• 대한화학회지
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• 제40권9호
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• pp.640-648
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• 1996

Chitin을 epichlorohydrin과 반응시켜 가교 chitin을 합성하고, $C_2$ 위치의 아세트아미드기를 탈아세틸화하여 가교 chitosan을 얻었다. 가교 chitosan을 증류수에 팽윤시킨 다음 글리세린과 silver sulfadiazine을 가하여 고분자 matrix를 제조하였다. 이렇게 제조된 matrix로부터 in vitro에서의 약물 방출 pattern을 고찰하기 위해 pH7.4 인산염 완충용액 중에서 약물의 함유량, 글리세린의 농도 변화 및 matrix 두께변화에 미치는 인자들에 관하여 연구 검토 하였다. 고분자 matrix내의 약물의 함유량과 matrix의 두께가 증가할수록 약물 방출 지속 시간은 지연되었다. 그러나 글리세린의 함유량이 증가함에 따라 약물 방출 지속 시간은 오히려 감소 하였다. 또한 약물의 함유량과 글리세린의 함유량이 증가할수록 겉보기 방출속도상수 (K)값도 증가하였으나, matrix 두께가 증가함에 따라서는 겉보기 방출속도상수(K)값이 일정하였다. 이상과 같이 가교 chitosan은 약품의 방출 조절형 제제로서 사용 가능성을 나타냈으며, 약물로 사용된 silver sulfadiazine의 방출거동은 Higuchi model에 따른 확산으로 생각되었다.

• 대한수학회지
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• 제15권2호
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• pp.167-176
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• 1979

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2003년도 추계학술발표대회 요약집
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• pp.476.1-476.1
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• 2003

• 환경영향평가
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• 제23권2호
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• pp.157-167
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• 2014

The purpose of this study is to seek the application of IUCN categories of overlapping protected areas which is legally designated in South Korea. Different government departments in South Korea have managed and designated as protected areas. However, the protected areas due to different management agencies can be confused with restricting behaviors and supporting residents. The IUCN presents the reasonal standardization classifying the protected areas which could be applied all over the world. Six categories issued by the IUCN could be applied to deal with the problems of the overlapping protected areas. We suggested the application of the IUCN categories compared with legal frame in South Korea. Most areas are overlapped in designation, but the areas are important for ecology and landscape. Moreover, each protected areas in South Korea have zone districts. Comprehensively considered all these things, we made rationale matrix correlated with the IUCN categories and the zone districts of the protected areas in South Korea. For the result of this study, this matrix could be helped to the application of the IUCN categories in domestic protected areas. Although the protected areas has been recognized as regulatory regions, it is expected to expand and sustain the areas based on the matrix.

• 대한화장품학회지
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• 제17권1호
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• pp.64-80
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• 1991

The SKINTEX Method is based on a two-compartment physico-chemical model which includes a Biomembrane Barrier in compartment one and an organized macromolecular matrix in compartment two. Test samples absorb onto or permeate through the keratin/collagen Biomembrane Barrier and then can interact with the organized macromolecular matrix. Changes in the integrity of the barrier release a dye indicator: Changes in the matrix can alter its transparency. The sum of these two responses is read spectrophotometrically at 470nm. An early investigation of 950 chemicals and formulations in the SKINTEX System produced results which were 89% concordance to in vivo Draize dermal irritation results obtained with 24-hour occluded application of test samples with-out abrasion and standard scoring. Alkaline materials were analyzed in a specialized SKINTEX AMA Protocol. In this early study, the model did not distinguish nonirritant test materials and formulation with PDII(Primary Dermal Irritation Index)in the range from 0 to 1.2, A High Sensitivity Assay Protocol(HSA)was developed to amplify the changes in both compartments of this model and provide more accurate calibration of these changes. A study of 60 low irritation test samples including cosmetics, household products, chemicals and petro-chemicals distinguished nonirritants with PDII $\leq$ 0.7 for 26 of 30 nonirritants. A second protocol was developed to evaluate the SKINTEX model predictability with respect to human irritation. The Human Response Assay (HRA )has been optimized based on differences in penetration and irritation responses in humans and rabbits. An additional 32 test materials with different mechanisms and degrees of dermal toxicity were evaluated by the HRA. These in vitro results were 86% concordant to human patch test results. In order to further evaluate this model, a Standard Chemical Labelling (SCL) Protocol was developed to optimize this system to predict Draize dermal irritation results after a 4-hour application of the test material. In a study of 52 chemicals including acids, bases, solvents, salts, surfactants and preservatives, the SCL results demonstrated 85% concordance to Draize results for a 4-hour application of test samples on non-abraded rabbit skin. The SKINTEX System, including three specialized protocols, provided results which demonstrated good correlation to the endpoint of dermal irritation in man and rabbits at different application times.

• 대한토목학회논문집
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• 제33권1호
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• pp.337-346
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• 2013

플랜트 설계는 매우 다양한 공학 분야가 참여하는 고도로 복잡한 시스템이다. 이 방대한 시스템에 관여된 각 서브시스템은 각기 다른 서브시스템과 수시로 정보를 주고 받으며 작업을 반복하게 되는 복잡한 관계를 형성한다. 이런 복잡한 프로세스에서 체계적인 설계관리는 성공적인 플랜트 설계를 위한 필수적인 요건이다. 이에 본 연구에서는 Design Structure Matrix를 이용하여 플랜트의 최적 설계 협업 체계를 도출하였다. 이를 위해 전문가 설문 및 워크샵을 수행하여 플랜트 설계의 주요 업무, 설계 서브시스템, 설계요소, 관련설계요소, 그리고 그들간의 관계를 파악하였다. 효율적인 분석을 위해 Visual Basic Application과 Matlab을 이용하여 자동화된 분석 프로그램을 개발하였다. 제안된 방법과 프로그램을 소각로 설계 시스템에 적용한 결과 유효한 주요 반복작업 그룹들을 도출할 수 있었다. 도출된 결과물은 설계 협업 전략 수립에 유용하게 활용될 수 있을 것으로 사료된다.

• Composites Research
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• 제30권2호
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• pp.94-101
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• 2017

$ZrB_2$, ZrC, $HfB_2$, HfC 및 TaC 등의 초고온 세라믹스들은 극초음속 체계의 노즈콘, 로켓 노즐 및 리딩 엣지 등에 적용하기 위하여 최근 활발한 연구가 진행되고 있다. 그러나 그 실제 적용은 다양한 원인 때문에 제약받고 있는데 취성 특성에 의한 낮은 열충격 저항 특성이 그 원인 중 하나이다. 그러한 문제는 세라믹 섬유강화 복합재료를 제조함으로써 개선될 수 있다. 본 리뷰에서는 초고온 세라믹스의 개념과 초고온 세라믹스 섬유강화 복합재료(UHTC-CMC)의 제조 공정 및 평가에 대하여 간단히 정리하였다. 또한 UHTC-CMC의 제조를 위한 세계적인 연구를 요약하였으며 한국에서 수행중인 초고온 세라믹스 연구에 대해 간단히 소개하였다.

• Journal of applied mathematics & informatics
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• 제31권1_2호
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• pp.299-309
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• 2013

In this paper, we introduce a new numerical technique which we call fractional Chebyshev finite difference method (FChFD). The algorithm is based on a combination of the useful properties of Chebyshev polynomials approximation and finite difference method. We tested this technique to solve numerically fractional BVPs. The proposed technique is based on using matrix operator expressions which applies to the differential terms. The operational matrix method is derived in our approach in order to approximate the fractional derivatives. This operational matrix method can be regarded as a non-uniform finite difference scheme. The error bound for the fractional derivatives is introduced. The fractional derivatives are presented in terms of Caputo sense. The application of the method to fractional BVPs leads to algebraic systems which can be solved by an appropriate method. Several numerical examples are provided to confirm the accuracy and the effectiveness of the proposed method.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2004년도 봄 학술발표회 논문집
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• pp.1-8
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• 2004

For the linearized differential algebraic equation of the nonlinear constrained system, exact initial values of the acceleration are needed to solve itself. It may be very troublesome to perform the inverse operation for obtaining the incremental quantities since the mass matrix contains the zero element in the diagonal. This fact makes the mass matrix impossible to be positive definite. To overcome this singularity phenomenon the mass matrix needs to be modified to allow the feasible application of predictor and corrector in the iterative computation. In this paper the proposed numerical algorithm based on the modified mass matrix combines the conventional implicit algorithm, Newton-Raphson method and Newmark method. The numerical example presents reliabilities for the proposed algorithm via comparisons of the 4th order Runge-kutta method. The proposed algorithm seems to be satisfactory even though the acceleration, Lagrange multiplier, and energy show unstable behaviour. Correspondingly, it provides one important clue to another algorithm for the enhancement of the numerical results.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2001년도 Proceedings ICPE 01 2001 International Conference on Power Electronics
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• pp.795-802
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• 2001

The commutation and control in matrix converters is more complicated as in voltage source converters. Natural freewheeling paths do not exist and the theoretic absent storage elements result in a direct coupled system of load and line currents as well as voltages. The paper offers an overview about staggered commutation and control policies in matrix converters. Based on the knowledge about load current direction and the signs of the line to line input voltages different multi-step commutation policies were derived. This paper examines the application of that policies in the case of space vector modulation and direct control methods with the focus on the resulting effects to the reference output voltage deviation.