• Title/Summary/Keyword: miR-29a

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Influence of Fear of Evaluation, Test Anxiety, and Social Anxiety among Nursing Students (간호대학생의 평가두려움과 시험불안이 사회불안에 미치는 영향)

  • Cho, Ok-Hee;Hwang, Kyung-Hye;Lim, Jong-mi
    • The Journal of the Korea Contents Association
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    • v.17 no.7
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    • pp.56-66
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    • 2017
  • This study is a descriptive research study conducted to investigate the influence of fear of evaluation and test anxiety on social anxiety among nursing students. The subjects were 383 nursing students in a university and surveyed the structured questionnaires for evaluation fear, test anxiety and social anxiety from June to July 2015. As a result, it was found that fear of positive evaluation, fear of negative evaluation and test anxiety were found to affect social anxiety, and these variables predicted social anxiety of nursing students by 30%. The social anxiety of nursing students verified differences according to the economic condition, satisfaction of major in nursing, and academic stress, and that there was a positive correlation between fear of positive evaluation (r=.45, p<.001), fear of negative evaluation (r=.29, p<.001) and test anxiety (r=.29, p<.001). This study is significant in that fear of evaluation and test anxiety of nursing students are verified to be factors affecting social anxiety. We suggest that a social anxiety intervention program be developed and applied for nursing students. Also, it is necessary secure a strategy to apply the intervention program by screening social anxiety of nursing students in advance.

Antiapoptotic Effect of Aurintricarboxylic Acid; Extracellular Action versus Inhibition of Cytosolic Protein Tyrosine Phosphatases

  • Lee, Dong-Yoon;Kim, Mee-Kyung;Kim, Mi-Jeong;Bhattarai, Bharatraj;Kafle, Bhooshan;Lee, Keun-Hyeung;Kang, Jae-Seung;Cho, Hyeong-Jin
    • Bulletin of the Korean Chemical Society
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    • v.29 no.2
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    • pp.342-346
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    • 2008
  • Aurintricarboxylic acid (ATA) prevents apoptosis in a wide range of cell types, including PC12 cells. ATA is known to increase the phosphorylation level of IGF-1 receptor (IGF-1R) and downstream signaling proteins. ATA can translocate across the plasma membrane of PC12 cells and inhibit protein tyrosine phosphatases (PTPs) and, therefore, it is not clear whether ATA exerted its antiapoptotic effect through activation of IGF-1R or by inhibition of cytosolic PTPs. When PC12 cells, deprived of serum, were treated with Fab fragment of anti-IGF-1R antibody to prevent the binding of ATA to the extracellular domain of IGF-1R, ATA was found to penetrate into the cytosolic space of the cells. Under these conditions, the survival-promoting effects of ATA were abolished, and the increase of phosphorylation and characteristic cleavage of IGF-1R were not observed. These results indicate that the antiapoptotic effect of ATA in PC12 cells is due to the binding of ATA to the extracellular domain of IGF-1R and subsequent activation of the IGF-1R, not inhibition of cytosolic PTP(s).

The Relationship between Change in Obesity Indices and Change in Serum Lipids in Adult Male Workers (성인 남성 근로자에서 비만 지표의 변화와 혈청지질치 변화와의 관련성)

  • Ha, Young-Ae;Chun, Byung-Yeol;Kam, Sin;Lee, Sung-Kook;Yeh, Min-Hae
    • Journal of Preventive Medicine and Public Health
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    • v.29 no.3 s.54
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    • pp.439-449
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    • 1996
  • This study was conducted to evaluate the relationship between change in obesity indices and change in serum lipids in adult male workers. Two-hundred-eight adult male workers of an industry in Taegu city were followed-up from 1991 to 1995. Height, weight, circumferences of hip and waist, blood pressure were measured and serum lipids were analysed. Data on life style were obtained using self-administered questionnaires. Mean differences of anthropometric measurements between 1991 and 1995 were as follows: 1.63kg in weight, 3.61cm in waist circumferences, 4.23cm in hip circumferences, $0.52kg/m^2$ in BMI and -0.021 in WHR. Those of lipids were as follows; 15.09mg/dl in total cholesterol, 20.43mg/dl in triglyceride, 9.40mg/dl in HDL-cholesterol, 2.87 in MI - index (p<0.01) and 350mg/dl in LDL-cholesterol. The changed value of BMI and Katsura index were strongly correlated with that of total cholesterol(r=0.174, p<0.05), the changed value of BMI correlated with that of triglyceride(r=0.374, p<0.01) and the changed value of weight correlated with that of MI index(r=-0.173, p<0.05). The changed value of WHR was signifiantly correlated with that of total cholesterol(r=0.162, p<0.05), however, was not significantly correlated with HDL-cholesterol, LDL-cholesterol, triglyceride and MI index. The changed value of weight, BMI and Katsura index were correlated with that of triglyceride (r=0.262, p<0.01; r=0.267, p<0.01; r=0.258, p<0.01) and the changed value of MI index(r=0.143, p<0.05; r=-0.158; r=-0.144, p<0.01), adjusting the pattern of change in life style. The changed values of HDL - cholesterol and MI index between 1991 and 1995 in low WHR group were significantly higher than those in high WHR group(p<0.05, p<0.01), adjusting the baseline value of them. Similar pattern was observed when considering Katsura index. When stratifying by BMI value of 1991, in low BMI group, the changed value of HDL - cholesterol and MI index showed the same pattern as above, however that of triglyceride was statistically higher in obese group than in non obese group(p<0.05). In conclusion BMI might be a better indicator to predict serum lipids change than other obesity indices.

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Period study of 1RXS J062518.2+733433 from the X-ray and optical data

  • Yun, A-Mi;Kim, Youg-Gi;Choi, Chul-Sung
    • Bulletin of the Korean Space Science Society
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    • 2008.10a
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    • pp.29.3-29.3
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    • 2008
  • 1RXS J062518.2+733433. The X-ray data was obtained in April 6, 2006 with the XMM-Newton and the optical data with CCD R filter at the 1m telescope of the Lemonsan observatory in 2005-2006 for 11 nights. This source is classified as a magnetic cataclysmic variable with a spin period of 1187.3 s in the optical region. We determine the spin period to be $1187.26\pm0.11$ s using the X-ray data, which is well consistent with the optical studies. However, we find that the pulse profile of the data (0.2-10 keV) folded at the period is different from the quasi-sinusoidal optical profile and is dependent on the selected X-ray energy bands. The results of period searching with times of extrema will be also presented.

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The effects of cardiopulmonary resuscitation and automated external defibrillator education for school teachers (교사 대상 심폐소생술 및 자동제세동기 교육의 효과)

  • Park, Jeong-Mi
    • The Korean Journal of Emergency Medical Services
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    • v.17 no.2
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    • pp.29-41
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    • 2013
  • Purpose : The purpose of this study was to investigate the effectiveness of cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) education for school teachers by questionnaire survey including the knowledge, self-efficacy and skills of CPR and AED after basic life support (BLS) education. Methods : The subjects were school teachers who participated in BLS education from 24 Nov. to 1 Dec. 2012. They completed the self-reported questionnaire based on BLS skill checklist. Results : There was a statistically significant increase in the knowledge(p <.001), self-efficacy (p <.001) and skills(p <.001) of CPR and AED after BLS education. The correlation existed conspicuously between knowledge versus self-efficacy(r =.409, r =.387), knowledge versus skill(r =.442, r =.084), and self-efficacy versus skills (r =-.148, r =.047) of CPR and AED before and after BLS education. Conclusion : After BLS education, most of the participants found the program was easy and useful to perform. Participants had the willingness to do CPR and AED and wanted to teach BLS to others. It is necessary to provide BLS education for school teachers by systematic approach.

Effects of Psychological Acceptance and Social Support on Posttraumatic Growth in Stomach Cancer Patients (위암 환자의 심리적 수용, 사회적 지지가 외상 후 성장에 미치는 영향)

  • Cho, Hyun Mi
    • Journal of Korean Clinical Nursing Research
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    • v.25 no.3
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    • pp.265-274
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    • 2019
  • Purpose: The purpose of this study was to identify the effects of psychological acceptance and social support on posttraumatic growth in stomach cancer patients. Methods: The questionnaires were administered from January 14 to February 11, 2015 to 123 subjects who had stomach cancer surgery six months prior. SPSS statistics 21.0 software was used to analyze the data for t-test, ANOVA, Pearson's correlations, Scheffé test and multiple regression analysis. Results: The results of this study are as follows: The major factors related to posttraumatic growth included gender (t=-2.72, p=.007), age (r=-.21, p=.016), having a religion (t=-3.40, p<.001), perceived importance of religion (r=.43, p<.001), seriousness of cancer diagnosis (r=.25, p=.005) and impact of cancer diagnosis (r=.32, p<.001). There were significant relationships between psychological acceptance (r=.18, p=.041) and social support (r=.32, p<.001) on posttraumatic growth. Significantly influential factors of posttraumatic growth were age (β=-.19, p=.021), perceived importance of religion (β=.41, p<.001) and family support (β=.29, p<.001), which together accounted for 36.5% of the variance in posttraumatic growth. Conclusion: The result of current study indicated that age, importance of religion, and family support influenced posttraumatic growth. Based on the findings of this study, developing nursing intervention programs focusing on increasing posttraumatic growth in stomach cancer patients is recommended.

Relationship of career-related stress, commitment to a career choice and career decision self-efficacy of college students (대학생의 진로스트레스, 진로선택몰입 및 진로결정 자기효능감과의 관계)

  • Lee, Mi-Ra
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.12
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    • pp.8767-8775
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    • 2015
  • The purpose of this study was to identify the relationship of career-related stress, commitment to a career choice and career decision self-efficacy of college students. The participants were 293 college students in P city. Data were collected by using self-report questionnaires from May 6 to 29, 2015. Data were analyzed with descriptive statistics, t-test, ANOVA, Pearson,s correlation coefficient and Hierarchical regression analysis by SPSS/WIN 23.0 program. The career-related stress was negatively correlated with commitment to a career choice (r=-.731, p<.001) and career decision self-efficacy(r=-.449, p<.001). The influencing factors of career-related stress were grade(${\beta}$=.99, p<.017) and commitment to a career choice(${\beta}$=-.707, p<.001). This study concludes that it is necessary to develop education program to improve commitment to a career choice and career decision self-efficacy.

CoMSIA 3D-QSAR Analysis of 3,4-Dihydroquinazoline Derivatives Against Human Colon Cancer HT-29 Cells

  • Kwon, Gi Hyun;Cho, Sehyeon;Lee, Jinsung;Sohn, Joo Mi;Byun, Joon Seok;Lee, Kyung-Tae;Lee, Jae Yeol
    • Bulletin of the Korean Chemical Society
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    • v.35 no.11
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    • pp.3181-3187
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    • 2014
  • A series of 3,4-dihydroquinazoline derivatives with anti-cancer activities against human colon cancer HT-29 cell were subjected to three-dimensional quantitative structure-activity relationship (3D-QSAR) studies using the comparative molecular similarity indices analysis (CoMSIA) approaches. The most potent compound, BK10001 was used to align the molecules. As a result, the best prediction was obtained with CoMSIA combined electrostatic, hydrophobic, and hydrogen-bond acceptor fields ($q^2=0.648$, $r^2=0.882$). This model was validated by an external test set of six compounds giving satisfactory predictive $r^2$ values of 0.879. This model would guide the design of potent 3,4-dihydroquinazoline derivatives as anti-cancer agent for the treatment of human colon cancer.

Design and Fabrication of an L-Band Digital TR Module for Radar (레이다용 L대역 디지털 송수신모듈 설계 및 제작)

  • Lim, Jae-Hwan;Park, Se-Jun;Jun, Sang-Mi;Jin, Hyung-Suk;Kim, Kwan-Sung;Kim, Tae-Hun;Kim, Jae-Min
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.29 no.11
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    • pp.857-867
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    • 2018
  • Active array radar is evolving into digital active array radar. Digital active array radar has many advantages for making several simultaneous radar beams from the digital receive data of each element. A digital-type transceiver(TR) module is suitable for this goal in radar. In this work, the design results of an L-band digital TR module are presented to verify the possibility of fabrication for a digital active array antenna. This L-band digital TR module consists of a gallium-nitride-type HPA to achieve a more than 350-W peak output power and one-chip transceivers that include a digital waveform generator and analog digital converter. The receiving gain was 47 dB, the noise figure was less than 2 dB, and the final output type of the four channel receiving paths was one optic signal.

Screening of Rice Germplasm for the Distribution of Rice Blast Resistance Genes and Identification of Resistant Sources

  • Ali, Asjad;Hyun, Do-Yoon;Choi, Yu-Mi;Lee, Sukyeung;Oh, Sejong;Park, Hong-Jae;Lee, Myung-Chul
    • Korean Journal of Plant Resources
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    • v.29 no.6
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    • pp.658-669
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    • 2016
  • Rice blast, caused by a fungus Magnaporthe oryzae, is one of the most devastating diseases of rice worldwide. Analyzing the valuable genetic resources is important in making progress towards blast resistance. Molecular screening of major rice blast resistance (R) genes was determined in 2,509 accessions of rice germplasm from different geographic regions of Asia and Europe using PCR based markers which showed linkage to twelve major blast R genes, Pik-p, Pi39, Pit, Pik-m, Pi-d(t)2, Pii, Pib, Pik, Pita, Pita/Pita-2, Pi5, and Piz-t. Out of 2,509 accessions, only two accessions had maximum nine blast resistance genes followed by eighteen accessions each with eight R genes. The polygenic combination of three genes was possessed by maximum number of accessions (824), while among others 48 accessions possessed seven genes, 119 accessions had six genes, 267 accessions had five genes, 487 accessions had four genes, 646 accessions had two genes, and 98 accessions had single R gene. The Pik-p gene appeared to be omnipresent and was detected in all germplasm. Furthermore, principal component analysis (PCA) indicated that Pita, Pita/Pita-2, Pi-d(t)2, Pib and Pit were the major genes responsible for resistance in the germplasm. The present investigation revealed that a set of 68 elite germplasm accessions would have a competitive edge over the current resistance donors being utilized in the breeding programs. Overall, these results might be useful to identify and incorporate the resistance genes from germplasm into elite cultivars through marker assisted selection in rice breeding.