• Journal of information and communication convergence engineering
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• 제3권4호
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• pp.201-204
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• 2005

Twofish is a 128-bit block cipher that accepts a variable-length key up to 256 bits. The cipher is a 16­round Feistel network with a bijective F function made up of four key-dependent 8-by-8-bit S-boxes, a fixed 4­by-4 maximum distance separable matrix over Galois Field$(GF (2^8)$, a pseudo-Hadamard transform, bitwise rotations, and a carefully designed key schedule. In this paper, the Twofish is modeled in VHDL and simulated. Hardware implementation gives much better performance than software-based approaches.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6161-6164
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• 2014

Background: We have reported the radiation could activate STAT3, which subsequently promotes the invasion of A549 cells. We here explored the dose- and time-response of STAT3 to radiation and the effect of radiation on upstream signaling molecules. Materials and Methods: A549 cells were irradiated with different doses of ${\gamma}$-rays. The expression of and nucleus translocation of p-STAT3 in A549 cells were detected by immunoblotting and immunofluorescence, respectively. The level of phosphorylated EGFR was also assessed by immunoblotting, and IL-6 expression was detected by real time PCR and ELISA. Results: Radiation promoted the phosphorylation of STAT3 at Y705 in a dose- and time-dependent manner and nuclear translocation. The level of phosphorylated EGFR in A549 cells increased after radiation. In additional, the mRNA and protein levels of IL-6 in A549 cells were also up regulated by radiation. Conclusions: STAT3 is activated by radiation in a dose-and time-dependent manner, probably due to radiation-induced activation of EGFR or secretion of IL-6 in A549 cells.

• ETRI Journal
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• 제43권2호
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• pp.344-356
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• 2021

CRAFT is a tweakable block cipher introduced in 2019 that aims to provide strong protection against differential fault analysis. In this paper, we show that CRAFT is vulnerable to side-channel cube attacks. We apply side-channel cube attacks to CRAFT with the Hamming weight leakage assumption. We found that the first half of the secret key can be recovered from the Hamming weight leakage after the first round. Next, using the recovered key bits, we continue our attack to recover the second half of the secret key. We show that the set of equations that are solvable varies depending on the value of the key bits. Our result shows that 99.90% of the key space can be fully recovered within a practical time.

• Biomolecules & Therapeutics
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• 제23권6호
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• pp.549-556
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• 2015

Consumption of herbal tea [flower buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae)] is associated with health beneficial effects against multiple diseases including diabetes, asthma, and inflammatory bowel disease. Emerging evidences have reported that High mobility group box 1 (HMGB1) is considered as a key "late" proinflammatory factor by its unique secretion pattern in aforementioned diseases. Dimethyl cardamonin (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone, DMC) is a major ingredient of C. operculatus flower buds. In this study, the anti-inflammatory effects of DMC and its underlying molecular mechanisms were investigated on lipopolysaccharide (LPS)-induced macrophages. DMC notably suppressed the mRNA expressions of TNF-${\alpha}$, IL-$1{\beta}$, IL-6, and HMGB1, and also markedly decreased their productions in a time- and dose-dependent manner. Intriguingly, DMC could notably reduce LPS-stimulated HMGB1 secretion and its nucleo-cytoplasmic translocation. Furthermore, DMC dose-dependently inhibited the activation of phosphatidylinositol 3-kinase (PI3K), phosphoinositide-dependent kinase 1 (PDK1), and protein kinase C alpha (PKC${\alpha}$). All these data demonstrated that DMC had anti-inflammatory effects through reducing both early (TNF-${\alpha}$, IL-$1{\beta}$, and IL-6) and late (HMGB1) cytokines expressions via interfering with the PI3K-PDK1-PKC${\alpha}$ signaling pathway.

• Bulletin of the Korean Chemical Society
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• 제32권7호
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• pp.2358-2368
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• 2011

Density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations, employing the B3LYP method and the LANL2DZ, 6-31G$^*$(LANL2DZ for Tc), 6-31G$^*$(cc-pVDZ-pp for Tc) and DGDZVP basis sets, have been performed to investigate the electronic structures and absorption spectra of the technetium-99m-labeled methylenediphosphonate ($^{99m}Tc$-MDP) complex of the simplest diphosphonate ligand. The bonding situations and natural bond orbital compositions were studied by the Mulliken population analysis (MPA) and natural bond orbital (NBO) analysis. The results indicate that the ${\sigma}$ and ${\pi}$ contributions to the Tc-O bonds are strongly polarized towards the oxygen atoms and the ionic contribution to the Tc-O bonding is larger than the covalent contribution. The electronic transitions investigated by TDDFT calculations and molecular orbital analyses show that the origin of all absorption bands is ascribed to the ligand-to-metal charge transfer (LMCT) character. The solvent effect on the electronic structures and absorption spectra has also been studied by performing DFT and TDDFT calculations at the B3LYP/6-31G$^*$(cc-pVDZ-pp for Tc) level with the integral equation formalism polarized continuum model (IEFPCM) in different media. It is found that the absorption spectra display blue shift in different extents with the increase of solvent polarity.

• ETRI Journal
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• 제33권5호
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• pp.791-801
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• 2011

Security in wireless sensor networks (WSNs) is an upcoming research field which is quite different from traditional network security mechanisms. Many applications are dependent on the secure operation of a WSN, and have serious effects if the network is disrupted. Therefore, it is necessary to protect communication between sensor nodes. Key management plays an essential role in achieving security in WSNs. To achieve security, various key predistribution schemes have been proposed in the literature. A secure key management technique in WSN is a real challenging task. In this paper, a novel approach to the above problem by making use of elliptic curve cryptography (ECC) is presented. In the proposed scheme, a seed key, which is a distinct point in an elliptic curve, is assigned to each sensor node prior to its deployment. The private key ring for each sensor node is generated using the point doubling mathematical operation over the seed key. When two nodes share a common private key, then a link is established between these two nodes. By suitably choosing the value of the prime field and key ring size, the probability of two nodes sharing the same private key could be increased. The performance is evaluated in terms of connectivity and resilience against node capture. The results show that the performance is better for the proposed scheme with ECC compared to the other basic schemes.

• International Journal of Control, Automation, and Systems
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• 제6권6호
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• pp.954-959
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• 2008

This paper is concerned with the reliable $H_{\infty}$ controller design problem for uncertain linear systems against actuator failures. In the design, the $H_{\infty}$ performance of the closed-loop system is optimized during normal operation(without failures) while the system satisfies a prescribed $H_{\infty}$ performance level in the case of actuator failures. Single and parameter-dependent Lyapunov function approaches are applied in designing suboptimal reliable $H_{\infty}$ controllers. Simulation studies are presented to demonstrate the effectiveness of the proposed design procedures.

• International Journal of Control, Automation, and Systems
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• 제5권5호
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• pp.594-600
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• 2007

A sufficient condition for the robust D-stability of dynamic interval systems is proposed in this paper. This D-stability condition is based on a parameter-dependent Lyapunov function obtained from the feasibility of a set of matrix inequalities defined at a series of partial-vertex-based interval matrices other than the total vertex matrices as previous results. This condition is also extended to the robust D-stabilization problem of dynamic interval systems, which supplies an effective synthesis procedure for any LMI D-region. The proposed conditions can be simplified to a set of LMIs, which can be solved by efficient interior point methods in polynomial time.

• Computers and Concrete
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• 제15권4호
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• pp.673-686
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• 2015

R-curve based on the size effect law previously developed for geometrically similar specimens (geometry type III) is extended to geometries with variable depth (geometry type I) as well as with variable notch (geometry type II), where the R-curve is defined as the envelope of the family of critical strain energy release rates from specimens of different sizes. The results show that the extended R-curve for type I tends to be the same for different specimen configurations, while it is greatly dependent on specimen geometry in terms of the initial crack length. Furthermore, the predicted load-deflection responses from the suggested R-curve are found to agree well with the testing results on concrete and rock materials. Besides, maximum loads for type II specimen are predicted well from the extended R-curve.

• Geomechanics and Engineering
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• 제7권3호
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• pp.279-295
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• 2014

A series of one-dimensional consolidation tests and triaxial creep tests were performed on Nansha clays, which are interactive marine and terrestrial deposits, to investigate their time-dependent behaviour. Based on experimental observations of oedometer tests, normally consolidated soils exhibit larger secondary compression than overconsolidated soils; the secondary consolidation coefficient ($C_{\alpha}$) generally gets the maximum value as load approaches the preconsolidation pressure. The postsurcharge secondary consolidation coefficient ($C_{\alpha}$') is significantly less than $C_{\alpha}$. The observed secondary compression behaviour is consistent with the $C_{\alpha}/C_c$ concept, regardless of surcharging. The $C_{\alpha}/C_c$ ratio is a constant that is applicable to the recompression and compression ranges. Compared with the stage-loading test, the single-loading oedometer test can evaluate the entire process of secondary compression; $C_{\alpha}$ varies significantly with time and is larger than the $C_{\alpha}$ obtained from the stage-loading test. Based on experimental observations of triaxial creep tests, the creep for the drained state differs from the creep for the undrained state. The behaviour can be predicted by a characteristic relationship among axial strain rate, deviator stress level and time.