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Effect of Substituents on Benzenesulfonyl Motif of 4-Phenyl-1-arylsulfonylimidazolidinones for Their Cytotoxicity

  • Lee, Hui-Soon;Park, Kyung-Lae;Choi, Sang-Un;Lee, Chong-Ock;Jung, Sang-Hun
    • Archives of Pharmacal Research
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    • v.23 no.6
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    • pp.579-584
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    • 2000
  • To explore the effect of substituents' on phenyl motif on sulfonyl function of novel anticancer 4-phenyl-1-benzenesulfonylimidazolidinones (1), electron donating or withdrawing sub-stituents were introduced at 3 or 4-position and the analogs were tested against human lung (A549) and colon (HCT-15) cancer cell lines. Quantitative structure activity relation-ship of the 4-substituted series shows that only STERIMOL L values are well correlated. The increment of substituent's volume enhances the activity against both cell lines. The small substituent at 3-position additionally increases the activity. However naphthyl group in place of phenyl reduces the activity, Therefore the phenyl motif with sterically large substituent at 4-position and small substituent at 3-position may be important for their activity. Integration of these substituents' effects into the structural design led to discover the more potent analog, 4-phenyl-1-(N-acetylindoline-5-sulfonyl) imidazolidinone (1n).

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A study on the Photovoltaic Tracker System Using Method of Intelligent control (지능형 제어기법을 이용한 태양추적시스템에 관한 연구)

  • Kim, Pyoung-Ho;Baek, Hyung-Lae;Cho, Geum-Bae
    • Journal of the Korean Solar Energy Society
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    • v.25 no.1
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    • pp.1-10
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    • 2005
  • In this paper, 150W photovoltaic system using neural network tracker is proposed, the system designed as the normal line of the solar cell always runs parallel the ray of the sun. This design can minimize the cosine loss of the system output results of solar cell are sensitive to the change of weather and insolation condition don't react rapidly to parameter condition change such as system circumstance and deterioration. To achieve precise operation of photovoltaic tracker system using method of intelligent control, Neural Network is used in the design of the photovoltaic tracker system drive. The control performance of this system drive influenced by the environment parameter such as weather condition and motor parameter variations. we used synchronous motor in this tracker and the experimental results show that the fixing system shows 10,159[Wh] and tracking system shows 12,360[Wh] electricity.

TRANSFER ORBIT THERMAL ANALYSIS FOR COMS (통신해양기상위성의 전이궤도 열해석)

  • Jun, Hyoung-Yoll;Kim, Jung-Hoon;Kim, Sung-Hoon;Yang, Koon-Ho
    • Journal of computational fluids engineering
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    • v.13 no.2
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    • pp.48-54
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    • 2008
  • COMS (Communication, Ocean and Meteorological Satellite) is a geostationary satellite and has been developing by KARI for communication, ocean and meteorological observations. It will be launched by ARIANE 5. Ka-band components are installed on South panel, where single solar array wing is mounted. Radiators, embedded heat pipes, external heat pipe, insulation blankets and heaters are utilized for the thermal control of the satellite. The Ka-band payload section is divided several areas based on unit operating temperature in order to optimize radiator area and maximize heat rejection capability. Other equipment for sensors and bus are installed on North panel. The ocean and meteorological sensors are installed on optical benches on the top floor to decouple thermally from the satellite. During the transfer orbit operation, satellite will be under severe thermal environments due to low dissipation of components, satellite attitudes and LAE(Liquid Apogee Engine) firing. This paper presents temperature and heater power prediction and validation of thermal control design during transfer orbit operation.

Development of Technology for Network Construction using Wide Area Energy (광역에너지이용 네트워크 구축 기술개발)

  • Kim, Lae-Hyun;Chang, Won-Seok;Hong, Jae-Jun
    • Journal of Energy Engineering
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    • v.17 no.3
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    • pp.125-138
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    • 2008
  • In order to diversify energy source and to utilize it effectively, it requires to construct an integrated energy management system in a wide area. This research paper explores the core technology of network construction using wide area energy and applies the technology to the field. In specific, it examines the business model by developing l) construction technology of optimum integrated system for thermal supply on wide area network related IT technology, 2) technology of unutilized energy as heat pump using exhaust gas latent heat, and 3) thermal transportation and storage technology using various sources, and by evaluating the applicability and marketability of the model in the field.

Study of Clinical Research Acupuncture Treatment on Post-stroke Depression (뇌졸중후 우울증 침치료의 임상연구에 대한 고찰)

  • Choi, Ji-Hye;Kim, Lae-Hee;Yun, Jong-Min;Moon, Byung-Soon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.6
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    • pp.1119-1128
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    • 2011
  • The aim of this study is to collect and analyze clinical studies on acupuncture therapies of Post-stroke depression, and to suggest a method on study about acupuncture therapies. In this thesis, electronic searches were performed. Also, 6 major journals associated with oriental medicine in Korea were searched manually. Through searching, 27 studies were selected and analyzed. There were 24 controlled studies and 3 non-controlled studies. Treatment methods were acupuncture, electronic-acupuncture, eye-acupuncture, abdominal-acupuncture and pharmaco-puncture. The percentages of these treatment method were 59.2%, 29.6%, 3.7%, 3.7% and 3.7%, respectively. Acupuncture points such as GV20, PC6, ST36, SP6, LV3, GV24, GV26, LI14, LI11, H7, ST40, GB20, GB34 and LI15 were used. In comparison of results before and after acupuncture treatment, there were statistically significant improvement in 26 studies. Based on the results from above, the studies on acupuncture for Post-stroke depression needs to be standardized and more appropriate high-quality study models should be introduced.

A Case Study on the Learning Characteristics of Science-Gifted Students in Jeonnam Province -Focused on Verbal and Nonverbal Interactions in Small Group- (과학영재 학생의 학습 특성에 관한 사례연구 -소집단에서의 언어적, 비언어적 상호작용을 중심으로-)

  • Han, Kwang-Lae;Park, Hae-Gyun;Ryu, Jae-In
    • Journal of Korean Elementary Science Education
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    • v.30 no.1
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    • pp.51-60
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    • 2011
  • The purpose of this study was to investigate gifted students' verbal-nonverbal interactions in small grouped classes and to classify them into characteristics. For this study, an instrument to measure gifted student's verbal-nonverbal interactions was developed. The subjects were 16 students of 5th and 6th grades at H-area gifted center in rural area. Video recorded was classified each 5minutes by researchers. The results were as follows; First, verbal interactions were about 27% and non-verbal interactions were about 73%. Activities unrelated to learning were about 20%. Second, high achievement gifted students enjoyed verbal interactions including discussions. Third, gifted students can be classified 3 types(Spoken-centered, Written-centered and Played-centered) by interactions. The results revealed that gifted student's verbal-nonverbal interactions played an important role in communication between students and teacher as well as students. Small-grouped instructions according to characteristic and levels of gifted students are needed in gifted science education.

Radical Scavenging Activity of Ethanol Extracts and Solvent Partitioned Fractions from Various Red Seaweeds (홍조류 에탄올 추출물 및 다양한 용매 분획물의 라디칼 소거능)

  • Cho, MyoungLae;Lee, Dong-Jin;You, SangGuan
    • Ocean and Polar Research
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    • v.34 no.4
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    • pp.445-451
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    • 2012
  • The EtOH extracts of red seaweeds (Symphyocladia latiuscula, Chondrus ocellatus and Carpopeltis affinis) and solvent partitioned fractions were investigated for their 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects and the total phenolic contents were correlated with ABTS and DPPH radical scavenging activities. The EtOH extracts and their solvent partitioned fractions exhibited strong ABTS and DPPH radical scavenging activities. Among the solvent partitioned fractions obtained from n-Hexane (HX), methylenchloride (MC), ethylacetate (EA), and buthanol (BuOH), the HX fraction from C. affinis showed higher radical scavenging activities than other fractions. Total phenolic contents showed significant correlation ($r^2$ = 0.709) with ABTS radical scavenging activity. The results of this study suggest that the strong radical scavenging activity of HX fraction from C. affinis is a promising natural antioxidant for healthcare products.

Development of a Wearable computer interface for aurally impaired persons (청각 장애인을 위한 웨어러블 단말 인터페이스 기술)

  • Park, Jin-Young;Ahn, Chong-Keun;Kim, Lae-Hyun;Ha, Sung-Do;Park, Se-Hyung
    • 한국HCI학회:학술대회논문집
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    • 2006.02a
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    • pp.57-62
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    • 2006
  • 최근 들어 IT 기술의 비약적인 발전과 더불어 사용자의 편의성을 극대화 시키는 웨어러블 컴퓨팅 기술이 주목을 받고 있다. 이러한 기술은 일반인 뿐만 아니라 장애인들에게 큰 도움이 될 것이고, 현재 관련된 연구들이 활발히 진행 중에 있다. 본 논문에서는 청각장애인을 위해 개발된 웨어러블 단말 인터페이스 기술을 소개하고자 한다. 웨어러블 단말장치는 소형 마이크로폰을 통해 입력된 주변의 소리로부터 미리 정해진 주요한 소리를 실시간 감지하여, 시각과 촉각 정보로 변환하여 소리의 종류 및 방향을 청각장애인에 알려주는 기능을 한다. 시각정보는 안경식 소형 디스플레이를 통해 상황에 맞는 그래픽아이콘을 보여주고 동시에 소형 진동자들이 부착된 햅틱 슈트를 통해 촉각 정보가 전달된다. 본 연구에서 개발한 웨어러블 단말장치를 통해 청각장애인이 일상생활에서 발생되는 여러 가지 위험상황 또는 긴급상황에 적절하게 대처할 수 있도록 도와주고자 한다.

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A Study on the Virtual Mouse Interface System (가상 마우스 인터페이스 시스템에 관한 연구)

  • Lee, Ki-Young;Lim, Myung-Jae;Kim, Kyu-Ho;Lee, Min-Ki;Kim, Jeong-Lae
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.11 no.2
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    • pp.57-62
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    • 2011
  • Recently, various interaction was demanded from rapid development and use of portable device. So, operation of touch interface in tablet and smart phone needs many requirements and proactivity. In this paper, for variety of users and convenient interaction, It is aimed to realize virtual reality mouse of portable device. It reflected similar interaction of an existing mouse and it used infrared image without intensity of illumination. Also, It analyzed finger point information of middle and index finger of users and it designed virtual mouse without proactivity and constraint of space.

Fundamental Study on Developing the Technology for the Removal of Fluorescent Whitening Agents from the Process Water (공정수에 존재하는 형광증백제의 제거 기술에 대한 기초연구)

  • Lee, Ji-Young;Youn, Hye-Jung;Lee, Hak-Lae
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.41 no.1
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    • pp.24-29
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    • 2009
  • The use of fluorescent whitening agents (FWAs) increases as the demand for the whiter and brighter printing papers increases. FWAs are used as internal and surface treatment chemicals. FWAs that are not used properly in the papermaking process, however, remain in the process water and may demage the paper quality and processes. In this study, a new idea to eliminate FWAs from the process water, consisted of the floc formation of FWAs with cationic chemicals, such as cationic polyelectrolytes and alum, and the removal of the floc by screening or sedimentation, was proposed. Flocculation of FWAs, that is the first step to remove FWAs from the process water, was investigated using turbidity and particle size measurement. Relationship between turbidity and particle size showed that the turbidity could reflect the particle size change of FWA flocs and was proper for the evaluation of flocculation phenomena. Poly-DADMAC was more efficient than PEI to induce the flocculation of FWAs. Alum was effective chemical for the flocculation and sedimentation of FWAs.