• Toxicological Research
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• 제17권
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• pp.299-304
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• 2001

Xenobiotics and their reactive intermediates bind to cellular macromolecules and/or generate oxidative stress. which provoke deleterious effects on the cell function. Induction of xenobiotic-biotrans-forming enzymes and antioxidant molecules is an important defense mechanism against such insults. A group of genes involved in the defense mechanism. e.g. genes encoding glutathione S-transferases. NAD(P)H: quinone oxidoreductase, UDP-glucuronosyltransferase (UDP-GT) and ${\gamma}$-glutamylcysteine synthetase (GGCS). have a common regulatory sequence, Antioxidant or Electrophile Responsive Element (ARE/EpRE). Recently. Nrf2. discovered as a homologue of erythroid transcription factor p45 NF-E2, was shown to bind ARE/EpRE and induce the expression of these defense genes. Mice that lack Nrf2 show low basal levels of expression and/or impaired induction of these genes. which makes the animals highly sensitive to xenobiotic toxicity. Indeed. we show here that nrf2-deficient mice had a higher mortality than did the wild-type mice when exposed to acetaminophen (APAP). Detailed analyses of APAP hepatotoxicity in the nrf2 knockout mice indicate that a large amount of reactive APAP metabolites was generated in the livers due to the impaired basal expression of two detoxifying enzyme genes, UDP-GT (Ugt1a6) and GGCS. while the cytochrome P450 content was unchanged. Thus. the studies using the nrf2 knockout mice clearly demonstrate significance of the expression of Nrf2-regulated enzymes in protection against xenobiotic toxicity.

• The Korean Journal of Physiology and Pharmacology
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• 제11권6호
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• pp.253-257
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• 2007

Among the arthritis symptoms, chronic pain is the most serious, and it can profoundly affect the quality of human life. Unfortunately, the mechanism of development in arthritis and arthritic pain has not yet been precisely elucidated. Accumulating evidence indicates that nitric oxide (NO) plays a pivotal role in nociceptive processing in the spinal cord. However, the modulation mechanism of NO in the peripheral site of arthritis and arthritic pain has not been clarified. Therefore, I determined in the present study which nitric oxide synthase (NOS) was involved in the induction of arthritis and arthritic pain. Monoarthritis was induced by intra-articular injection of carrageenan (2%, $50{\mu}l$) into rats, and resulted in the reduction of weight load on the injected leg, increase of knee joint diameter and inflammatory response. Pre-treatment of rats with L-N6-(1-iminoethyl)-lysine (L-NIL, $500{\mu}g$, in $50{\mu}l$), an inhibitor of inducible NOS (iNOS), partially prevented the induction of pain-related behavior and partially reduced inflammatory response in the synovial membrane in the knee joint. These results suggest that iNOS in the knee joint may play an important role in the induction of pain-related behavior and inflammation, and that NO produced by iNOS may be associated with nociceptive signaling in the peripheral site.

• 폴리머
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• 제35권3호
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• pp.272-276
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• 2011

선택 반사를 보여주는 콜레스테릭 액정의(cholesteric liquid crystal; CLC) planar 배열이 유도되는 메카니즘을 CLC 셀의 선택 반사율과 FTIR $C{\equiv}N$ 피크 세기를 측정하여 조사하였다. 배향막을 사용한 경우보다는 planar 배열 유도가 완전하지는 않았지만 shear force를 이용하거나 또는 고분자 기판을 연신하여 배향막을 사용하지 않은 상태에서 planar 배열을 유도하였다. CLC의 planar 배열이 유도되는 메카니즘은 기판 표면에 접촉하는 액정분자들이 한 방향으로 늘어서면, 그 액정분자 위에 CLC의 나선 구조들이 기판에 수직으로 형성되며 planar 배열이 유도되는 것이다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 학술대회 논문집 정보 및 제어부문
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• pp.660-662
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• 2004

This paper proposes an Intelligent Speed Estimator in order to realize the speed-sensorless vector control of an induction motor. Intelligent Speed Estimator used Model Reference Adaptive System which has Fuzzy-Neural adaptive mechanism as Speed Estimation method. The Intelligent Speed Estimator estimates the speed of an induction motor with a rotor flux of a reference model and adjustable model in MRAS. The Intelligent Speed Estimator reduces the error of the rotor flux between the voltage flux model and the current flux model using the error and the change of error as input of the Estimator. The computer simulation is executed to verify the propriety and the effectiveness of the proposed speed estimator.

• 대한기계학회논문집A
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• 제30권7호
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• pp.865-872
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• 2006

High frequency induction welding is widely employed for longitudinal seam welding of small scale tubes and pipes because of its relatively high processing speed and efficiency. This research is aimed at understanding the variables that affect the quality of the high frequency induction welding. The welding variables include the welding frequency, weld speed, V-angle and tube thickness. Temperature distribution of the tube is calculated through three dimensional coupled electromagnetic and thermal FE analysis. The skin and proximity effects are considered in the electromagnetic analysis. The influence of the impeder is also analyzed. The effects of the operating welding variables on the temperature distribution are investigated quantitatively by exhibiting the heat affected zone (HAZ). The results explain the mechanism of significant enhancement of welding efficiency when the impeder is used. The proper welding conditions without the overheated edge are obtained through FE analysis.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제54권8호
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• pp.395-401
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• 2005

This paper presents Hybrid PI(HBPI) controller of induction motor drive using fuzzy control. In general, PI controllers used in computer numerically controlled machines process fixed gain. They may perform well under some operating conditions, but not all. To increase the robustness of fixed gain PI controller, HBPI controller proposes a new method based self tuning PI controller. HBPI controller is developed to minimize overshoot and settling time following sudden parameter changes such as speed, load torque, inertia, rotor resistance and self inductance. The results on a speed controller of induction motor are presented to show the effectiveness of the proposed gam tuner. And this controller is better than the fixed gains one in terms of robustness, even under great variations of operating conditions and load disturbance.

• 대한전기학회논문지:시스템및제어부문D
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• 제53권8호
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• pp.545-550
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• 2004

This paper is proposed a fuzzy neural network controller based on the vector controlled induction motor drive system. The hybrid combination of fuzzy control and neural network will produce a powerful representation flexibility and numerical processing capability. Also, this paper is proposed estimation and control of speed of induction motor using ANN Controller. The back propagation neural network technique is used to provide a real time adaptive estimation of the motor speed. The error between the desired state variable and the actual one is back-propagated to adjust the rotor speed, so that the actual state variable will coincide with the desired one. The back propagation mechanism is easy to derive and the estimated speed tracks precisely the actual motor speed. This paper is proposed the theoretical analysis as well as the simulation results to verify the effectiveness of the new method.

• Journal of Microbiology and Biotechnology
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• 제25권6호
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• pp.759-764
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• 2015

Antimicrobial peptides (AMPs) are one of the critical components in host innate immune responses to imbalanced and invading microbial pathogens. Although the antimicrobial activity and mechanism of action have been thoroughly investigated for decades, the exact biological properties of AMPs are still elusive. Most AMPs generally exert the antimicrobial effect by targeting the microbial membrane, such as barrel stave, toroidal, and carpet mechanisms. Thus, the mode of action in model membranes and the discrimination of AMPs to discrepant lipid compositions between mammalian cells and microbial pathogens (cell selectivity) have been studied intensively. However, the latest reports suggest that not only AMPs recently isolated but also well-known membrane-disruptive AMPs play a role in intracellular killing, such as apoptosis induction. In this mini-review, we will review some representative AMPs and their antimicrobial mechanisms and provide new insights into the dual mechanism of AMPs.

• International Journal of Oral Biology
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• 제46권2호
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• pp.74-80
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• 2021

Autophagy is an evolutionarily well-conserved cellular homeostasis program that responds to various cellular stresses and degrades unnecessary or harmful intracellular materials in lysosomes. Accumulating evidence has shown that autophagy dysfunction often results in various human pathophysiological conditions, including metabolic disorders, cancers, and neurodegenerative diseases. The discovery of an autophagy machinery protein network has revealed underlying molecular mechanisms of autophagy, and advances in the understanding of its regulatory mechanism have provided novel therapeutic targets for treating human diseases. Recently, reports have emerged on the involvement of autophagy in oral squamous cell carcinoma (OSCC). Although the role of autophagy in cancer therapy is controversial, the beneficial use of the induction of autophagic cell death in OSCC has drawn significant attention. In this review, the types of autophagy, mechanism of autophagosome biogenesis, and modulating molecules and therapeutic candidates affecting the induction of autophagic cell death in OSCC are briefly described.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제49권10호
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• pp.577-582
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• 2000

This paper analyze the interference problems, especially Ac corrosion when the gas pipeline is buried with power cable in the same submarine tunnel. This paper present the results of the study about interference mechanism(inductive coupling, conductive coupling, resistive coupling), AC corrosion, limitation of safety voltage, modeling of power cables, gas pipeline and grounding systems, analysis of induction voltage and optimal arrangement of power cables.