• Title/Summary/Keyword: miR34a

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The Influence of Post-operative Discomfort, Sense of Loss, and Family Support on Resilience in Patients after Breast Cancer Surgery (유방암 수술환자의 수술 후 불편감, 상실감, 가족지지가 회복력에 미치는 영향)

  • Kwan, An Na;Kim, Tae Hyun;Lee, Yun Mi
    • Journal of Korean Critical Care Nursing
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    • v.10 no.2
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    • pp.34-44
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    • 2017
  • Purpose: The purpose of this study was to identify post-operative discomfort, sense of loss, family support, and resilience in breast cancer surgery patients, and to investigate factors that affect resilience. Method: The sample of this study consisted of 108 patients who underwent surgery for breast cancer in two university hospitals located in B city. The collected data was analyzed with descriptive statistics, t-test, ANOVA, and Scheffé test, Pearson's correlation coefficients, and hierarchical multiple regression. Results: The factors that significantly affected resilience were as follows: having a religion (${\beta}=-.20$, p=.006), having an occupation (${\beta}=.14$, p=.049), having a high school diploma (${\beta}=.31$ p=.001), making less than 2-3 million won (${\beta}=-.19$, p=.036) per month, experiencing a sense of loss (${\beta}=-.22$, p=.003) and family support (${\beta}=.44$, p<.001). The total explanatory power amounted to 53.8% (F=14.83, p<.001, $AdjR^2=.54$). Conclusion: Educational intervention programs for breast cancer surgery patients that improve resilience by reducing the sense of loss and increasing family support must be developed.

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Evaluation of the Anti-inflammatory and Immunomodulatory Effects of BSASM Using in vitro Experiments (시험관내에서 천연물제제 BSASM의 항염증 및 면역억제 효능 평가)

  • Lee, Jong-Sung;Park, Yu-Mi;Park, Byung-Hwa;Jung, Kwang-Seon;Kim, Kuk-Hyun;Lee, Won-Hee;Park, Deok-Hoon
    • Korean Journal of Pharmacognosy
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    • v.34 no.3 s.134
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    • pp.228-232
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    • 2003
  • For effective management of atopic dermatitis, it is important to introduce a therapeutic agent although having the fewest side effects, has the greatest anti- inflammatory effect. In the course of screening anti-inflammatory agents, we obtained BSASM composed of several plant extracts. This study was designed to investigate anti-inflammatory and immunomodulatory effects of BSASM. As a first step, $NF-{\kappa}B$ luciferase reporter assay was performed to know the involvement of BSASM in the production of proinflammatory cytokines because $NF-{\kappa}B$ element has been known to play a major role in expression of cytokine genes such as interleukin-8 (IL-8) or tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$. LPS (lipolysaccharide)-induced $NF-{\kappa}B$ activation was inhibited by BSASM. In addition, we found the fact that BSASM inhibits LPS-induced produced production of IL-8 and $TNF-{\alpha}$ proinflammatory cytokines, indicating BSASM has anti-inflammatory effect. In interleukin-2 (IL-2) luciferase reporter assay in Jurkat T cells, BSASM reduced PHA (Phytohemagglutinin)-induced IL-2 luciferase activity, suggesting the possibility that BSASM might also have an immunomodulatory function in T cell-mediated immune response. Based on these results, we suggest the possibility that BSASM can be introduced to improve symptom of immune-related skin diseases, namely, atopic dermatitis.

A Meta-Analysis on Factors Related to Quality of Life in Heart Transplant Recipients (심장이식 수혜자의 삶의 질 관련 요인에 대한 메타분석)

  • Jang, Mi Ra;Im, Se Rah;Choi, Mona
    • Journal of Korean Clinical Nursing Research
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    • v.25 no.3
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    • pp.251-264
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    • 2019
  • Purpose: This study was a systematic review and meta-analysis to explore the factors related to quality of life in heart transplant recipients. Methods: To identify studies that suggested the factors related to the quality of life in heart transplant recipients, we searched the articles published from 1974 to November 2018 using Six databases, PubMed, CINAHL, EMBASE, Cochrane, KMBASE and RISS. A total of 22 studies were selected out of 5,234 for the systematic review and meta-analysis on the basis of the PRISMA flow. The quality of study was assessed by assessment tool form the NIH and meta-analysis was performed using the 'R 3.5.2' version to analyze the correlated effect sizes. Results: Factors related to quality of life in heart transplant recipients were categorized into six domains based on the health-related quality of life model introduced by Ferrans: individual, environmental, biological function, symptoms, functional status, and general health perception. In the meta-analysis, 34 factors were used and 17 factors having significant effect sizes were as follows: self-efficacy, demoralization, perceived control, current occupational status, age, marital status, health promotion life style in the individual characteristics; stress in environmental characteristics; physical function status, creatinine level, left ventricular ejection fraction (LVEF) in biological function; anxiety, depression, symptom frequency and distress in symptoms domain; coping, self-care compliance in functional status. Conclusion: The findings indicate that the multi-dimensional factors influencing the quality of life in heart transplant recipients and provide the evidence for developing effective interventions for improving the quality of life of recipients.

Reduction of Trimethylamine by Saccharomyces cerevisiae Isolated from Fermented Food (발효식품에서 분리된 Saccharomyces cerevisiae를 이용한 Trimethylamine 저감화)

  • Park, Seul-Ki;Lee, Jae-Hwa;Jo, Du-Min;Kang, Min-Gyun;Jang, Yu-Mi;Cho, Yeon-jin;Hong, Dong-lee;Kim, Young-Mog
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.52 no.2
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    • pp.121-126
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    • 2019
  • Trimethylamine (TMA) is a nitrogen-based aliphatic organic compound. It is a major odorous component of fish and fishery products and is often used as an indicator of fish quality. The efficacy of TMA removal by various yeast strains was investigated. The five yeast strains found to be most effective in removing TMA were isolated from fermented foods and were identified as Saccharomyces cerevisiae based on biochemical and 18S rRNA sequence analyses. These strains were designated as S. cerevisiae SK1511, SK1512, SK1513, SK1514 and SK1515. Yeast cultures were treated with a TMA solution (0.3%, v/v), and the level of TMA reduction was analyzed by headspace gas chromatography. The five S. cerevisiae strains removed 32.02-50.34% of the TMA from the solution. This study is the first to demonstrate TMA reduction by microbial treatment.

Prevalence of Anaplasma sp. in Thrushes (Family Turdidae) in Jeju Island, Republic of Korea (제주도와 마라도내 지빠귀과 조류에서 Anaplasma spp. 감염 조사)

  • Oh, Mi-Rae;Moon, Kyoung-Ha;Kim, So-Yeon;Kim, Yun-Gi;Choi, Chang-Yong;Kang, Chang-Wan;Kim, Hwa-Jung;Lee, Kyoung-Kap;Yun, Young-Min
    • Journal of Veterinary Clinics
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    • v.31 no.3
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    • pp.206-211
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    • 2014
  • Anaplasmosis is a rickettsial zoonosis mediated by blood-sucking arthropods, such as ticks, flies, and mosquitos. Migratory birds are common hosts of ticks that are mediators of anaplasmosis, in particular, the tick infection rate in thrushes (family Turdidae) has been known to be high. The main purpose of this study is to survey the occurrence and prevalence of Anaplasma spp. from the migratory thrushes in Jeju island. We collected blood samples from 6 thrushes rescued at the Jeju Wildlife Rescue Center and from 34 wild-caught thrushes on Mara island which is a satellite island of Jeju. As a result, the nested PCR confirmed that seven out of 40 individuals (17.5%) were infected by Anaplasma spp. and all of them were identified as A. phagocytophilum based on sequences obtained from partial 16S rRNA. All the infected birds were on their northward migration in spring, our results suggest that the Turdidae family, which is a common and abundant migrant group passing through Jeju island, may act a role as active reservoir and disperser of A. phagocytophilum causing potential influx of the zoonotic pathogens from its wintering grounds in lower latitude to the mainland Korea as well as Jeju.

Prevalence and Risk Factors of Fatty Liver among Industrial Male Workers (산업장 남성 근로자의 지방간 유병율 및 위험요인 연구)

  • Paek, Yun-Mi;Choi, Tae-In;Kim, Yun-Jeong;Choi, Eun-Ok
    • The Korean Journal of Rehabilitation Nursing
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    • v.10 no.2
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    • pp.141-146
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    • 2007
  • Purpose: This study was conducted to estimate the prevalence rate, and related factors,of fatty liver in male industrial workers. Method: Fatty liver was diagnosed using ultrasonography. The data for abdominal ultrasonography, BMI, smoking, alcohol drinking, exercise, liver enzymes, and lipid profiles were collected in 4,604 male who were examined with a health screening program in 2005. Prevalence rate and associated factors of fatty liver were analyzed using SPSS v. 12.0. Results: Overall prevalence of fatty liver was 34.1% and higher in the 30-39 year male group. Age, body mass index(BMI), hypertriglyceridemia, hypercholesterolemia, HDL cholesterol, r-GTP level were independently associated factors with presence of fatty liver in logistic regression analysis. Conclusion: The prevalence of fatty liver and tendency of associated factors were similar to those in the western world. To prevent development of this hepatic disorder, which may result in end-stage liver disease, risk factors such as obesity and dyslipidemia must be monitored and controlled within normal levels. The results of this study suggested maintenance of a healthy lifestyle, including diet, exercise, and behavioral change, as fundamental rehabilitation nursing implications.

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Comparative Pathogenicity of Fusarium graminearum Isolates from Wheat Kernels in Korea

  • Shin, Sanghyun;Son, Jae-Han;Park, Jong-Chul;Kim, Kyeong-Hoon;Yoon, Young-mi;Cheong, Young-Keun;Kim, Kyong-Ho;Hyun, Jong-Nae;Park, Chul Soo;Dill-Macky, Ruth;Kang, Chon-Sik
    • The Plant Pathology Journal
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    • v.34 no.5
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    • pp.347-355
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    • 2018
  • Fusarium head blight (FHB) caused by Fusarium species is a major disease of wheat and barley around the world. FHB causes yield reductions and contamination of grains with trichothecene mycotoxins including; nivalenol (NIV), deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), and 15-acetyldeoxynivalenol (15-ADON). The objectives of this study were to identify strains of F. graminearum isolated in Korea from 2012-harvested wheat grain and to test the pathogenicity of these NIV- and DON-producing isolates. Three hundred and four samples of wheat grain, harvested in 2012 in Chungnam, Chungbuk, Gyeongnam, Jeonbuk, Jeonnam, and Gangwon provinces were collected. We recovered 44 isolates from the 304 samples, based on the PCR amplification of internal transcribed spacer (ITS) rRNA region and sequencing. Our findings indicate that F. asiaticum was the predominant (95% of all isolates) species in Korea. We recovered both F. asiaticum and F. graminearum from samples collected in Chungnam province. Of the 44 isolates recovered, 36 isolates had a NIV genotype while 8 isolates belonged to the DON genotype (3-ADON and 15-ADON). In order to characterize the pathogenicity of the strains collected, disease severity was assessed visually on various greenhouse-grown wheat cultivars inoculated using both NIV- and DON-producing isolates. Our results suggest that Korean F. graminearum isolates from wheat belong to F. asiaticum producing NIV, and both F. graminearum and F. asiaticum are not significantly different on virulence in wheat cultivars.

A Correlational Study on ICU Nurses' Job Stress, the Way of Coping, and the Turnover Intention (중환자실 간호사의 직무스트레스와 대응방법, 이직의도에 대한 연구)

  • Cho, Yong Ae;Kim, Geum Soon;Kim, Eul Soon;Park, Han Mi;Yoo, Mi;Lim, Eun Ok;Hyun, Suk Gyung;Kim, Jung Yeon
    • Journal of Korean Clinical Nursing Research
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    • v.15 no.3
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    • pp.129-141
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    • 2009
  • Purpose: This descriptive survey was aimed to investigate the ICU nurses' job stress, the way of coping, and the turnover intention and to identify the correlation among them. Methods: A 58 items-questionnaire composed of 7 sub-dimensions revised by Park, J. S. (2003) was used to measure the ICU nurses' job stress, and an questionnaire by Han, J. S. and Oh, G. S. (1990) which has 34 items from 6 sub-dimensions were used to measure the ICU nurses' way of coping. To figure out the ICU nurses' turnover intention, a 3 items-questionnaire used. A total of 456 nurses were participated in the study. Results: The participants' job stress was 2.86(4-point scale), and the way of stress coping was 2.27. Job stress had a positive correlation with the way of coping (r=.134, p=.004) and the turnover intention. The 54.1% of nurses addressed that they had some level of turnover intention. The turnover intention had a significant difference according to job stress(t=-2.041, p=.042), the type of hospital (${\chi}^2=8.052$, p=.005) and the total number of hospital beds (${\chi}^2=9.232$, p=.010). Conclusion: The findings of the study illustrated that the ICU nurses had at least moderate-high level of stress. The subjects' job stress showed a positive correlation with the way of coping and the turnover intention. These findings demonstrate necessity to develop an intervention for ICU nurses' stress management.

A Review on Major Factors for Microalgae Biofuel Commercialization (미세조류 바이오연료 상용화를 위한 주요 인자 연구)

  • Kang, Do-Hyung;Heo, Soo-Jin;Oh, Chulhong;Ju, Se-Jong;Jeon, Seon-Mi;Choi, Hyun-Woo;Noh, Jae Hoon;Park, Se Hun;Kim, Tae-Young
    • Ocean and Polar Research
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    • v.34 no.4
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    • pp.365-384
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    • 2012
  • Microalgae are photosynthetic microorganisms that are highly productive in the presence of basic renewable natural sources (light, $CO_2$, water and nutrients). They can synthesize lipids, carbohydrates and proteins in a small number of days. Subsequently, these carbon-captured products can be processed into both biofuels and valuable co-products. Additionally, microalgae would be an ideal feedstock for replacing land-based food crops with cellular products as high energy density transportation fuels. These microscopic organisms could contribute a significant amount of renewable energy on a global scale. In Korea, microalgae biofuel research was common in the early 1990s. The research activities were unfortunately stopped due to limited governmental funds and low petroleum prices. Interest in algal biofuels in Korea has been growing recently due to an increased concern over oil prices, energy security, greenhouse gas emissions, and the potential for other biofuel feedstock to compete for limited agricultural resources. The high productivity of microalgae suggests that much of the Korean transportation fuel requirements can be met by biofuels at a production cost competitive with the increasing cost of petroleum seen in early 2008. At this time, the development of microlalgal biomass production technology remains in its infancy. This study reviewed microalgae culture systems and biomass production, harvesting, oil extraction, conversion, and technoeconomical bottlenecks. Many technical and economic barriers to using microalgal biofuels need to be overcome before mass production of microalgal-derived fuel substitutes is possible. However, serious efforts to overcome these barriers could become a large-scale commercial reality. Overall, this study provides a brief overview of the past few decades of global microalgal research.

A Safety Survey on Pesticide Residues in Dried Agricultural Products (건조농산물의 잔류농약 안전성 조사)

  • Lee, Hyo-Kyung;Oh, Moon-Seog;Jeong, Jin-A;Kim, Ki-Yu;Lee, Seong-Bong;Kim, Han-Taek;Kang, Hyang-Ri;Son, Ji-Hee;Lee, Yun-Mi;Lee, Mi-Kyoung;Lee, Byoung-Hoon;Kim, Ji-Won;Park, Yong-Bae
    • Journal of Food Hygiene and Safety
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    • v.34 no.4
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    • pp.340-347
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    • 2019
  • We performed a safety survey on residual pesticides in dried agricultural products. A total of 110 samples of dried agricultural products distributed in Gyeonggi-do were analyzed for 263 pesticides according to multi class pesiticide multiresidue method. Ten types of pesticides were detected in 10 samples. Chlorpyrifos was detected in Ricinus communis leaves, chlorpyrifos, hexaconazole, pyridalyl in Chwinamul (wild aster), diniconazole, isoprothiolane, lufenuron in radish leaves, hexaconazole in Cirsium setidens (Korean thistle), bifenthrin, and chlorothalonil, boscalid, and pyraclostrobin in pepper leaves. The detection rate of pesticides was 9.1%, and among these samples, one was detected over Maximum Residue Limits (MRLs). In the validation study, the values of limit of detection (LOD), limit of quantitation (LOQ), coefficient of determination ($R^2$) and recovery were in the range of 0.002~0.027 mg/kg, 0.006~0.083 mg/kg, 0.9964~1.0000 and 74.8~118.9%, respectively. The Positive List System (PLS) was newly introduced as part of the safety management of residual pesticide in agricultural products in Korea in 2019. With the application of the PLS, if the MRL is not established, 0.01 mg/kg limit is applied uniformly. In spite, these of strengthened residue limits, the MRLs of dried agricultural products are still insufficient. Therefore, this study could be utilized as basic data for the setting of proper MRLs.