DOI QR코드

DOI QR Code

Herbal Patch Analysis in Korean Patent

국내 한방 패치 특허 현황에 대한 분석연구

  • Park, Sunju (Department of Preventive Medicine, College of Korean Medicine, Daejeon University) ;
  • Woo, Seong-Cheon (College of Korean Medicine, Daejeon University) ;
  • Park, Ji-Yeun (College of Korean Medicine, Daejeon University)
  • 박선주 (대전대학교 한의과대학 예방의학교실) ;
  • 우성천 (대전대학교 한의과대학) ;
  • 박지연 (대전대학교 한의과대학)
  • Received : 2018.03.12
  • Accepted : 2018.04.10
  • Published : 2018.04.30

Abstract

Objectives : The purpose of this study is to present trends and contents of herbal Korean Medicine patches by analyzing the herbal patches in Korean patents. Methods : Electronic search for herbal patch patents was conducted in KIPRIS (Korea Intellectual Property Rights Information Service). Korean patents that were registered by January 1, 2018 were selected in study. Patents that were not using herbal medicine or not related to patch were excluded in this study. The applicant, application date, International Patent Classification (IPC), contents and adhesive site of patches, target diseases, model of experiment and extraction methods were analyzed. Results : A total of 17 patents were included in this study. In applicant analysis, 61.5% of applicants were corporations. All IPCs in patents were involved in Section A (Human necessities & Agriculture) and 66.7% of IPCs were A61K (Preparations formedical, dental, ortoiletpurposes). In types of patch, 8 patents were hydrogel patches (47.1%), followed by 3 heating patches (17.6%). Skin related symptoms were the most targeted diseases (52.9%), Human was the most used model in experiments. Solvent extraction and hot water extraction were used frequently, and some patents had no limit for extraction were also existed. Conclusions : The study results will be helpful to diversify formulation of herbal medicine, to expand market scale of patent and to develop new application using Korean medicine. In order to establish sufficient data for utilizing patent technologies, more patent studies providing analyzed patent information are needed.

Keywords

References

  1. Pastore MN, Kalia YN, Horstmann M, Roberts MS. Transdermal patches: history, development and pharmacology. British Journal of Pharmacology. 2015:2179-209.
  2. Harvey RA. Lippincott's Illustrated Review: Pharmacology 5th ed.(Lim D. Y., Tran.). Seoul: Shinilbooks. 2012.
  3. Winged B. Essentials of Pharmacology for Heath Occupations 1th ed. (Son E. D. et al. Trans.). Seoul: Fornurse. 2010.
  4. June. KB, Kim HJ. Pressure Sensitive Adhesives for Transdermal Drug Delivery System(TDDS). Adhesion & Interface. 2003;4:43-50.
  5. Miller K. Transdermal patches: past, present and future. Therapeutic delivery. 2015;6:639-41. https://doi.org/10.4155/tde.15.16
  6. Siegel SJ, O'Neill C, Dube LM, Kaldeway P, Morris R, Jackson D et al. A unique iontophoretic patch for optimal transdermal delivery of sumatriptan. Pharmaceutical research. 2007;24:1919-26. https://doi.org/10.1007/s11095-007-9317-1
  7. Norman JJ, Arya JM, McClain MA, Frew PM, Meltzer MI, Prausnitz MR. Microneedle patches: usability and acceptability for selfvaccination against influenza. Vaccine. 2014;32:1856-62. https://doi.org/10.1016/j.vaccine.2014.01.076
  8. Chung JY, Han HS. The Recent Trend of Percutaneous Absorption Used in Cosmetics. Kor J Aesthet Cosmetol. 2014;12:597-605.
  9. Park CS, Hwang YS, Koo ST. Review on the Stimulating Technologies of Acupuncture Points in the Patents. Korean Journal of Acupuncture. 2011;28:113-26.
  10. Kim DI, Kim SH, Choi MS, Park SD. A Study on Application of Korean Medical Presciptions Theory in Developing Transdermal Medicine and Korean Medical Cosmetic Preparation Using Oral Herbal Medicine. J Korean Obstet Gynecol. 2015;28:74-86. https://doi.org/10.15204/jkobgy.2015.28.3.074
  11. Kim SJ, Choi DK, Yoo SH, Kim YS, Sohn YJ, Sohn NW. Effects of Yeosin-dan on dystocia caused by abnormal expulsive forces in Primipara. The Journal of Oriental Obstetrics & Gynecology. 2005;18:219-29.
  12. Lee SH, Kim CY, Chang GT. Impact on Respiratory Diseases of Acupoint Sticking in Dog-Days. The Journal of Korean Oriental Pediatrics. 2012;26:1-12.
  13. Min DL, Park EJ, Kang KH. Review of Clinical and Experimental Studies on External Application Treatment for Atopic Dermatitis in the Korean Literature. J Pediatrics of Korean Medicine 2013;27:36-49. https://doi.org/10.7778/jpkm.2013.27.1.036
  14. Kim MA, Kim BM, Shin SH, Byun SM, Ko WS, Lee HS et al. The study on external treatment of oriental medical care on acne. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 2008;21:102-11.
  15. Jo SJ, Choi YD, Jang JT, Kim KS, Lee SD. A Randomized Contrilled Clinical Trial of Topical Herbal Gel Treatment for Chronic Shoulder Pain. The Journal of Korean Acupuncture & Moxibustion Medicine Society. 2014;31:1-9.
  16. McKay L, Gemmell H, Jacobson B, Hayes B. Effect of a Topical Herbal Cream on the Pain and Stiffness of Osteoarthritis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial. Journal of Clinical Rheumatology. 2003;9:164-9. https://doi.org/10.1097/01.RHU.0000073450.85179.55
  17. Li LC, Wong RW, Rabie AB. Clinical effect of a topical herbal ointment on pain in temporomandibular disorders: a randomized placebocontrolled trial. Journal of alternative and complementary medicine. 2009;15:1311-7. https://doi.org/10.1089/acm.2009.0129
  18. Hwang HS, Han KJ, Kim YS, Jeong SY. Analysis on the recent trends of acupuncture related patents. Korean Journal of Oriental Medicine. 2007;13:101-7.
  19. Shin MS, Han CH, Park SH, Choi SM. Analysis on trends of moxibustion patents. Korean Journal of Oriental Medicine. 2007;13:113-20.
  20. Cheon JH, Kim KB, Jeong AR. Analysis on the trends of Korean Medicine Prediatrics related patents. Journal of Society of Preventive Korean Medicine. 2014;18:147-54.
  21. Brown MB, Martin GP, Jones SA, Akomeah FK. Dermal and transdermal drug delivery systems: current and future prospects. Drug delivery. 2006;13:175-87. https://doi.org/10.1080/10717540500455975
  22. Kim IR, Kim HC, Guk YB, Park SJ, Park YG, Park JH et al. Herbal Medicine 3th ed. Seoul: Yeong Lim Publisher. 2011.
  23. Lee SM, Kim MG, Lee SY, Kang TH. Effects of Artemisia princeps Extract on Bone Metabolism. Journal of Korean Society of Food Science and Nutrition. 2010;39:363-8. https://doi.org/10.3746/jkfn.2010.39.3.363
  24. Hwang GS, Lee JS, Yun YP. A Mechanism of Gastric Antiulceration by the Extract of Artemisiae asiatica. Journal of Society of Preventive Korean Medicine. 1997;1:118-25.
  25. Park CE, Park CH. Inhibition of Urease Activity of Helicobacter pylori by Artemisia asiatica Nakai. Korean journal of biotechnology and bioengineering. 2004;19:348-51.
  26. Kim YH, Shin HK, Kim KS. Depressor Responses to Intravenously Administered Artemisia asiatica Nakai Juice in Cats. Korean journal of physiology. 1981;15:91-6.
  27. Park SH, Cho DM, Choi BH, Choi YJ, Choi JH. Antioxidative Effects of Skinned Mugwort (Artemisia vulgaris L.) Extracts on UV-Irradiated Hairless Mouse Skin. Journal of Korean Society of Food Science and Nutrition. 2008;37:20-6. https://doi.org/10.3746/jkfn.2008.37.1.20
  28. Park SH, Hong YM, Choi YJ, Choi JH, Choi BK. Antiwrinkle Effects of Mugwort (Artemisia vulgaris) Extracts on UVB-Irradiated Hairless Mouse Skin. Journal of Korean Society of Food Science and Nutrition. 2008;37:1136-41. https://doi.org/10.3746/jkfn.2008.37.9.1136
  29. Woo HS, Lee YH, Kim CH. The Review and Study Trend of Moxibustion. The Journal of Korean Acupuncture & Moxibustion Society. 2002;19:1-15.
  30. Lee TW, Kim SN, Jee UK, Hwang SY. Antiwrinkle Effect of Pressure Sensitive Adhesive Hydrogel Patches Containing Ulmi Cortex Extract. Journal of Korean pharmaceutical sciences. 2004;34:193-9.
  31. Oh SS, Kim CJ, Kim HS, Shin YH. Efficacy of Hydrogel Patch in Wound Rat Model. Journal of Korean pharmaceutical sciences. 2009;39:55-8.
  32. Ahn YS. Lee U-Ju's Pharmacology Lecture 6th ed.Seoul: Eui-Hak publishing Co. 2008.
  33. Park JH, Shin YW, Lee SH, Kwak HS, Lee CH. A Study on Networks for Drug Delivery Systems: Microneedle and Skin. Journal of the Korea knowledge information technology society. 2013;8:127-35.
  34. Perez-Calderon R, Gonzalo-Garijo MA, Rodriguez-Nevado I. Generalized allergic contact dermatitis from nitroglycerin in a transdermal therapeutic system. Contact dermatitis. 2002;46:303. https://doi.org/10.1034/j.1600-0536.2002.460513.x
  35. Alfaya T, Mur Gimeno P, Iglesias AM, Ventura P. Allergic contact dermatitis caused by an ethinylestradiol-norelgestromin transdermal therapeutic system. Contact dermatitis. 2011;64:242-4. https://doi.org/10.1111/j.1600-0536.2011.01880.x
  36. Kim JY, Kim KJ, Park SW, Bang JS, Lee WJ. Investigation on Adhesion Control Standards and Skin Adverse Effect of Skin Attached Formulations. Official Journal of Korean College of Clinical Pharmacy. 2014;24:219-28.
  37. Yun IS, Kim SJ, Jeong ES. Evaluation of Technology Activity, Innovation and Productivity using Korean Patent Information. Journal of Information Management. 2011;42:151-65. https://doi.org/10.1633/JIM.2011.42.2.151
  38. Song MY, Lee JH, Ahn SW. A Study of Patentability on the paper in Traditional Korea Medicine by using technology information search to detect all existing similar patents. Korean Journal of Oriental Medicine. 2005;11:53-66.
  39. Jang YG. Mugwort patch complex for moxa treatment. 1020140001073. 2014.
  40. Kim JS. A process for producing a composition presenting aneffect of moxacautery and pharmaceutically acceptable preparations using the same. 1020020049148. 2002.
  41. Kim JS. Composition having effect of moxibustion and presspellet using the same. 1020050068646. 2005.
  42. Kim MS. Bio Pad. 1020160038931. 2016.
  43. Kim TJ. Patch for treating constipation using crude drugs and method for treating constipation using its patch. 1020090014979. 2009.
  44. Jung HC, Lee SS, Son IC, Kim JH, Yang JH. Manufacturing method of wormwood ferment and patch device using wormwood ferment. 1020110050762. 2011.
  45. Um KA, Oh JK, Hwang SS. Cooling patch including aroma of mugwort. 1020010021423. 2001.
  46. Yun SY, Kim JI. Patches for acne treatments. 1020120020239. 2012.
  47. Mun JM, Kim JH, Choi SS. Manufacturing method of neck patch therof. 1020140141963. 2014.
  48. Kim JH, Shin MC, Mun JM, Kim SB. Relaxation of hangove patch and manufacturing method of same. 1020150189778. 2015.
  49. Kim JH, Shin MC, Mun JM, Kim SB. Visage improvement patch and manufacturing method of same. 1020150189783. 2015.
  50. Kim JH, Lee HJ, Shin MC, Mun JM, Kim SB. Manufacturing method of alleviate fever patch thereof. 1020150028182. 2015.
  51. Choi SS, Mun JM, Kim JH. Manufacturing method of hips up patch therof. 1020140141962. 2014.
  52. Kim JH, Lee HJ, Kim CM, Choi SS. Manufacturing method of freckles improvement patch therof. 1020140034817. 2014.
  53. Mun JM, Kim JH, Choi SS. Manufacturing method of breast bouncy improvement patch therof. 1020140141961. 2014.
  54. Kim JH, Mun JM, Choi SS. Manufacturing method of breast bouncy improvement patch therof. 1020140141964. 2014.
  55. Park CM, Lee YJ, Kim YJ, Joe JC, Han SH, Jung YH. Hanbang heating patch composed of Korean paper and the method for preparing thereof. 1020080119980. 2008.