• Korean Journal of Medicinal Crop Science
• /
• v.18 no.1
• /
• pp.15-21
• /
• 2010

This study was conducted to investigate the effects of Lycii fructus and Astragalus membranaceus mixed extracts on immunomodulators and prevention in a streptozotocin-induced diabetes rat model. A total of 28 male rats were divided into four dietary groups and fed a commercial diet (A), commercial diet plus induced diabetes by a streptozotocin (STZ) injection (B), induced diabetes by STZ plus medicinal crop extracts(I&$H^{(R)}$) diet (C), and medicinal crop extracts (I&$H^{(R)}$) diet (D). Immunoblotting analyses revealed cytokine expression, and ELISA analyses revealed immunoglobulin E and nitric oxide production. As a results, the tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and inducible nitric oxide synthase (iNOS) as a inflammatory cytokine were decreased. Interleukin-6 (IL-6) and signal transducer and activation of transcription 3 (STAT3) cytokine related in diabetes expression through JAK/STAT3 pathway were also decreased. Furthermore, immunoglobulin E and nitric oxide production were decreased in the serum and lens, respectively. These results suggest that Lycii fructus and Astragalus membranaceus mixed extracts provide positive effects on immunomodulators and prevention in diabetes and eye disease complications.

• Journal of the Korea Concrete Institute
• /
• v.23 no.3
• /
• pp.289-294
• /
• 2011

The installation of joint is to prevent random cracking due to drying shrinkage stress of concrete slab. However contraction joint spacing is empirically implemented into slab constructions without detail calculation based on quantitative criteria. In this study, shrinkage strain of concrete due to concrete shrinkage stress was measured to suggest joint spacing based on the study results. The test environmental conditions were applied temperature of $15^{\circ}C$ and relative humidity of 60%. The design compressive strength used was 30 MPa and 40 MPa, which are currently used in concrete slab designs. The drying shrinkage test result was applied to drying shrinkage models (ACI 209R, CEB MC 90, B3, GL 2000 and Sakata). The results showed that the most appropriate model was ACI 209R model. Based on the research findings, quantitative contraction joint spacing locations were calculated.

• Journal of Ginseng Research
• /
• v.42 no.3
• /
• pp.379-388
• /
• 2018

Background: Ginsenosides are the main ingredients of Korean Red Ginseng. They have extensively been studied for their beneficial value in neurodegenerative diseases such as Parkinson's disease (PD). However, the multitarget effects of Korean Red Ginseng extract (KRGE) with various components are unclear. Methods: We investigated the multitarget activities of KRGE on neurological dysfunction and neurotoxicity in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. KRGE (37.5 mg/ kg/day, 75 mg/kg/day, or 150 mg/kg/day, per os (p.o.)) was given daily before or after MPTP intoxication. Results: Pretreatment with 150 mg/kg/day KRGE produced the greatest positive effect on motor dysfunction as assessed using rotarod, pole, and nesting tests, and on the survival rate. KRGE displayed a wide therapeutic time window. These effects were related to reductions in the loss of tyrosine hydroxylase-immunoreactive dopaminergic neurons, apoptosis, microglial activation, and activation of inflammatory factors in the substantia nigra pars compacta and/or striatum after MPTP intoxication. In addition, pretreatment with KRGE activated the nuclear factor erythroid 2-related factor 2 pathways and inhibited phosphorylation of the mitogen-activated protein kinases and nuclear factor-kappa B signaling pathways, as well as blocked the alteration of blood-brain barrier integrity. Conclusion: These results suggest that KRGE may effectively reduce MPTP-induced neurotoxicity with a wide therapeutic time window through multitarget effects including antiapoptosis, antiinflammation, antioxidant, and maintenance of blood-brain barrier integrity. KRGE has potential as a multitarget drug or functional food for safe preventive and therapeutic strategies for PD.

• Journal of the Korean Solar Energy Society
• /
• v.22 no.3
• /
• pp.39-46
• /
• 2002

The results of experiment on the performance of natural ventilation by insulation thickness and height system of solar chimney are described. The 3-inside wall was made of concrete and 1-wall was made of glass. The two kinds of model experiment were performed. One was the varition of the 60cm, 90cm and 120cm of solar chimney, the other was the variation of the insulation thickness 10mm and 50mm and without insulation of outside wall of solar cimney. As the temperature difference between bottom and top expressed $1.7\sim2.9^{\circ}C$, air velocity measured $0.5\sim0.8m/s$ and ventilation rate was $194.4m^3/h$ in the case of the 120cm height of solar chimney, the respect of natural ventilation performance was superior to others cases in the first model experiment. Though the case of 120cm height of solar chimney was attached 50mm insulation the ventilation rate was not so much as the case of solar chimney was attached 10mm insulation. the temperature difference between bottom and top was the largest in the other cases. From this research, the natural ventilation performance of solar chimney was affected by not only height and insulation thickness of solar chimney but also wind velocity and directon.

• Fisheries and Aquatic Sciences
• /
• v.24 no.12
• /
• pp.406-414
• /
• 2021

The objective of this study was to investigate the yield and characteristics of collagen protein extracted from the muscle of four different species of mantis shrimp: Miyakella nepa, Harpiosquilla harpax, Erugosquilla woodmasoni, and Odontodactylus cultrifer. Mantis shrimp muscle was extracted by using a pepsin-solubilization technique, with 0.5 M acetic acid and 5% pepsin enzyme. The highest collagen yield was from M. nepa muscle (0.478 ± 0.06%), which was significantly greater (p < 0.05) than that from H. harpax, O. cultrifer, and E. woodmasoni (0.313 ± 0.03%, 0.123 ± 0.02%, and 0.015 ± 0.00%, respectively). The freeze-dried collagen appeared as thin fibers, and formed an opaque film. The pepsin-soluble collagen (PSC) from four mantis shrimp species was analyzed by gel electrophoresis. The results showed that all species of mantis shrimp contained type I collagen, consisting of β, α1, and α2 subunits with average molecular weights of 250, 145, and 118 kDa, respectively. The study of the solubility of collagen showed that, for NaCl, collagen had the highest relative solubility in 2% NaCl (80.20 ± 4.95%). In contrast, the solubility decreased at higher NaCl concentrations. However, in terms of pH, collagen had the highest relative solubility at pH 3 (91.32 ± 5.14%), and its solubility decreased at higher pH. FT-IR spectroscopy was used to compare the collagen with a model compound. Five wavenumbers in the spectrum for model collagen were identified: Amide A (3,406-3,421 cm^-1), amide B (2,916-2,940 cm^-1), amide I (1,639-1,640 cm^-1), amide II (1,539-1,570 cm^-1), and amide III (1,234-1,250 cm^-1).

• Journal of Veterinary Science
• /
• v.21 no.3
• /
• pp.21.1-21.14
• /
• 2020

Background: Physical exercise is known to cause significant joint changes. Thus, monitoring joint behavior of athletic horses is essential in early disorders recognition, allowing the proper management. Objectives: The aims of this study were to determine the morphological patterns, physical examination characteristics and ultrasound findings of show jumping horses in training and to establish a score-based examination model for physical and ultrasound follow-ups of metacarpophalangeal joint changes in these animals. Methods: A total of 52 metacarpophalangeal joints from 26 horses who were initially in the taming stage were evaluated, and the horses' athletic progression was monitored. The horses were evaluated by a physical examination and by B-mode and Doppler-mode ultrasound examinations, starting at time zero (T0), which occurred concomitantly with the beginning of training, and every 3 months thereafter for a follow-up period of 18 months. Results: The standardized examination model revealed an increase in the maximum joint flexion angles and higher scores on the physical and ultrasound examinations after scoring was performed by predefined assessment tools, especially between 3 and 6 months of evaluation, which was immediately after the horses started more intense training. The lameness score and the ultrasound examination score were slightly higher at the end of the study. Conclusions: The observed results were probably caused by the implementation of a training regimen and joint adaptation to physical conditioning. The joints most likely undergo a pre-osteoarthritic period due to work overload, which can manifest in a consistent or adaptive manner, as observed during this study. Thus, continuous monitoring of young athlete horses by physical and ultrasound examinations that can be scored is essential.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2023.05a
• /
• pp.358-358
• /
• 2023

본 연구에서는 그동안 수자원분야 강우유출 해석분야에 활용되었던 대표적인 머신러닝&딥러닝(ML&DL) 모델을 활용하여 모델의 하이퍼파라미터 튜닝뿐만 아니라 모델의 특성을 고려한 기상 및 수문데이터의 조합과 전처리(lag-time, 이동평균 등)를 통하여 데이터 특성과 ML&DL모델의 조합시나리오에 따른 일 유입량 예측성능을 비교 검토하는 연구를 수행하였다. 이를 위해 소양강댐 유역을 대상으로 1974년에서 2021년까지 축적된 기상 및 수문데이터를 활용하여 1) 강우, 2) 유입량, 3) 기상자료를 주요 영향변수(독립변수)로 고려하고, 이에 a) 지체시간(lag-time), b) 이동평균, c) 유입량의 성분분리조건을 적용하여 총 36가지 시나리오 조합을 ML&DL의 입력자료로 활용하였다. ML&DL 모델은 1) Linear Regression(LR), 2) Lasso, 3) Ridge, 4) SVR(Support Vector Regression), 5) Random Forest(RF), 6) LGBM(Light Gradient Boosting Model), 7) XGBoost의 7가지 ML방법과 8) LSTM(Long Short-Term Memory models), 9) TCN(Temporal Convolutional Network), 10) LSTM-TCN의 3가지 DL 방법, 총 10가지 ML&DL모델을 비교 검토하여 일유입량 예측을 위한 가장 적합한 데이터 조합 특성과 ML&DL모델을 성능평가와 함께 제시하였다. 학습된 모형의 유입량 예측 결과를 비교·분석한 결과, 소양강댐 유역에서는 딥러닝 중에서는 TCN모형이 가장 우수한 성능을 보였고(TCN>TCN-LSTM>LSTM), 트리기반 머신러닝중에서는 Random Forest와 LGBM이 우수한 성능을 보였으며(RF, LGBM>XGB), SVR도 LGBM수준의 우수한 성능을 나타내었다. LR, Lasso, Ridge 세가지 Regression모형은 상대적으로 낮은 성능을 보였다. 또한 소양강댐 댐유입량 예측에 대하여 강우, 유입량, 기상계열을 36가지로 조합한 결과, 입력자료에 lag-time이 적용된 강우계열의 조합 분석에서 세가지 Regression모델을 제외한 모든 모형에서 NSE(Nash-Sutcliffe Efficiency) 0.8이상(최대 0.867)의 성능을 보였으며, lag-time이 적용된 강우와 유입량계열을 조합했을 경우 NSE 0.85이상(최대 0.901)의 더 우수한 성능을 보였다.

• Bulletin of the Society of Naval Architects of Korea
• /
• v.25 no.4
• /
• pp.13-27
• /
• 1988

Two version of the TUMMAC(Tokyo University Modified Marker-And-Cell) method, i.e., $TUMMAC-IV_{vm1}$ and TUMMAC-VI are applied to two water-wave problems. The ship wave of a Series 60 model($C_B=0.6$) and of the fore-body of a HSVA tanker model are simulated by the $TUMMAC-IV_{vm1}$ method are the results are compared with the experimental results. From the comparison with the experimental data it is ascertained that the $TUMMAC-IV_{vm1}$ method is useful for the analysis of the realized by the TUMMAC-VI method is useful for the analysis of the characteristics of nonlinear ship waves. Three-dimensional wave breaking is realized by the TUMMAC-VI method in the simulation of a flow about a vertical rectangular cylinder. From the results of this simulation, it is shown that the TUMMAC-VI method is very available for the simulation of 3-dimensional wave breaking phenomena.

• Restorative Dentistry and Endodontics
• /
• v.28 no.4
• /
• pp.341-347
• /
• 2003

This study was conducted to evaluate the temperature rise on the root surface while the root canal is being obturated using continuous wave of condensation technique. Maxillary central incisor was prepared for repeated canal obturation. Ten thermocouples (Omega Engineering Inc., Stanford, USA) were placed at 1 mm increment from the anatomical root apex. The real temperature of Buchanan plugger was recorded before insertion into the root canal. The root canal was obturated with continuous wave of condensation technique as described by Buchanan and the root surface temperature was recorded during obturation at $150^{\circ}C,{\;}200^{\circ}C,{\;}250^{\circ}C{\;}and{\;}300^{\circ}C$ temperature settings of System B HeatSource (Model 1005, Analytic technologies, Redmond, WA, USA). After completion of the temperature recording, the dentinal-cementum thickness at each sites was measured. The data were analyzed using one-way ANOVA followed by Scheffe's test and linear regression test. The results were as follows. 1. When the temperature was set at $150^{\circ}C,{\;}200^{\circ}C,{\;}250^{\circ}C{\;}and{\;}300^{\circ}C$ on the digital display of System B HeatSource, the real temperature of the plugger at the 1mm point from the tip revealed $130.82{\pm}2.96^{\circ}C,{\;}158.00{\pm}5.26^{\circ}C,{\;}215.92{\pm}6.91^{\circ}C{\;}and{\;}249.88{\pm}3.65^{\circ}C$ respectively. 2. The position of 8 mm from the anatomical apex showed the highest temperature increase at each temperature settings and it was significantly higher than those of other positions (p<0.0l). The temperature rise was constantly increased toward coronal portion from apex of the root. 3. The maximum temperature increase on the root surface was $2.37{\pm}0.09^{\circ}C{\;}at{\;}150^{\circ}C{\;}setting,{\;}3.11{\pm}0.12^{\circ}C{\;}at{\;}200^{\circ}{\;}setting,{\;}3.93{\pm}0.09^{\circ}C{\;}at{\;}250^{\circ}C{\;}setting{\;}and{\;}5.69{\pm}0.15^{\circ}C{\;}at{\;}300^{\circ}C$ setting respectively. These results suggest that it be relatively kind to the supporting tissues of the root that the root canal is obturated using continuous wave of condensation technique at $150^{\circ}C,{\;}200^{\circ}C,{\;}250^{\circ}C{\;}and{\;}300^{\circ}C$ temperature settings on digital temperature display of System B HeatSource.

• Food Science and Preservation
• /
• v.15 no.5
• /
• pp.774-781
• /
• 2008

was performed and Staphylococcus sciuri, Bacillus cereus, Escherichia coli, Proteus mirabilis, and Enterococcus faecalis were identified. No Salmonella strain, a typical contaminant of eggs, was found. The radiation sensitivities of isolated bacteria and Salmonella typhimurium, in an inoculated model system, were expressed in $D_{10}$ values. The ranges of $D_{10}$ values shown by S. typhimurium, S. sciuri, B. cereus, E. coli, P. mirabilis, and E. faecalis were 0.365-0.399 kGy, 0.418-0.471 kGy, 1.075-1.119 kGy, 0.280-0.304 kGy, 1.132-1.330 kGy, and 0.993-1.290 kGy, respectively. The growth of all six test bacteria in eggs (inoculated at $10^6-10^7\;CFU/g$) during 3 days of post-irradiation storage at ambient conditions ($25^{\circ}C$) was recorded. S. typhimurium was eliminated by irradiation at 3 kGy, and E. coli and S. sciuri were eliminated by irradiation at 5 kGy. The viable cell counts of B. cereus, P. mirabilis, and E. faecalis in eggs showed 4-6 log reductions after irradiation with 5 kGy.