• Radiation Oncology Journal
• /
• v.36 no.1
• /
• pp.71-78
• /
• 2018

Purpose: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. Materials and Methods: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-$D_{near-max}$ ($D_2$), $D_{near-min}$ ($D_{98}$), $D_{mean}$, $V_{95}$, and $V_{107}$-homogeneity index (HI), and conformity index (CI) were compared. The mean doses of lung and heart, percentage volume of ipsilateral lung receiving 5 Gy ($V_5$), 20 Gy ($V_{20}$), and 55 Gy ($V_{55}$) and that of heart receiving 5 Gy ($V_5$), 25 Gy ($V_{25}$), and 45 Gy ($V_{45}$) were extracted from dose-volume histograms and compared. Results: PTV parameters were comparable between the two groups. CI was significantly improved with IMRT (1.127 vs. 1.254, p < 0.001) but HI was similar (0.094 vs. 0.096, p = 0.83) compared to 3DCRT. IMRT in comparison to 3DCRT significantly reduced the high-dose volumes of lung ($V_{20}$, 22.09% vs. 30.16%; $V_{55}$, 5.16% vs. 10.27%; p < 0.001) and heart ($V_{25}$, 4.59% vs. 9.19%; $V_{45}$, 1.85% vs. 7.09%; p < 0.001); mean dose of lung and heart (11.39 vs. 14.22 Gy and 4.57 vs. 8.96 Gy, respectively; p < 0.001) but not the low-dose volume ($V_5$ lung, 61.48% vs. 51.05%; $V_5$ heart, 31.02% vs. 23.27%; p < 0.001). Conclusions: For left sided breast cancer, IMRT significantly improves the conformity of plan and reduce the mean dose and high-dose volumes of ipsilateral lung and heart compared to 3DCRT, but 3DCRT is superior in terms of low-dose volume.

• Korean Journal of Microbiology
• /
• v.20 no.3
• /
• pp.125-133
• /
• 1982

Mutational experiments were performed to imporve the cellulase productivity of Aspergillus phoenicis KU175, isolated from the southern part of Korea, as a high cellulase producer. By treatment ultra-violet light nad 4-NQO(4-Nitroquinoline-N-Oxide), mutation waas induced, and treatment ultra-violet light and 4-NQO (4-Nitroquinoline-N-Oxide), mutation was induced, and A.phoenicis KU175-115 was finally selected for its highest avicelase production. Avicelase production of the mutant was increased about 2 times compared with those of the wild strain. However, activities of other hydrolytic enzymes, such as amylase, protease and nuclease, of the mutant strain didn't show a marked difference compared with those of the nuclease, of the mutant strain didn't show a marked difference compared with the wild strain, except slight increase in ribonuclease activity and slight decrease in glucoamylase activity. Avicelases from the mutant strain selected were purified from wheat bran culture by successive salting out, followed by dialysis and column chromatography, and their charcteristics were compared with thosw of the wild strain. Avicelase was separated into three peaks in the mutant strain as well as in the case of wild strain. Avicelase II activity of the mutant strain was prominently higher than that of the wild strain, while avicelase I and III activities of those were equivalent. The optimal pH ranges and stability of avicelase II from the mutant strain were pH4-5 and pH3.5-6.0, respectively, as well as in the case of the wild strain. The optimal temperature and thermal stability of avicelase II from the mutant strain were $40{\sim}50^{\circ}C\;and\;20{\sim}55^{\circ}C$, respectively. These results were same as those of the wild strain. By the using of Eadie-Hofastee plot, $K_m\;and\;V_{max}$ of avicelase II from the mutant and the wild strain were calculated to be 2.29mg/ml and $4.84{\mu}g$ reducing sugar as glucose per min equally, from the line fitted to the data by the least square method. Activity of avicelase II from the mutant strain was slightly activated by $Mg^{++}\;but\;inhibited\;by\;Cu^{++}, \;Mn^{++}\;and\;Zn^{++}$, as well as in the case of the wild strain. Therefore, it was concluded that the mutant didn't induce the formation of another avicelase isozyme, or the changes in the properties of avicelase, but induce the changes in the productively of the same avicelase II by the action of regulatory gane.

• Korean Journal of Microbiology
• /
• v.37 no.3
• /
• pp.197-203
• /
• 2001

An ubiquitous bacterium, Pseudomonar cepacia KH410 was isolated from fresh water plant root and identified. Adsorption of heavy metals of lead, cadmium and copper by this strain was investigated. Optimal conditions foradsorption was 1.0 dry g-biomass, at pH 4.0 and temperature of $40^{\circ}C$. Adsorption equilibrium reached max-imum after 120 min in 1000 mg/l metal solutions. The adsorption capacity (K) of lead was 5.6 times higher thancadmium and 4.0 times higher than that of copper. Adsorption of lead was applicable for Langmuir modelwhereas Freundlich model for cadmium and copper, respectively. Adsorption strength (1/n) of heavy metal ionswere in the order of lead>copper>cadmium. Uptake capacity of lead, cadmium and copper by dried cell was83.2,42.0,65.2 mg/g-biomass, respectively. Effective desorption was induced 0.1 M HCI for lead and 0.1 $HNO_3$ for cadmium and copper. Pretreatment to increase ion strength was the most effective with 0.1 M KOH.Uptake by immobilized cell was 77.8,58.5,71.2 mg/g-biomass for lead, cadmium and copper, respectively. Theimmobilized cell was more effective than ion exchange resin on removal of heavy metals in solution containinglight metals.

• Economic and Environmental Geology
• /
• v.34 no.4
• /
• pp.355-373
• /
• 2001

Palaeomagnesim of Paleozoic Tuwibong Type Sequence in Yemi area was studied with a total of 256 core-samples collected from 23 sites. The study area (geographical coordinates: 37.l8$^{\circ}$N, l28.610E) is located between Taebaek and Yongwol belonging to the northeastern part of the Okchon Belt. Thermal cleaning was a most effective method to extract stable characteristic remanent magnetization (ChRM) direction, even though AF cleaning also worked on some specimens. Mean ChRM direction of the Cambrian Hwajol Formation was different from the present-day field direction and showed maximum clustering (max. k value) at 100% bedding-tilt correction. However, it could not pass the fold test. Ordovician Makkol and Kosong Limestones as well as Permian Sadong and Kobangsan Formations have very weak NRM, and were remagnetized into the present-day field direction. ChRM directions from the Carboniferous Hongjom Formation passed both fold and reversal tests. IRM experiments and blocking temperature spectrum indicate that both magnetite and haematite are carrier of the primary magnetization. Palaeomagnetic pole position from the Carboniferous Hongjom Formation is very similar to that of contemporary North China Block (NCB) suggesting that the study area was a part of, or located very near to, the NCB during Carboniferous.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.49 no.4
• /
• pp.325-330
• /
• 2004

This study was carried out to determine adequate planting date, to compare the growth characteristics between early and late maturing cultivars, and to provide the data for the cultivation techniques of soybean [Glycine max (L.) Merr.] in double cropping system with winter crops on paddy field in Korea. Cultivars were planted on 26 May, 16 June, and 7 July with a planting density of $70cm(row\;widtb)\;{\times}\;10cm$ (planting spacing). Seed yield of soybean planted on June 16 and July 7 was approximately $37\%\;and\;53\%$, respectively, less than that of conventional planting date of May 26 in Pungsan-namulkong, and planted on June 16 and July 7 was about $30\%\;and\;37\%$, respectively, less then that of conventional planting date of May 26 in Hanamkong. The number of pods and seeds per plant decreased as planting date delayed. Seed weight increased in Pungsan-namulkong but decreased in Hannamkong as planting date delayed. The flowering date was late in delayed planting plots, but it was shorted for days from emergence to flowering and from emergence to maturity. The plant height of Hannamkong was greater than Pungsan-namulkong from the emergence to flowering stages, but in contrast, it was greater in Pungsan-namulkong than Hannamkong after flowering stage (50d after emergence) when it planted on May 26. There were no significant differences between two soybean cultivars at planting dates of June 16 and July 7. Leaf number, leaf area, and dry matter were also reduced by late planting, and Both of them were shown in high reduction at the later planting. There was a high significant difference at the flowering $(r\;=\;0.87^{**})$ and pod formation $(r\;=\;0.91^{**})$ stages between leaf dry matter and seed yield. Crop growth rate (CGR) was greater at $R2\~R3$ growth stages compared to $R3\~R4\;or\;R4\~R5$ growth stages in two soybean cultivars and the greatest CGR was obtained at planting date of May 26 in two soybean cultivars except for R4-R5 growth stage in Pungsan-namulkong. There was a highly significant positive difference between the seed yield and the leaf area index (LAI) across R3 to R4 and R2 to R3 stages. The photosynthetic rate $(P_N)$ of the uppermost leaf position had no significant difference among planting dates and between two soybean cultivars. However, $P_N$ of the $7^{th}$ leaf position increased as the planting date delayed.

• Radiation Oncology Journal
• /
• v.34 no.3
• /
• pp.193-201
• /
• 2016

Purpose: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. Materials and Methods: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed. Of 33 patients, 17 patients (51.5%) were Helicobacter pylori (HP) negative and 16 patients (48.5%) were HP positive but refractory to HP eradication (HPE). The 2D-RT (n = 14) and 3D-CRT (n = 19) were performed and total dose was 30.6 Gy/17 fractions. Of 11 patients who RT planning data were available, dose-volumetric parameters between 2D-RT and 3D-CRT plans was compared. Results: All patients reached complete remission (CR) eventually and median time to CR was 3 months (range, 1 to 15 months). No local relapse occurred and one patient died with second primary malignancy. Tumor response, survival, and toxicity were not significantly different between 2D-RT and 3D-CRT (p > 0.05, each). In analysis for dose-volumetric parameters, $D_{max}$ and CI for PTV were significantly lower in 3D-CRT plans than 2D-RT plans (p < 0.05, each) and $D_{mean}$ and V15 for right kidney and $D_{mean}$ for left kidney were significantly lower in 3D-CRT than 2D-RT (p < 0.05, each). Conclusion: Our data suggested that involved field RT with moderate-dose for gastric MALT lymphoma could be promising and 3D-CRT could be considered to improve the target coverage and reduce radiation dose to the both kidneys.

• Journal of Life Science
• /
• v.22 no.8
• /
• pp.1085-1091
• /
• 2012

The purpose of this study is to investigate the effects of indoor and outdoor exercise environments on bone mineral density and body composition in old women. A total of 26 old women were randomly divided into two groups: an indoor exercise group (IE, n=13) and an outdoor exercise group (OE, n=13). The exercise groups performed moderate exercise (HR max 50~70%; RPE 11-15) three times a week for 60 minutes over 20 weeks. After exercise training, bone mineral density was significantly improved in the OE group as compared with the IE group. Body fat mass was significantly decreased in the IE group. Weight, lean body mass, and body fat mass were significantly decreased in the OE group. Body mass index was significantly decreased in the outdoor exercise group as compared to the IE group. Our findings show that a 20-week program of outdoor exercise training improves bone mineral density and body composition in old women. As mentioned above, it has been found that engaging in an outdoor exercise program for 20 weeks has a positive effect on bone mineral density and body composition in old women. In conclusion, engaging in the outdoor exercise program, including aerobic and resistance exercises, for 20 weeks improved bone mineral density and inhibited bone loss in old women and had a positive influence on vitamin D levels, thereby potentially lowering the risk of osteoporosis.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1998.11a
• /
• pp.170-170
• /
• 1998

In order to discover new types of 5-hydroxytryptamine antagonists, we have devoted our attention to investigating naturally occurring compounds having anti-5HT activity in vitro. Recently, ${\gamma}$-mangostin [1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-bytenyl)-9H-xanthen-9-one] from the fruit hull of Garcinia mangostana Linn has been shown to be a selective antagonist for 5-hydroxytryptamine$_{2A}$ receptors in smooth muscle and platelets. It is of interesting that y-mangostin which does not have a nitrogen atom, possesses marked 5-$HT_{2A}$ receptor blocking activity. The present study was undertaken to investigate the effects of ${\gamma}$-mangostin on central 5-HT receptors by using animal behavioural models. Intracerebronventricular injection of ${\gamma}$-mangostin (10-40n mol/mouse) inhibited 5-fluoro-${\alpha}$-methyltryptamin (5-FMT) (45 mg kg$^{-1}$, i.p.)-induced head-twitch response in mice in the presence or absence of citalopram (5-HT-uptake inhibitor). Neither the 5-FMT- nor the 8-hydroxy-2-( di-n-propylamino )tetralin (5-HT$_{1A}$-agonist)-induced 5-HT syndrome (head weaving and hindlimb abduction) was affected by ${\gamma}$-mangostin. The locomotor activity stimulated by 5-FMT through the activation of at-adrenoceptors did not alter in the presence of ${\gamma}$-mangostin. 5-HT-induced inositol phosphates accumulation in mouse brain slices was abolished by ketanserin. ${\gamma}$-Mangostin caused a concentration-dependent inhibition of the inositol phosphates accumulation and the binding of [$^3H$]-spiperone, a specific 5-$HT_{2A}$ receptor antagonist, to mouse brain membranes. Kinetic analysis of the [$^H3$]-spiperone binding revealed that ${\gamma}$-mangostin increased the $_{d}$ value without affecting the $B_{max}$ value, indicating the mode of the competitive nature of the inhibition by ${\gamma}$-mangostin. These results suggest that ${\gamma}$-mangostin inhibits 5-FMT-induced head-twitch response in mice by blocking 5-$HT_{2A}$ receptors not by blocking the release of 5-HT from the central neurone. ${\gamma}$-Mangostin is a promising 5-$HT_{2A}$ receptors antagonist in the central nervous system.m.

• Journal of Life Science
• /
• v.16 no.6
• /
• pp.949-954
• /
• 2006

Soybean [Glycine max (L.) Merr.] is an important crop, accounting for 48% of the world market in oil crops. Improvement of the quality and quantity of soybean seed constituents is one of the most important objectives in soybean breeding. Protein content and seed size are important properties to determine the quality of tofu and soy sprouts respectively. The objective of this study was to identify quantitative trait loci (QTLs) that control seed weight, protein and oil content in soybean. The 117 $F_{2:10}$ recombinant inbred lines (RlL) developed from a cross of 'Keunolkong' and 'Shinpaldalkong' were used. Narrow-sense heritability estimates based on a plot mean on seed weight, protein and oil content were 0.8, 0.78 and 0.71, respectively. Four independent QTLs for seed weight were identified from linkage group (LG) F, I and K. Five QTL for protein content were located on LG D1b, E, H, I and L. Oil content was related with six QTLs located on LG D1b, E, G, I, J and N. Protein and oil content have three common QTLs on LG D1b, E and I. Thus, we identified major loci improving soybean seed quality.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.29 no.3
• /
• pp.259-271
• /
• 2013

The purpose of this study was to make the stress distribution produced by simulated different load under two types of internal connection implant system (stepped and tapered type) by means of 3D finite element analysis, The finite element model was designed with the parallel placement of the one fixtures ($4.0mm{\times}11.5mm$) with reverse buttress thread on the mandibular 1st molar. Two models were loaded with 200 N magnitude in the vertical direction on the central position of the crown, the 1.5 mm and 3 mm buccal offset point from the central position of the fixture. The oblique load was applied at the angle of $30^{\circ}$ on the crown surface. Von Mises stress value was recorded and compared in the fixture-bone interface in the bucco-lingual dimension. The results were as follows; 1. The loading conditions of two internal connection implant systems (stepped and tapered type) were the main factor affecting the equivalent bone strain, followed by the type of internal connections. 2. The stepped model had more mechanical stability with the reduced max. stress compared to $11^{\circ}$ tapered models under the distributed oblique loading. 3. The more the contact of implant-abutment interface to the inner wall of implant fixture, the less stress concentration was reduced.