• 대한예방한의학회지
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• 제22권1호
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• pp.45-59
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• 2018

Objectives : The purpose of this study is to present trends and contents of herbal Korean Medicine patches by analyzing the herbal patches in Korean patents. Methods : Electronic search for herbal patch patents was conducted in KIPRIS (Korea Intellectual Property Rights Information Service). Korean patents that were registered by January 1, 2018 were selected in study. Patents that were not using herbal medicine or not related to patch were excluded in this study. The applicant, application date, International Patent Classification (IPC), contents and adhesive site of patches, target diseases, model of experiment and extraction methods were analyzed. Results : A total of 17 patents were included in this study. In applicant analysis, 61.5% of applicants were corporations. All IPCs in patents were involved in Section A (Human necessities & Agriculture) and 66.7% of IPCs were A61K (Preparations formedical, dental, ortoiletpurposes). In types of patch, 8 patents were hydrogel patches (47.1%), followed by 3 heating patches (17.6%). Skin related symptoms were the most targeted diseases (52.9%), Human was the most used model in experiments. Solvent extraction and hot water extraction were used frequently, and some patents had no limit for extraction were also existed. Conclusions : The study results will be helpful to diversify formulation of herbal medicine, to expand market scale of patent and to develop new application using Korean medicine. In order to establish sufficient data for utilizing patent technologies, more patent studies providing analyzed patent information are needed.

• 대한한의진단학회지
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• 제17권2호
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• pp.169-177
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• 2013

The perpose of this study is to report the effect of oriental demonstration treatment for Acne. Acne is an facial skin problems with depress, white head on the facial skin and bad smell. Objectives We experienced one case of Acne through acupuncture, cupping, herbal medication and herbal patch. 24 years old female patient suffered from acne with bad smell and depress. Method She was taken 23 times of acupuncture and cupping treatment, 30days of taking herb medicine and 7days for herbal patch(brand named Lee Myung Lae patch). Results After 23 times treatment her acne symtoms was improved. Conculusion Asian medical treatment could be safe and effective to American patient.

• 생약학회지
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• 제31권3호
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• pp.259-263
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• 2000

This study was designed to evalulate the biological activity, particularly induction of IgA in primary Peyer's patches cells, of herbal medicines for a long time in Asia. Among fifty four herbal medicines tested, Ephedra sinica, Magnolia officinalis, Lonicera japonica and Lithospermum erythorhizon induced IgA production. The polar and high molecular weight component in Ephedra sinica was capable of inducing IgA in primary Peyer's patches cells. Therefore, we suggest that some herbal medicines could use for the treatment of food allergy.

• 혜화의학회지
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• 제14권2호
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• pp.189-195
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• 2005

Purpose: The purpose of this case study is to report the effect of just oriental treatments to the breast cancer. Methods: A 37-year-old woman had breast cancer of stage II according AJCC staging system, but she dosen't want be operated for a tumor. So, she was treated with herbal medicine, acuputure, moxa, patch made from herb medicine and depletion for four weeks. In herbal theraphy sihosogansan and saengmaksan. The patch made from herb medicine is put on the skin of the cancer. Depletion is done on the breast cancer, too. In acuputure theraphy, Sojangjeonggyeok(小腸正格) was used. In Moxa theraphy Chungwan, Kwanwon were used. Results: After oriental medicine for 27 days, she was on the mend about the size, complexion, solidity and pain of the breast cancer. Conclusion: This study shows that breast cancer is improved if only oriental treatments. But after this, further approach and studys on the breast cancer.

• 방사선산업학회지
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• 제17권4호
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• pp.327-332
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• 2023

This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice. Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal, aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant, and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibody-induced arthritis(CAIA), which is similar to human rheumatoid arthritis(RA), alleviated symptoms. In this study, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacy as oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, and paw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patch containing IK was attached. These results show that IK is effective in alleviating arthritis not only through oral administration but also through patches applied to skin, and that it has potential as a material for future patch development.

• 한국유기농업학회지
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• 제19권spc호
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• pp.63-66
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• 2011

An Intergenerational Horticultural Program in a rural community in Korea was tried out to enhance social interaction between elderly citizens and children, to promote the positive self-esteem of the elderly in a rural community, to change the attitude of children towards the elderly, and to create a rural community full of vitality. The clients were 20 elderly (60-80 years old) and 40 preschool children (6-7 years old). The activities in this program included seed of hope, round autumn garden, dish garden, in the vegetable patch, flower decoration for the Chuseok Festival, rainbow flower basket, heart card, fragrance of love, and a kimchi party. The results were a decrease in depression among the elderly from 44.0% to 33.7%. General satisfaction among the elderly was 100%. The desire to rejoin among the elderly was 100%. General satisfaction among the children was 100%. The desire to rejoin among the children was 93.5%.

• 한국식품영양과학회지
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• 제33권4호
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• pp.626-632
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• 2004

30종의 생약으로부터 조제된 열수추출물 중, 가시오가피 (대조군의 75.6% 억제), 백출(71.3%), 인삼(70.0%), 감초 (66.3%) 및 당귀 (63.1%)는 2.5 mg/kg body weight의 농도에서 colon 26-M3.1 lung carcinoma에 대한 매우 높은 종양전이 억제활성을 나타내었으나, 갈근(58.6%)과 진피(54.9%)를 제외한 다른 생약의 열수추출물은 그다지 높은 활성을 보여주지 않았다. 또한 진피(대조군의 1.80배),백출(1.73배), 가시오가피와 감초(1.64배) 등은 100$\mu\textrm{g}$/mL의 농도에서 Peyer's patch 세포를 매개로 한 조혈작용도 증강시킴을 알 수 있었다. 한편, 음료로서의 식품학적인 물성을 개선하고 비활성 성분을 제거하기 위하여, 열수추출물에서 활성을 나타낸 생약을 수증기 증류물로 조제하여 면역활성을 비교한 결과, 백출, 감초와 가시오가피가 2.5 mg/kg body weight에서 유의적인 종양전이 억제활성을 나타내었으며(각각 58.7%, 50.3%와 41.9%), 백출은 0.25 mg/kg body weight의 저농도에서도 높은 종양전이 억제활성을 보여주었다(49.7%). 또한 수증기 증류물을 Peyer's patch 세포와 처리한 결과, 백출과 가시오가피는 10 $\mu\textrm{g}$/mL의 낮은 농도에서도 골수세포의 증식작용을 유의적으로 증가시키고 있음을 나타내었다(각각 1.49배와 1.28배). 수증기 증류물이 열수추출물보다 다소 낮은 면역 활성을 가지고 있다 할지라도, 백출 및 가시오가피 등과 같은 전통 생약은 열수추출물 뿐만 아니라 수증기 증류물에서도 높은 면역 활성을 가지고 있음을 보여주었다. 그러므로 이러한 결과는 생약으로부터 조제된 수증기 증류물이 기능성 음료로서 식품산업에 이용될 수 있는 가능성을 시사하고 있다.

• 대한한의학회지
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• 제43권1호
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• pp.33-41
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• 2022

Objectives: Drug-induced blockade of the human ether-à-go-go related gene (hERG) potassium ion channel causes acquired long QT syndrome, which is known to cause cardiac arrhythmias and be fatal. To establish safety evidence of herbal formulae, we evaluated the effects of 31 herbal formulae on hERG channel activity. Methods: The current through hERG channel was measured by changing the membrane voltage before and after treatment with 31 herbal formulae in HEK 293 cell overexpressing hERG channel using a whole-cell patch clamp system. The current-voltage curves and the activity curves were fitted, and the hERG activity and 50% inhibitory concentration (IC₅₀) according to each herbal formula were calculated. Results: Chokyungjongok-tang, Oncheong-eum, and Cheongsangbangpung-tang strongly inhibited the hERG activity, with IC₅₀ values of 67.67, 141.2, and 296.3 ㎍/mL, respectively. Yeonkyopaedok-san, Eunkyo-san, Ukgan-san gajinphibanha, Daegunjoong-tang (except Oryzae gluten), Insamyangyoung-tang, Banhahubak-tang, SokyungHwalhyul-tang, Jodeung-san, Hyeonggaeyeongyo-tang, and Bangkeehwangkee-tang weakly inhibited hERG activity, with IC₅₀ values ranging from 400 to 1000 ㎍/mL. The other 18 herbal formulae showed very weak hERG activity inhibition of less than 50% at the highest concentration (1000 ㎍/mL). Conclusion: This study provided safety information on cardiotoxicity by cardiac arrhythmia risk assessment of herbal formulae, and is expected to be a reference data for predicting the safety and risk of herbal formulae.

• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.268-275
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• 2007

Objectives : Pityriasis rosea is a rash that occurs most commonly in people between the ages of 10 and 43, but may occur at any age. It is common disease but I was haven't meet any case by oriental medical treatment. Methods : We experienced one case of Pityriasis rosea treated with oriental medical treatment, acupuncture and herbal medication. Results : The patient suffer from a large, scaly, pink patch on the chest and back and arm and leg. He have very terrible itching sign. After treatment his itching was subsided and large, scaly, pink patch was disappear. Conclusions: Oriental medical treatment could be safe and effective method in pityriasis rasea

• 대한한방소아과학회지
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• 제27권1호
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• pp.50-58
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• 2013

Objectives The purpose of this study is to know the present uses of pre-packed herbal medicine and their usefulness in Korean University Oriental Medicine Hospitals. Methods We selected 29 university hospitals to survey by using telephone and by mail. Results 1. The kind of packages that 29 hospitals uses were 2 layers, 3 layers and 3 layers with aluminum as the component layer, standing or non-standing pouch. 2. Total 24.1% hospitals are using 3 layers patch with aluminum because of their merits. The merits are preserving the quality of packaged drugs, blocking sun lights and beautiful looking, gas barrier properties and an opening convenience. 3. However, the 3 layers with aluminum packages were little bit more expensive and it can't be used in the microwaves. Conclusions This study revealed that 3 layers with aluminum packages were superior to any other packages because it can keep original flavor and properties, block sun light, and an easy opening convenience. Thus, aluminum contained 3 layer packages are better to preserve herbal medicines.