• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.5
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• pp.1146-1165
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• 2013

Collaborative awareness between persons with various smart multimedia devices is a new trend in the Internet of Things (IoT). Because of the mobility, randomness, and complexity of persons, it is difficult to achieve complete data awareness and data transmission in IoT. Therefore, research must be conducted on mobile-aware service models. In this work, we first discuss and quantify the social relationships of mobile nodes from multiple perspectives based on a summary of social characteristics. We then define various decision factors (DFs). Next, we construct a directed and weighted community by analyzing the activity patterns of mobile nodes. Finally, a mobile-aware service routing algorithm (MSRA) is proposed to determine appropriate service nodes through a trusted chain and optimal path tree. The simulation results indicate that the model has superior dynamic adaptability and service discovery efficiency compared to the existing models. The mobile-aware service model could be used to improve date acquisition techniques and the quality of mobile-aware service in the IoT.

• Journal of Digital Convergence
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• v.15 no.6
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• pp.29-38
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• 2017

The purpose of this study was to examine the effects of users' organization-public relationship of the donation activities of corporate via social network service on corporate image and reputation focused on social network service users. The subjects were 228 SNS users selected. The data were analyzed by the correlation analysis, reliability analysis and structural equation modeling analysis using SPSS 21 and AMOS 21 program. The results were as follow. First, Organization-public relationships influenced positively on corporate image. Second, Organization-public relationships influenced positively on corporate reputation. Third, Corporate image influenced positively on corporate reputation. These results will contribute to develop a marketing strategy via social network service of corporate.

• Journal of Ginseng Research
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• v.42 no.1
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• pp.98-106
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• 2018

Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases.

• Journal of Technology Innovation
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• v.18 no.1
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• pp.1-20
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• 2010

Firm’s social network has been known as an important firm strategy because it could promote technological innovation and also minimize economic uncertainty. In this study, we identify four types of firm’s social network activities such as Collaboration, Manufacturing/Marketing/Distribution Agreements, Financing, and M&A, and analyze how these activities affect firm performance using U.S biotechnology firm data. We found that Manufacturing/Marketing/Distribution Agreements increased firm performance in short-run. Also, collaboration with pharmaceutical and biotechnology firms had a positive effect on firm performance, too. However, collaboration with public institutes or universities had a negative effect on firm performance in short run, which implies its collaboration would be mainly focused on research in pure science area. These empirical results provide two policy implications. First, social network strategy should be encouraged in the Korean biotechnology industry. Secondly, governments should consider developing polices that support collaboration of biotechnology with public institutes or universities, to promote technological innovation.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.137-145
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• 2010

Humans are social existences who connect with others and live together. Communication between human has evolved into diverse formats and contents beyond time and space. Social Network Service builds social relationship based on web and its users increase rapidly in a global environment due to the user-friendly web circumstances, easy access and wide-spread supply of the smart phones. One of the aspect that is taking the center of Social Network Service is a Social Game. Social Games are based on web that has simple rules to play in fictional time and space background. This research is to analyze the relationship between social game, Social Network and user behavior through the Social Games Farm Villand Cafe World.This paper, firstly, is going to observe the characteristics of people who participate in the two social games 'Farm Ville' and 'Cafe World'. It, then, attempts to analyze individual and social human desires depicted in the games. In the social games, personal perception is revealed through an image of "possession", while one's social activity is displayed by an image of "consumption."

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.10a
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• pp.517-520
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• 2009

Healthcare application system has been actively researched to apply WSN technology to healthcare area with a mobile sensor node of low cost, low power, and small size. Sensor node has the problem for transmission range of RF power and time delay of the wireless routing connectivity between sensor nodes. In this paper, we proposes a new method utilizing mobile sensor nodes with relay sensor nodes for quick network routing changing using query technique in healthcare system. A query processor to control and manage the routing changing of sensor nodes in a wireless sensor network was designed and implemented. The user's PC transmits the beacon message which will change the quick link routing according to activity status of patient in wireless sensor network. We describe the implementation for query protocol that is very effective of power saving between sensor nodes.

• Korea Trade Review
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• v.41 no.4
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• pp.293-313
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• 2016

In the East Asian region, the advancement of trade networks is being facilitated, which turns out that economic integration across borders is being advanced due to FTA expansion, freedom of business activity growing through the reform of regulatory system in each country, and the processing of division of labor between processes across borders. Trans-Pacific Partnership(TPP), which is a U.S. led multilateral FTA, was signed on February 4 2016 in Auckland, New Zealand by 12 countries, by which changes in the East Asia Trade Network are also expected. For this reason, this study examined the impact that TPP would have on East Asia Trade Network. According to the result of this study, it was determined that TPP, as the regulation and system which will lead globalization of the supply chain, will change Supply Chain structure and result in a positive effect on Value Chain. This will have a significant impact on the East Asian trade network, and connect to enhanced competitiveness of participating enterprises. In addition, TPP seems to be the basis for realization of FTAAP(Free Trade Area of the Asia-Pacific) in the future, Therefore, Korea who has high Degree of Dependence upon Foreign Trade will have to pay make political effort to effectively deal with this changing trading environment in East Asia.

• Herbal Formula Science
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• v.31 no.3
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• pp.171-182
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• 2023

Objectives : Saposhnikoviae Radix (SR) and Glehniae Radix (GR) have been frequently used in traditional medicine to treat diseases related to 'wind' syndrome, but there have been cases where it has been mixed in a state where the plant of origin is not clear. In this study, to select materials for conducting preclinical cerebral infarction research, the network pharmacology analysis method was used to select suitable medicinal materials for the study. Methods : In this study, a Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) based network pharmacology analysis method was used, and oral bioavailability (OB), drug likeness (DL), Caco-2 and BBB permeability were utilized to select compounds with potential activity. For the values of each variable used in this study, OB ≥ 20%, DL ≥ 0.18, Caco-2 ≥ 0, and BBB ≥ -0.3 were applied, then networks of bioactive compounds, target proteins, and target diseases was constructed. STRING database was used to construct a protein-protein interaction network. Results : It was confirmed that SR rather than GR has various target proteins and target diseases based on network pharmacological analysis using TCMSP database. And it was analyzed that the bioactive compounds only in SR act more on neurovascular diseases, and both drugs are expected to be effectively used for cardiovascular diseases. Conclusions : In our future study, SR will be used in an ischemic stroke mouse model, and the mechanism of action will be explored focusing on apoptosis and cell proliferation.

• The Korea Journal of Herbology
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• v.39 no.3
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• pp.37-47
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• 2024

Objectives : Because predicting the potential efficacy and mechanisms of Korean medicines is challenging due to their high complexity, employing an approach based on network pharmacology could be effective. In this study, network pharmacological analysis was utilized to anticipate the effects of YunPye-Hwan (YPH) in treating Chronic obstructive pulmonary disease (COPD). Methods : Compounds and their related target genes of YPH were gathered from the TCMSP and PubChem databases. These target genes of YPH were subsequently compared with gene sets associated with COPD to assess correlation. Next, core genes were identified through a two-step screening process, and finally, functional enrichment analysis of these core genes was conducted using both Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways. Results : A total of 15 compounds and 437 target genes were gathered, resulting in a network comprising 473 nodes and 14,137 edges. Among them, 276 genes overlapped with gene sets associated with COPD, indicating a significant correlation between YPH and COPD. Functional enrichment analysis of the 18 core genes revealed biological processes and pathways such as "miRNA Transcription," "Nucleic Acid-Templated Transcription," "DNA-binding Transcription Factor Activity," "MAPK signaling pathway," and "TNF signaling pathway" were implicated. Conclusion : YPH exhibited significant relevance to COPD by modulating cell proliferation, differentiation, inflammation, and cell death pathways. This study could serve as a foundational framework for further research investigating the potential use of YPH in the treatment of COPD.

• Journal of the Korean Geophysical Society
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• v.6 no.1
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• pp.1-11
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• 2003

There are numerous adjustment techniques that deal with the adjustment of geodetic networks but the least squares adjustment is the most common one. During the network adjustment procedure two techniques can be used, the free network adjustment technique and the constrained network adjustment technique. In order to determine the optimum technique for adjusting the geodetic networks, which used for the geodynamical purposes, data from two different geodetic networks "Sinai geodetic network, Egypt, and HGN network, South Korea" had been examined. The used networks had a different configuration and located in different areas with different seismic activity. The results show that both techniques have a high accuracy and no remarkable differences in terms of RMS. On the contrary, the resulted coordinates shows that the constrained network adjustment technique not only cause a remarkable distortion in the station final coordinates but also if the fixed points that define the datum parameters are changed different solutions for the coordinates will be determined. This distortion affect not only in the determination of point displacement but also in the estimation of the deformation parameters, which play a significant role in the geodynamical interpretation of results. Comparing the results which obtained from both techniques with the widely known geodynamical models of the area reviles that the free network adjustment technique results are clearly match with these models, while those obtained from the constrained technique didn’t match at all. By considering the results it seams to be that the free network adjustment technique is the optimum technique, which can be used for the geodetic network adjustment.