Toxicological Research
- Volume 17
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- Pages.299-304
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- 2001
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Nrf2 Knockout Mice that Lack Control of Drug Metabolizing and Antioxidant Enzyme Genes - Animals Highly Sensitive to Xenobiotic Toxicity
- Enomoto, Akiko (Institute of Environmental Toxicology) ;
- Itoh, Ken (University of Tsukuba) ;
- Harada, Takanori (Institute of Environmental Toxicology) ;
- Yamamoto, Masayuki (University of Tsukuba)
- Published : 2001.07.01
Abstract
Xenobiotics and their reactive intermediates bind to cellular macromolecules and/or generate oxidative stress. which provoke deleterious effects on the cell function. Induction of xenobiotic-biotrans-forming enzymes and antioxidant molecules is an important defense mechanism against such insults. A group of genes involved in the defense mechanism. e.g. genes encoding glutathione S-transferases. NAD(P)H: quinone oxidoreductase, UDP-glucuronosyltransferase (UDP-GT) and