• Journal of Applied Biological Chemistry
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• v.64 no.1
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• pp.89-96
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• 2021

The aim of this study is to examine the effect of Caulerpa okamurae ethanol extract (COE) on glucose metabolism and insulin sensitivity as one of the drug targets for treatment of type2 diabetes. COE significantly inhibited protein tyrosine phosphatase (PTP1B) and dipeptidyl peptidase-IV (DPP-IV) enzyme activities in vitro assay. Also, COE significantly enhanced the glucose uptake and the expression of insulin receptor substrate-1 (IRS-1) and glucose transporter4 (GLUT4) proteins in 3T3-L1 adipocytes or zebrafish larvae compared with control. In dexamethasone-induced resistance model of L6 myotubes, the protein expression of insulin signaling and glucose uptake was effectively increased by the treatment of COE. In contrast, the elevated phosphorylation of IRS-1 Ser307 was normally suppressed by treatment of COE. However, COE had no effect on insulin secretion in pancreatic beta cells. Thus, our results suggest that COE improves the glucose metabolism and insulin sensitivity through the regulation of insulin signaling and GLUT4 protein in insulin's target cells and zebrafish larvae.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.2 s.245
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• pp.136-143
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• 2006

A particle image velocimetry (PlV) technique has been applied to measure the quantitative flow field characteristics behind a road vehicle with/without an air spoiler attached on its trunk and to estimate its effect on the wake. A vehicle model scaled in the ratio of 1/43 is set up in the mid-section of a closed-loop water tunnel. The Reynolds number based on the vehicle length is $10^5$. To investigate the three-dimensional structure of the recirculation zone and vortices, measurements are carried out on the planes both parallel and perpendicular to the free stream, respectively. The results show significant differences in the recirculation region and the vorticity distributions according to the existence of the air spoiler. The focus and the saddle point, appearing just behind the air spoiler, are disposed differently along the spanwise direction. Regarding the streamwise vortices, the air spoiler produces large wing tip vortices. They have opposite rotational directions to C-pillar vortices which are commonly observed in case that the air spoiler is absent. The wing tip vortices generate the down-force and as a result, they can make the vehicle more stable in driving.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.51 no.6
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• pp.298-306
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• 2002

We performed an safety evaluation on constructing of a common grounding system for electrical railway in view of its efficacy and technical fit. In order to compare the conventional grounding method, which has been individually conducted, with the common grounding with all ground wires connected in common to the counterpoise buried below the surface of the earth in parallel with rail, we set up scenarios with several cases of fault and load conditions in Chungbuk railway sections with the common grounding system. Based on models for railway conductors including the grounded system, line Parameters of railway power system are computed. The circuit model for power system with up and down lines, auto-transformers and railway substations is used to compute impedances of counterpoise and substation ground net. For each scenario with faults and operation conditions of railway, the induced potentials on signal and communication lines are also computed. It is shown that the common grounding for Chungbuk railway is superior experimentally to the conventional method in three respects: (1) the lower rail potentials during operation of railway in line, (2) the lower rail potentials for short-circuit faults between catenary and rail, and (3) the lower stress voltages on signal and communication lines for short-circuit or ground faults. The analysis results confirm that the grounding system for electric railway is required to be built by the common grounding and be evaluated on its safety in design.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.3
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• pp.129-134
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• 2004

To analyze the performance of the gas circuit breaker(GCB), the flow field variables such as temperature, pressure and density should be evaluated accurately In the puffer chamber of puffer type GCB, the pressure rise may Exceed 20 bar and in this range of high pressure, $SF_6$ gas deviates the ideal gas property. Therefore, the real gas property of $SF_6$ should be taken into consideration for the accurate analysis of flow field. This paper presents the analysis technique of cold gas flow in GCB employing the real gas state equation of SF6. The FVFLIC method is Employed to solve the axisymmetric Euler equation. To reduce the computational effort of real gas state equation, the relationship between density and pressure is approximated by the polynomial at the temperature of 300K. The proposed method is applied to the test GCB model and simulation results show good agreement with the experimental ones.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.3
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• pp.164-172
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• 2004

This paper presents the comparison results of some kinds of control method in circumstance of eccentric load. The plant to be controlled is a computed tomography(CT) driven by a permanent magnet synchronous motor. In a CT system, many units are attached on the rotationally part of a gantry such as x-ray tube, detector, heat exchanger, and data acquisition unit etc. Therefore keeping many components to balance which have different weight is not easy; this is inescapable problem in the all CT systems. To solve this problem against eccentric load, some kinds of control method have been compared and analysed by using protype CT. From the experimental results it is vilified that the CT drive system with model reference control method indicates higher speed regulation ability regardless of variable eccentric weight and uncertain position, and also in the limit condition of constant eccentric weight and fixed position, the compensation method with sinusoidal form is a strong candidate in view of speed ripple reduction.

• Journal of the Society of Naval Architects of Korea
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• v.37 no.3
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• pp.21-26
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• 2000

For coastal service ships, the water depth is a very important parameter in the design stage of the hull form that has an influence on the restriction of the speed and draft of ships. In this study, the water depth is important for ship design. In this research, the change of total resistance, trim and sinkage due to the variation of water depth are measured by using on equipment for shallow water condition. For the basic research step about the shallow water effect, the effects on Series60($C_B=0.6$) hull form are experimented. To compare with existing experiment results, the test conditions are same with those. The water depth conditions are 10, 15, 20, 25% of LPP of the model ship, respectively.

• Journal of Information Technology Applications and Management
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• v.10 no.3
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• pp.121-142
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• 2003

Most of companies related to the area of B2B electronic commerce are making their efforts to innovate their existing business process into new designed process based on the concept of virtual enterprise. Virtual enterprise can take on many forms and definitions. Nevertheless, the rationale for this business model is clear cooperate to compete, the virtual organization advocates collaboration, partnerships, alliance and similar ideas. This studyintends to suggest an empirical clue to test several hypotheses related to the influence of environmental. organizational, and technological factor to the successful implementation of virtual enterprise in automobile industry. This research surveyed 91 corporations in Korean automobile part industry. Among those samples 86 data of corporate general managers turned out to be statistically valid. This study performed the factor analysis, Cronbach-alpha test. Pearson correlation analysis for testing the validity and the reliability of this research. The results of factor analysis and reliability test indicate that thirty issues to be surveyed are to be grouped into nine factors. The result of multiple regression shows that the influencing factors of eight independent variables on a dependent variable are cooperation between partners, information intensity, IT compatibility, IS maturity. The partners in the strategic alliance will have to trust each other in carrying out their designated roles and responsibilities. and supplying the correct information critical for creating value in virtual business environment.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1753-1756
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• 2005

The sheet parts are formed with dies conventionally. But this conventional forming process is not suited to small volume and varied production for the reason of high cost. For the solution of this problem, a new forming process, which is called CNC incremental sheet forming, is being introduced. This process can form sheet parts without die, and is very well suited to small volume and varied production in space flight and automobile. In this paper, dieless CNC forming system based on a machining center is developed. A special device to grasp and pull the blank sheet built in the machining center and tool path generation S/W from STL file of 3-D model are developed. Several sheet parts are incrementally formed to verify the effectiveness of the developed system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.531-536
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• 2005

The purpose of this paper is to improve the hysteresis characteristics of a stack type piezoelectric actuator using system identification and tracking control. Recently, several printing methods that cost less and are faster than previous semiconductor processes have been developed for the production of electric paper and RFID. The system proposed in this study prints by spraying the molten metal, and consists of a nozzle, heating furnace, operating actuator, and an XYZ 3-axis stage, As an operating system, the piezoelectric(PZT) method has very valuable uses. However, the PZT actuator has a very big hysteresis characteristic due to the ferroelectric characteristics of the PZT element. This causes problems in the system position control characteristics and deteriorates the performance of the system. In this study, an investigation was conducted to improve the hysteresis characteristics of the PZT actuator that has an output displacement for the input voltage. The study proposed a inverse hysteresis model, a mathematic modeling method that can express the geometric relationship between voltage and displacement, in order to reduce the hysteresis of the PZT actuator. In addition, system identification and PID control methods were examined. Also, it was confirmed that the proposed control strategy gives good precision position control performance.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.10
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• pp.1427-1435
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• 2002

The main aim of the present article is numerically to investigate the micro-scale heat transfer phenomena in a silicon microstructure irradiated by picosecond-to-femtosecond ultra-short laser pulses. Carrier-lattice non-equilibrium phenomena are simulated with a self-consistent numerical model based on Boltzmann transport theory to obtain the spatial and temporal evolutions of the lattice temperature, the carrier number density and its temperature. Especially, an equilibration time, after which carrier and lattice are in equilibrium, is newly introduced to quantify the time duration of non-equilibrium state. Significant increase in carrier temperature is observed for a few picosecond pulse laser, while the lattice temperature rise is relatively small with decreasing laser pulse width. It is also found that the laser fluence significantly affects the N 3 decaying rate of Auger recombination, the carrier temperature exhibits two peaks as a function of time due to Auger heating as well as direct laser heating of the carriers, and finally both laser fluence and pulse width play an important role in controlling the duration time of non-equilibrium between carrier and lattice.