Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Evaluation on the Quality of Research Field with Traditional Herbal Prescriptions for Dementia Therapy

치매 치료용 한약 처방의 연구성과에 대한 정성평가

  • Heo, Eun-Jung (Herbal Medicine Research division, Korea Institute of Oriental Medicine) ;
  • Kang, Jong-Seok (Information Analysis Center, Korea Institute of S&T Information) ;
  • Kang, Hyung-Won (Dept. of Neuropsychiatry, College of Oriental Medicine, Won-Kwang University) ;
  • Jeon, Won-Kyung (Herbal Medicine Research division, Korea Institute of Oriental Medicine)
  • 허은정 (한국한의학연구원 한의신약연구그룹) ;
  • 강종석 (한국과학기술정보연구원 정보분석본부) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 전원경 (한국한의학연구원 한의신약연구그룹)
  • Received : 2012.02.28
  • Accepted : 2012.03.07
  • Published : 2012.03.30
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Abstract

Objective : This study aimed to review the performance of traditional herbal prescriptions for treating dementia and present a strategy for research on dementia therapy utilizing herbal medicine. Methods : A definition was made to clarify the technology regarding the development of herbal prescriptions for treating dementia. The queries were compounded based on the initial keywords provided by experts in the field, then applied to the Web of Science database search engines from January 1986 to September 2011 to search related scientific articles. Before performing the analysis, papers were extracted from the initial search reviewed by experts and 80 articles were selected. Then, the selected papers were analyzed in terms of publish year, country, and type of herbal prescriptions. Furthermore, the research performance evaluation for treating dementia by herbal prescriptions was also created in terms of country and organization based on forward citation analysis. In addition to, for the evaluation regarding research quality, we classified and reviewed papers into two types: clinical studies and experimental studies. Results : According to the quantitative information analysis of 80 articles, the number of papers has increased by 21.9% per the yearly mean from 1995, and Japan had the largest portion within this research field. There were 34 kinds of traditional herbal prescriptions, among them Ukgansan had the highest number of studies followed by Jodeungsan, Dangkisoosan and so on. In addition, quality index as calculated by cites per paper is higher than average in Switzerland, Turkey and Japan. In the view of the evaluation on quality there were 12 clinical studies, 8 RCT reported that herbal prescriptions had efficacy at cognition, behavioral & psychological symptoms (BPSD) and activity of daily life (ADL) in various type of dementia. In experimental studies most of the studies were performed using animal models. The studies using Ukgansan were aimed at improving BPSD. The papers studied with Jodeungsan and Dangkisoosan targeted vascular dementia. Conclusions : In this study, research to develop traditional herbal prescriptions for treating dementia has the potential to improve symptoms since herbal medicines work as both multi-function and multi-target in dementia with multiple pathological or neurotoxic pathways. Therefore, the results of the research should be used in order to establish strategies to develop technology for treating dementia with traditional herbal prescriptions in the future.

Keywords

References

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