• International journal of advanced smart convergence
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• 제4권2호
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• pp.154-162
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• 2015

This paper focuses on how cognitive and emotional structures affect humans during long-term interaction. We design an interaction with a turn-based game, the Chopstick Game, in which two agents play with numbers using their fingers. While a human and a robot agent alternate turn, the human user applies herself to play the game and to learn new winning skills from the robot agent. Conventional valence and arousal space is applied to design emotional interaction. For the robotic system, we implement finger gesture recognition and emotional behaviors that are designed for three-dimensional virtual robot. In the experimental tests, the properness of the proposed schemes is verified and the effect of the emotional interaction is discussed.

• Genomics & Informatics
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• 제1권1호
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• pp.7-19
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• 2003

The latest measure of the relative evolutionary age of protein structure families was applied (based on taxonomic diversity) using the protein structural interactome map (PSIMAP). It confirms that, in general, protein domains, which are hubs in this interaction network, are older than protein domains with fewer interaction partners. We apply a hypothesis of 'biological network evolution' to explain the positive correlation between interaction and age. It agrees to the previous suggestions that proteins have acquired an increasing number of interaction partners over time via the stepwise addition of new interactions. This hypothesis is shown to be consistent with the scale-free interaction network topologies proposed by other groups. Closely co-evolved structural interaction and the dynamics of network evolution are used to explain the highly conserved core of protein interaction pathways, which exist across all divisions of life.

• Structural Engineering and Mechanics
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• 제83권6호
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• pp.729-744
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• 2022

In this paper, an analytical formulation is proposed to predict the vertical vibration response due to the pedestrian walking on a footbridge considering the human-structure interaction, where the footbridge and pedestrian are represented by the Euler beam and linear oscillator model, respectively. The derived coupled equation of motion is a nonlinear fourth-order partial differential equation. An uncoupled solution strategy based on the combined weighted residual and perturbation method) is proposed to reduce the tedious computation, which allows the separate integration between the bridge and pedestrian subsystems. The theoretical study demonstrates that the pedestrian subsystem can be treated as a structural system with added mass, damping, and stiffness. The analysis procedure is then applied to a case study under the conditions of single pedestrian and multi pedestrians, and the results are validated and compared numerically. For convenient vibration design of a footbridge, the simplified peak acceleration formula and the idea of decoupling problem are thus proposed.

• 대한인간공학회지
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• 제25권2호
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• pp.135-146
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• 2006

Multimodal interfaces are recognition-based technologies that interpret and encode hand gestures, eye-gaze, movement pattern, speech, physical location and other natural human behaviors. Modality is the type of communication channel used for interaction. It also covers the way an idea is expressed or perceived, or the manner in which an action is performed. Multimodal Interfaces are the technologies that constitute multimodal interaction processes which occur consciously or unconsciously while communicating between human and computer. So input/output forms of multimodal interfaces assume different aspects from existing ones. Moreover, different people show different cognitive styles and individual preferences play a role in the selection of one input mode over another. Therefore to develop an effective design of multimodal user interfaces, input/output structure need to be formulated through the research of human cognition. This paper analyzes the characteristics of each human modality and suggests combination types of modalities, dual-coding for formulating multimodal interaction. Then it designs multimodal language and input synchronization method according to the granularity of input synchronization. To effectively guide the development of next-generation multimodal interfaces, substantially cognitive modeling will be needed to understand the temporal and semantic relations between different modalities, their joint functionality, and their overall potential for supporting computation in different forms. This paper is expected that it can show multimodal interface designers how to organize and integrate human input modalities while interacting with multimodal interfaces.

• 로봇학회논문지
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• 제8권2호
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• pp.75-81
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• 2013

This research would investigate deeply the operation of an omni-directional mobile robot that is able to move with high acceleration. For the high acceleration performance, the vehicle utilizes the structure of Active Split Offset Casters (ASOCs). This paper is mainly focused on inverse kinematics of the structure, hardware design to secure durability and preserve the wheels' contact to the ground during high acceleration, and localization for the real time position control.

• 한국융합학회논문지
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• 제12권6호
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• pp.1-8
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• 2021

본 연구는 시설원예 스마트팜의 인터랙션 구조 연구를 목적으로 한다. 연구 방법으로는 스마트팜의 생산, 유통, 판매, 소비 단계 중 생산 단계에서 상호작용의 주체인 사람과 식물, 스마트팜 간의 관계를 파악하고, 식물의 생육 단계를 정의하여 인터랙션 요소를 분석하였다. 또한 현장방문 조사를 통해 상호작용 주체의 행동과 작동, 시간에 따라 일회성, 단기적, 장기적 상호작용으로 구분할 수 있었다. 그 결과, 1) 사람과 식물은 '일회성, 단기적', 2) 식물과 스마트팜은 '단기적', 3) 스마트팜과 사람은 '단기적, 장기적' 측면으로 상호작용 한다는 결론을 도출해 낼 수 있었다. 이에 본 연구는 시설원예 스마트팜 생산 단계에서 주체들 간의 관계와 상호작용 요소를 도출하고, 이를 구조화 하여 새로운 인터랙션 구조 모형을 제시하는데 의의가 있다.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2317-2325
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• 2014

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily and mediates transmembrane efflux of many drugs. Since it is involved in multi-drug resistance activity in various cancer cells, the development of P-gp inhibitor is one of the major concerns in anticancer therapy. Human P-gp protein has at least two "functional" drug binding sites that are called "H" site and "R" site, hence it has multi-binding-specificities. Though the amino acid residues that constitute in drug binding pockets have been proposed by previous experimental evidences, the shapes and the binding poses are not revealed clearly yet. In this study, human P-gp structure was built by homology modeling with available crystal structure of mouse P-gp as a template and docking simulations were performed with inhibitors such as verapamil, hoechst33342, and rhodamine123 to construct the interaction between human P-gp and its inhibitors. The docking simulations were performed 500 times for each inhibitor, and then the interaction frequency of the amino acids at the binding poses was analyzed. With the analysis results, we proposed highly contributing residues that constitute binding pockets of the human P-gp for the inhibitors. Using the highly contributing residues, we proposed the locations and the shapes of verapamil binding site and "R" site, and suggested the possible position of "H" site.

• 디자인학연구
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• 제16권1호
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• pp.117-126
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• 2003

인간과 컴퓨터의 상호작용은 컴퓨터의 기술적 발달과 함께 다양하게 변화하여 왔으며 웹의 보편화와 함께 웹의 특성을 반영한 다양한 형식과 방법의 상호작용이 시도되고 있다. 이러한 다양한 상호작용의 개념중 대화형 에이전트는 대화의 대상으로 캐릭터를 사용하며 대화에 의한 상호작용을 통해 자연스럽고 인간적이며 직관적인 상호작용을 제시하고 있다. 그러나 현재까지의 연구는 그 구현을 중심으로 진행되고 있으며 웹에서의 실질적인 적용은 시험적 단계를 거치고 있다. 따라서 본 연구에서는 가상 강좌 사이트에서 보다 적극적인 활용대상으로서 대화형 에이전트를 적용하기 위해 대화형 에이전트의 상호작용 방식의 주요 개념인 대화에 대하여 고찰하였다. 다음으로 웹에서 이루어지는 대화적 특성을 연구하고 웹에서의 대화 구성 방식을 도출하였다. 이를 바탕으로 대화형 에이전트를 구현하여 가상 강좌 사이트에 적용하였으며 사이트 운영 및 평가를 통해 대화형 에이전트의 적용 가능성을 살펴보았다.

• Molecules and Cells
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• 제44권1호
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• pp.26-37
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• 2021

Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a well-defined tumor suppressor, and found that this intermolecular interaction plays a key role in E7-driven transformation and tumorigenesis. In this study, we carried out a molecular analysis of the interaction between CR3 of HPV18 E7 and the PTP domain of PTPN21, a PTP protein that shares high sequence homology with PTPN14 but is putatively oncogenic rather than tumor-suppressive. Through the combined use of biochemical tools, we verified that HPV18 E7 and PTPN21 form a 2:2 complex, with a dissociation constant of 5 nM and a nearly identical binding manner with the HPV18 E7 and PTPN14 complex. Nevertheless, despite the structural similarities, the biological consequences of the E7 interaction were found to differ between the two PTP proteins. Unlike PTPN14, PTPN21 did not appear to be subjected to proteasomal degradation in HPV18-positive HeLa cervical cancer cells. Moreover, knockdown of PTPN21 led to retardation of the migration/invasion of HeLa cells and HPV18 E7-expressing HaCaT keratinocytes, which reflects its protumor activity. In conclusion, the associations of the viral oncoprotein E7 with PTPN14 and PTPN21 are similar at the molecular level but play different physiological roles.

• Steel and Composite Structures
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• 제37권4호
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• pp.391-404
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• 2020

Human-induced vibration could present a serious serviceability problem for large-span and/or lightweight floors using the high-strength material. This paper presents the results of heel-drop, jumping, and walking tests on a large-span composite steel rebar truss-reinforced concrete (CSBTRC) floor. The effects of human activities on the floor vibration behavior were investigated considering the parameters of peak acceleration, root-mean-square acceleration, maximum transient vibration value (MTVV), fundamental frequency, and damping ratio. The measured field test data were validated with the finite element and theoretical analysis results. A comprehensive comparison between the test results and current design codes was carried out. Based on the classical plate theory, a rational and simplified formula for determining the fundamental frequency for the CSBTRC floor is derived. Secondly, appropriate coefficients (β_rp) correlating the MTVV with peak acceleration are suggested for heel-drop, jumping, and walking excitations. Lastly, the linear oscillator model (LOM) is adopted to establish the governing equations for the human-structure interaction (HSI). The dynamic characteristics of the LOM (sprung mass, equivalent stiffness, and equivalent damping ratio) are determined by comparing the theoretical and experimental acceleration responses. The HSI effect will increase the acceleration response.