• Journal of the Korea Institute of Military Science and Technology
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• v.6 no.4
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• pp.29-37
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• 2003

Using a wind tunnel testing, the aerodynamic load characteristics of an elliptic airfoil was described. The experimental data was obtained for angles of attack $-20^{\circ}$ to $+20^{\circ}$ with $2^{\circ}$ increments at a chord Reynolds number of $0.99{\times}105$ and $2.48{\times}105$. For each test case, chordwise suction pressure distributions and wake surveys were obtained. Static pressure measurements were made over a 10 sec averaging time at a 10 Hz sampling rate. For each case, wake survey was conducted with a pilot-static probe at 1.0c downstream from the trailing edge at very fine spacing to resolve the wake velocity deficit profile. As can be expected, suction pressure coefficient was increased with angle of attack. The normal force, CNmax, appeared peak value at the incidence angle of $12^{\circ}~14^{\circ}$, and the significant increase in profile drag at this range of angles of attack.

• The korean journal of orthodontics
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• v.8 no.1
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• pp.49-58
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• 1978

This investigation was undertaken to know how the bony facial profile could be changed with age. The 5 serial lateral cephalometric roentgenograms of the fourteen boys and fourteen girls between 7 and 11 years of age were studied and the findings seems to warrant the following conclusions. 1. The manaible tended to become more prognathic in relation to the cranial base (S-N) during growth, but the maxilla showed very little change. 2. There was increase in the inclination of the lower border of mandible associated with the increase in mandibular prognathism. 3. There was a tendency to being straight in bony facial profile due to the decrease in angle ANB with age. 4. The chin portion had a tendency to forward and downward growth in relation to the cranial base but there was slight strong tendency in downward growth. 5. The vertical growth was more prominant in the maxilla than in the mandible. 6. There was uniform and gradual increase of all measurements during growth. 7. Dimension of the craniofacial complex was larger in the boys than in the girls but this difference was not statistically significant. 8. Individual variation in skeletal growth was a normal occurrence.

• BMB Reports
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• v.37 no.5
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• pp.612-617
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• 2004

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the formation of fluid-filled cysts in the kidney and progressive renal failure. Other manifestations of ADPKD include the formation of cysts in other organs (liver, pancreas, and spleen), hypertension, cardiac defects, and cerebral aneurysms. The loss of function of the polycystin -1 and -2 results in the formation of epithelium-lined cysts, a process that depends on initial epithelial proliferation. cDNA microarrays powerfully monitor gene expression and have led to the discoveries of pathways regulating complex biological processes. We undertook to profile the gene expression patterns of epithelial cells derived from the cysts of ADPKD patients using the cDNA microarray technique. Candidate genes that were differently expressed in cyst tissues were identified. 19 genes were up-regulated, and 6 down-regulated. Semi-quantitative RT-PCR results were consistent with the microarray findings. To distinguish between normal and epithelial cells, we used the hierarchical method. The results obtained may provide a molecular basis for understanding the biological meaning of cytogenesis.

• Journal of Pharmaceutical Investigation
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• v.26 no.3
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• pp.215-219
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• 1996

Active component was sought among three herb medicines, which are used in combination as a traditional medicine prescribed for patients with hyperlipidemia related diseases. Antihyperlipidemic effect of this remedy has previously been shown model by the authors on the animal model. Hyperlipidemia was induced on male Wistar rats by keeping them on high lipid diet for one week, as previously described by the authors. Blood lipid profile was verified on these rats by measuring total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Then, the diet was changed to normal. At the same time, methanol extracts of Scutellaris baicalensis Georg.(radix), Coptidis japonica Makino(rhizoma) or Rhei koreanum Nakai(rhizoma) were given on daily basis, and changes in the blood lipid profile were monitored for 4 weeks. Methanol extract of Scutellaris baicalensis Georg. significantly reduced the TC value, implying the in vivo antihyperlipidemic effect.

• Proceedings of the KIEE Conference
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• 2002.11a
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• pp.245-247
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• 2002

The paper represents the effects of the drive-in process parameters on the residual stress profile of the p+ silicon film. For the quantitative determination of the residual stress profiles, the test samples are doped via the fixed boron diffusion process and four types of the thermal oxidation processes and consecutively etched by the improved process. The residual stress measurement structures with the different thickness are simultaneously fabricated on the same silicon wafer. Since the residual stress profile is not uniform along the direction normal to the surface, the residual stress is assumed to be a polynomial function of the depth. All of the coefficients of the polynomial are determined from the deflections of cantilevers and the displacement of a rotating beam structure. As the drive-in temperature or the drive-in time increases, the boron concentration decreases and the magnitude of the average residual tensile stress decreases. Also, near the surface of the p+ film the residual tensile stress is transformed into the residual compressive stress and its magnitude increases.

• Investigative Magnetic Resonance Imaging
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• v.23 no.1
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• pp.34-37
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• 2019

Gadolinium contrast agents (CAs) are integral components of clinical magnetic resonance imaging (MRI). However, safety concerns have arisen regarding the use of gadolinium CAs, due to their association with nephrogenic systemic fibrosis (NSF). Furthermore, recently the long-term retention of $Gd^{3+}-based$ CAs in brains patients with normal renal function raised another possible safety issue. The safety concerns of $Gd^{3+}-based$ CAs have been based on the ligand structure of $Gd^{3+}-based$ CAs, and findings that $Gd^{3+}-based$ CAs with linear ligand structures showed much higher incidences of NSF and brain retention of CAs than $Gd^{3+}-based$ CAs with macrocyclic ligand structure. In the current study, we report the in vivo biodistribution profile of a new highly stable multifunctional $Gd^{3+}-based$ CA, with macrocyclic ligand structure (HNP-2006). MR imaging using HNP-2006 demonstrated a significant contrast enhancement in many different organs. Furthermore, the contrast enhanced tumor imaging using HNP-2006 confirmed that this new macrocyclic CA can be used for detecting tumor in the central nervous system. Therefore, this new multifunctional HNP-2006 with macrocyclic ligand structure shows great promise for whole-body clinical application.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.2
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• pp.333-342
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• 2017

In order to understand the mechanism of the cross-shore evolution of storm (barred) and normal (nonbarred) profiles of a sandy beach, the vertically two-dimensional laboratory experiment was performed with a movable bed. The beach profiles and free surface motion were measured under monochromatic wave conditions evolving the storm and normal beach profiles. The observation was conducted in the surf zone during the alternation of the two wave conditions to reach its quasi-equilibrium state. The sandbar-crest and trough and the steep berm were evolved due to the plunging breakers in the storm case, and the bar-trough was decayed due to the spilling breakers in the normal case. From the measurements, it was found that the storm wave case was in an erosion state and the normal wave case was in an accretion state. The strong undertow, which is a dominant factor of the offshore migration mechanism, was developed in the storm wave case, and the weak undertow was developed in the normal wave case. The skewness and the asymmetry of the nonlinear wave motion, which is a dominant factor of the onshore migration mechanism, was measured similarly in both cases.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.8 no.3
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• pp.448-453
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• 1998

An inverted, stagnation point flow OMVPE reactor was studied by laser Raman spectroscopy. Pure rotational Raman scattering by the carrier gas $(N_2; or; H_2)$ was used to determine the axial centerline temperature profile in the reactor as a function of the inlet flow velocity and the rector aspect ratio. A larger temperature gradient normal to the susceptor surface was obtained with higher gas glow velocity, larger aspect ratio, and the use of a $N_2$ carrier gas.

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.13-19
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• 1999

MRI imaging provides many benefits such as noninvasive, 3-dimensional imaging capabilities. But it has relatively serious drawback that is the long data collection time, compared with other imaging modality. Many studies have been performed for fast MR imaging. But EPI and SEPI (4-6) are required to expensive hardware. In this paper, we introduce to Burst imaging technique. It can reduce imaging time by use of a mulitple RF excitation technique. Further it is easily implemented to the normal MRI system. But a pixel profile in the conventional burst sequence is so poor that excited area by burst sequence is a small portion of a pixel. This causes poor signal to noise ratio in burst image. therefore frequency sweeping of RF pulse for burst imaging sequence is proposed to improve pixel profile. A burst pulse train is shaped by liner or nonlinear frequency sweeping function so that all the spins within a pixel are excited, thereby improving the signal to noise ratio. It also shows that the pixel profiles are dependent on how frequency sweep is made. Computer simulations with Bloch equation and experimental results obtained using a 1.0 T NMR imaging system are presented.

• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.43-47
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• 1997

Effects of Bupleuri Radix, Paeonie Radix or Uncariae Ramulus et rncus on experimental yperlipidemia were studied. Hyperlipidemia was induced on male Wistar rats by feeding them on high holesterol diet for one week, as previously described by the authors. Blood lipid profile was verified on these ats by measuring total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL) and low ensity lipoprotein cholesterol(LDL). Then, the rats were followed by feeding normal diet. At the same time, ethanol extracts of the three individual herb medicines were orally administered to the rats for 4 weeks and the parameters above mentioned were monitored. Methanol extract of 5Bupleuri radix reduced the TC value significantly at 2 week point and Paeoneae Radix reduced the TC value at 4 week point in compare to control group, suggesting the antihyperlipidemic effect of the two herbal medicines in vivo. The extract of Uncariae Ramulus et Uncus however did not show antihyperlipidemic effect in our experiment.