• Journal of Oriental Neuropsychiatry
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• v.12 no.2
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• pp.157-171
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• 2001

Astrocytes are glial cells that play a major role in the inflammation observed in Alzheimer's disease (AD). Upon stimulation from various agents, these cells adopt a reactive phenotype, a morphological hallmark in AD pathology, during which they themselves may produce still more inflammatory cytokines. Substance P (SP) can stimulate secretion of tumor necrosis $factor-\;{\alpha}$ $(TNF-\;{\alpha})$ from astrocytes stimulated with lipopolysaccharide (LPS). Here I report that Sunghyangjungkisan- ga- pogokyoung(Sgp) can modulate cytokines secretion from primary cultures of rat astrocytes. Sgp $(10\;to\;1000\;{\mu}g/ml)$ significantly inhibited the $TNF-\;{\alpha}$ secretion by astrocytes stimulated with LPS and SP. Interleukin-1 (IL-1) has been shown to elevate $TNF-\;{\alpha}$ secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. Treatment of Sgp $(10\;to\;1000\;{\mu}g/ml)$ to astrocytes stimulated with both LPS and SP decreased IL-1 secretion significantly. The secretion of $TNF-\;{\alpha}$ by LPS and SP in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. Neurodegenerative processes in AD are thought to be driven in part by the deposition of ${\beta}\;-amyloid\;(A\;{\beta})$, a 39- to 43-amino acid peptide product resulting from an alternative cleavage of amyloid precursor protein. Sgp $(10\;to\;1000\;{\mu}g/ml)$ significantly inhibited the $TNF-\;{\alpha}$ secretion by astrocytes stimulated with $A-{\beta}-$and IL-1. These results suggest that Sgp may inhibit $TNF-\;{\alpha}$ secretion by inhibiting IL-1 secretion and that Sgp has an antiinflammatory activity in AD brain

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.3
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• pp.149-156
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• 2018

Traditional medicines (TM) in Korea, China, and Japan share most of the theories and therapeutic tools, but there are also differences due to their unique histories and cultures. Here, we aim to identify the differences in the utilization of TM theory between three countries by analyzing herb usage data in terms of the related traditional theories. Herb usage data of each country was collected from "Investigation of Korean medicine use and herbal medicine consumption survey" (Korea), "Analytical report on circulation of key Chinese medicinal materials" (China), and "Survey report on raw material crude drug usage" (Japan). Fifty five herbs with sixty features belonging to five theoretical categories (four properties, five tastes, targeting meridians, treatment strategies, and herbal parts) were selected and analyzed. Weight Sum Model (WSM) and Network-Based Group Features (NBGF) were used to compare the theoretical characteristics of TM between three countries. For the statistical evaluation, we developed and applied Herb Set Enrichment Analysis (HSEA) for WSM and NBGF results. HSEA for WSM results revealed the kidney meridian were targeted more in Korea than Japan, while the spleen meridian were targeted more in Japan than Korea. Herbs with sour taste were used more in Japan than China. HSEA for NBGF results found that NBGF including warm, neutral, sweet, and tonifying features were more dominant in Korea and than Japan, while NBGF including cold, bitter, heat-clearing features were more dominant in Japan than the others. These results suggest that TM in Korea, China, and Japan have unique aspects of practice patterns and theoretical utilization.

• Korea-Australia Rheology Journal
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• v.19 no.4
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• pp.233-242
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• 2007

We performed a numerical investigation to find out the optimal choice of the spatial discretization in the distributed-Lagrangian-multiplier/fictitious-domain (DLM/FD) method for the solid/fluid interaction problem. The elastic solid bar attached on the bottom in a pressure-driven channel flow of a Newtonian fluid was selected as a model problem. Our formulation is based on the scheme of Yu (2005) for the interaction between flexible bodies and fluid. A fixed regular rectangular discretization was applied for the description of solid and fluid domain by using the fictitious domain concept. The hydrodynamic interaction between solid and fluid was treated implicitly by the distributed Lagrangian multiplier method. Considering a simplified problem of the Stokes flow and the linearized elasticity, two numerical factors were investigated to clarify their effects and to find the optimum condition: the distribution of Lagrangian multipliers and the solid/fluid interfacial condition. The robustness of this method was verified through the mesh convergence and a pseudo-time step test. We found that the fluid stress in a fictitious solid domain can be neglected and that the Lagrangian multipliers are better to be applied on the entire solid domain. These results will be used to extend our study to systems of elastic particle in the Stokes flow, and of particles in the viscoelastic fluid.

• Tunnel and Underground Space
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• v.7 no.2
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• pp.100-107
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• 1997

In case of a fire outbreak in a uni-directional road tunnel, the flow of traffic immediately behind the fire disaster will be stalled all the way back to the entrance of the tunnel. Furthermore, when the vehicle passengers try to flee away from the fire toward the entrance of the tunnel, the extremely hot fume that propagates in the same direction will be fatal to the multitudes evacuating, but may also cause damage to the ventilation equipments and the vehicles, compounding the evacuation process. This paper will present the 3-dimensional modelling analysis of the preventive measures of such a fume propagation in the same direction as the evacuating passengers. For the analysis, the fire hazard was assumed to be a perfect combustion of methane gas injected through the 1 m X 2 m nozzle in the middle of the tunnel, and the product of $CO_2$ as the indicator of the fume propagation. From the research results, when the fire hazard occurred in middle of the 400 m road tunnel, the air density decreased around the fire point, and the maximum temperatures were 996 K and 499 K at 210 m and 350 m locations, respectively, 60 seconds after fire disaster occurred, when the fumes were driven out only towards the exit-direction of the tunnel. By tracing the increase of $CO_2$ level over 1% mole fraction, the minimum longitudinal ventilation velocity was found to be 2.40 m/sec. Furthermore, through Analysis of the temperature distribution graphs, and observation of the cross-sectional distribution of $CO_2$ over 1% mole fraction, it was found that the fume did not mix with the air, but rather moved far in a laminar flow towards exit of the tunnel.

• Informatization Policy
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• v.27 no.2
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• pp.84-105
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• 2020

This paper is designed to deal with the gaps and differences between the two Koreas, which have gradually increased since the Korean War. The purpose of this study, in particular, is to assess the digital and AI gap between the two parts of the peninsula in the emerging 4^th industrial revolution era that is rapidly innovating the industrial structures, and to present a cooperation plan for the realization of a peace economy and economic prosperity of the Korean Peninsula in the future. In this study, policy alternatives for assessing and bridging the digital gap between South and North were drawn using the comprehensive policy (model) for closing the digital divide, which was one of Korea's past informatization policies. The derived alternatives are meaningful in that they can spark discussions for building the AI-driven society that realizes the integrated economy of the two Koreas complying with the future industrial structure.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.1
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• pp.32-37
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• 2011

The present study has been conducted to propose an algorithm regarding real-time load estimation of a gas engine-driven heat pump. In the study, thermal load of an indoor unit is estimated in terms of air-side and refrigerant-side. The air-side estimation is based on a typical heat exchanger model and is found to be in good agreement with experimental data. When it comes to the refrigerant-side load, a pressure difference across a valve must be estimated. For the estimation, it is assumed to be proportional to a bigger pressure difference that is available either by measurement or by estimation. Relative good agreement between the air- and refrigerant-sides suggests that the assumption may be plausible for the load estimation. The summed flow rate of all of indoor units is in good agreement with the throughput of the compressor which are calculated from the manufacturer's software. Accordingly, estimated thermal loads are also in good agreement. The proposed algorithm may be further developed for improved control algorithm and fault diagnosis.

• Journal of Ocean Engineering and Technology
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• v.25 no.6
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• pp.1-8
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• 2011

This paper describes a new method for a digital gas metal arc welding (GMAW) system. The GMAW system is an arc welding process that incorporates the GMAW power source (PS-GMAW) with a wire feed unit (WFU). The PS-GMAW requires an electric power of constant voltage. A constant magnitude is maintained for the arc current by controlling the wire-feed speed of the WFU. A mathematical model is derived, and a self-tuning fuzzy proportional-integral-derivative (PID) controller is designed and applied to control the welding current. The electrode wire feeding mechanism with this controller is driven by a DC motor, which can compensate for both the molten part of the electrode and undesirable fluctuations in the arc length during the welding process. By accurately maintaining the output welding current and welding voltage at constant values during the welding process, excellent welding results can be obtained. Simulation and experimental results are shown to prove the effectiveness of the proposed controller.

• Journal of Environmental Science International
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• v.16 no.8
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• pp.921-928
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• 2007

The objective of this work is the air quality modeling according to the scenarios of emission on complex terrain. The prognostic meteorological fields and air quality field over complex areas of Seoul, Korea are generated by the PSU/NCAR mesoscale model (MM5) and the Third Generation Community Multi-scale Air Quality Modeling System (Models - 3/CMAQ), respectively. The emission source was driven from the Clean Air Policy Support System of the Korea National institute of Environmental Research (CAPSS), which is a 1 km x 1 km grid in South Korea during 2003. In comparison of air quality fields, the simulated averaged $PM_{10},\;NO_2,\;and\;O_3$ concentration on complex terrain in control case were decreased as compared with base case. Particularly $PM_{10}$ revealed most substantial localized differences by $(18{\sim}24{\mu}g/m^3)$. The reduction rate of $PM_{10},\;NO_2,\;and\;O_3$ is respectively 18.88, 13.34 and 4.17%.

• Journal of Intelligence and Information Systems
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• v.7 no.1
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• pp.177-197
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• 2001

This paper is aimed at proposing a data mining-driven analysis to manage the customer defection rate in the bank. After 1997 IMF crisis, Korean banks were suffering from hard-pressed restructuring. At the heart of such restructuring effects, there was the need to manage the customer more effectively than ever. So far, many banks in Korea used to a poor management of customers without any highly-skillful techniques. In line with this argument, we propose several data mining techniques to determine more effective technique far managing customer deflection. We applied three data mining techniques such as logit model, neural network, and C5.0. Experiment data were collected from personal deposit account data of a specific bank in Korea. After experiments, we found that C5.0 showed more robust performance compared to other two techniques. On the basis of those experiment results, we proposed customer defection management policy.

• Atmosphere
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• v.27 no.4
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• pp.455-466
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• 2017

In Korea, property and human damages occur annually due to heavy precipitation during the summer. On August 8, 2015, heavy rainfall occurred in the Seoul metropolitan area due to an outflow boundary, and $77mmhr^{-1}$ rainfall was recorded in Gwangju, Gyeonggi Province. In this study, the simulation of the WRF numerical model is performed to understand the cause and characteristics of heavy rainfall using the Conditional Instability of the Second Kind (CISK), potential vorticity (PV), frontogenesis function, and convective available potential energy (CAPE) analyses, etc. Convective cells initiated over the Shandong Peninsula and located on the downwind side of an upper level trough. Large amounts of water vapor were supplied to the Shandong Peninsula along the southwestern edge of a high pressure system, and from the remnants of typhoon Soudelor. The mesoscale convective system (MCS) developed through CISK process and moved over to the Yellow Sea. The outflow boundary from the MCS progressed east and pushed cold pool eastward. The warm and humid air over the Korean Peninsula further enhanced convective development. As a result, a new MCS developed rapidly over land. Because of the latent heat release due to convection and precipitation, strong potential vorticity was generated in the lower atmosphere. The rapid development of MCS and the heavy rainfall occurred in an area where the CAPE value was greater than $1300Jkg^{-1}$ and the fronto-genesis function value of 1.5 or greater coincided. The analysis result shows that the MCS driven by an outflow boundary can be identified using CISK process.