• 종양간호연구
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• 제8권1호
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• pp.50-60
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• 2008

Purpose: The purpose of this study was to compare Quality of life (QOL) in type and time after Hematopoietic stem cell tansplantation (HSCT) for patients with hematologic cancer. Method: This study was cross-sectional. The autologous recipients was 120, the allogeneic recipients was 237. The obtained data were analyzed using T-test, One-way ANOVA, Scheffe's test. Results: No significant differences were total QOL between the autologous and allogeneic recipients. But the autologous recipients reported better status than the allogeneic recipients in physical domain, especially 1-3 yr after HSCT. There was poorer QOL of 1-3 yr compared to 1 yr after HSCT in physical, psychological and social domain between the two groups. QOL in time after HSCT of the autologous recipients was significance differences in psychological, social domain. And QOL in time after HSCT of the allogeneic recipients was significant differences in physical, psychological and social domain. Conclusions: QOL of recipients undergoing HSCT is recovered beyond 3 yr point. Accordingly, long term care and service is essential to recipients undergoing HSCT. And further studies with a longitudinal design are necessary.

• 성인간호학회지
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• 제21권3호
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• pp.269-280
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• 2009

Purpose: To examine the effect of back massage on immune response, symptom distress, and mood state of patients undergoing allogeneic hematopoietic stem cell transplantation (allogeneic HSCT). Methods: Subjects were thirty-seven patients undergoing sibling allogeneic HSCT (including 16 in the experimental group and 21 in the control group). Experimental subjects participated in an intervention group of back massage for 10 minutes, once a day and 5 times a week, from one week prior to the HSCT to the third week after the HSCT or a control group. A non-equivalent pretest-posttest design was used. t-test and Repeated measures ANOVA were used to examine group differences by using SAS. Results: No significant group differences were found in Immune response (CD4+, CD8+,CD19+, CD56+) and symptom distress. The experimental group had significantly less mood state (anxiety, confusion) than the control group. Conclusion: The back massage for the patients undergoing allogeneic HSCT may be effective in altering the anxiety and confusion during hematopoietic stem cell transplantation. However, this study did not provide evidence in improving immune response and symptom distress.

• 종양간호연구
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• 제12권1호
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• pp.110-116
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• 2012

Purpose: This study was performed to identify the pre-and post-transplant nutritional assessment for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Methods: The subjects of this study were 25 patients undergoing allogeneic HSCT. The data collection was performed from January 31st to March 31st, 2011. The Patient-Generated Subjective Global Assessment (PG-SGA), anthropometrics and biochemical test were collected from the time they entered the isolation unit until they left. Results: Pre-transplant nutritional assessment status indicated moderate malnutrition which scored $7.32{\pm}1.68$ in PG-SGA. There were 22 patients (88.0%) with moderate malnutrition and 3 patients (12.0%) with severe malnutrition. Post-transplant nutritional assessment indicated severe malnutrition status which scored $11.92{\pm}3.26$ in PG-SGA. Pre-and post-transplant nutritional assessment displayed significant differences (p<.001) in PG-SGA score. Hematopoietic stem cell transplantation led to a deterioration of patients' nutritional status. Pre-transplant patients were already in malnutrition status and patients undergoing allogeneic HSCT were at risk for malnutrition. Conclusion: Pre-and post-transplant patients were categorized as having undernutritional and malnutritional status. Pre-transplant nutrition status impacted on post-transplant nutritional status. Health care personnel should pay attention to patient's nutrition status when undergoing allogeneic HSCT with appropriate nutritional assessment tools.

• Applied Biological Chemistry
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• 제32권2호
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• pp.137-142
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• 1989

인삼 에칠아세테이트 추출 분획을 silica gel column chromatography하여 Fr. I, Fr. II 및 Fr. III으로 나눈 다음 항암제 투여로 조혈기능이 억제된 흰쥐에 투여해 본 결과 Fr. III이 감소된 백혈구 및 적혈구 수를 90%까지 회복시켰다. Fr. III에서 두성분을 분리하여 구조를 동정한 결과 ginsenoside $Rh_1$ 및 $Rg_2$로 확인하였다.

• Journal of Microbiology
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• 제45권1호
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• pp.29-33
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• 2007

Salmonella typhimurium, causing mouse typhoid, infects hosts such as macrophage cells, and proliferates in intracellular vacuoles causing infected cells to trigger numerous genes to respond against the infection. In this study, we tried to identify such genes in RAW264.7 cells by using the PCR screening method with degenerate primers. Fourteen genes were found to be differentially expressed after a 4 h infection in which the expression of 8 genes increased while expression of the others decreased. Most of the genes were involved in proinflammatory responses such as cytokines production and cell death. The mutation in msbB gene encoding the myristoyl transferase in lipid A of lipopolysaccharide (LPS) resulted in much lower toxicity to the inoculated animals. We compared the expression of the identified genes in wild-type and msbB-mutated S. typhimurium infections and found that Lyzs encoding lysozyme type M was differentially expressed. This gene is quite likely to be related to bacterial survival in the host cells.

• 한국어병학회지
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• 제36권2호
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• pp.389-394
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• 2023

Infectious hematopoietic necrosis virus (IHNV) is s significant viral pathogen affecting cultured rainbow trout (Oncorhynchus mykiss) in Korea. In this study, five monoclonal antibodies (mAbs) (IHNV-1, 2, 3, 4, and 5) were produced using purified IHNV. Reactivities of these mAbs were analyzed by western blot (WB), enzyme-linked immunosorbent assay (ELISA), and indirect fluorescent antibody test (IFAT). These mAbs recognized glycoprotein (69 kDa, IHNV-1), nucleocapsid protein (39 kDa, IHNV-3, 4, and 5), or phosphoprotein (27 kDa, IHNV-2) of IHNV by WB analysis. ELISA results indicated that these five mAbs were specific to IHNV without showing any cross-reactivity against other fish viruses (hirame rhabdovirus, infectious pancreatic necrosis virus, and viral hemorrhagic septicemia virus). IFAT demonstrated specific fluorescence signals of IHNV-infected epithelioma papulosum cyprini (EPC) cells, whereas no reactivity of normal EPC cells was observed. These mAbs can be very useful for immuno-diagnosis of IHNV infection.

• 대한한방내과학회지
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• 제23권2호
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• pp.212-221
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• 2002

Objectives : Acording to the fact that Juakium has been frequently used in a lot of prescriptions to tonify bone marrow, We examined the hematopoietic effects of Juakium-derivative on aplastic anemia. Methods : After C57BL/6 mice were oral administrated with Juakium-derivative and injected with benzene, we counted the number of WBC, RBC, hemoglobin, platelet, nucleated cells and other erythroid parameters and weighed the spleen. Also we measured the expression of $CD34^+$ cell activity and analyzed the bone marrow tissue and spleen tissue histologically. Results : The results are summerized as follow: 1. The Juakium-derivative plus benzene group showed the improvement in the number of WBC, RBC, hemoglobin. platelet, nucleated cells and other erythroid parameters, compared with the benzene only group. 2. The spleen weight and the percent of $CD34^+$ cell of Juakium-derivative plus benzene group was higher, compared with the benzene only group. 3. The bone marrow tissue and spleen tissue of the Juakium-derivative plus benzene group showed the decrease of the infarcted area compared with the benzene only group. Conclusions : These results suggest that Juakium-derivative has hematopoietic effects on aplastic anemia induced by benzene through increasing the blood cells and stimulating the activity of $CD34^+$ cells. Therefore it is expected that Juakium-derivative can be used clinically to the patient with hematopoietic system disorder.

• Tuberculosis and Respiratory Diseases
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• 제66권2호
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• pp.122-126
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• 2009

조혈모세포이식 후 1년 이내에 발생하는 폐 합병증의 진단 및 분류는 확립되어 있으나, 수 년 이상 장기간 생존자에게서 발생하는 폐 합병증에 대해서는 잘 알려져 있지 않다. 저자들은 8년 전 동종 조혈모세포이식을 시행받고, 호흡곤란을 주소로 내원한 18세 여자 환자에서, 폐조직 생검을 통해 비분류성 간질성 폐렴을 진단하였으나, 스테로이드 치료에도 불구하고 급격한 악화를 보여 호흡부전으로 사망한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Restorative Dentistry and Endodontics
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• 제49권2호
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• pp.22.1-22.12
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• 2024

Objectives: This systematic review addressed the question: "What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?" Materials and Methods: A systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report. Eligibility criteria were based on the condition, content, and population strategy: the condition was the radiographic prevalence of apical periodontitis, the content comprised patients scheduled for hematopoietic stem cell transplantation, and the population consisted of adult and pediatric patients. The revised Risk of Bias in Nonrandomized Studies of Exposure tool was used to assess the quality of studies. The Grading Recommendations Assessments, Development, and Evaluation (GRADE) tool was used to assess the quality of evidence. Results: Eight studies were included in this review. The average number of patients with apical periodontitis was 15.65% (range, 2.1%-43.34%). One study was classified as having a very high risk of bias, 1 with a high risk of bias, and 6 with some concern for bias. GRADE analysis showed a very low certainty of evidence. Significant limitations concerning the absence of control over confounding variables were identified. Conclusions: With the caveat of the very low quality of evidence in the studies reviewed, there was a low to moderate prevalence of apical periodontitis in patients prior to undergoing hematopoietic cell transplantation.

• 정신신체의학
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• 제10권1호
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• pp.8-17
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• 2002

연구목적: 본 조혈모세포 이식술의 광범위한 사용 및 시술 후 생존율의 증가와 함께 조혈모세포 이식환자의 심리적 적응에 대한 관심이 증가하였다. 이에 본 연구에서는 조혈모세포 이식환자의 스트레스 대처방식과 발현될 수 있는 정신과적 증상에 대해 알아보고자 하였다. 방법: 동종 조혈모세포 이식을 전후하여 환자들의 심리적 스트레스 증상을 평가하였으며 스트레스 대처방식에 심리적 변인의 차이에 대해 알아보았다. 29명의 조혈모세포 이식 환자가 본 연구에 참여하여 조혈모세포 이식 직전과 직후에 평가를 시행하였으며, 30명의 정상 대조군이 본 연구에 참여하였다. 평가방법으로는, 면담을 통한 정신상태검사와 여러 가지 표준화된 설문지(스트레스 대처방식 척도, 스트레스 지각 척도, Short-Form 36 Health Survey)를 사용하였다. 결과: 환자군에서 정상 대조군에 비해 우울(p<0.001) 이나 불안(p=0.011) 의 정도가 유의하게 높았으나, 환자군의 조혈모세포 이식 전후에 우울과 불안은 차이가 없었다 또한 소극적인 대처방식을 사용하는 환자군에서 우울(p=0.046) 이나 불안(p<0.001)의 정도가 유의하게 높았다. 결론: 본 연구를 통해 조혈모세포 이삭 환자들이 정상 대조군에 비하여 심한 우울과 불안 증상을 경험하고 있으며, 비적응적인 수동적 대처방식을 사용함으로써 이런 부정적 감정 경험의 정도가 심해짐을 알 수 있었다. 이는 조혈모세포 이식을 받는 환자의 스트레스 대처방석에 대한 적절한 평가와 정신과적 개입의 필요성을 시사한다고 하겠다.