• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.4B
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• pp.309-314
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• 2011

Analysis of discharge characteristics through control gates at river crossing structures is important for an effective water level control and water resources management. In recent years, many river control structures in four major rivers are under construction but only few researches on discharge characteristics at control gates could be found in Korea. The discharge characteristics depend on both shape of control gates and the effects of downstream water-depth. In this research, classification index for discharge patterns (free weir, submerged weir, free orifice, submerged orifice) through a control gate were reviewed with $h_g/h_1$, $h_3/h_g$, and $h_3/h_1$. Classification criteria of discharge patterns were also suggested. Representative discharge estimation equations for each discharge patterns were adopted and discharge coefficients were developed from a hydraulic model for a specific control gate which will be constructed in Nakdong river. Reliability of the derived discharge equation and coefficients were confirmed by comparisons between the real discharge in a model and the predicted discharge from the results of this research.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.23 no.3
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• pp.236-247
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• 2011

This study investigates sea level (SL) rise due to global warming in the Northwestern Pacific (NWP) and Seas around the Korean peninsula (KP) using outputs of IPCC AR4 climate models. Particularly, components of the SL rise induced by a local steric effect, which was not considered in most climate models, were computed using model-projected 3-dimensional temperature and salinity data. Analysis of the SL data shows that the ratio of the SL rise in the NWP and KP was about two times higher than that in global mean and particularly the ratio in the Kuroshio extension region was the highest. The SL rises over 100 years estimated from MPI_ECHAM5 and GFDL_CM2.1 model by A1B scenario considering the thermosteric effect were 24 cm and 28 cm for the NWP and 27 cm and 31 cm for the Seas around the KP, respectively. Statistical analysis reveals that these SL rises are caused by the weakening of the Siberian High in winter as well as variations of pressure system in the NWP and by the resultant change of water temperature. It also found that the highest SL rise in the Kuroshio extension region of the NWP was connected with the large increase of water temperature in this area.

• Tunnel and Underground Space
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• v.29 no.3
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• pp.197-213
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• 2019

We simulated the fault reactivation experiment conducted at 'Main Fault' intersecting the low permeability clay formations of Mont Terri Underground Research Laboratory in Switzerland using TOUGH-FLAC simulator. The fluid flow along a fault was modelled with solid elements and governed by Darcy's law with the cubic law in TOUGH2, whereas the mechanical behavior of a single fault was represented by creating interface elements between two separating rock blocks in FLAC3D. We formulate the hydro-mechanical coupling relation of hydraulic aperture to consider the elastic fracture opening and failure-induced dilation for reproducing the abrupt changes in injection flow rate and monitoring pressure at fracture opening pressure. A parametric study was conducted to examine the effects of in-situ stress condition and fault deformation and strength parameters and to find the optimal parameter set to reproduce the field observations. In the best matching simulation, the fracture opening pressure and variations of injection flow rate and monitoring pressure showed good agreement with field experiment results, which suggests the capability of the numerical model to reasonably capture the fracture opening and propagation process. The model overestimated the fault displacement in shear direction and the range of reactivated zone, which was attributed to the progressive shear failures along the fault at high injection pressure. In the field experiment results, however, fracture tensile opening seems the dominant mechanism affecting the hydraulic aperture increase.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.1B
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• pp.11-20
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• 2008

The spillway type of small and midsize dams in Korea is almost overflow weir. To examine flood control capacity of overflow spillway, FLOW-3D was applied to Daesuho dam and analysis was focused on the discharge of dam spillway by changing weir shape. Overflow phases and discharges of linear labyrinth weir and curved labyrinth weir were compared with those of existing linear ogee weir. Hydraulic model experiment was performed to verify numerical result. Verification results showed that overflow behaviors and flow characteristics in the side channel by hydraulic model experiment and numerical simulation are well matched, and water surface elevation at side wall coincides with each other. When the reservoir elevation was increased up to design flood level, in case of the linear ogee weir the flow over the crest ran through smoothly in the side channel, whereas in cases of linear labyrinth weir and curved labyrinth weirs, the flow discharge was increased by 40 cms, and the flow over the weir crest, rotating counter-clockwise, was submerged in the side channel. The results of the water level-discharge curve revealed that labyrinth weir can increase discharge by 71% compared to the discharge of linear ogee weir at low reservoir elevation since it can have longer effective length. But as water surface elevation rises, the slope of water level-discharge curve of labyrinth weir becomes milder by submergence and nappe interference in the side channel.

• Toxicological Research
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• v.29 no.3
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• pp.195-201
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• 2013

The anti-inflammatory effects of glycosaminoglycan (GAG) derived from Isaria sinclairii (IS) and of IS extracts were investigated in a complete Freund's adjuvant (CFA)-treated chronic arthritis rat model. Groups of rats were treated orally with 30 mg/kg one of the following: [1] saline control, extracts of [2] water-IS, [3] methanol-IS, [4] butanol-IS, [5] ethyl acetate-IS, or [6] Indomethacin(R) as the positive control for a period of two weeks. The anti-paw edema effects of the individual extracts were in the following order: water-IS ex. > methanol ex. > butanol ex. > ethyl acetate ex. The water/methanol extract from I. sinclairii remarkably inhibited UV-mediated upregulation of NF-${\kappa}B$ activity in transfected HaCaT cells. GAG as a water-soluble alcohol precipitated fraction also produced a noticeable anti-edema effect. This GAG also inhibited the pro-inflammatory cytokine levels of prostaglandin $E_2$-stimulated lipopolysaccharide in LAW 264.7 cells, cytokine TNF-${\alpha}$ production in splenocytes, and atherogenesis cytokine levels of vascular endothelial growth factor (VEGF) production in HUVEC cells in a dose-dependent manner. In the histological analysis, the LV dorsal root ganglion, including the articular cartilage, and linked to the paw-treated IS GAG, was repaired against CFA-induced cartilage destruction. Combined treatment with Indomethacin(R) (5 mg/kg) and IS GAG (10 mg/kg) also more effectively inhibited CFA-induced paw edema at 3 hr, 24 hr, and 48 hr to levels comparable to the anti-inflammatory drug, indomethacin. Thus, the IS GAG described here holds great promise as an anti-inflammatory drug in the future.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.3 no.1
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• pp.3-13
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• 1993

This study was conducted at seven degreasing processes in plating plants located in Seoul, Incheon, Ansan, and Taejeon areas from July 21 to august 27, 1992. This study was performed to assess the TWA exposures to trichloroethylene (TCE) and evaluate factors affecting TCE concentrations in degreasing process. Two-Point Eddy Diffusional Model suggested by Wadden et al. was employed to calculalte emission factors according to degreaser type. Results are summarized as follows. 1. The TWA exposures of the degreasing operators ranged from 1.4 ppm to 123 ppm, and those of three plants out of seven were exceeding 50 ppm of both the Korean and U.S. OSHA standards. Degreasing assistant of Plant B, was exposed to 59 ppm. 2. The average concentrations at the distance 0, 1.5, 3.0 m from the degreasers were 1.014, 24, and 18 ppm, respectively, and showed a signifficant difference by distance (p<0.01). 3. The emission of TCE was reduced by installing local exhaust systems, condensers, and refrigeration lines at the degreasers (p<0.01). 4. The major factors related to exposure of operators were workload (r=.9621. p<0.01) and dimensions of degreansing room(r=-.8667, p<0.05). 5. If the air in degreasing room is mixed violently by other factors in addition to diffusion, the emission factors can not be evaluated because the important hypothesis of the Two-Point Eddy Diffusional Model can not be accepted. 6. The ultrasonic degreaser without the local exhaust ststem, condenser, and refrigeration lines emitted TCE three times greater than the ultrasonic degreaser with condenser and refrigeration 1ines only.

• Publications of The Korean Astronomical Society
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• v.27 no.3
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• pp.39-47
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• 2012

MIRIS, Multi-purpose Infra-Red Imaging System, is the main payload of STSAT-3 (Korea Science & Technology Satellite 3), which will be launched in the end of 2012 (the exact date to be determined) by a Russian Dnepr rocket. MIRIS consists of two camera systems, SOC (Space Observation Camera) and EOC (Earth Observation Camera). During a shock test for the flight model stability in the launching environment, some lenses of SOC EQM (Engineering Qualification Model) were broken. In order to resolve the lens failure, analyses for cause were performed with visual inspections for lenses and opto-mechanical parts. After modifications of SOC opto-mechanical parts, the shock test was performed again and passed. In this paper, we introduce the solution for lens safety and report the test results.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.12B
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• pp.2359-2368
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• 1999

In this paper we propose a 2D FLIR image-based 3D target recognition system which performs group-to-ground vehicle recognition using the target contour and its degree of reliability extracted from FLIR image. First we extract target from background in FLIR image. Then we define contour points of the extracted target which have high edge gradient magnitude and brightness value as reliable contour point and make reliable contour by grouping all reliable contour points. After that we extract corresponding reliable contours from model contour image and perform comparison between scene and model features which are calculated by DST(discrete sine transform) of reliable contours. Experiment shows that the proposed algorithm work well and even in case of imperfect target extraction it showed better performance then conventional 2D contour-based matching algorithms.

• Oncology Letters
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• v.18 no.3
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• pp.3256-3264
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• 2019

The induction of apoptosis is a useful strategy in anti-cancer research. Various Moon Hyung Yang (MHY) compounds have been developed as novel anti-cancer drug candidates; in the present study, the pro-apoptotic effects of (Z)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one (MHY695) on HCT116 human colon cancer cells were assessed. MTT assays were performed to investigate the dose-dependent cytotoxic effects of MHY695 on HCT116 cells. Immunofluorescence staining and flow cytometry analyses were performed to identify apoptotic cell death, and western blot analysis was used to investigate the apoptotic-signaling pathways. A mouse xenograft model was also used to determine the effects of MHY695 in vivo. MHY695 decreased the viability of HCT116 cells and induced apoptotic cytotoxicity. The apoptotic mechanisms induced by MHY695 involved the dephosphorylation of Bcl-2-associated agonist of cell death protein following protein kinase B inactivation, induced myeloid leukaemia cell differentiation protein and BH3-interacting domain death agonist truncation, caspase-3 and -9 activation and poly (ADP-ribose) polymerase cleavage. In addition, MHY695 significantly suppressed tumor growth in the mouse xenograft model, compared with the vehicle control. Notably, MHY695 exhibited potent anti-cancer effects in four different types of human colon cancer cell line, including Caco-2, DLD-1, HT-29 and HCT116. Additionally, MHY695 showed reduced cytotoxicity in NCM460, normal colonic epithelial cells. Furthermore, MHY-induced cytotoxicity in colon cancer cells was independent of the tumor suppressor protein p53. Collectively, these observations suggested that MHY695 may be a novel drug for the treatment of colon cancer.

• Journal of Food Hygiene and Safety
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• v.26 no.2
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• pp.120-124
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• 2011

Predictive mathematical models were developed for predicting the kinetics of growth of Listeria monocytogenes in smoked salmon, which is the popular ready-to-eat foods in the world, as a function of temperature (4, 10, 20 and $30^{\circ}C$). At these storage temperature, the primary growth curve fit well ($r^2$=0.989~0.996) to a Gompertz equation to obtain specific growth rate (SGR) and lag time (LT). The Polynomial model for natural logarithm transformation of the SGR and LT as a function of temperature was obtained by nonlinear regression (Prism, version 4.0, GraphPad Software). Results indicate L. monocytogenes growth was affected by temperature mainly, and SGR model equation is $365.3-31.94^*Temperature+0.6661^*Temperature^{\wedge^2}$ and LT model equation is $0.1162-0.01674^*Temperature+0.0009303^*Temperature{\wedge^2}$. As storage temperature decreased $30^{\circ}C$ to $4^{\circ}C$, SGR decreased and LT increased respectively. Polynomial model was identified as appropriate secondary model for SGR and LT on the basis of most statistical indices such as bias factor (1.01 by SGR, 1.55 by LT) and accuracy factor (1.03 by SGR, 1.58 by LT).