• 대한조현병학회지
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• 제23권1호
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• pp.29-37
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• 2020

Objectives: This study aimed to investigate the characteristics of early maladaptive schemas and their associations with clinical symptoms in patients with schizophrenia. Methods: Forty-eight patients with schizophrenia, 49 patients with major depressive disorder, and 50 healthy controls completed the Young Schema Questionnaire and symptom measures including the Brief Psychiatric Rating Scale-Expanded (BPRS-E). Results: The schizophrenia group had significantly higher scores than the healthy controls and lower scores than the depression group in most schemas. Compared with healthy controls, the schizophrenia group exhibited higher scores in 10 schemas, i.e., mistrust, social isolation, failure, dependence, vulnerability to harm, enmeshment, insufficient self-control, subjugation, emotional inhibition, and negativity schemas (all p<0.001). Moreover, vulnerability to harm, enmeshment, subjugation, and negativity schemas were correlated with total scores of the BPRS-E (0.37≤r≤0.43, all p<0.05). Regarding the five BPRS domains, emotional deprivation schema showed significant relationships with negative (r=0.50, p=0.005) and disorganization (r=0.39, p=0.033) symptoms, while no schemas showed correlations with positive symptoms. Conclusion: These results suggest that most schemas in patients with schizophrenia pertain to impaired autonomy and performance as well as disconnection and rejection domains and may improve our understanding and the treatment of schizophrenia from a perspective of schema therapy focused on these domains.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제29권1호
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• pp.43-51
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• 2023

Purpose: To accommodate the increasing number of patients during the COVID-19 pandemic, numerous portable HEPA filter units (PHUs) were installed in the general wards of existing medical facilities(EMFs) to convert them into emergency conversion facilities (ECFs). The purpose of this study was to build a dataset in preparation for emerging infectious diseases in the post-COVID-19 era by analyzing the construction and operation of ECFs. Methods: Field investigations were conducted during ECF operation periods based on the analysis of heating, ventilation, and air conditioning (HAVC) system design documents for six ECFs across Korea. Interviews were conducted with facility managers during the field investigations. Results: When constructing an ECF within an EMF, the installation status and characteristics of the existing system should be considered. Field investigations and verifications of the operation of HAVC systems must be conducted beforehand for smooth ECF operations. If heating and cooling are required with indoor air circulation type equipment in an ECF zone, the implementation of a heating and cooling method that can satisfy the comfort requirements of the occupants while minimizing cross-contamination is essential. When using PHUs that do not meet the performance standards required by medical equipment, the noise level resulting from such equipment operation must be evaluated and improved. Implications: For EMFs, various guidelines that can be referred to for the construction and operation of ECFs must be developed to prepare for emerging infectious diseases in the future.

• 우주기술과 응용
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• 제2권3호
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• pp.187-194
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• 2022

안테나의 고속 정밀 지향성 확보를 위해 동작되는 모터의 구동에 의한 외란의 크기는 극히 미소함에도 불구하고, 정밀 지향 성능이 요구되는 관측 위성의 영상 품질을 저해하는 주요 원인으로 작용하게 된다. 고해상도 관측위성의 지향 성능 향상을 통한 고해상도 영상정보 획득을 위해서는 지향성 안테나의 모터 구동시 발생하는 미소진동(Jitter)이 주요 임무 장비에 전달되지 않도록 적절한 진동절연 및 저감 설계가 요구된다. 본 논문에서는 실제 위성에 적용된 지향성 안테나 진동저감 장치에 대해 개발과정과 적용 전후의 미소 진동 저감 효과에 대해 살펴보고자 한다. 이 장치는 별다른 인터페이스 추가 장비 없이, 지향성 안테나 구동부 내에 있는 기어 하나만을 스프링 댐퍼 기어 형태로 교체함으로서, 발생되는 지터문제를 획기적으로 개선할 수 있는 방법으로 고안되었으며, 이 방식은 2015년에 발사된 서브미터급 고해상도 지구관측 위성에 처음으로 적용되어 발사되었으며, 현재까지 성공적으로 운용 중에 있다.

• 한국음향학회지
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• 제41권6호
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• pp.680-690
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• 2022

일반적으로 배관에서 발생하는 진동은 배관을 파손시키는 문제를 넘어 배관 파손으로 유발되는 다른 위험한 문제의 원인이 된다. 배관 진동의 원인 분석과 이를 줄이기 위한 수많은 연구들이 존재하는데, 그 중 마찰 지지대를 이용한 배관 진동저감에 대한 연구가 소수 진행되고 있다. 하지만 마찰 지지대에 관한 연구들은 마찰 지지대 성능 예측과 평가에만 집중하였고, 지지대 설치 위치에 따라 달라지는 마찰 지지대의 효과는 고려하지 않았다. 따라서, 본 연구에서는 마찰 지지대의 설치 위치에 따른 배관 진동 저감 효과를 입증하고 전체 시스템의 진동을 줄이기 위한 마찰 지지대 위치 선정 방법을 제시한다. 설계단계에서 최적화 방법을 효과적으로 적용하기 위해 선형 해석으로만 마찰 지지대의 최적 위치를 예측하고, 설계된 마찰 지지대를 시간 영역 해석을 통해 방법론의 타당성을 입증하였다. 또한, 배관 시스템에서 마찰 지지대의 우수한 진동 저감 효과를 정량적으로 해석하여, 지지대 설치 위치를 예측하는 방법의 효용성을 증명하였다.

• Earthquakes and Structures
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• 제23권2호
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• pp.129-138
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• 2022

One of the objectives to prevent building pounding between two adjacentstructures is to considerseparation distance or decrease relative displacement during seismic excitation. Although the majority of building codes around the world have basically suggested some equations or approximately recommended various distances between structuresto avoid pounding hazard, but a lot of reportsin zone of pounding have obviously shown thatsafety situation or economic consideration are not always provided due to the collisions between buildings and the cost of land, respectively. For this purpose, a dynamic MDOF model by having base isolation system is numerically considered and using various earthquake records, relative displacements are mathematically investigated. Different equations to determine the value of damping ratio are collected and the results of evaluations are listed for comparison among them to present a new equation for determination of impact damping ratio. Presented equation is depends significantly on impact velocity before and after impact based on artificial neural network, which the accuracy of them is investigated and also confirmed. In order to select the optimum equation, hysteresisloop of impact between base of building and rubber bumper is considered and compared with the hysteresis loop of each impact, calculated by different equations. Finally, using representative equation, the effect of thickness, number and stiffness of rubber bumpers are numerically investigated. The results of analysis indicate that stiffness and number of bumpers have significantly affected in zone of impact force while the thickness of bumpers have not shown significant influence to calculate impact force during earthquake. For instance, increasing the number of bumpers, gap size between structures and also the value of stiffness is caused to decrease impact force between models. The final evaluation demonstrates that bumpers are able to decrease peak lateral displacement of top story during impact.

• International Journal of Advanced Culture Technology
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• 제12권1호
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• pp.43-50
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• 2024

Patients with acute respiratory diseases, such as Middle East Respiratory Syndrome (MERS) due to COVID-19, must wear masks, protective clothing, face shields, and gloves to prevent infection during treatment and performance. Even if it is applied to disabled people, families who protect them are severely mentally tired from severe physical fatigue and stress from exposure to high-risk infectious diseases. As such, the spread of infectious diseases such as respiratory diseases has not only caused difficulties in using existing welfare and medical services but also caused various problems throughout the daily life of disabled people due to the prolonged infectious disease, and its scope is gradually expanding. Therefore, it should not be overlooked that disabled people may experience various difficulties, from the spread of infectious diseases such as respiratory diseases to isolation, diagnosis, and treatment, and it is time to actively assess the life changes felt by families caring for disabled people and consider and research to provide adequate services. According to the survey of disabled people is being conducted in the context of the spread of infectious diseases such as respiratory diseases, while research on the spread of infectious diseases such as respiratory diseases is rare for parents with disabilities. There is a need for additional investigation into the characteristics in other areas of everyday life, including the health field, which is deteriorating through prior research. Therefore, through this survey, the purpose of this study is to investigate the life changes of parents with disabilities in the context of the spread of infectious diseases such as respiratory diseases and to compare and analyze them to find out how parents were affected by each type of disability. It will be used as evidence to identify more necessary needs and problems for parents with disabilities in the spread of infectious diseases such as respiratory diseases and to provide more appropriate health care and welfare services in the future.

• Journal of Microbiology and Biotechnology
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• 제10권3호
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• pp.349-354
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• 2000

Abstract A facultative alkalophilic gram-negative Vibrio metschnikovii strain RH530, isolated from the wastewater, produced several alkaline proteases (VAP) including six alkaline serine proteases and a metalloprotease. From this strain, high yielding YAP mutants were isolated by NTG treatment. The isolated mutant KS1 showed nine times more activity than the wild-type after optimization of the culture media. The production was regulated by catabolite repression when glucose was added to the medium. The effects of several organic nitrogen sources on the production of the YAP were investigated to avoid catabolite repression. The combination of 4% wheat gluten meal (WGM), 1.5% cotton seed flour (eSF), and 5% soybean meal (SBM) resulted in the best production when supplemented with 1% NaCl. The YAP showed a resistance to surfactants such as $sodium-{\alpha}-olefin$ sulfonate (AOS), polyoxy ethylene oxide (POE), and sodium dodecyl sulfate (SDS), yet not to linear alkylbenzene sulfonate (LAS). However, the activity of the YAP was restored completely when incubated with LAS in the presence of POE or $Na_2SO_4$. The YAP was stable in a liquid laundry detergent containing 6.6% SLES (sodium lauryl ether sulfate), 6.6% LAS, 19.8% POE, and stabilizing agents for more than two weeks at $40^{\circ}C$, but the stability was sharply decreased even after 1 day when incubated at $60^{\circ}C$. A washing performance test with the YAP exhibited it to be a good washing power by showing 51 % and 60% activity at $25^{\circ}C{\;}and{\;}40^{\circ}C$, respectively, thereby indicating that the YAP also has a good detergency at a low temperature. All the results suggest that the YAP produced from the mutant strain KSI has suitable properties for use in laundry detergents.rgents.

• 생명과학회지
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• 제28권3호
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• pp.300-306
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• 2018

라이소자임은 선천성 면역 물질로 개불을 포함하는 여러 무척추동물의 병원균에 대한 방어에 주요하게 작용한다. 본 논문은 개불(Urechis unicinctus)의 체벽 조직 추출물로부터 무척추형 라이소자임의 정제와 그 특성에 관한 분석을 기술하고 있다. 체벽 추출물은 우선적으로 Sep-Pak C18 cartridge를 사용하여 부분적으로 분리되었으며, 분리된 분획 중 60% 메탄올에 용출된 분획이 Bacillus subtilis KCTC 1021에서 강한 항균활성을 나타내었다. 그 후 여러 단계의 역상과 이온교환 고속액체크로마토그래피(High Performance Liquid Chromatography, HPLC)를 사용하여 항균성 물질이 정제되었으며, 분자량은 약 14 kDa이었다. 이 단백질의 일차서열은 LC-MS/MS를 통해 분석되었으며, 얻은 부분적 아미노산 서열을 NCBI BLAST를 통하여 분석해 본 결과, 이 항균성 물질은 다른 동물들로부터 동정된 무척추동물형 라이소자임(invertebrate-type lysozyme)의 서열과 유사도를 가지고 있어, 체벽으로부터 정제된 개불 라이소자임(Urechis unicinctus invertebrate-type lysozyme from body wall, Uu-iLysb)으로 명명하였다. 개불 라이소자임의 활성을 확인하기 위하여 항균활성 및 라이소자임 효소 활성실험을 진행한 결과, 개불 라이소자임이 항균활성과 라이소자임 효소활성 모두 강하게 가지고 있는 것을 확인하였다.

• Applied Biological Chemistry
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• 제50권4호
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• pp.262-267
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• 2007

토양에는 생존하지만 현 기술로는 배양이 불가능한 미생물로부터 천연 항생제를 탐색하기 위해 한국 토양 DNA 단편들을 가진 cosmid library을 대장균에서 제작하였고 약6만개의 clone들을 대상으로 항세균 활성을 보여주는 YS92B를 최종 선발하였다. YS92B클론 배양액의 ethyl acetate추출액은 다양한 병원성 세균의 성장을 in vitro에서 강력히 저해하였다(Listeria monocytogenes, Bacillus subtilis, Pseudomonas syringae, Xanthomonas campestris pv. oryzae, Staphylococcus epidemis). 이 항균활성의 주 물질인 YS92B-VII는 ethyl acetate추출, Sephadex LH20 column chromatography와 HPLC(High Performance Liquid Chromatography)에 의해 순차적으로 분리하였으며 이 과정에서 주 활성물질은 각 피크를 항균검정으로 추적하여 최종 정제하였다. 이 물질은 NMR(Nuclear Magnetic Resornance)에 의한 구조 분석 결과에서 탄소 12개의 포화지방산인 lauric acid가 tyrosine에 결합된 N-lauroyl tyrosine임을 최종 확인하였다. 따라서 본 보고는 한국 토양에서 유래한 고유의 N-acyl amino acid synthase(NAS)유전자가 대장균에 발현되어 생산되는 N-acyl amino acid tyrosine의 특성을 밝히는 것이다.

• 한국재난정보학회 논문집
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• 제14권2호
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• pp.107-114
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• 2018

연구목적 : 본 연구는 전통시장의 화재확산 방지를 위해 지붕 위에 적용한 벽면녹화 기술을 활용한 벽체개발이다. 연구방법 : 개발한 벽면에서 설치된 살수헤드는 평상시에 식물을 위해 사용하다가 화재발생시 인접 건물로 화재가 확산되지 않도록 할 수 있도록 살수배관 겸용 사용이 가능하도록 설계하였다. 또한, 벽면에 식재된 식물의 생장을 위하여 최 상층부 및 일부 구간에 살수헤드를 부착하여 필요시 살수 할 수 있는 시스템을 구축하였으며, 화재발생과 같은 유사시에 보다 많은 양의 물을 살수하여 화재확산방지효과를 극대화 할 수 있도록 설계하여 객관성을 입증하고자 하였다. 연구결과 : 이러한 기술을 통해 전통시장과 같이 밀접건물 상층부에 설치 가능한 벽체개발을 제안하였으며, 구조물과 스프링클러와의 일체형으로 별도의 차단설비가 불필요하게 설계하였다. 그리고 스프링클러가 식물의 살수와 화재확산방지 기능을 동시에 수행이 가능하다. 이는 국내에서 유일하게 제안한 화재확산방지용 대안기술이라 판단된다. 결론 : 본 연구에서는 화재확산 저감효과의 정량화 성능 도출을 위해 직접 디자인한 벽체설계를 통해 벽면시스템의 화재진압 방법, 그리고 벽면자체의 내구성 및 난연성능을 검증하였다.