, shear force, bending movement, normal stress, and horizontal movement; slightly larger impacts on the inter-story drift and acceleration; and a significant impact on the relative slip. The influence ranges of the axial force and normal stress are approximately 20 m. The influence ranges of the acceleration and inter-story drift can reach 30 m. Therefore, the seismic fortification level of the underground structure in the earth fissure site needs to be improved.

• 대한의생명과학회지
• /
• 제22권1호
• /
• pp.9-17
• /
• 2016

Unfortunately, the five-year survival rate of lung cancer is relatively low compared with other cancers. Therefore, better predictors are need for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer. Recently, increasing data suggest that Glasgow Prognostic Score (GPS) and procalcitonin levels are useful predictor cancer prognosis. In this study, we retrospectively investigated the correlation of GPS or procalcitonin to clinical variables in patients with pretreatment lung cancer. In 135 patients with pretreatment lung cancer, GPS, procalcitonin, demographic characteristics, hematological, coagulation, biochemical, inflammatory and cardiac markers were measured. Monocyte, eosinophil, basophil, neutrophil to lymphocyte ratio, red cell distribution width (RDW), platelet to lymphocyte ratio, mean platelet volume to platecrit ratio, D-dimer and prothrombin time (PT) levels were higher, whereas mean platelet volume was lower than their normal ranges. Glucose and sodium levels were low, whereas gamma glutamyl transferase (GGT), total bilirubin, creatinine and inorganic phosphorus concentrations were increase compared their normal ranges. Procalcitonin, high sensitivity C-reactive protein and troponin-I concentrations were elevated compared with their normal ranges. GPS had significantly positive or negative relations to cancer stage, hematological, coagulation, biochemical, inflammatory and troponin-I. Based on the data, we suggest that GPS may be a potent and useful predictor for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer.

• 한국전자통신학회논문지
• /
• 제11권2호
• /
• pp.215-222
• /
• 2016

걸음 인식과 그 활용에 대하여 연구가 활발하게 진행되고 있다. 본 연구는 보행자의 비정상적인 보행을 인식하는 방안을 제안한다. 기존의 정상적인 걸음을 인식하는 것이 신체활동을 측정하거나, 인증을 위한 것이었다면, 본 연구의 비정상적인 걸음 인지는 보행자의 생활안전 보장을 위한 것이다. 보행자가 스스로 자신의 취약한 상태를 인지하고 도움을 요청하지 못하는 상황이 있기 때문에, 근래의 IoT기술을 도입하여 본인의 인지와 자발적 도움 요청이 없더라도 위험과 어려움을 벗어날 수 있도록 하고자 함이다. 이에 본 연구는 3축 가속도 센서를 활용하여 보행자의 정상적인 걸음을 분석함으로써 정상적인 걸음이 유지되는 상태에 대한 범위를 정하고, 이후 3축 가속도 센서를 활용하여 걸음을 측정하여 그 결과를 정상적인 걸음 범위에 대조하여 정상과 비정상 여부를 판단하도록 한다. 정상적인 걸음을 유지하는 상태를 벗어날 때, 이를 비정상적인 걸음으로 인지하는 방안을 제안한다.