• Journal of Digital Convergence
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• v.19 no.9
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• pp.453-461
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• 2021

This study aimed to explore the influences of safety attitude for patient and moral sensitivity in practice of standard precaution in small and medium hospital nurses. Data were collected from 150 small and medium hospital nurses in January 11, 2021 to January 22, 2021 and were analyzed using Descriptive statistics, Independent t-test, one-way ANOVA, Pearson correlation coefficients, and multiple regression. Practice of standard precaution was significantly correlated with safety attitude for patient (r=.539, p<.001) and moral sensitivity(r=.249, p=.002). Practice of standard precaution was associated safety attitude for patient, and work unit with 33.8% of the variance(F=18.47, p<.001). Based on the findings of this study, each institution needs to make efforts to strengthen the safety attitude for patient of small and medium hospital nurses for practice of standard precaution.

• Molecules and Cells
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• v.40 no.8
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• pp.587-597
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• 2017

MicroRNAs (miRNAs) are essential small RNA molecules that regulate the expression of target mRNAs in plants and animals. Here, we aimed to identify miRNAs and their putative targets in Hibiscus syriacus, the national flower of South Korea. We employed high-throughput sequencing of small RNAs obtained from four different tissues (i.e., leaf, root, flower, and ovary) and identified 33 conserved and 30 novel miRNA families, many of which showed differential tissuespecific expressions. In addition, we computationally predicted novel targets of miRNAs and validated some of them using 5' rapid amplification of cDNA ends analysis. One of the validated novel targets of miR477 was a terpene synthase, the primary gene involved in the formation of disease-resistant terpene metabolites such as sterols and phytoalexins. In addition, a predicted target of conserved miRNAs, miR396, is SHORT VEGETATIVE PHASE, which is involved in flower initiation and is duplicated in H. syriacus. Collectively, this study provides the first reliable draft of the H. syriacus miRNA transcriptome that should constitute a basis for understanding the biological roles of miRNAs in H. syriacus.

• Journal of Korean Academy of Dental Administration
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• v.6 no.1
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• pp.11-18
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• 2018

The aim of this study was to evaluate the competency of the Easyperio test, a genetic test method based on real time PCR for the detection of bacteria that cause dental caries and periodontal disease. To verify the validity of this text, various dental health evaluations were administered to 33 boys between the ages of 12 to 14, as this age group commonly experiences dental caries. These evaluations included a dental caries experience survey, a first molar health evaluation, the Dentocult Streptococcus mutans (SM) strip mutans, the Dentocult Lactobacillus spp (LB) test, and the Easyperio test. The correlation coefficients between the level of the Dentocult SM strip mutans and the dental caries experience were DT (R=0.570, p=0.001), DMFT (R=0.376, p=0.031), and first molar health (R=-0.395, p=0.023). The correlation coefficients between the amount of SM in the Easyperio test and dental caries experience were DT (R=0.528, p=0.002), DMFT (R=0.369, p=0.035), and first molar health (R=-0.426, p=0.013). The correlation coefficients between the level of the dentocult SM strip mutans and the SM amounts of the Easyperio test were S.mi (R=0.564 p=0.001) and S.mu (R=0.621, p=0.002). The correlation coefficients between the level of the Dentocult LB test and the SM amount of Easyperio test was S.mi (R=0.495, p=0.003). In conclusion, Easyperio test may be an easy and effective method for the differentiation and diagnosis of dental caries through quantitative and qualitative analysis of oral bacteria.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.2
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• pp.219-229
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• 2020

Objective: Considering the physiological and clinical importance of leptin receptor (LEPR) in regulating obesity and the fact that porcine LEPR expression is not known to be controlled by lncRNAs and miRNAs, we aim to characterize this gene as a potential target of SSC-miR-323 and the lncRNA TCONS_00010987. Methods: Bioinformatics analyses revealed that lncRNA TCONS_00010987 and LEPR have SSC-miR-323-binding sites and that LEPR might be a target of lncRNA TCONS_00010987 based on cis prediction. Wild-type and mutant TCONS_00010987-target sequence fragments and wild-type and mutant LEPR 3'-UTR fragments were generated and cloned into pmiRRB-REPORT^TM-Control vectors to construct respective recombinant plasmids. HEK293T cells were co-transfected with the SSC-miR-323 mimics or a negative control with constructs harboring the corresponding binding sites and relative luciferase activities were determined. Tissue expression patterns of lncRNA TCONS_00010987, SSC-miR-323, and LEPR in Anqing six-end-white (AQ, the obese breed) and Large White (LW, the lean breed) pigs were detected by real-time quantitative polymerase chain reaction; backfat expression of LEPR protein was detected by western blotting. Results: Target gene fragments were successfully cloned, and the four recombinant vectors were constructed. Compared to the negative control, SSC-miR-323 mimics significantly inhibited luciferase activity from the wild-type TCONS_00010987-target sequence and wild-type LEPR-3'-UTR (p<0.01 for both) but not from the mutant TCONS_00010987-target sequence and mutant LEPR-3'-UTR (p>0.05 for both). Backfat expression levels of TCONS_00010987 and LEPR in AQ pigs were significantly higher than those in LW pigs (p<0.01), whereas levels of SSC-miR-323 in AQ pigs were significantly lower than those in LW pigs (p<0.05). LEPR protein levels in the backfat tissues of AQ pigs were markedly higher than those in LW pigs (p<0.01). Conclusion: LEPR is a potential target of SSC-miR-323, and TCONS_00010987 might act as a sponge for SSC-miR-323 to regulate LEPR expression.

• Journal of the Korea Society of Computer and Information
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• v.24 no.5
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• pp.113-120
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• 2019

This study was conducted to identify the level of cultural empathy, self-esteem, and cultural competence and factors affecting cultural competence of nursing students. Participants were 157 nursing students who were 2nd, 3rd, and 4th grade in one university located at the Chungbuk provinces. Data collected using questionnaires which consisted of general characteristics, cultural empathy, self-esteem, and cultural competence. The mean score for cultural empathy was $3.63{\pm}.34$(scores ranged from 1 to 5), The mean score for self-esteem was $2.91{\pm}.42$(scores ranged from 1 to 4). The mean score for cultural competence was $3.31{\pm}.43$(scores ranged from 1 to 5). There were significant differences between cultural competence and age(t=-2.242, p=.027), grade(F=3.473, p=.033), and fluency of foreign language(F=5.053, p=.007). There were significant correlation between cultural competence and cultural empathy(r=.49, p<.001), and self-esteem(r=.33, p<.001)), and self-esteem and cultural empathy(r=.33, p<.001). Cultural empathy and self-esteem explained 29.4% of cultural competence and major predictor variable for cultural competence was cultural empathy. In this paper, we propose various multicultural education programs in curriculum and extra curriculum that can enhance cultural empathy and self-esteem to improve cultural competence of nursing students. Especially, continuous education of cultural knowledge among cultural competence will be done.

• Journal of Science Education
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• v.36 no.1
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• pp.14-21
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• 2012

We investigated the relationship of brain dominance with mathematics and science achievement. The participants were 131 middle school students (male: 74, female: 57). It was found that the above average group in mathematics and science achievement had the highest frequency with left lower brain (LLB) (mathematics: 33.8%, science: 35.0%), whereas the below average group in mathematics and science achievement had the highest frequency with right lower brain (RLB) (mathematics: 38.7%, science: 36.1%). The LLB score showed a significant difference between the above average group and the below average group in science (p<.05). In the correlational analysis, the LLB scores had the highest correlation coefficients (mathematics: r=.28, science: r=.26). The LUB scores had the second highest correlation coefficients (mathematics: r=.18, science: r=.24). These results suggest that LLB and LUB are related to mathematics and science achievement. Therefore, we insist that the assessment of mathematics and science achievement should consider brain dominance.

• Research in Community and Public Health Nursing
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• v.14 no.4
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• pp.686-698
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• 2003

Purpose: This is a descriptive correlation study purposed to provide basic data for comprehensive nursing care by analyzing the relationship between the burden and the quality of life of family caregivers of cancer patients treated with chemotherapy. Methods: As for the subjects of this study, 66 family caregivers who take care of cancer patients hospitalized and treated with chemotherapy participated in the research. The tool of this study was a structured questionnaire including questions concerning burden(19 items) and the quality of life(33 items). Collected data were analyzed using SPSS PC+ program through descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple linear regression. Results: 1) The mean score of burden was 2.6383. The mean score of quality of life was 3.3034. These score show that family caregivers perceive a moderate level of burden and the quality of life. 2) Family caregivers' burden was significantly related to symptoms in the cancer patient (r= 0.3501, P=0.0042) and family caregivers(r= 0.5340, P=0.0001). Family caregivers' quality of life was significantly related to symptoms in the cancer patient(r= -0.3528, P=0.0039) and family caregivers(r= -0.5472, P=0.0001). According to the result of examining' the relationship between burden and the quality of life, there was a statistically negative correlation(r= -0.6326, P=0.0001). 3) 'Family income after the onset of the patient' was the most important predictor of the burden of family caregivers($R^2$=0.158). 'Usual relationship with the patient' was the most important predictor of the quality of life of family caregivers($R^2$=0.138). Conclusions: The results presented above indicate that we must consider burden of family caregivers and symptoms experienced by them in order to improve the quality of life of family caregivers of cancer patients treated with chemotherapy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.81-90
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• 2016

The objective of this study was to investigate the effect of an education method applying the flipped learning technique for college students. Both self-directed learning readiness and educational performance before and after applying the flipped learning were examined. After applying the flipped learning technique, teacher-student interaction, learning satisfaction, and learning motivation were identified. The correlation of each variable was examined after applying the flipped learning technique to investigate its influence on learning motivation. A total of 68 second-year nursing students enrolled in E University were analyzed. A difference between before and after applying the flipped learning was analyzed by the paired t-test; a correlation between the variables was analyzed via Pearson's correlation coefficient; and an influence on the dependent variable learning motivation was analyzed using the stepwise multiple regression analysis. The results showed that self-directed learning readiness increased before and after applying the flipped learning technique with statistical significance, and the difference of educational performance was not significant. After an education session applying the flipped learning technique, a learning motivation demonstrated a significantly positive correlation with self-directed learning readiness (r=0.33, p=.006), college student educational performance (r=0.51, p<.001), teacher-student interaction (r=0.72, p<.001), and learning satisfaction (r=0.79, p<.001). A significantly positive correlation was also observed between the other variables. Factors influencing learning motivation were learning satisfaction and teacher-student interaction. The explanatory power for learning motivation in the regression model considering these two variables was 71.3% (F=80.66, p<.001). Therefore, to enhance learning motivation in applying the flipped learning technique, it is necessary to increase learning satisfaction and to establish a strategy that further vitalizes the teacher-student interaction.

• Women's Health Nursing
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• v.19 no.4
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• pp.295-305
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• 2013

Purpose: The objective of this study was to identify the relationships among symptom bother, physical and mental stress and health-related quality of life (HRQoL) in women with overactive bladder (OAB) syndrome. Methods: The participants were 106 women who were diagnosed with OAB (urgency, urge urinary incontinence, frequency, and/or nocturia) at P university hospital. Data were collected from Dec 23, 2011 to Aug 31, 2012. Results: The mean score for symptom bother was 43.1 points, for physical stress, 12.8 which was slightly higher than mental stress (11.8), and for HRQoL, 63.9. For symptom type, there were statistically significant differences in the symptom bother (F=8.67, p<.001) and HRQL (F=3.32, p=.023). The Symptom bother of OAB was positively correlated with physical stress (r=.23, p=.014) and mental stress (r=.33, p<.001) and negatively correlated with the subscales of HRQoL; coping (r=-.66, p<.001), concern (r=-.71, p<.001), sleep (r=-.59, p<.001), and social interaction (r=-.58, p<.001). Conclusion: From the results, bother symptom was associated with physical, mental stress and HRQoL. These results suggest that nursing intervention programs for OAB should be developed not only to relieve the symptoms but also to reduce stress and improve the quality of life.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.138.2-139
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• 2003

The inhibitory effects of (1R, 9S)- and (1S, 9R)-enantiomers of $\beta$-hydrastine (BHS) on dopamine biosynthesis in PC12 cells were investigated. (1R, 9S)-BHS decreased the intracellular dopamine content with the $IC_{50}$ value of 14.3 $\mu\textrm{M}$ at 24 h, but (1S, 9R)-BHS did not. In these conditions, (1R, 9S)-BHS inhibited TH activity mainly in a concentration-dependent manner(33％ inhibition at 20 $\mu\textrm{M}$) and decreased TH mRNA level. (omitted)