• Korean Journal of Medicinal Crop Science
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• v.19 no.2
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• pp.103-110
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• 2011

This study was performed to enhance anticancer activities of Lithospermum erythrorhizon by eluting high amount of shikonin through ultra high pressure process. Extraction yield was increased up to 5~10% by ultra high pressure process, compare to the normal extraction processes such as water solvent extraction, 70% ethyl alcohol solvent extraction. The cytotoxicity of the extracts ($1.0{\mu}g/m{\ell}$) from ultra high pressure process was showed the lowest cytotoxicity 13.4% for human lung cell (HEL299). The anticancer activities showed 80~85% by adding $1.0{\mu}g/m{\ell}$ of the extracts from ultra high pressure process in several cancer cell lines such as AGS, Hep3B, MCF-7 and HeLa cells. Among them, MCF-7 cell of the endocrine system was highest inhibited than other cells. The anticancer activities of the extracts from ultra high pressure extraction process showed 10~15%, which was higher than the extracts from normal extraction processes. From HPLC analysis of the extracts, the contents of shikonin in the extracts from ultra high pressure process was 11.42% (w/w), which was 20% higher than others. This results indicate that ultra high pressure process could increase the extraction yield of shikonin and other contents, which resulted in higher anticancer activities.

• Korean Journal of Medicinal Crop Science
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• v.22 no.2
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• pp.134-139
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• 2014

This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolata by stepwise steaming process and high pressure process. The phenol contents was $8.742{\mu}g/mg$ which was higher than that from conventional extraction using 70% ethyl alcohol at $80^{\circ}C$ for 24 hours. All of extracts at a concentration of $1.0mg/m{\ell}$ showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cell growth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to $180{\times}10^4cells/m{\ell}$ and $96{\times}10^4cells/m{\ell}$, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-${\alpha}$ from the stepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure process effectively released active biomaterials which could important role in enhancing immune activity in the body.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.11 no.6
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• pp.55-61
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• 2012

In this study, it was grasped to the flow characteristics of injection nozzle installed in high pressure holder for improving productivity. Chip curling occurred during cutting process for difficult-to-cut material detracts product qualities and productivity. Among of method preventing the phenomenon, high pressure injecting cutting oil is an alterative. In this study, the optimal nozzle was designed by CFD method and it was conducted to analyse on the effect of high pressure injection on chip shape generated during cutting process and wear of insert by experimental method. As the result, it could be confirmed that high pressure injection is favorable for preventing chip curling and insert from wearing.

• Clean Technology
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• v.21 no.4
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• pp.217-223
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• 2015

In the present study, modelling and optimization of ethanol-n-heptane separation process were performed using pressure-swing distillation. The pressure-swing distillation process optimization was performed to obtain high purity ethanol and high purity n-heptane into a low-high pressure columns configuration and a high-low pressure columns configuration. The results of pressure-swing distillation process simulation and optimization using high-low pressure column configuration showed a reduced total reboiler heat duty at 5.8% which confirmed a more economical energy consumption.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.16 no.6
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• pp.81-86
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• 2017

The high-pressure resin transfer molding (HP-RTM) process has a very effective for the mass production of carbon fiber reinforced plastic (CFRP) for light weight in the automotive industry. In developing robust equipment, new process and fast cure matrix systems reduces significantly the cycle time less than 5 minutes in recent years. This paper describes the cavity pressure, temperature and molding characteristics of the HP-RTM process. The HP-RTM mold was equipped with two cavity pressure sensors and three temperature sensors. The cavity pressure characteristics of the HP-RTM injection, pressurization, and curing processes were studied. This experiment was conducted with selected process parameters such as mold cap size, maximum press force, and injection volume. Consequently, this monitoring method provides correlations between the selected process parameters and final forming characteristics in this work.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.1
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• pp.94-100
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• 2019

This study was conducted on a high-temperature/high-pressure washer in which low-pressure cold water in a boiler is heated to a temperature range of $70{\sim}80^{\circ}C$ by supplying diesel combustion heat. The high-temperature water is sent to a compressor to increase its pressure to 200 bar, thereby making high-temperature/high-pressure water, which is sprayed through a spray nozzle. In the results of this study, the spray temperature of the high-pressure washing was shown to be the highest when the ratio between the actual amount of combustible air and the theoretical amount of air was 1:1 and the energy consumption rate of the low-pressure boiler type high-pressure washer was shown to be much lower than that of the high-pressure boiler type high-pressure washer.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.16 no.5
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• pp.157-165
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• 2017

The high-pressure resin transfer molding (HP-RTM) technology has been commercialized for fast production of fiber reinforced composite materials. The high-pressure mixing head was one of the most core component of the HP-RTM process. In this study, a mixing head was systematically designed, manufactured and evaluated. This mixing head was composed of a nozzle, a mixing chamber, a cleaning piston part, and an internal mold release part. In actual, a straight-type structure was newly designed instead of the conventional L-type structure for improving the maximum mixing pressure and mixing ratio precision. The performance of mixing head was showed maximum mixing pressure of 15.22MPa and mixing ratio precision of 0.12%. CFRP molding experiments were successfully obtained a 6~11 laminating carbon sheet using HP-RTM presses and specimen molds.

• International journal of advanced smart convergence
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• v.10 no.1
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• pp.159-165
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• 2021

Electronic devices used in the mobile environments fabricated under the plasma conditions in high vacuum system. Especially for the development of advanced electronic devices, high quality plasma as the process conditions are required. For this purpose, the variable conductance throttle valves for controllable plasma employed to the high vacuum system. In this study, we analyzed the effects of throttle valve applications on vacuum characteristics simulated to obtain the optimum design modelling for plasma conditions of high vacuum system. We used commercial simulator of vacuum system, VacSim(multi) on this study. Reliability of simulator verified by simulation of the commercially available models of high vacuum system. Simulated vacuum characteristics of the proposed modelling agreed with the observed experimental behaviour of real systems. Pressure limit valve and normally on-off control valve schematized as the modelling of throttle valve for the constant process-pressure of below 10-3 torr. Simulation results plotted as pump down curve of chamber, variable valve conductance and conductance logic of throttle valve. Simulated behaviors showed the applications of throttle valve sustained the process-pressure constantly, stably, and reliably in plasma process.

• Korean Journal of Medicinal Crop Science
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• v.16 no.6
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• pp.439-445
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• 2008

This study was performed to investigate a methodology of improving immune activities of Berberis koreana Palibin by ultra high pressure on low temperature extraction process. Extraction yield was enhanced up to more than 35% by above process, compare to the control and extraction average. The cytotoxicity on human kidney cell (HEK293) was showed below 20.4%, 21.6% in adding 1.0 mg/ml of the highest concentration. Generally, the extracts by ultra high pressure extraction process showed less toxicity about 5% than the other processes. It could tell that toxic materials that existing in the plant could be reduced or broken by ultra high pressure process due to can be broken bond such the hydrogen bond, the electrostatic bond, the van der Waals bond, and the hydrophobic bond, can be broken by high pressure. The result could be employed to develop a new type of functional food from B. koreana Palibin by low temperature high pressure process.

• Membrane Journal
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• v.12 no.3
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• pp.182-191
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• 2002

Polyamide reverse osmosis (RO) membrane with thin film composite structure was commercialized for seawater desalination process. Recently, it has been reported that some RO processes for high pressure and recovery leads to reducing in energy cost and pretreatment scale compared with earlier process. The development of energy recovery, pumping device and RO elements with high pressure and rejection made high pressure and recovery process possible. In this study, permeation properties of commercialized seawater RO membrane were investigated under the condition of high pressure and recovery. In the RO sheet membrane test 3.5% NaCl of synthetic seawater was used. The synthetic seawater contained only sodium chloride. In the RO module test, natural seawater was used at Happo Bay, Masan city. As the results, RO membrane with high durability of pressure was better than that with high rejection of seawater for high pressure and recovery process. Seawater rejection of high concentrate tends to be improved by high pressure operation.