• Title/Summary/Keyword: nm23 단

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The Clinical Eelevance of nm23 Protein Expression in Resected Gastric Cancer Patient (위암 절제조직에서 nm23 단백질 발현의 임상적 의의)

  • Song, Sun-Kyo;Kim, Hong-Jin;Kim, Sang-Woon
    • Journal of Yeungnam Medical Science
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    • v.16 no.1
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    • pp.43-51
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    • 1999
  • The aim of present study was to elucidate whether the expression of nm23 protein might be of clinical value as a prognostic factor in gastric cancer. The expression of nm23 protein was analyzed using an immunohistochemical method with formalin-fixed and paraffin embedded tissue samples from 76 gastric carcinoma patients. The cytoplasmic immunoreactivity of nm23 protein were detected in 53.9% of the sample tissues(41/76). When the immunoreactivity of nm23 protein with TNM status and other histopathologic findings were compared by using Chi-Square test, nm23 was found to have correlations with lymph node metastasis(p=0.04), a number of metastatic lymph node, and the invasion of lymphatic vessels(p=0.007); however, it had no correlation with TNM status. The conventional prognostic factors such as the depth of invasion, the degree of lymph node metastasis and the presence of distant metastasis, a Borrmann type, size of tumor, and the curability with operation were found to have a strong correlation with the survival time(p<0.003). However, the expression of nm23 protein was not significantly correlated with survival time in survival analysis. These results showed that the expression of nm23 protein is not a useful prognostic indicator in gastric cancer.

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Design of V-Band Differential Low Noise Amplifier Using 65-nm CMOS (65-nm CMOS 공정을 이용한 V-Band 차동 저잡음 증폭기 설계)

  • Kim, Dong-Wook;Seo, Hyun-Woo;Kim, Jun-Seong;Kim, Byung-Sung
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.28 no.10
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    • pp.832-835
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    • 2017
  • In this paper, V-band differential low noise amplifier(LNA) using 65-nm CMOS process for high speed wireless data communication is presented. The LNA is composed of 3-stage common-source differential amplifiers with neutralization of feedback capacitances using MOS capacitors and impedance matching utilizing transformers. The fabricated LNA has a peak gain of 23 dB at 63 GHz and 3 dB bandwidth of 6 GHz. The chip area of LNA is $0.3mm^2$ and the LNA consumes 32 mW DC power from 1.2 V supply voltage.

Virus-like Particles from Abnormal Growing Oyster Mushrooms, Pleurotus florida and P. ostreatus (균사생장(菌絲生長)이 부진(不進)한 사철느타리 및 느타리버섯으로부터 Virus입자(粒子)의 분리(分離))

  • Go, Seung-Joo;Cha, Dong-Yeul;Shin, Gwan-Chull
    • The Korean Journal of Mycology
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    • v.20 no.2
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    • pp.149-153
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    • 1992
  • This study aimed to investigate possible cause of slow and abnormal growth of oyster mushrooms, Pleurotus florida and P. ostreatus collected from bad crop farms. Spherical virus particles of 30 nm in diameter from P. florida, 23 nm particles from P. ostreatus, and both 23 and 30 nm particles were also found from interspecies mated culture between P. florida and P. osreatus. The virus particles might be associated with the bad crop of Pleurotus species.

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A Study of the Prognostic Factors in Resected Stage I Non-Small Cell Lung Cancer (제1병기 비소세포폐암 절제례의 예후인자에 대한 연구)

  • 김창수;천수봉;조성래
    • Journal of Chest Surgery
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    • v.31 no.10
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    • pp.973-981
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    • 1998
  • Background: About 30% to 40% of the patients with pathologic stage I non-small cell lung cancer (NSCLC) die within 5 years after complete resection. The identification of poor prognostic factors and the application of additional treatment are very important to improve the survival rate in resected stage I NSCLC. Materials and methods: Sixty-eight(68) patients who had been diagnosed postoperatively between Janury 1989 and December 1995 as having stage I non-small cell lung cancer according to the TNM classification were studied. The postoperative 5-year survival rate was calculated with the Kaplan-Meier method, and clinico- histopathologic factors including age, sex, operative method, type of tumor cell, T factor, grade of the differentiation in a squamous cell carcinoma, invasion of blood vessel and expression of the nm23-H1 protein were investigated and analyzed. Results: The median survival of the entire group of patients was 58$\pm$3 months, with a 5-year survival of 58.9%. In univariate analysis, invasion of blood vessel and poor differentiation of the tumor cell in a squamous cell carcinoma significantly worsened the survival. In multivariate analysis, invasion of blood vessel and grade of the differentiation of the tumor cells in a squamous cell carcinoma remained independent prognostic factors. High expression of the nm23-H1 protein was related to a high postoperative 5-year survival in comparision with low expression of the nm23-H1 pretein (73.0% vs 50.7%), but there was no statistical significance. Conclusions: These results highlight the negative prognostic value of poor differentiation of tumor cells in a squamous cell carcinoma and invasion of blood vessel in stage I non-small cell lung cancer. Also, further studies are necessary to be determined prognostic value of the T factor and expression of the nm23 protein in non-small cell lung cancer.

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Ku-Band Three-Stack CMOS Power Amplifier to Enhance Output Power and Efficiency (출력 전력 및 효율 개선을 위한 3-스택 구조의 Ku 대역 CMOS 전력 증폭기)

  • Yang, Junhyuk;Jang, Seonhye;Jung, Hayeon;Joo, Taehwan;Park, Changkun
    • Journal of IKEEE
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    • v.25 no.1
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    • pp.133-138
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    • 2021
  • We propose a Ku-band three-stack CMOS power amplifier to enhance the output power and efficiency. To minimize the dc power consumption, the driver stage is designed using common-source structure. To obtain high output power and utilize a voltage combining method, the power stage is designed using stack structure. To verify the proposed power amplifier structure, we design a Ku-band power amplifier using 65-nm RFCMOS process which provide nine metal layers. The P1dB, power-added efficiency, and gain are higher than 20 dBm, 23 dB, and 25%, respectively, while the operating frequency is 14 GHz-16 GHz.

Structural and Optical Properties of ZnO/Glass Thin Films Grown by Radio-Frequency Magnetron Sputtering with a Powder Target (ZnO 분말 타겟을 스퍼터링하여 Glass 기판위에 증착한 ZnO 박막의 구조적, 광학적 특성)

  • Sun, J.H.;Kang, H.C.
    • Journal of the Korean Vacuum Society
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    • v.18 no.5
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    • pp.394-401
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    • 2009
  • This paper reports the structural and optical properties of ZnO/glass thin films grown by radio-frequency magnetron sputtering with a powder target. In contrast to ZnO ceramic target typically used, a ZnO raw powder target was sputtered in this study. ZnO grew with the (0002) preferred orientation along the surface normal direction. Initially, the surface of ZnO thin films was flat considerably and then it became rougher as the thickness increased. The optical transmittance was as high as 88% in the range of 400-1000 nm. The bandgap energy of 3.23 eV at the 220 nm thick sample was estimated.

Measurement of Spectral Loss and Cut-off Wavelength of Single Mode Opticla Fiber by Variable Wavelength (파장변화에 따른 단 모드 광섬유의 스펙트랄 로스 및 차단파장 측정)

  • Hong, Bong Sik;Han, Byoung Sung;Koo, Kyoung Wan
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.23 no.2
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    • pp.264-268
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    • 1986
  • A thchnique has been studied for the measurement of the spectral loss and the cut-off wave length, at which the first high-order mode disappears. The near-field patterns of a fiber which is excited by a variable wavelength source are used for the measurement of cut-off wavelength. Because of the absorptive phenomenon of OH- molecular vibration, spectral loss of a single mode optical fiber sample is 5.6dB/km at 1380 nm wavelength and 1dB/km at 1240 nm wavelength. From the near field intensity patterns and the mode field diameter graph for the half power width, the cut-off wavelength of the fiber is measured to be 1120 nm.

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A 2.4-GHz Dual-Mode CMOS Power Amplifier with a Bypass Structure Using Three-Port Transformer to Improve Efficiency (3-포드 변압기를 이용한 바이패스 구조를 적용하여 효율이 개선된 이중 모드 2.4-GHz CMOS 전력 증폭기)

  • Jang, Joseph;Yoo, Jinho;Lee, Milim;Park, Changkun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.6
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    • pp.719-725
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    • 2019
  • We propose a 2.4-GHz CMOS power amplifier (PA) with a bypass structure to improve the power-added efficiency (PAE) in the low-power region. The primary winding of the output transformer is split into two parts. One of the primary windings is connected to the output of the power stage for high-power mode. The other primary winding is connected to the output of the driver stage for low-power mode. Operation of the high power mode is similar to conventional PAs. On the other hand, the output power of the driver stage becomes the output power of the overall PA in the low power mode. Owing to a turning-off of the power stage, the power consumption is decreased in low-power mode. We designed the CMOS PA using a 180-nm RFCMOS process. The measured maximum output power is 27.78 dBm with a PAE of 20.5%. At a measured output power of 16 dBm, the PAE is improved from 2.5% to 12.7%.

Luminescence properties of novel Sr-Y-Si-Oxynitride yellow phosphor for LED applications (LED용 Sr-Y-Si-계 산질화물 황색 형광체의 발광 특성)

  • Jeong, Ok Geun;Park, Jong Cheon;Ryu, Jeong Ho;Cho, Hyun
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.23 no.4
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    • pp.195-200
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    • 2013
  • Novel Sr-Y-Si-Oxynitride yellow phosphors were synthesized and the effect of calcination temperature, reduction temperature and $Eu^{2+}$ concentration on their luminescence properties were studied. Optimal temperature conditions were found to be $1400^{\circ}C$ and $1300^{\circ}C$ for solid-state reaction and reduction, respectively. The synthesized $Ba_9Y_{2+y}Si_6O_{24-3y}N_{3y}:Eu^{2+}$ phosphors showed a single intense broadband emission in the range of 571~587 nm for 450 nm excitation light source. The highest luminescence intensity was obtained with Eu concentration of 3 mol% and concentration quenching was observed beyond 5 mol%. FE-SEM and PSA showed that the synthesized phosphors consists of particles with an average size of ${\sim}8.2{\mu}m$.

Transition Metal Oxide Multi-Layer Color Glass for Building Integrated Photovoltaic System (BIPV 시스템을 위한 전이금속 산화물 다중층 컬러 유리 구현 기술 연구)

  • Ahn, Hyeon-Sik;Gasonoo, Akpeko;Jang, Eun-Jeong;Kim, Min-Hoi;Lee, Jae-Hyun;Choi, Yoonseuk
    • Journal of IKEEE
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    • v.23 no.4
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    • pp.1128-1133
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    • 2019
  • This paper proposed colored front panel glass for Building Integrated Photovoltaic (BIPV) systems using multi-layered thin films composed of transition metal oxide (TMO) layers. Molybdenum oxide (MoO3) and tungsten oxide (WO3) provided complementary and suitable materials in making effective interference of reflected light from interfaces with significant difference in refractive indices. A simple, fast, and cheap fabrication method was achieved by depositing the multi-layer films in a single thermal evaporator. Magenta colored glass with optical transmittance of more than 90% was achieved with MoO3 (60nm)/WO3(100nm) multi-layered film. This technology could play in a critical role in commercial BIPV system applications.