• Journal of Korean Neurosurgical Society
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• 제54권4호
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• pp.329-335
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• 2013

Objective : Brain metastases in primary breast cancer patients are considerable sources of morbidity and mortality. Gamma knife radiosurgery (GKRS) has gained popularity as an up-front therapy in treating such metastases over traditional radiation therapy due to better neurocognitive function preservation. The aim of this study was to clarify the prognostic factors for local tumor control and survival in radiosurgery for brain metastases from primary breast cancer. Methods : From March 2001 to May 2011, 124 women with metastatic brain lesions originating from a primary breast cancer underwent GKRS at a tertiary medical center in Seoul, Korea. All patients had radiosurgery as a primary treatment or salvage therapy. We retrospectively reviewed their clinical outcomes and radiological responses. The end point of this study was the date of patient's death or the last follow-up examination. Results : In total, 106 patients (268 lesions) were available for follow-up imaging. The median follow-up time was 7.5 months. The mean treated tumor volume at the time of GKRS was 6273 $mm^3$ (range, 4.5-27745 mm3) and the median dose delivered to the tumor margin was 22 Gy (range, 20-25 Gy). Local recurrence was assessed in 86 patients (216 lesions) and found to have occurred in 36 patients (83 lesions, 38.6%) with a median time of 6 months (range, 4-16 months). A treated tumor volume >5000 $mm^3$ was significantly correlated with poor local tumor control through a multivariate analysis (hazard risk=7.091, p=0.01). Overall survival was 79.9%, 48.3%, and 15.3% at 6, 12, and 24 months, respectively. The median overall survival was 11 months after GKRS (range, 6 days-113 months). Multivariate analysis showed that the pre-GKRS Karnofsky performance status, leptomeningeal seeding prior to initial GKRS, and multiple metastatic lesions were significant prognostic factors for reduced overall survival (hazard risk=1.94, p=0.001, hazard risk=7.13, p<0.001, and hazard risk=1.46, p=0.046, respectively). Conclusion : GKRS has shown to be an effective and safe treatment modality for treating brain metastases of primary breast cancer. Most metastatic brain lesions initially respond to GKRS, though, many patients have further CNS progression in subsequent periods. Patients with poor Karnofsky performance status and multiple metastatic lesions are at risk of CNS progression and poor survival, and a more frequent and strict surveillance protocol is suggested in such high-risk groups.

• Child Health Nursing Research
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• 제7권1호
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• pp.35-50
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• 2001

The ability of neonates to perceive and react to pain, has been acknowledged recently. Recent researches have been shown that even short term pain can have lasting negative effects. We know that most of the anatomical pathway and neurotrans-mitter function necessary for pain perception are fully or nearly fully developed in the neonatal period. Many people are still reluctant to believe that pain felt by neonates may be as severe as that felt by older children or adults yet. The objective of the study is to assess and compare the analgesic effects of orally administered sucrose and pacifiers. And to determine the synergistic analgesic effects of sucrose and pacifiers. The tools for this study is Lawrence's NIPS (neonatal infant pain scale) with behavioural pain responses and index for pain physiological reponses as heart rate, respiratory rate and degree of SaO₂. The participants are 96 healthy infants of neonatal age 1-7days and randomised to receive heel prick before 2minutes to blood sampling and physiological test in Nursery of K Medical University Hospital on May-July, 2000. The experimental group assigned to one of three treatment groups : no treatment; a pacifier; placebo(2ml 25％ sucrose). Collected data were analyzed with the SAS program using X²-test, ANOVA and Duncan's multiple range test as post hoc. The results were as follows. 1) Pain behaviour responses: The pain score of placebo group(2ml 25％ sucrose) is lower than no treatment group and pacifier group significantly(P=.000). Placebo group is different from no treatment and pacifier group with Duncan's multiple range test. 2) Pain physiologic responses (1) heart rate: The heart rate of placebo group(2ml 25％ sucrose) is different from that of no treatment group and pacifier group significantly(P=.000). The heart rate change of placebo group is less than the other groups. (2) respiratory rate: The respiratory rate of placebo group(2ml 25％ sucrose) is different from that of no treatment group and pacifier group insignificantly (P=.2340). But, the respiratory rate of placebo group is lower than the other groups. (3) SaO₂: The SaO₂ score of placebo group(2ml 25％ sucrose) is different from that of no treatment group and pacifier group insignificantly (P=.3265). But, the change of SaO₂ score of placebo group is less than the other groups. In conclusion, the sucrose placebo showed pain relief effect in behavior responses and less physiological responses. Accordingly, the sucrose placebo should be applied nursing intervention for simple pain management as heel prick.

• 전자공학회논문지
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• 제51권10호
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• pp.96-106
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• 2014

기존 학계의 FPGA 툴 연구는 단순한 가상 아키텍처 모델 가정에 의존해 왔다. 이러한 제약을 극복하기 위한 첫걸음으로 분석적 배치 및 배치 적법화의 기본 알고리즘들을 상용 FPGA의 아키텍처에 적용하는 실제 상황에서 발생되는 이슈들을 도출하여 대안을 제시한 후 그 효과를 평가하였다. 먼저, 코어 사용률이 낮은 FPGA에서 배치된 셀들의 무게 중심이 칩 중심에서 벗어나는 현상이 발생할 수 있는데 이 변위를 최소화하는 함수를 분석적 배치의 목적 함수에 추가하였다. 또한 배치 밀도 평가의 정확도를 높이기 위해 셀 종류별로 별도의 밀도 행렬을 사용하는 다층 분석, 그리고 자원이 매우 한정된 블록의 조기 고정 방안을 제안하였다. 그밖에, 슬라이스 내에서 두 개의 플립플롭이 제어 핀들을 공유하기 때문에 발생하는 호환성 문제를 개선하기 위한 플립플롭 사전 패킹도 제안하였다. 제안된 기법은 상용 FPGA 아키텍처를 정확하게 모델링하고 수정 개선할 수 있는 K-FPGA 패브릭 평가 툴킷을 근간으로 구현되었으며 12개의 실용 예제에 적용하여 기존 방식에 비해 평균적으로 배선길이 22%, 슬라이스 사용량 5%를 감축하는 효과를 확인하였다. 본 연구는 신규 FPGA 아키텍처 개발을 위한 최적화 CAD 툴 개발 연구의 기초가 될 것으로 기대한다.

• 기본간호학회지
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• 제10권1호
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• pp.96-107
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• 2003

Objective: The purpose of this study was to identify the effects of tracheal suction and the effects of different methods of bronchodilator inhalation (Ultrasonic nebulizer: MDI puff, MDI puff with spacer) in VSD surgery patients. Material & Method: From June 2001 to March 2002, sixty consecutive patients were randomly assigned to a control group (n= 15), ultrasonic nebulizer group (n=15), metered dose inhalation (MDI) puff group (n=15) and MDI with spacer group (n=15). Vital signs (HR, BP, CVP), ABGA and pulmonary functions were measured before suction (baseline for suction), after suction, 15 minutes after suction (base of bronchodilator inhalation), 30 minutes after bronchodilator inhalation, and 2 hours after bronchodilator inhalation. Stastistical analysis was performed using SPSS software. Repeated measure ANOVA was used to examine the effects of tracheal suction. One way ANOVA with Bonferroni's correction and multiple range test (the least significant difference test) were used to examine the effects of albuterol inhalation. Result: 1. Heart .ate increased significantly immediately after suction (p<.01) and recovered 15 minutes after suction. 2. $PaO_2$ and PH decreased significantly immediately after suction (p<.05) and $PaO_2$ recovered 15 minutes after suction. $PaCO_2$ increased immediately after suction and significantly 15 minutes after suction (p<.01). But changes in vital signs and ABGA were within the normal range. 3. Tidal volume decreased significantly 15 minutes after suction (p<.05). 4. Changes of HR and tidal volume were greater in the nebuizer group compared to the other groups (p<.05) 30 minutes after bronchodilator inhalation and recovered 2 hours after bronchodilator inhalation. 5. Changes of airway deadspace was greater in the nebulizer group compared to the control group and MDI puff group 30 minutes after albuterol inhalation (p<.05) and at 2 hours (p<.01). Conclusion: Tracheal suction did not have significant effect on vital signs and pulmonary functions after OHS. Although the methods of bronchodilator inhalation did not showed any significant difference on pulmonary function, the nebulizer method increased $PaO_2$ (20%) and tidal volume transiently. If the patient needs bronchodilator inhalation with bronchospasm after OHS, the nebulizer method is the best choice. More study on the effects of bronchodilator inhalation in bronchospasm group is needed.

• 대한간호학회지
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• 제19권2호
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• pp.160-172
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• 1989

This research was done to clarify the factors related to sexual satifaction in women who have had a hysterectomy, and to idenify which factors had statistically significant influence of sexual satisfaction of the subjacts. The objective of this study was to identify the variables related to sexual adaptation which might be changed by nursing intervention. This was a cross-sectional descriptive correlation study. There were 230 subjects in the study, and they were selected by a convenient sampling method. The tool. for this study was developed by the researcher through modification of the Dergatis Sexual Function Inventory(DSFI). A pilot study was done to determine the necessary modifications. Data collection was done between Sept. 1987 and Du. 1987 using a mailed questionnaire. The characteristics of the subjects were as follows : The mean age of the subjects was 42.3 years and 204(87.4%) of the subjects had nine or more years of education. The mean income of the subjects was 85.8870 won / month, and 179(77%) of them were housewives. The mean number of pregnancies and children were 4.9 and 2.5 respectively. Oophorectomies were included in the surgery for 66(28.7%) of the subjects. Only 12(5.2%) were planning to have more children. Only 88(38.3%) of the subjects had received information prior to the surgery regarding health problems related to the operation and less than half, 111 (48.3%), had received this kind of information before discharge. Lay persons were the source of information about the post-operation status for 196 (85.2%) of the subjects, but the content of the information did not significantly influence the sexual satisfaction score. Only 16(7.0%) of the subjects said they regretted having a hysterctomy while 102(44.3%) said they were pleased to have had a hysterectomy. Ninety (39.1 %) of the subjects reported that their husbands had “stress” and 164(71.3%) of the subjects reported “stress”. The results of this study are summarized as follows : 1. The mean score for sexual satisfaction of the subjects was 34.24 with a possible maximum score of 50.00. Eighty two(35.8%) were responded that they were satisfied with their sexual life but 61 (26.5%) were responded that they were dissatisfied with their sexual life 2. The following 15 factors extracted from the results of the data analysis were significantly related to sexual satisfaction(p＜.05) ; support of husband, body image, emotion, knowledge of sex, menopausal symptoms, sexual behavior, the feelings the subjects had about the hysterectomy, stress for both subject and husband, the number of children, health information given before operation, job, age, level of education and income. The five most important factors influencing sexual satisfaction were identified by using stepwise multiple regression analysis. The most important factor was support of husband, which explained 17.83% of the total variance. The remaining factors in order of significance were : Knowledge of sex, income, job, and emotional status. Those five factors explained 35.16% of the sexual satisfaction. In conclusion, for the care of women who are going to be discharged from hospital after having had a hysterctomy, nurses have to work with the husbands to help them to understand the importance of their support. Nurses also need to make sure that the subjects have an adequeate knowledge of sexual life after a hysterectomy. Also nursing interventions should focus on subjects who do not have a job, who are of low economic status, and the subjects who are under the unpleasant mood.

• Journal of Periodontal and Implant Science
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• 제29권3호
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• pp.507-519
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• 1999

The ultimate objective of periodontal treatment is to stop disease progression and to regenerate destroyed periodontal tissues and thereby regain normal function. Growth factors are naturally found polypetides which stimulate many cellular activities pertaining to wound healing by acting as signal molecule in controlling cell movement, proliferation, and matrix production. Platelet derived growth factor (PDGF) is 28,000-35,000 Da molecular weight dimeric protein with 2 long positively charged polypeptide chains connected by sulfide bonds. The purpose of this study is to evaluate histologically the initial guided tissue regeneration in a periodontal defect f a beagle dog treated with a biodegradable membrane formed with polylactic acid (poly-L-lactic acid) and polyglycolic acid loaded with 200ng/$cm^2$ platelet derived growth factor. 2 beagle dogs were used in he experiment. $5mm{\times}6mm$ alveolar bone defect was formed in upper and lower canines and third premolars and a reference notch was placed. PDGF-BB non-containing membrane was used as control. Each defect was randomly assigned to the test roup or the control group. The dogs were sacrificed 3 weeks after membrane placement. Toluidine blue and multiple staining was done for histological analysis. In the 3 week specimen in the control group, no new one formation could be seen. Small amount f bone resorption below the notch could be seen. In the notch, loose connective tissue with infiltration of inflammatory cells could be seen. Also thin discontinuous new cementum could be seen and the membrane still retained its structure. Where PDGF-BB containing membrane was used, new bone formation could be seen in the notch at weeks and also continuous thin cementum could be seen. PDL cells were observed between new bone and new cementum and some were attached to bone and cementum. These results suggest that new bone and cementum formation seen when PDGF-BB loaded membrane was used was due to inhibition of downgrowth of epithelial cells and also due to continuous release of the growth factor. Further study on the resorption characteristics of the membrane nd the release characteristics of the PDGF-BB is necessary. Also, development of a membrane easier to use clinically is necessary.

• 한국의류학회지
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• 제31권12호
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• pp.1772-1783
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• 2007

본 연구의 목적은 외모에 대한 관심과 호기심이 왕성한 한, 중, 일 세 국가의 여대생들의 화장품구매실태를 조사하고 화장품이용과 관련한 만족, 불만족이유에 대한 세 국가 간의 차이점을 비교 분석하여 그 결과를 국내 화장품업계의 국내외 진출시 마케팅자료로 활용하고자 함이었다. 본 연구는 서울, 베이징, 도쿄에 거주하는 남녀공학대학에 재학중인 여대생 1,200명을 대상으로 하여 자료수집을 하였다. 연구결과, 세 국가의 여대생들의 화장품구매실태와 화장품과 관련한 만족, 불만족의 차이가 있었다. 중국여대생들은 구매처의 신뢰도와 브랜들 이미지를 중요하게 생각하고 불만족 화장품에 대해서는 교환을 통해 적극적으로 대처하는 것으로 나타났기 때문에 소비자들의 불만족경험을 줄이고 고급스럽고 믿을 수 있는 품질의 제품으로 백화점에 진출하는 마케팅전략이 중국시장진출 시 필요하며, 일본여대생들은 광고와 잡지모델이 중국, 한국과 비교하여 상대적으로 구매 시 중요한 요인으로 작용하고 슈퍼마켓과 약국을 통해 저렴한 화장품구매를 하는 것으로 나타나 일본시장진출 시 광고를 통해 브랜드인지도를 높이고 슈퍼마켓과 약국으로 유통망을 확대하고 품질대비 저렴한 가격전략이 필요하며 한국여대생들은 화장품구매시 친구나 동료 등과 같은 인적네크워크를 통한 구전과 저렴한 가격을 중요하게 생각하고 있어 품질대비 저렴한 가격으로 긍정적인 구전효과를 통한 마케팅전략이 필요하다고 사료된다.

• 지능정보연구
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• 제17권3호
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• pp.147-168
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• 2011

상품 및 서비스에 대한 개인화된 추천 서비스가 중요해짐에 따라, 많은 연구자들은 추천시스템 개발을 위한 다양한 지식과 기법들을 제공해왔다. 이러한 기법들 중에서 협업 필터링(Collaborative Fitering) 기법은 여러 분야에서 널리 사용되고 있으며, 그 유용성이 입증되었다. 하지만, 추천시스템의 성능을 더욱 높이기 위해서 현재의 협업 필터링 기법은 다음과 같은 점들을 고려해야 한다. 첫째, 대부분의 추천시스템과 관련한 연구에서 특정 고객과 성향이 유사한 다른 고객들을 찾기 위해 사용되는 유사도 함수들(Similarity Functions)은 대부분 특정한 관점에 초점을 두고 있기 때문에 다양한 관점에서 성향이 유사한 다른 고객들을 찾는데 한계를 가진다. 따라서, 특정 관점에 치우치지 않는 통합된 유사도 함수를 사용해야 할 필요가 있다. 둘째, 고객들의 성향은 시간이 지남에 따라 변화하기 때문에, 이를 추천결과에 반영하기 위해서는 시간에 따른 고객들의 구매 성향의 변화를 고려해야 한다. 본 연구는 여러 실험들을 통해 다음의 가설을 검정하는 것을 목적으로 하였다-다양한 관점이 동시에 반영된 통합 유사도 함수의 이용과 시간정보를 이용한 사용자의 구매 성향의 변화를 반영할 경우 추천의 정확도가 향상될 것이다. 다양한 실험을 통해, 본 연구에서 제시한 추천시스템은 전통적인 협업 필터링 기반의 추천시스템들에 비해 일반적으로 상당히 높은 정확도를 보였으며 이를 통해, 본 연구에서 제시한 가설이 채택될 수 있음을 확인하였다.

• 구강회복응용과학지
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• 제26권3호
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• pp.323-337
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• 2010

본 연구는 임플란트 상부 구조물 제작을 위한 pick-up 인상 채득시 flag type의 새로운 인상용 코핑을 이용하여 제작된 모형과 기존에 사용되고 있는 인상용 코핑에 의해 제작된 모형의 정확성을 3차원적으로 비교하여 새로운 형태의 인상용 코핑을 사용한 인상법의 유용성을 알아보고자 하였다. 아크릴릭 레진 블록으로 좌측은 전부 무치악, 우측은 제 2 소구치가 상실된 상악 기준 모형을 제작하였다. 상악 우측 제 2소구치, 좌측 중절치, 좌측 견치, 좌측 제 2 소구치, 좌측 제 2 대구치 부위에 외부 육각 연결 방식의 임플란트 고정체를 식립하였다. 기준 모형에 사용된 인상용 코핑 및 코핑 간에 연결 여부에 따라 세 가지 실험군으로 분류하였다; 임플란트 고정체에 flag type 의 인상용 코핑을 체결한 경우 (실험군 I), 기존 형태인 원통형의 인상용 코핑을 체결한 후 인상용 코핑을 자가 중합 아크릴릭 레진으로 연결한 경우 (실험군 Ii), 원통형 인상용 코핑을 체결한 후 자가 중합 레진으로 연결하지 않은 경우 (실험군 III). 총 15개의 모형을 제작하여 인상 채득하여 작업 모형을 제작한 후 기준 모형 및 작업 모형을 5번씩 측정하여 통계 처리하였다. flag type의 인상용 코핑을 이용하여 인상 채득한 군, 기존의 인상용 코핑을 자가 중합 레진으로 splinting하여 인상 채득한 군, 기존의 인상용 코핑을 splinting 하지 않고 인상 채득한 군의 작업 모형에서 각 임플란트 유사체 간 거리 차이는 통계적으로 유의하지 않았다(P >.05). 또한 동일 수평면에 대한 수직적 거리를 비교한 결과 flag type의 인상용 코핑을 사용하여 제작한 작업 모형이 Point 2에서는 기준 모형에 가장 근접한 수치를 보였고 Point 3에서는 오차가 가장 컸으며 이는 통계적으로 유의하였다(P <.05). 그 외 Point에서는 세 가지 방법 간에 통계적으로 유의한 차이는 없었다(P >.05). 새로운 인상용 코핑을 사용한 인상법은 기존의 인상용 코핑을 사용한 인상법과 비교적 유사한 정확성을 보여주었다.

• 동의신경정신과학회지
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• 제23권1호
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• pp.93-114
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• 2012

Objective : This study aimed to review the performance of traditional herbal prescriptions for treating dementia and present a strategy for research on dementia therapy utilizing herbal medicine. Methods : A definition was made to clarify the technology regarding the development of herbal prescriptions for treating dementia. The queries were compounded based on the initial keywords provided by experts in the field, then applied to the Web of Science database search engines from January 1986 to September 2011 to search related scientific articles. Before performing the analysis, papers were extracted from the initial search reviewed by experts and 80 articles were selected. Then, the selected papers were analyzed in terms of publish year, country, and type of herbal prescriptions. Furthermore, the research performance evaluation for treating dementia by herbal prescriptions was also created in terms of country and organization based on forward citation analysis. In addition to, for the evaluation regarding research quality, we classified and reviewed papers into two types: clinical studies and experimental studies. Results : According to the quantitative information analysis of 80 articles, the number of papers has increased by 21.9% per the yearly mean from 1995, and Japan had the largest portion within this research field. There were 34 kinds of traditional herbal prescriptions, among them Ukgansan had the highest number of studies followed by Jodeungsan, Dangkisoosan and so on. In addition, quality index as calculated by cites per paper is higher than average in Switzerland, Turkey and Japan. In the view of the evaluation on quality there were 12 clinical studies, 8 RCT reported that herbal prescriptions had efficacy at cognition, behavioral & psychological symptoms (BPSD) and activity of daily life (ADL) in various type of dementia. In experimental studies most of the studies were performed using animal models. The studies using Ukgansan were aimed at improving BPSD. The papers studied with Jodeungsan and Dangkisoosan targeted vascular dementia. Conclusions : In this study, research to develop traditional herbal prescriptions for treating dementia has the potential to improve symptoms since herbal medicines work as both multi-function and multi-target in dementia with multiple pathological or neurotoxic pathways. Therefore, the results of the research should be used in order to establish strategies to develop technology for treating dementia with traditional herbal prescriptions in the future.