• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.414-422
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• 2019

There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in various diseases and inflammation response processes. However, whether miR-15a/16 participates in the regulation of neuroinflammation and neuropathic pain development remains unknown. In this study, we established a mouse model of neuropathic pain by chronic constriction injury (CCI) of the sciatic nerves. Our results showed that both miR-15a and miR-16 expression was significantly upregulated in the spinal cord of CCI rats. Downregulation of the expression of miR-15a and miR-16 by intrathecal injection of a specific inhibitor significantly attenuated the mechanical allodynia and thermal hyperalgesia of CCI rats. Furthermore, inhibition of miR-15a and miR-16 downregulated the expression of interleukin-$1{\beta}$ and tumor-necrosis factor-${\alpha}$ in the spinal cord of CCI rats. Bioinformatic analysis predicted that G protein-coupled receptor kinase 2 (GRK2), an important regulator in neuropathic pain and inflammation, was a potential target gene of miR-15a and miR-16. Inhibition of miR-15a and miR-16 markedly increased the expression of GRK2 while downregulating the activation of p38 mitogen-activated protein kinase and $NF-{\kappa}B$ in CCI rats. Notably, the silencing of GRK2 significantly reversed the inhibitory effects of miR-15a/16 inhibition in neuropathic pain. In conclusion, our results suggest that inhibition of miR-15a/16 expression alleviates neuropathic pain development by targeting GRK2. These findings provide novel insights into the molecular pathogenesis of neuropathic pain and suggest potential therapeutic targets for preventing neuropathic pain development.

• The Journal of Engineering Geology
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• v.28 no.4
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• pp.687-699
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• 2018

Understanding rain infiltration into the ground is an important feature of landslide risk evaluation. In this study, a landslide risk index for the study area is suggested, wherein the result of the landslide risk evaluation, based on the factor of safety (FS), is used. The landslide risk index is a landslide risk prediction index that utilizes the saturated depth ratio of the ground. Based on the landslide risk result for the study area, it was found that the FS was first to decrease. However, it gradually became convergent over the 50-year rainfall intensity study period, a result that is similar to the relationship between the saturated depth ratio and soil thickness. Moreover, saturated depth was also found to be deeper on gentle slopes than steep slopes. As such, the landslide risk index, based on the Inhu-ri study result, is thus suggested. Additionally, the suggested landslide risk index was compared and analyzed against the rainfall intensity of previous landslide experience. Results thus revealed that almost all landslides that occurred were over 0.7, which is the second grade, based on the landslide risk index.

• Journal of Digital Convergence
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• v.17 no.1
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• pp.111-122
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• 2019

This study suggests that even if the consulting is started by the consulting of the company, it is difficult for the consulting firm to operate the consulting firm Consulting performance differs depending on the degree of understanding of consulting. Although consulting firms have been studying various prior research papers in view of the fact that there are many cases where they proceed with the sales strategy of repurchasing in mind, most of them deal with research on consulting performance on the supplier side, The purpose of this study is to investigate whether a company has a high level of participation in consulting in the event of a situation or situation and consequently influences the intention to purchase consulting. In order to find out whether they are visible, the reliability of the measured values and the fit of the measurement model by CFA were obtained through the exploratory factor analysis. The results were as follows: The results of this study are as follows. As a result of the study, it is necessary for the consultant to improve the participation of the consulting company and the understanding of the consulting in order to increase the intention of the consulting repurchase intention. Since the consultant shows the result in an empirical way, the consulting company participates in the role and process The results of this study are as follows. First, it is suggested that firms should be very careful about the participation and consulting understanding because they affect the repurchase intention of consulting firms.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.528-534
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• 2019

This study analyzes the factors affecting China's carbon emissions from 1985 to 2016. In recent years, the whole industries of China are in the midst of industrialization and have several problems. Now, the low-carbon economy has become the main task of China's economic development. This study analyzes the factors affecting China 's carbon emissions by selecting relevant data onto the Chinese yearbook and using a time series model. The analysis shows that related industries continue to innovate and increase the use of green energy such as electricity, but coal is still the largest share of the energy consumed. As energy use efficiency increases and industrial R&D investment increases year by year, carbon emissions are increasing every year. In addition, there is a stereotype that industry is the biggest factor affecting carbon emissions. The research found that the impact of the industry on China's carbon emissions is declining gradually. While controlling industrial carbon emissions, keeping continue to improve technology development and focusing on carbon emissions from other industries are critical to reduce overall carbon emissions. Based on the empirical results, if we can change stereotypes starting from the nature of the data, we will quickly reach a low carbon sustainable development economy.

• Journal of Digital Convergence
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• v.17 no.4
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• pp.159-166
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• 2019

This paper investigated convergent factors to turnover intention among some Administrative Staff in Medical Institutions(ASMI). The survey used self-administered questionnaires for 320 administrative staffs of 27 medical institutions in the J region, selected arbitrarily from July 2, 2018 to July 27, 2018. The hierarchical multiple regression analysis shows the following results. The turnover intention of respondents turned out to be significantly higher in following groups: a group in which organizational commitment is lower, a group in which organizational loyalty is higher, a group in which exhaustion, cynicism, reduced professional efficacy, sub-areas of job burnout are higher. The results show explanatory power of 50.9%. The results of the study indicate that the efforts, to increase organizational commitment and organizational loyalty, and to decrease exhaustion, cynicism, reduced professional efficacy, sub-areas of job burnout, are required to improve the turnover intention among ASMI. These results could be used in hospital organization personnel management and industrial health education to lower the level of turnover intention in ASMI, vocational aptitude education of health care college students. In following studies, it is necessary to present and analyze the structural model affecting the turnover intention of ASMI.

• Journal of Life Science
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• v.29 no.5
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• pp.614-620
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• 2019

The purpose of this study was to examine the growth plate, femoral bone length, bone mineral density, and blood composition in various experimental animals fed with oriental medicinal herbs containing growth factors. First, the lengths of the bone growth plates of the positive control (PC) group (fed with Astragalus membranaceus) and the Gh-199 and Sh-188 groups were increased when compared to group N. The Gh-199 group showed a greater increase in bone growth when compared with the PC group. In terms of the femoral bone length and bone mineral density, the effect of both Gh-199 and Sh-188 powders were as good as those of the PC group, and the Gh-199 powder showed a positive effect. Conversely, in the PC group, unlike the Gh-199 and Sh-188 groups, the aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities in the blood were increased, indicating that A. membranaceus is toxic to the body. Both the PC and Sh-188 groups also showed higher insulin-like growth factor-1(IGF-1) activity when compared with the Gh-199 group. Overall, the bone growth plate, femoral bone length, and bone mineral density measurements, and the blood analysis showed positive results in the group treated with Gh-199, and no specific toxicity of the herbal medicine in the body was evident.

• Journal of Korean Society of Health-System Pharmacists
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• v.35 no.4
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• pp.409-417
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• 2018

Background : Febrile neutropenia (FN) is one of the side effects in the patients treated with chemotherapy, and the patients who have FN generally need immediate treatment with extended-spectrum antibiotics and hospitalization. Pegfilgrastim and pegteograstim, which are used for the prevention of FN as a granulocyte-colony stimulating factor (G-CSF), have been granted insurance coverage in the Republic of Korea for certain breast cancer patients using doxorubicin and cyclophosphamide (AC) from September 2016. Methods : The data of the patients with breast cancer using AC regimen and G-CSF were collected retrospectively. This study involves cost-utility analysis of pegfilgrastim and pegteograstim. In this study, we constructed a simple decision tree model for short-term observation and calculated quality-adjusted life year (QALY) and the direct medical costs from the medical provider's perspective. Results : From September 2016 to May 2017, 15 patients were treated with pegfilgrastim and 15 patients were treated with pegteograstim. As a result of dividing the average cost by QALY for each treatment group, it was observed that pegfilgrastim and pegteograstim were consumed 24,923,384 won and 22,808,336 won per 1QALY, respectively. Consequently, incremental cost effectiveness ratio (ICER) showed 2,115,048 won more per pegfilgrastim than pegteograstim per 1QALY, and the cost per 1QALY of both the drugs was lower than 30,500,000 won; the Koreans were willing to pay this amount. Conclusions : This study suggests that pegfilgrastim and pegteograstim can be used to improve the quality of life of breast cancer patients undergoing AC therapy. Among the two drugs, pegteograstim seems to be more cost-effective. However, since this study was conducted as a retrospective observation method on a small scale, it is associated with many limitations. Therefore, a long-term prospective cohort study is needed to supplement the present findings.

• Journal of Life Science
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• v.31 no.8
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• pp.745-754
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• 2021

Deterioration of the immune function weakens the body's resistance to various infections, leading to a series of diseases. Immunomodulatory biomaterials have been used to reduce the side effects of immunosuppressants or to enhance immunity. Agarwood is the aromatic resinous portion of Aquilaria trees that has been traditionally used as a medicinal herb for the treatment of various diseases. Although previous studies have shown that agarwood can improve the body's immunity, evidence for this claim is still lacking. In this study, the immune-enhancing effects of the agarwood methanol extracts of Aquilaria malaccensis Lamk were evaluated in a RAW 264.7 macrophage model. Based on the results, the agarwood extracts markedly enhanced phagocytosis in the absence of cytotoxicity. The agarwood extract-treated RAW 264.7 cells exhibited the typical morphology of activated macrophages, which are spindle-shaped with elongated filopodia. Agarwood extract also significantly increased the production of nitric oxide (NO), which is associated with the increased expression of inducible NO synthase. Moreover, the secretion and expression levels of cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β and IL-6, were increased by agarwood treatment. Notably, these are also associated with a mitogen-activated protein kinase signaling pathway. Taken together, our findings provide scientific evidence that agarwood has potential immune-enhancing effects in vitro.

• Industry Promotion Research
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• v.6 no.2
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• pp.37-46
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• 2021

The purpose of this study is to examine the necessity of providing new perspectives by conveying the various psychological changes and realities experienced by victims of incest sexual violence after the incident, And it is meaningful to understand and record it through. The results of the analysis through the phenomenological methodology are as follows: First, participants were disturbed by the emotional neglect of their parents and forced violence, threats, and silence by their family members, resulting in disbelief in interpersonal relationships and low self-esteem and suffered constant difficulties in daily life. Second, the suffering and aftereffects of sexual violence experienced the conflict of roles by repeating the real maladjustment and social activity avoidance as the fear of being informed about the event, the negative thought about oneself, and the difficulty of interpersonal relationship. Third, the aftereffects of incest sexual violence in childhood·adolescence were found to be extreme with regard to PTSD. The PTSD experience has become a factor that forces participants to rely on substances, such as psychiatric medications and alcohol, and further avoids external activities with hallucinations and delusions. Fourth, the change through the adaptation process is a new perspective on life, facing and separating the events. During the adaptation program, they tried to express their words and feelings that they could not express because of the past hurts, to set goals for living their life, and to move forward. The experience of overcoming reality has enhanced participants' confidence in self-esteem, self-efficacy, and healthy self-control ability. In this study, it is meaningful to suggest a model in which the incest sexual violence trauma is reexperienced through the new daily crisis and the new adaptation process is repeated for each process.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.444-456
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• 2021

Economic abundance and the development of medical technology led to an aging society with an average life expectancy of 100 years, but retiring from the labor market at the age of 65 has become more difficult. This study aims to identify the influence of entrepreneurship, social support, and entrepreneurship mentoring as an effective support method to increase the entrepreneurial intention in order to enhance the entrepreneurial intention as an adult's second career development. In this study, data were collected using questionnaires from 340 adults, but only 319 were selected because 21 were judged to be inappropriate. For statistical analysis, SPSS 18.0 was used, and reliability test, factor analysis, and multiple regression analysis were used for hypothesis testing. The research results are as follows. First, as a result of examining the effects of adult entrepreneurship factors on entrepreneurship, it was found that among entrepreneurship, innovation and initiative had a significant positive (+) effect on entrepreneurship. Second, as a result of examining the effect of social support on entrepreneurial intention, it was found that family support had a significant negative (-) effect on entrepreneurial intention. Third, as a result of examining the effect of entrepreneurship mentoring on entrepreneurial intentions, it was found that role models and mentors had a positive (+) effect on entrepreneurial intentions. Fourth, as for the mediating effect of entrepreneurial efficacy, there were significant mediating effects of innovativeness → entrepreneurial efficacy → entrepreneurial intention, role model → entrepreneurial efficacy → entrepreneurial intention, mentor → entrepreneurial efficacy → entrepreneurial intention.