• International Journal of Stem Cells
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• v.16 no.3
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• pp.281-292
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• 2023

Background and Objectives: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM) hold great promise as a cellular source of CM for cardiac function restoration in ischemic heart disease. However, the use of animal-derived xenogeneic substances during the biomanufacturing of hiPSC-CM can induce inadvertent immune responses or chronic inflammation, followed by tumorigenicity. In this study, we aimed to reveal the effects of xenogeneic substances on the functional properties and potential immunogenicity of hiPSC-CM during differentiation, demonstrating the quality and safety of hiPSC-based cell therapy. Methods and Results: We successfully generated hiPSC-CM in the presence and absence of xenogeneic substances (xeno-containing (XC) and xeno-free (XF) conditions, respectively), and compared their characteristics, including the contractile functions and glycan profiles. Compared to XC-hiPSC-CM, XF-hiPSC-CM showed early onset of myocyte contractile beating and maturation, with a high expression of cardiac lineage-specific genes (ACTC1, TNNT2, and RYR2) by using MEA and RT-qPCR. We quantified N-glycolylneuraminic acid (Neu5Gc), a xenogeneic sialic acid, in hiPSC-CM using an indirect enzyme-linked immunosorbent assay and liquid chromatography-multiple reaction monitoring-mass spectrometry. Neu5Gc was incorporated into the glycans of hiPSC-CM during xeno-containing differentiation, whereas it was barely detected in XF-hiPSC-CM. Conclusions: To the best of our knowledge, this is the first study to show that the electrophysiological function and glycan profiles of hiPSC-CM can be affected by the presence of xenogeneic substances during their differentiation and maturation. To ensure quality control and safety in hiPSC-based cell therapy, xenogeneic substances should be excluded from the biomanufacturing process.

• International Journal of Knowledge Content Development & Technology
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• v.14 no.2
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• pp.29-46
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• 2024

Academic libraries are at the forefront of supporting their parent institutions in teaching and learning, research activities, and community services for the students and faculty members, but, the researchers observed that some of the research emanating from faculty members in academic institutions particularly universities remains largely unknown, unrecognized and invisible on the global scene. This present paper is therefore a modest attempt towards addressing the issue of enhancing the faculty research visibility in the institutions of higher learning by the academic libraries. It also examines the extent academic libraries in public universities in Nigeria use research visibility channels to increase the global visibility of their faculty members. Difficulties encountered by librarians and ways of tackling the visibility of the faculty were also examined. A descriptive survey research design was adopted and the population consisted of all the 162 librarians in public universities in South-East (S.E), Nigeria. Telephone calls and Online Questionnaire were used for data collection. The number of librarians was obtained through phone calls from the Heads of each of the Libraries. The Online Questionnaire was submitted to the WhatsApp platforms of librarians in Nigeria- Academic and Research Libraries (ARL) and Chartered Librarians in Nigeria Connect (CLN-Connect). The questionnaire was structured in such a way that only the Librarians in Public universities in the S.E. Nigeria will respond to it. At the end of the day only 120 librarians responded, at a response rate of 74%. The study was analysed using tables, percentages and charts. The study recommended that librarians who are unaware of RVCs and its utilization should go for training to acquire the knowledge that will enable them enhance the global visibility of faculty staff, Management of Public universities in S.E, Nigeria should in addition to addressing copyright issues by the use of disclaimer notices and creative common licensing and provision of infrastructural facilities e.g. steady power supply, High power brand Internet connectivity, establishment of an Institutional Repository, etc, also should mandate the faculty staff to release their productive work to the library for onward submission to the RVCs platforms for enhancement of their global visibility.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.215-224
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• 2024

The purpose of this study was to examine research trends related to neonatal simulation practice education of domestic nursing students. It was a descriptive research study. For literature collection, a total of 17 journals were selected as a result of a search using ('Newborn Simulation') AND ('Nursing Student' OR 'Nursing College Student' OR 'Student Nurse') in 6 domestic electronic databases. The research results showed that it started with 7 journals from 2011 to 2015 and decreased slightly to 5 journals from 2016 to 2020 and 5 journals from 2021 to 2023. The research design was mostly quantitative with a total of 16 journals(94%). Among them, there were 15 intervention journals(88%), 1 descriptive research journals(6%), and 1 mixed method journals(6%). The key topics in simulation practice were high-risk newborns with 9 journals(52%), respiratory distress syndrome in neonatal intensive care units appeared with 3 journals(18%), neonatal care with 3 journals(18%), normal newborn care with 1 journal(6%), and neonatal emergency airway care with 1 journals(6%). The main outcome variables were clinical performance, accounting for 5 journals(19.2%), followed by practice satisfaction 3 journals(11.5%). clinical competency and practice satisfaction were found to have significant positive effects. In conclusion, various research methods are required, such as expansion of nursing students' neonatal simulation practice education, repeated research, and qualitative research.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.357-363
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• 2024

As AR display virtual technology enters public learning life extensively, the way in which reality and virtual connection are connected is also changing. The purpose of this paper is to study the expression between the 3D connection sensory information visualization experience and virtual reality enhancement through the visual direction sensory information visualization experience of the plane. It is analyzed by examining the basic setting method compared to the current application of AR display and flat visualization cases. The scope of this paper is to enable users to have a better experience through the relationship with sensory visualization, centering on eye tracking technology in the four categories of AR display connection design: gesture connection, eye tracking, voice connection, and sensor. Focusing on eye tracking technology through AR display interaction and current application and comparative analysis of flat visualization cases, the geometric consistency of visual figures, light and color consistency, combination of multi-sensory interaction methods, rational content display, and smart push presented sensory visualization in virtual reality more realistically and conveniently, providing a simple and convenient sensory visualization experience to the audience.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.555-563
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• 2024

We were selected oriental medicinal herbs known to be effective in strengthening muscles, improving sarcopenia, treating arthritis and osteoporosis. Amino acids have been reported to be associated with the above-mentioned effects. During the manufacturing process of water extracts of ginseng and samchae, the content of arginine, a basic amino acid, was significantly reduced. The decrease was 99.48mg/100ml for steamed red ginseng compared to 114.07mg/100ml for dried white ginseng, and 54.69mg/100ml for steamed samchae compared to 118.90mg/100ml for dried samchae. The extracts of the wild roots of Acanthus apias and the above-ground twigs of Acanthus apias showed significantly higher DPPH and ABTS radical scavenging activities. Meanwhile, DPPH activity was higher in steamed red ginseng and steamed samchae compared to dried white ginseng and dried samche, but ABTS activity increased to 66.88% for steamed red ginseng compared to 41.96% for dried white ginseng, but was 77.48% for dried samchae and 77.52% for steamed samchae.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.237-244
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• 2024

We studied the effects on their academic achievement of chemistry II and advanced chemistry subjects of science high school students according to the type of class (face-to-face and non-face-to-face). The subjects of this study were 195 first-year students of G Science High School located in Gyeongnam. The average scores of Chemistry II and Advanced Chemistry in non-face-to-face classes in 2020 and face-to-face classes in 2021 were compared and analyzed. As a result of comparing and analyzing the academic achievement according to the class type, students' grades in Chemistry II and Advanced Chemistry were higher in non-face-to-face classes. In the comparison of academic achievement by level according to class type, Chemistry II showed higher average grades in non-face-to-face classes as the lower level were, and in advanced chemistry, the higher the upper grades in non-face-to-face classes. In addition, in terms of the effect of changes in class form on the upper and lower 10% levels of academic achievement of Chemistry II, the upper 10% showed high grades in face-to-face classes and the lower 10% in non-face-to-face classes. On the other hand, in advanced chemistry, the average grade of non-face-to-face classes was higher than that of face-to-face classes in the top 10%, and the average grade of face-to-face classes was higher than that of non-face-to-face classes in the bottom 10%. Through these results, it was found that in the teaching-learning of science high school students, instructors need to design and treat teaching-learning appropriate to the level of academic achievement.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.365-371
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• 2024

The purpose of this study was to investigate the effect of leisure satisfaction according to calligraphy activities of the elderly on self-efficacy and psychological well-being. In order to conduct this study, the researchers surveyed 306 elderly people aged 65-76 or older from late November to early December 2023 in Anyang City and Xinxiang City, Henan Province, China. In order to verify the research hypothesis, the researchers performed frequency analysis, descriptive statistics analysis, and Pearson correlation analysis using IBM SPSS Statistics 25, and then performed independent sample T-test and one-way analysis of variance (One-Way ANOVA). To verify the hypothesis through the measurement concept, related verification was conducted for Hayes PROCESS macro and Bootstrap. As a result of the study, first, there is a gender difference in leisure satisfaction, leisure satisfaction, self-efficacy, and psychological well-being, and leisure satisfaction and psychological well-being differ significantly according to age. Second, it was found that leisure satisfaction had a positive effect on self-efficacy. Third, it was found that leisure satisfaction had a positive effect on psychological well-being. Fourth, leisure satisfaction was found to have a positive effect on psychological well-being. Therefore, in order to increase the leisure satisfaction and psychological well-being of the elderly, it is necessary to carefully develop a calligraphy activity system to increase self-efficacy.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.565-574
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• 2024

ChatGPT is causing significant reverberations across all sectors of our society, and this holds true for the field of education as well. However, scholarly and societal discussions regarding ChatGPT in academic settings have primarily focused on issues such as plagiarism, with relatively limited research on the positive effects of utilizing generative AI. Additionally, amidst the educational crisis of the post-COVID era, there is a growing recognition of the need to enhance academic engagement. In light of these concerns, we investigated how academic engagement varies based on students' levels of ChatGPT literacy and examined whether students' academic confidence and perceived academic competence serve as mediators between ChatGPT literacy and academic engagement. An analysis using SPSS was conducted on the data collected from 406 college students. The results showed that ChatGPT literacy had a positive effect on academic engagement, and academic confidence mediated the relationship between ChatGPT literacy and academic engagement. Also, when the mediating effect of perceived academic competence was significant only when it was serially mediated. Based on these findings, we discussed the theoretical contributions of identifying the theoretical mechanism between ChatGPT literacy and academic engagement. In addition, practical implications regarding the importance of ChatGPT literacy education were described.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.133-139
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• 2024

The purpose of this study was to investigate the effects of robot play linked to environmental picture books on the Environmentally Friendly attitudes of 5-year-old children. For this purpose, 24 5-year-old children from Seoul Y Kindergarten and 20 5-year-old children from E Kindergarten were selected as comparison subjects. In order to examine the differences between the groups, the experimental group performed 'Robot Play Linked to Environmental Picture Books' and the comparative group performed 'Free Play After Appreciating Environmental Picture Books'. The collected data were analyzed through independent sample t-test, which compares the average between the two groups using SPSS 29.0 statistical program. As a result of the study, there was a significant difference in all sub-areas of children's environment-friendly attitude(nature-friendly attitude, environmental preservation attitude), and these findings are meaningful as a basis for the direction of new environmental education of play-centered early childhood environmental education based on the value of new play media support called robot.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.373-382
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• 2024

This study attempted to identify the relationship between nursing competency, clinical reasoning competence, and empathy ability according to the center of enneagram power for nursing students. The subjects of the study were 218 students enrolled in the department of nursing at two universities located in one region, data collection was conducted from 16 October to 27 October 2023. Data analysis was performed using SPSS/WIN version 26.0 program, descriptive statistics, and difference verification were analyzed by t-test, ANOVA, pearson's correlation coefficient, Results, The enneagram personality type of the subjects of this study was the most common type 9. And in the enneagram center of power, the instinct-centered type had the highest nursing competence, the thought-centered type had the highest clinical reasoning competence, and the emotion-centered type had the highest empathy ability. In addition, nursing competence and clinical reasoning competence showed a significant positive correlation, and clinical reasoning competence and empathy ability were also found to be positively correlated. Therefore, it is important to continue to develop and apply individualized competency building programs that reflect personality type tests to nursing students. In addition, the higher the empathy ability, the higher the clinical reasoning competence, so it is thought that it is necessary to develop a standardized curriculum that can improve nursing competence and clinical reasoning competence and verify its effectiveness.