• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.2
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• pp.210-218
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• 2010

This study was carried out to investigate the effect of Yacon (Polymnia sonchifolia Poepp. & Endl.) powder on cholesterol-lowering and anti-obesity effects in rats fed a high fat-high cholesterol diet for 4 weeks to induce hyperlipidemic and obese rat model. Weight-matched male Sprague-Dawley rats were assigned to four groups according to dietary fat, cholesterol levels and Yacon powder levels. Experimental groups were normal diet group (N), high fat-high cholesterol diet group (HFC), high fat-high cholesterol diet with 5% Yacon powder group (HFC-PSL) and high fat-high cholesterol diet with 10% Yacon powder group (HFC-PSH). The body weight gain and FER were increased by a high fat-high cholesterol diet, but gradually decreased in the Yacon powder fed groups compared with the HFC group. Food intake was lower in HFC groups compared with N group. The liver and adipose tissue weights of HFC group were heavier than those of N group, whereas those of groups administered Yacon powder were gradually decreased. The serum ALT, AST, ALP and LDH activities elevated by a high fat-high cholesterol diet were significantly decreased by Yacon powder administration. Levels of serum total cholesterol, LDL-cholesterol, atherogenic index and cardiac risk factor showed a decreasing tendency in the Yacon powder fed groups compared with HFC group. The serum HDL-cholesterol level decreased in the HFC group and markedly increased in the Yacon powder fed groups. Levels of total cholesterol and triglyceride in liver and adipose tissues were lower in Yacon powder administered groups than those in HFC group. These results suggest that Yacon powder may improve lipid metabolism of serum, liver, and adipose tissue and potentially reduce lipid storage.

• Journal of Life Science
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• v.7 no.1
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• pp.1-9
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• 1997

For the recent years, considerable efforts have been made to rationalize the techniques of research and monitoring of biological effects of marine pollutants such as heavy metals, polychlorinate biphenyls (PCBs), organochlorine pesticides, polycyclic aromatic hydrocarbons (PAHs), organophosphorus pesticides. This study was designed as a part of efforts to investigate the biochemical pollutant markers for diagnosis of marine pollutions by the changes in lipid components of the flounder (Paralichthys olivaceus) in Yellow Sea of Korea. Homoglobin levels in serum of cultured and wild flounders in Yellow Sea were significantly lower (5 - 15% and 20 -25 % , respectively) than those of wild flounder in Pohang. Triglyceride (TG) contents in serum of cultured flounders in Yellow Sea were 10 - 40% higher than those of wild flounder in Pohang. Total and low density lipoprotein (LDL)-cholesterol contents in serum of flounders in Yellow Sea were significantly 10-15% and 30-35% (cultured), and 10-20% (wild), respectively, higher than those of wild flounder in Pohang. Atherogenic index (AI) and T-Chol/PL rations in serum of cultured and wild flounders in Yellow sea were significantly 20-45% and 10-!5%, 6-35% and 15-35%, respectively, higher than those of wild flounder in pohang. These results suggest that near-coastal waters as well as neritic waters of the Yellow Sea might be affected by pollutant input.

• Journal of Life Science
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• v.20 no.1
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• pp.90-96
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• 2010

Menopause increases the onset of hypertension and heart disease. Whereas it increases the blood LDL-cholesterol, triglyceride and total-cholesterol levels, the HDL-cholesterol concentration is reduced. Accordingly, we examined the effect of internal organs of Todarodes pacificus (IOT) on improvement in blood flow ability and changes in serum lipid content by using ovariectomized rats. For this study, the following four groups of 9-week-old Sprague-Dawley strain female rats were evaluated over 6 weeks: normal rats (SHAM), ovariectomized rats (CON) and ovariectomized rats that were treated with IOT extracts. Ovary removal promoted platelet aggregability. However, IOT administration in the CON group after ovary excision resulted in a hinderance of coherence. The blood vessel passing time of ovariectomized rats was slower than the SHAM group. But the blood flow ability, which was slowed down for ovary removal, was improved by IOT administration. Serum triglyceride levels were significantly reduced by IOT administration. Moreover, blood HDL-cholesterol levels were reduced by ovary removal. However, IOT administration after ovary excision significantly increase HDL-cholesterol levels. The biological activity of IOT could be confirmed from these results. Moreover, IOT can be used in the development of functional foods which are meant to improve blood circulation and anti-platelet aggregation function. According to these results, we could know that IOT improved blood flow and anti-platelet aggregation. Therefore, it is expected that IOT can be used for the development of functional foods.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.4
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• pp.538-543
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• 2011

This study was conducted for the antihyperlipidemic effect of ethanol extract from Portulaca oleracea in high fat diet-induced obese mice after having injected the ethanol extract from Portulaca oleracea to the obese mice with high fat diet. The 30 six-week-old male C57BL/6J mice were divided into 3 groups of 10 and fed for 5 weeks to be obese with high fat diet. Thereafter, for 4 weeks, ethanol extract from Portulaca oleracea was provided through oral injection to the 3 groups: control group (HFD), group injected with 75 mg/kg of ethanol extract from Portulaca oleracea (HFD+POE 75) and the group injected with 125 mg/kg of ethanol extract from Portulaca oleracea (HFD+POE 125). The serum and liver lipid and the alanine transaminase (ALT) and aspartate transaminase (AST) activity were measured. The result showed that there was no significant difference in weight gain and feed intake, and the feed efficiency ratio was significantly low in the group provided with ethanol extract from Portulaca oleracea. Serum total cholesterol was significantly low in the group of ethanol extract from Portulaca oleracea (HFD+POE 125). It appeared that all the groups provided with ethanol extract from Portulaca loeracea reduced plasma triglyceride significantly according to the ethanol extract from Portulaca oleracea dose. There was no dose dependency of HDL-cholesterol to the dose of ethanol extract of Portulaca oleracea. LDL-cholesterol was low in the group dosed with high ethanol extract from Portulaca oleracea (HFD+POE 125). There was difference of total cholesterol, triglyceride and total lipid contents in liver. AI (atherogenic index) and CRF (cardiac risk factor) were significantly low in the group with high dose of ethanol extract from Portulaca oleracea (HFD+POE 125). There was no difference of serum AST activity, however, serum ALT activity was significantly low in the group with high dose of ethanol extract from Portulaca oleracea (HFD+POE 125).

• Korean Journal of Poultry Science
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• v.30 no.2
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• pp.135-143
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• 2003

This study was conducted to investigate feeding effects of the high pressure boiled extract(HPBE) of the Ogol chicken on weight gain and serum lipid composition of rat. Rats(S.D,♂) were fed with normal feed(T$_1$), normal feed ＋ herb HPBE(T$_2$), normal feed ＋ Ogol chicken HPBE(T$_3$), normal feed ＋ mixture of cross­bred Ogol chicken HPBE hydrolyzed with Flavourzyme 0.1% for 35 days. During experimental period, the effects of the treatments on growth performance, plasma triglyceride(TG) and cholesterol were determined. The effects of feeding HPBE on growth performance and serum triglyceride levels in rat. After a 6 day treatment, body weights were 39.96g, 44.56g, 43.34g, and 45.99g for T$_1$, T$_2$, T$_3$ and T$_4$ groups respectively. The growth rates of T$_2$ and T$_4$ groups were significantly(P<0.05) higher than T$_1$ group, but the differences were not observed after 18 days of feeding period. Triglyceride contents were 62.89${\pm}$6.24mg/dl, 55.70${\pm}$6.76mg/dl, 43.60${\pm}$4.68mg/dl and 45.00${\pm}$3.75mg/dl for T$_1$, T$_2$, T$_3$ and T$_4$ groups respectively, where T$_1$ group was significantly (P<0.05) higher than T$_3$ and T$_4$ groups. In serum total cholesterol contents, there was no significant difference among the groups. GOT(glutamic oxaloacetic transaminase) and GPT(glutamic pyruvic transaminase) also showed similar levels among the treatments.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.2
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• pp.174-182
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• 2003

Purpose: Non-alcoholic fatty liver disease (NAFLD) has been recognized as an important childhood liver disease, especially where the prevalence of childhood obesity is increasing. The purpose of this study is to clarify the usefulness of elevated serum aminotransferase activities and their ratio for predicting the presence of fatty liver and its severity in obese children. Methods: Forty-four children (M/F 29/15, age 4 to 16 years) with obesity (weight excess>20%) were analyzed retrospectively with medical records based on degree of obesity, bioelectrical impedence, serum aminotransferase activities, lipid profiles and ultrasonography. Results: 1) Ultrasonography was carried out in 34 cases. Elevated serum ALT was found in 89.7% (26/29) of the patients diagnosed as fatty liver by ultrasonography and decreased AST/ALT ratio (<1) was found in 96.6% (28/29). There was a strong correlation between elevated serum ALT (>45 IU/L) or decreased AST/ALT ratio (<1) and the fatty liver in obese children (p<0.05). 2) There was no significant correlation between the serum ALT or AST/ALT ratio and the degree of fatty liver (p>0.05). 3) There was a significant correlation between total cholesterol, triglyceride and fatty liver (p<0.05). Conclusion: Serum ALT activity and AST/ALT ratio were useful to predict the presence of fatty liver diagnosed by ultrasonography in obese children, whereas they were not useful to predict the degree of fatty liver. Therefore, to prevent fatty liver progressing to advanced liver disease, it is necessary to manage and monitor the obese children continuously, especially those who have predicting factors of fatty liver.

• Korean Journal of Veterinary Research
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• v.32 no.4
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• pp.531-542
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• 1992

The present study was performed to identify the factors influencing on early pregnacy and embryo implantation in rabbit. Serum, uterine fluid, and uterine tissue were collected on day 0, 3, 5, 7 and 9 of pregnancy. The intrauterine environment of receptive phase and refractory phase was compared by measuring protein synthetic capacity of endometrium, amino acid composition and concentrations of lipids(phospholipid, cholesterol). The results obstained were as follows : 1. The concentrations of total protein were significantly increased (p<0.01) on day 5 ($7.00{\pm}0.55$), 7($6.29{\pm}0.65$), and 9($6.34{\pm}0.61$), compared to those on day 0($5.50{\pm}0.12g/100m{\ell}$) in serum. The concentration of albumin on day 0 was $0.81{\pm}0.05$ and reached maximum on day 5 ($1.59{\pm}0.07g/100m{\ell}$) in serum. The concentrations of total protein were significantly increased(p<0.01) on day 5($1.56{\pm}0.10$), 7($1.99{\pm}0.22$), compared to those on day 0($0.38{\pm}0.02g/100m{\ell}$) in uterine fluid. The concentration of albumin on day 5($0.78{\pm}0.05g/100m{\ell}$) was higher than those on the other days in uterine fluid. 2. The incorporation rates of [$^3H$]-leucine into protein were significantly increased(p<0.01) on day 5 ($919.6{\pm}97.5$), 7($1445.4{\pm}95.9$) and 9($450.38{\pm}28.71$), compared to those on day 0($328.2{\pm}38.9cpm/mg$ protein) in endometrium. The incorporation rates in colehicine-treated endometrium on day 5 ($1341.9{\pm}73.8$), 7($1729.4{\pm}63.3cpm/mg$ protein) were significantly higher(p<0.01) than those on the other days. 3. The compositions of amino acid were not distinctly changed during early pregnancy in serum. The composition ratios of methione, lysine were distinctly decreased on day 3, compared to those on day 0 in uterine fluid. Those of glycine, alanine were increased on day 9, compared to those on other days but his tidine decreased in uterine fluid. 4. The concentrations of total phospholipid and total cholesterol were significantly decreased(p<0.01) on day 3($77.9{\pm}15.5$, $61.5{\pm}21.2$), compared to those on day 0($164.0{\pm}33.9$, $167.2{\pm}46.2mg/100m{\ell}$)in serum. The concentrations of total phospholipid and total cholesterol on day 9 ($47.3{\pm}13.4$, $37.7{\pm}9.6mg/100m{\ell}$) were significantly higher(p<0.01) than those on the other days in uterine fluid. 5. Total phopholipid/total cholesterol ratios were not significantly changed during early pregnancy in serum. However, total phospholipid/total cholesterol ratios on day 5 ($2.00{\pm}0.42$), 7 ($1.11{\pm}0.77$) and 9 ($1.47{\pm}0.30$) were higher than those on day 3($0.84{\pm}0.41$) in uterine fluid. 6. The concentrations of phosphatidylcholine and phosphatidylserine were significantly increased (p<0.01) on the other days, compared to those on day 0 during early pregnancy in serum. The concentrations of phosphatidylcholine were significantly increased(p<0.01),compared to those on day 0 and those of phosphatidyl-ethanolamine were consistently increased but not significant in early pregnancy in uterine fluid.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.9
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• pp.1120-1127
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• 2007

This study was designed to examine the effects of n-6 PUFA rich corn oil, n-3 PUFA rich perilla oil and their conjugated double bond derivatives on serum lipids status in rats. Experimental diets containing lard (control), corn oil (CO), perilla oil (PO), conjugated double bond derivatives of n-6 PUFA rich corn oil (TCO) and n-3 PUFA rich perilla oil (TPO) at the level of 10% (w/w) were fed to male Sprague Dawley rats for 4 weeks. TCO was found to have three derivatives of linoleic acid and TPO had five derivatives of linolenic acid by GC. Serum total cholesterol levels were significantly lower in the all experimental groups than in the control group, and particularly, the lowest in TCO and TPO groups. HDL-cholesterol concentrations were a little higher in the all experimental groups than in the control group, and TCO and TPO groups were not significantly different from CO and PO groups. Serum LDL, LDL-cholesterol, chylomicron and triglyceride concentrations were significantly lower in the all experimental groups than in the control group, remarkably lower in TCO group and particularly, the lowest in the TPO group. Serum free cholesterol and cholesteryl ester concentrations were lower in TCO and TPO groups than in CO and PO groups. From the above research, TCO and TPO groups were effective on the improvement of the lipid compositions in serum and particularly, TPO group was the most effective on the improvement of serum lipids.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.6
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• pp.226-232
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• 2016

In the elderly, a lower muscle mass and higher body fat mass are induced by a lower level of physical activity. A negatively changed body composition with an advanced age can lead to a higher falling risk and rate of diseases. On the other hand, aerobic-type exercise positively influences the body composition and hyperlipidemia in the elderly. Therefore, this study examined the effects of aquarobic training for 12 weeks on the body composition and blood lipid levels in obese old women. The subjects (n = 31, body fat: 33.42%) completed a 12 week water based aerobic training at 12 - 13 of Borg Scale of intensity (three times per week, each session: an hour). The body composition was measured by bioelectrical impedance analysis (Inbody 770-Biospace, Seoul, Korea) and the concentrations of blood lipids (high-density lipids cholesterol (HDL), low-density lipids cholesterol (LDL), triglyceride (TG) total cholesterol (TC)) were determined at pre and post training. A paired t-test was used for data analysis with ${\alpha}=0.05$. In the results, the body composition (% body fat (p < 0.05) and waist circumference (p < 0.05)) were reduced significantly. The LDL (p < 0.05), TG (p < 0.001) and TC (p < 0.05) were reduced significantly. In conclusion, a 12 week aquarobic exercise program helps improve the body composition and concentrations of serum lipids. Therefore, aquarobic exercise can enhance lipolysis using fat as energy to induce an improvement of the body composition and induce hyperlipidemia.

• Journal of Life Science
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• v.18 no.10
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• pp.1342-1347
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• 2008

The purpose of present study was to investigate the protective effect of silkworm excrement powder (SEP) on alcohol-induced hepatotoxicity in rats. Semisynthetic diet supplemented with SEP (3%, w/w) given to alcohol-feeding rats for 30 days, then blood and tissues were collected, processed and used for alcohol concentration mensuration, various biochemical estimations and histopathological examination. Chronic alcohol administration resulted in significantly increase in the activities of the clinically important liver marker enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), $\gamma$-glutamyl transpeptidase ($\gamma$-GTP) and lactate dehydrogenase (LDH). Also, a highly significant increase in the blood alcohol level by alcohol treatment was observed. But alcohol-induced elevation of ALT and LDH levels markedly prevented and the level of blood alcohol decreased in SEP treated rats as compared to alcohol-administered control rats. SEP supplementation showed highly decreased the concentrations of total lipid, triglyceride and cholesterol in serum, as compared with alcohol treated control rats. Alcohol treatment induced the marked accumulation of large lipid droplets, hepatocytes necrosis and inflammation in the liver, but SEP administration attenuated to alcohol-induced accumulation of lipid droplets and hepatocyte necrosis. The results indicated that SEP may exert a protective effect against alcoholic hepatotoxicity through decreasing the activity of hepatic marker enzymes.