• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.549-555
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• 2007

In order to study cortical properties in human, it is necessary to obtain an accurate and explicit representation of the cortical surface in individual subjects. Among many approaches, surface-based method that reconstructs a 3-D model from contour lines on cross-section images is widely used. In general, however, medical brain imaging has some problems such as the complexity of the images, non-linear gain artifacts and so on. Due these limitations, therefore, extracting anatomical structures from imaging data is very a complicated and time-consuming task. In this paper, we present an improved method for extracting contour lines of cortical surface from magnetic resonance images that simplifies procedures of a conventional method. The conventional method obtains contour lines through thinning and chain code process. On the other hand, the proposed method can extract contour lines from comparison between boundary data and labeling image without supplementary processes. The usefulness of the proposed method has been verified using brain image.

• 한국멀티미디어학회논문지
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• 제3권5호
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• pp.454-460
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• 2000

영상과 같은 다양하고 복잡한 데이터 검색은 기존의 키워드를 이용한 검색이 아닌 내용 기반 검색 방법이 요구된다. 본 논문에서는 물체의 위치 이동이나 회전, 크기 변화 등과 같은 각종 변환에 민감하지 않은 불변모멘트(invariant moments)값의 특성을 이용하여 사용자 질의로서 입력된 객체를 효율적으로 검색할 수 있는 시스템을 구현하였다. 영상내의 단일 객체뿐만 아니라 다중 객체들도 효과적으로 검출하기 위해 레이블링(labeling) 알고리즘을 적용해 각각의 객체를 따로 분리하여 불변모멘트를 적용하는 방법을 이용했다. 또한, 검색 시간 단축 및 영상의 효율적인 인덱싱(indexing)을 위해 해싱을 응용한 기법을 적용하였다. 실험결과, precision 85%, recall 23%의 높은 검색효율을 보였고 기존의 전체 영상의 특징을 가지고는 정확히 표현할 수 없는 객체들의 모양을 정확히 표현해 줌으로써 보다 정화한 검색 결과를 얻을 수 있었다.

• 한국기계가공학회지
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• 제21권5호
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• pp.67-76
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• 2022

The customer demand for diverse colors in home appliances has increased. However, this has led to issues for manufacturers, such as ensuring cost effectiveness and high-level quality control. To resolve these issues, production engineers utilize computer-aided engineering (CAE) tools for injection-molding processes and assess the suitability of process parameters for products manufactured using the in-mold labeling method. CAE can solve various problems in manufacturing processes, thereby increasing production efficiency and decreasing manufacturing cost. In addition, it can be used analyze customer complaints related to surface defects, such as part differences and irregular spacing between parts, and ultimately reduce product returns. In this study, CAE was used to solve quality problems and implement the most economical manufacturing process.

• 대한핵의학회지
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• 제22권2호
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• pp.193-197
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• 1988

Measurement of gastric emptying rate has been performed by a variety of techniques. Nuclear medicine method is a major advance in the quantitative evaluation of gastric function and also of pharmacologic intervention. Normal gastric emptying rate was measured in 48 healthy volunteers using live chicken liver labeled with $^{99m}Tc-Tin$ Colloid as a solid phase marker. In vitro studies were performed to evaluate the labeling efficiency and stability in hydrochloric acid and in human gastric juice of intracellularly labeled chicken liver. Anterior image counts only were compared with the geometric mean of anterior and posterior counts in 12 healthy volunteers who were studied by both anterior count and posterior count. The results were as follows: 1) The labeling efficiency in gastric juice and hydrochloric acid were $95.5{\pm}1.23%,\;95.7{\pm}1.15%$, respectively. 2) Half gastric emptying time by anterior count only was $126{\pm}21$ minutes 3) Although standard deviation of geometric mean method was smaller than anterior count method, gastric emptying curves from both method were similar. In daily practice, anterior count method may be useful alternative to geometric mean method in evaluation of gastric emptying rate.

• 한국정보통신학회논문지
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• 제17권4호
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• pp.935-944
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• 2013

본 논문에서는 영상 분할을 이용한 다시점 영상의 조명보상 기법을 제안한다. 제안하는 기법에서는 깊이 정보를 이용하여 일정 거리에 따라 참조 영상의 깊이 영상을 레이어로 분리한다. 분리된 레이어에서 서로 다른 객체를 분리하기 위하여 각 레이어에 레이블링 과정을 수행한다. 레이블링 된 참조 영상의 깊이 영상은 3D 워핑 기법을 통하여 왜곡 영상의 시점으로 변환되고 레이블링 된 영역을 찾아 히스토그램을 이용한 조명 보상을 각 영역에서 독립적으로 수행한다. 3D 워핑으로 발생하는 가려짐 영역은 전역적인 방법을 이용하여 보상하게 된다. 다양한 실험을 통해 제안하는 기법으로 조명보상 전처리를 수행한 다시점 영상의 부호화 효율이 향상되는 것을 확인할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제23권4호
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• pp.527-533
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• 2013

Polyclonal antibodies labeled with a tracer have been commonly used as secondary antibodies in immunochemical assays to quantify the concentration of antibody-antigen complexes. The majority of these antibodies conjugated with a tracer are commercially available, with the exception of few untouched targets. This study focused on the production and application of mouse anti-quail IgY as an intermediate antibody to link between quail egg yolk IgY and goat anti-mouse IgG-HRP as primary and secondary antibodies, respectively. Subsequently, the produced mouse anti-quail IgY was labeled with horseradish peroxidase (HRP) and its efficiency on enzyme linked immunosorbent assay (ELISA) was compared with that of commercial rabbit anti-chicken IgY-HRP. As an intermediate antibody, mouse anti-quail IgY was successfully produced with good affinity and sensitivity (1:10,000) to the primary and secondary antibodies. Subsequently, mouse anti-quail IgY was effectively conjugated with HRP enzyme, resulting in a secondary antibody with good sensitivity (1:10,000) to quail anti-V. parahaemolyticus and V. vulnificus IgY. The detection limit was $10^5$ CFU/ml for both V. parahaemolyticus and V. vulnificus. The efficiency of the produced conjugate to detect quail IgY on ELISA was comparable to that of the commercial rabbit anti-chicken IgY-HRP, and hence the produced and labeled mouse anti-quail IgY-HRP can be used as a secondary antibody to detect any antibody produced in quail.

• 대한방사성의약품학회지
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• 제1권2호
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• pp.104-108
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• 2015

Human serum albumin (HSA) has potential for diagnosis and therapy in clinical setting. The purpose of experiments was to develop and evaluate $^{68}Ga$-HSA as a PET agent for diagnosis of acute inflammation. NOTA-HSA was synthesized by conjugating 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid to HSA in 0.1 M sodium carbonate buffer (pH 9.5) and then purified using a PD-10 size-exclusion column. NOTA-HSA was labeled with $^{68}Ga$ at room temperature for 10 min, and 8.4% sodium hydrogen carbonate buffer was added for neutralization. $^{68}Ga$-NOTA-HSA was purified using alumina N plus light cartridge and $0.22{\mu}m$ syringe filter. Labeling efficiency and radiochemical purity were determined by ITLC-SG with 0.1 M citric acid. Biodistribution study was performed in a male BALB/c mice model of Carrageenan-induced acute inflammation. Animal PET study was performed in acute inflammation mice model after tail vein injection of $^{68}Ga$-HSA. This radiotracer showed high labeling efficiency (>99%) around pH 7. Biodistribution study showed higher inflamed footpad uptake than control footpad uptake. Animal PET study revealed 2 times higher uptake on inflamed footpad compared to control footpad. In these experiments, we developed $^{68}Ga$-HSA for acute inflammation PET imaging and evaluated it in a mouse disease model. The results demonstrated that $^{68}Ga$-HSA has potential as a PET imaging agent for diagnosis of acute inflammation.

• 한국BIM학회 논문집
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• 제13권4호
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• pp.96-105
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• 2023

This study focuses on developing a building object recognition technology for efficient use in the remodeling of buildings constructed without drawings. In the era of the 4th industrial revolution, smart technologies are being developed. This research contributes to the architectural field by introducing a deep learning-based method for automatic object classification and recognition, utilizing point cloud data. We use a TD3D network with voxels, optimizing its performance through adjustments in voxel size and number of blocks. This technology enables the classification of building objects such as walls, floors, and roofs from 3D scanning data, labeling them in polygonal forms to minimize boundary ambiguities. However, challenges in object boundary classifications were observed. The model facilitates the automatic classification of non-building objects, thereby reducing manual effort in data matching processes. It also distinguishes between elements to be demolished or retained during remodeling. The study minimized data set loss space by labeling using the extremities of the x, y, and z coordinates. The research aims to enhance the efficiency of building object classification and improve the quality of architectural plans by reducing manpower and time during remodeling. The study aligns with its goal of developing an efficient classification technology. Future work can extend to creating classified objects using parametric tools with polygon-labeled datasets, offering meaningful numerical analysis for remodeling processes. Continued research in this direction is anticipated to significantly advance the efficiency of building remodeling techniques.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2006년도 춘계 종합학술대회 논문집
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• pp.470-474
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• 2006

헤어드라이어의 경우 소비자들이 상품에 대한 충분한 지식을 갖고 구매를 하게 되므로 특별히 판매원의 의견과 서비스를 받지 않고 직접 선택하는 경향이 높아 상품의 포장과 라벨링이 매우 중요한 요소로 지적되고 있다. 본 개발에서는 기존의 금속 열선에서 벗어나 "세라믹 히터"를 이용하여 원적외선의 방사 및 고효율의 열량을 낼 수 있는 방법과 가전제품에서 가장 전자파가 발생되는 헤어드라이기에 전자파 차폐 기술을 적용하여 고성능 및 다기능성의 요구에 부합하고자 한다.

• 대한핵의학회지
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• 제29권1호
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• pp.98-104
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• 1995

필자는 서울대학교 의과대학 병리학 교실에서 만든 항 백혈병 항체(항 CALLA 항체, 항 JL-1 항체)에 대해 $^{99m}Tc$과 $^{125}I$의 표지 방법 및 면역학적 성상을 연구하여 임상 응용의 토대를 만들고자 하였다. $^{99m}Tc$은 pretargeting transchelation법으로 $^{125}I$는 lodogen법으로 표지하였다. 각 항체에 대해 결합 반응검사, Scatchard 분석, 변조 현상 검사를 시행하였다. $^{125}I$는 두 항체 모두에서 90%전후의 높은 표지율을 보인 반면, $^{99m}Tc$ 경우 70%이하의 표지율을 보여 개선점이 요구되었다. 결합반응검사에서도 $^{99m}Tc$을 표지한 항체는 30%정도의 낮은 면역 반응성을 보였다. Scatchard 분석 결과 결합상수 모두가 $10^9$으로 좋은 친화력을 보였고, 세포당 항체 결합 수는 $10^4$으로 비교적 높은 농도로 나타났다. 변조 현상은 모든 경우에서 나타나지 않았다. 항 CALLA 항체, 항 JL-1 항체는 향후 림프종과 백혈병의 진단 및 치료에 도움이 될 수 있으리라 기대된다.