• Title/Summary/Keyword: long-term safety

Search Result 1,306, Processing Time 0.025 seconds

Full-Endoscopic versus Minimally Invasive Lumbar Interbody Fusion for Lumbar Degenerative Diseases : A Systematic Review and Meta-Analysis

  • Son, Seong;Yoo, Byung Rhae;Lee, Sang Gu;Kim, Woo Kyung;Jung, Jong Myung
    • Journal of Korean Neurosurgical Society
    • /
    • v.65 no.4
    • /
    • pp.539-548
    • /
    • 2022
  • Objective : Although full-endoscopic lumbar interbody fusion (Endo-LIF) has been tried as the latest alternative technique to minimally invasive transforaminal lumbar interobody fusion (MIS-TLIF) since mid-2010, the evidence is still lacking. We compared the clinical outcome and safety of Endo-LIF to MIS-TLIF for lumbar degenerative disease. Methods : We systematically searched electronic databases, including PubMed, EMBASE, and Cochrane Library to find literature comparing Endo-LIF to MIS-TLIF. The results retrieved were last updated on December 11, 2020. The perioperative outcome included the operation time, blood loss, complication, and hospital stay. The clinical outcomes included Visual analog scale (VAS) of low back pain and leg pain and Oswestry disability index (ODI), and the radiological outcome included pseudoarthosis rate with 12-month minimum follow-up. Results : Four retrospective observational studies and one prospective observational study comprising 423 patients (183 Endo-LIF and 241 MIS-TLIF) were included, and the pooled data analysis revealed low heterogeneity between studies in our review. Baseline characteristics including age and sex were not different between the two groups. Operation time was significantly longer in Endo-LIF (mean difference [MD], 23.220 minutes; 95% confidence interval [CI], 10.669-35.771; p=0.001). However, Endo-LIF resulted in less perioperative blood loss (MD, -144.710 mL; 95% CI, 247.941-41.478; p=0.023). Although VAS back pain at final (MD, -0.120; p=0.586), leg pain within 2 weeks (MD, 0.005; p=0.293), VAS leg pain at final (MD, 0.099; p=0.099), ODI at final (MD, 0.141; p=0.093) were not different, VAS back pain within 2 weeks was more favorable in the Endo-LIF (MD, -1.538; 95% CI, -2.044 to -1.032; p<0.001). On the other hand, no statistically significant group difference in complication rate (relative risk [RR], 0.709; p=0.774), hospital stay (MD, -2.399; p=0.151), and pseudoarthrosis rate (RR, 1.284; p=0.736) were found. Conclusion : Relative to MIS-TLIF, immediate outcomes were favorable in Endo-LIF in terms of blood loss and immediate VAS back pain, although complication rate, mid-term clinical outcomes, and fusion rate were not different. However, the challenges for Endo-LIF include longer operation time which means a difficult learning curve and limited surgical indication which means patient selection bias. Larger-scale, well-designed study with long-term follow-up and randomized controlled trials are needed to confirm and update the results of this systematic review.

Longitudinale Study on the Psychological Trauma of Victims of Housing Damage (주택파손 피해자의 심리적 충격 변화에 관한 추적조사 연구)

  • Son, Hee Joo;Choi, Yeol
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.43 no.1
    • /
    • pp.119-129
    • /
    • 2023
  • In many cases, trauma is overcome in a short periodtime, but for some, trauma results in long-term mental health issues such as in the form of post-traumatic stress disorder (PTSD). Natural disasters cause different types and extent of damage, meaning the degree of stress experienced also varies. In the case of damage to a house, the impact can be considerable. Therefore, this study examined the trauma experienced by households whose homes were damaged by natural disasters and to confirm the characteristics of psychological trauma. It was confirmed that traumas was greater when a house was damaged, compared with damage to other types of items. In addition, even in the case of trauma occurring, factors that affect the pattern of change to someone's mental state vary depending on the state's classification. And In addition, health services is significantly analyzed in all variables, and it was considered that the provision of basic services related to safety after a disaster is paramount. However, while psychological counseling has a positive effect on short-term traumas that manifests as anxiety and depression, it has an adverse effect on PTSD because of the depth and complexity of the suffering in PTSD, meaning the type of psychological support needs changing.

Soil Residues and Absorption-translocation into Crops of Veterinary Antibiotics Treated in Red Pepper Crop Fields (고추작물 재배지에 처리된 축산용 항생제의 토양중 잔류와 작물체로의 흡수·이행)

  • Park, Young-Jae;Tae, Eun-Ha;Cho, Jae-Young
    • Korean Journal of Organic Agriculture
    • /
    • v.32 no.2
    • /
    • pp.233-245
    • /
    • 2024
  • In a field study, we investigated the consequences associated with the irrigation of red pepper with water contaminated by three types of veterinary antibiotics (amoxicillin, oxytetracycline, and chlortetracycline) on the soil residue, the absorption-translocation, and crop yields. As a result of evaluating the residue of veterinary antibiotics in pepper cultivation soil treated with veterinary antibiotics a total of 7 times from June 7 to August 26, 2023, the three antibiotics were not detected at the background level, but in the group treated with 10-fold and 50-fold of the background level was detected at a level of 2-10 ㎍/kg. For the leaf (stem) and fruit of red pepper, all three types of veterinary antibiotics were found to be below the detection limit at all treatments. However, trace levels were detected in red pepper roots. If veterinary antibiotics are unintentionally introduced into agricultural soil in the short term, the soil environment and crop safety will not be a problem. However, long-term introduction of veterinary antibiotics in agricultural soil may have negative effects by affecting soil microbial diversity and antibiotic resistance problems, so continuous monitoring and risk assessment are deemed necessary.

Long-term Monitoring of Pesticide Residues in Arable Soils in Korea (전국 농경지 토양 중 농약 잔류량 모니터링 및 연차별 변화)

  • Park, Byung-Jun;Lee, Byeong-Moo;Kim, Chan-Sub;Park, Kyung-Hun;Park, Sang-Won;Kwon, Hyeyoung;Kim, Jin-Hyo;Choi, Geun-Hyoung;Lim, Sung-Jin
    • The Korean Journal of Pesticide Science
    • /
    • v.17 no.4
    • /
    • pp.283-292
    • /
    • 2013
  • A series of monitoring studies were carried out to evaluate the residue level of pesticides in different native soils from 1999 to 2006. The nation-wide collection of soil samples from paddy, greenhouse, upland and orchard, were analyzed by GLC (ECD or NPD) and GC/MS. The results obtained are summarized as follows; out of 14 pesticides detected from paddy soils in 1999, the highest residue level was 0.25 mg $kg^{-1}$, and the frequency was 21.7% as butachlor, 20.0% as isoprothiolane, and 16.7% as iprobenfos. In 2003, 7 pesticides were detected and their frequencies were 0~36.0%; the frequency was 36.0% as isoprothiolane and 33.3% as oxadiazon. In the year 2000, 57 pesticides in the greenhouse soil samples were detected with the highest frequency of 65.3%. Of the pesticides detected, endosulfan and procymidone showed the frequency of 65.3 and 50.0%, respectively. In 2004, 19 pesticides were detected from greenhouse soils, and their frequencies and residue levels were decreased. Endosulfan and procymidone showed high detection frequencies and concentrations of 21.3 and 9.3% and 0.76 and 0.31 mg $kg^{-1}$, respectively. In 2001, a total of 25 pesticides were detected through monitoring in 170 upland soils and the highest residue level was 2.24 mg $kg^{-1}$. The detection frequencies showed the range of 0~53.5%. Especially, endosulfan showed the highest frequency of 53.5%. Residue levels and frequencies of pesticide in the year 2005 were almost the same compared with that of the year 2001. As a result of monitoring in 150 orchard soils in 2002, 26 pesticides were detected and the highest residue level was 1.43 mg $kg^{-1}$. Of them, the frequency of endosulfan showed the highest as 45.3%. In 2006, 20 pesticides were detected in orchard soils. The frequency of total endosulfan was the highest as 5.3% but was lower than that of the year 2002.

Technical Review on Thorium Breeding Cycle (토륨 핵연료 주기 기술동향)

  • Noh, Taewan
    • Journal of Energy Engineering
    • /
    • v.25 no.2
    • /
    • pp.52-64
    • /
    • 2016
  • The production of nuclear energy from thorium which is non-fissile material was a main issue until the middle of 1970's, because of the thorium's abundance as energy resources, its capability of breeding fissile material U233, and the reduction of long-lived actinides. However, to use thorium as nuclear fuel, some obstacles such as the necessities of external neutron source and long-term neutron irradiation for effective breeding, and the production of high radioactive isotopes in the course of thorium breeding cycle should be overcome. The difficulties to resolve these cons of thorium cycle became the reason of interruption of the related researches in the middle of 1970's. But in the 21st century, the change of societal perspective regarding nuclear energy and the appearance of accelerator-driven nuclear reactor shift those cons into pros and rehabilitate the study of thorium. The high activity of thorium cycle turned out to be a good option as higher resistance and easier detectibility of nuclear proliferation and the employment of subcritical accelerator-driven reactor as external neutron sources is considered to enhance the nuclear safety. In this study we compare the thorium cycle with the currently-used uranium cycle and analyze the technical status and perspective of thorium researches which use accelerator-driven reactors.

A Study on the Development of Long-term Self Powered Underground Pipeline Remote Monitoring System (자가 발전형 장기 지하매설배관 원격감시 장치 개발에 관한 연구)

  • Kim, Youngsear;Chae, Hyun-Byung;Seo, Jae-Soon;Chae, Soo-Kwon
    • Journal of the Korean Society for Environmental Technology
    • /
    • v.19 no.6
    • /
    • pp.576-585
    • /
    • 2018
  • Systematic management during the whole life cycle from construction to operation and maintenance is very important for the seven underground pipelines (waterworks, sewerage, electricity, telecommunications, gas, heating, oil including waterworks and sewerage). Especially, it is the construction process that affects the whole life cycle of underground buried pipeline. In order to construct a new city or to maintain different underground pipes, it is always necessary to dig the ground and carry out construction and related work. There is a possibility that secondary and tertiary breaks frequently occur in the pipeline construction process after the piping constructed first in this process. To solve this problem, a system is needed which can monitor damage in real time. However, the supply of electric power for continuous operation of the system is limited according to the environment of underground buried pipelines, so it is necessary to develop a stable electric power supply system using natural energy rather than existing electric power. In this study, we developed a system that can operate the pipeline monitoring system for long time (24 hours and 15 days) using natural energy using wind and solar light.

Study on Oral Administration of Egg White Combined Chalcanthite and Bamboo-Salt with Egg White Combined Chalcanthite (난담반 단독제와 난담반과 죽염 혼합제 경구 투여의 독성 연구)

  • Choi, Eun-A;Lee, Jong-Hoon;Youn, Dae-Hwan;Yoo, Hwa-Seung
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.26 no.2
    • /
    • pp.189-198
    • /
    • 2012
  • Our former study indicated efficacy of apoptotic cell death on animal study by using Egg white combined Chalcanthite (EC). Clinically, bamboo salt is using because of safety. Hence we investigated a toxicity study for determining safety by adding bamboo salt in former materiel. We had two studies: toxicity of EC and of Bamboo salt with egg white combined Chalcanthite (BC). Both were studied in 1-week single and 5-week repeated oral dose toxicity tests on male Imprinting Control Region mice. In EC, doses used in 1 week single oral dose toxicity tests were 0, 0.05, 0.5, 5 and 50 mg/kg/day and 0, 0.01, 0.05, 0.25 and 0.5 mg/kg/day. In BC, doses used by 0, 0.08, 8.3, 83.3 and 166.6 mg/kg/day in single oral dose toxicity and 0, 4.2, 8.3, 41.7 and 83.3 mg/kg/day in repeated oral dose toxicity tests. Their blood and urine were assayed and organ morphology were examined. Mann-Whitney U test and ANOVA tests were used by analysing methods. First, significant increased left renal weight in all groups of EC and BC. Second, increased ALT score was found in EC-S2 and increased relative liver weight was found in EC-S3. In addition, increased relative weight and urine bilirubin and urobilinogen were found in EC-R2 and EC-R3. There was no significant toxic change in BC. The Mixture of EC had a possibility of hepatotoxicity in the short and long term. Processed BC appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) was established at 83.3 mg/kg/day in mice. Relatively, The BC were safer than The EC.

Reviews on the Adaptation Strategy to Climate Change -Application to the Sea Level Rise- (기후변화 적응방안 연구 -해수면 상승을 중심으로-)

  • Cho Kwangwoo;Maeng Jun-Ho;Kim Hae-Dong;Oh Young Min;Kim Dong-Sun;Kim Mu Chan;Yoon Jong Hwui
    • Journal of the Korean Society of Marine Environment & Safety
    • /
    • v.10 no.2 s.21
    • /
    • pp.81-88
    • /
    • 2004
  • We review the adaptation strategies of the 21st climate change in an application to sea level rise. For the development of appropriate adaptation strategies on the coast vulnerable to the sea level rise, we have to consider the issues such as where to adapt, how to adapt, and when to adapt. The coastal target needed adaptation can be found by the evaluation of adaptive capacity of the coastal zone which requires the understanding of impacts and adaptive potential of the natural and socioeconomic systems in the coastal zone. Planned adaptation options to sea level rise can be classified into three generic approaches as managed retreat, accommodation, and protection In practice, the implementation of the options requires the analysis of land use, degree of vulnerability, cost and benefit, etc, and may be combination of the options rather than one approach. In terms of the response timing, the adaptation can be grouped as anticipatory and reactive ones. Generally it is more effective to consider both anticipatory and reactive adaptations at the same time for the impacts of future sea level rise. Due to the scientific uncertainty of climate change issues including sea level rise, the adaptation processes have to be designed to deal with a series of processes such as information md awareness establishment, planning and design implementation, and monitoring and evaluation in continuity and long-term period.

  • PDF

Estimation of Stocking Density using Habitat Suitability Index and Ecological Indicator for Oyster Farms in Geoje-Hansan Bay (서식적합도와 생태지표를 이용한 거제한산만 굴양식장의 입식밀도 산정)

  • Cho, Yoon-Sik;Lee, Won-Chan;Hong, Sok-Jin;Kim, Hyung-Chul;Kim, Jeong-Bae;Park, Jung-Hyun
    • Journal of the Korean Society of Marine Environment & Safety
    • /
    • v.18 no.3
    • /
    • pp.185-191
    • /
    • 2012
  • Most of Korean farms have been developed in the semi-closed bay, and its position is very vulnerable to the coastal contamination due to the long term and the high density. So, mariculture management is very essential for the sustainable aquaculture. Some of the specific ways would be the assessment of the optimal stocking density for mariculture management zone and this has to consider both the suitable site selection and the assessment of ecological carrying capacity. Habitat suitability index(0.0 totally unsuitable habitat, 1.0 optimum habitat) and ecological indicator(Filtration pressure indicator) was used to assess the stocking density for oyster farms in Geoje-Hansan Bay. Geoje Bay showed the higher habitat suitability index value 0.75 than Hansan Bay 0.53, indicating that Geoje Bay is more suitable for oyster farming. Ecological indicator showed different stocking density according to the coastal characteristics in Geoje-Hansan Bay. Consequently, it is desirable that the stocking density in Geoje Bay should reduce average 40% and Hansan Bay, average 60% than present, in order to meet the ecological carrying capacity. The assessment of the stocking density could solve various problems such as the coastal contamination, environmental aggravation and the productivity decrease and this study could be a scientific basis to establish the policies for mariculture management.

National Policy and Status on Management of Spent Nuclear Fuel (사용후 핵연료 관리 정책과 국제 동향)

  • Park Won-Jae
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
    • /
    • v.4 no.3
    • /
    • pp.285-299
    • /
    • 2006
  • At the end of 2005, 443 nuclear reactors were operating in 32 countries worldwide. They had provided about 3,000 TWh, which was just over 16 percent of global electricity supply. With the generating capacity of 368 GWe in 2004, the spent fuel generation rate worldwide, now becomes at about 11,000 tHM/y. Projections indicate that cumulative amounts to be generated by the year 2020, the time when most of the existing NPP will be closed to the end of their licensed lifetime, may be close to 445,000 tHM. In this regard, spent fuel management is a common issue in all countries with nuclear reactors. Whatever their national policy and/or strategy is selected for the backend of the nuclear fuel cycle, the management of spent fuel will contribute an impending and imminent issues to be resolved in the foreseeable future. The 2nd Review Meeting of the Contracting Parties to the Joint Convention was held in Vienna from 15 to 24 May 2006. The meeting gave an opportunity to exchange information on the national policy and strategy of spent fuel management of the Contracting Parties, to discuss their situations, prospects and the major factors influencing the national policies in this field and to identify the most important directions that national efforts and international co-operation in this area should be taken. In this paper, an overview of national and global trends of spent fuel management is discussed. In addition, some directions are identified and recent activities of each Member States in the subject area are summarized.

  • PDF