• Physical Therapy Korea
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• v.12 no.1
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• pp.80-90
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• 2005

The purpose of this study was to evaluate the effects of pulsed ultrasound on wound healing and observe during the wound healing process the distribution of mast cells according to histopathologic findings. Eighty Sprague Dawley rats which were divided into 4 groups received full thickness skin wounds on the back. Each of the 5 animals was sacrificed immediately and then sacrificed again 1, 3, 6, and 12 days after injury. Specimens from the wounds were removed during healing and routinely processed with a hematoxylin-eosin stain and a toluidine blue stain. The authors then observed the distribution of mast cells under a light microscope. The results of this study were as follows: The rate of wound healing and the length of the wounds of the pulsed ultrasound group II was significantly faster than group I on day 6 and day 12 (p<.001). Group III showed the most significant effect after12 days (p<.001). Group IV also showed a significant effect at 12 days (p<.01). A low-intensity ultrasound .5 $W/cm^2$ resulted in a fast healing rate. During the wound healing process mast cells had a tendency to decrease in the acute inflammatory phase. During the wound healing process mast cells were thought to contribute to the healing of the wound.

• Korean Journal of Environment and Ecology
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• v.30 no.2
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• pp.277-286
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• 2016

This study was performed to investigate main psychological phenomena and healing process through qualitative analysis on the 115 handwriting healing experience in the forest. Main psychological phenomena experienced in the forest were important in order happiness, comfort, and understanding. The process of healing in the forest was first characterized by emotional changes, and was led to cognitive changes and behavioral changes. Healing stage of the forest has followed with six steps of stimulus, accommodating, purification, insight, filling, and change. This process was associated with nature sympathetic, rapport with oneself, and with the world. Previous studies, which were focused on the measurement of transient state after the comparative study between control and experimental groups, could not verify the continuity and process of psychological healing. this study suggests a new approach to understand the subjective psychological phenomena and healing processes in the forest, and will be a basis for developing and performing of forest healing program.

• Journal of Korean Home Economics Education Association
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• v.31 no.1
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• pp.21-37
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• 2019

This study states a perennial question of "what should we do to heal oneself?" so that teenagers can build the ability to healing themselves at home economics education. The purpose of this study is to development a practical problem focused pedagogical programs and teaching-learning process plans for healing education in the home economics education. For this study, perennial concern and practical problem of healing related to home economics education were identified through the review of the literature related to the Korean and United States' home economics education curricula, and based on the analysis of educational cases in Korea and the United States, a practical-problem-focused program was designed for healing education. Teaching-learning process plans have been developed for practical reasoning instruction based on the designed practical-problem-focused programs and three systems of action. Finally, experts evaluated the developed practical-problem-focused program and teaching-learning process plans for healing education. This study is expected tp serve as the basis for Healing Education in Home Economics Education.

• Korean Institute of Interior Design Journal
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• v.22 no.4
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• pp.158-166
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• 2013

The purpose of this study is to suggest a direction for eco-friendly healing space design for healthcare facilities in the future. Theoretical review and case study on the concept of sustainable design, spatial expression and behavioral affordance were used as research method. Through these reviews, the 3 elements of the total healing environment -physical, psychological and social- have correspondence with elements of spatial expression; Refuge, Flow, Prospect and Void. And these are related to the eight kinds of Behavioral affordance which are subdivided into WORK&STUDY, REST, CIRCULATION, VISUAL SEQUENCE, SOCIAL EXCHANGE, REFRESHMENT, COMMUNITY and MEDITATION. And the concept of sustainable design consists of 6 principles ; Natural system, People, Place, The cycle of life, Energy & natural resources and Process. Through correlation analysis of behavioral affordance and 6 principles, the result of this study presents that the physical elements of the total healing space was mainly associated with the principles of people, place and the cycle of life. Psychological element was related to principle of natural system, human, place and process. And social element was associated with the principles of human, place and process. According to this analysis, the case study of four low-rise eco-friendly medical facilities was undertaken. Sustainability was evaluated in total healing environmental through this case study.

• Molecules and Cells
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• v.37 no.9
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• pp.637-643
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• 2014

Wound healing is a complex multi-step process that requires spatial and temporal orchestration of cellular and non-cellular components. Hypoxia is one of the prominent microenvironmental factors in tissue injury and wound healing. Hypoxic responses, mainly mediated by a master transcription factor of oxygen homeostasis, hypoxia-inducible factor-1 (HIF-1), have been shown to be critically involved in virtually all processes of wound healing and remodeling. Yet, mechanisms underlying hypoxic regulation of wound healing are still poorly understood. Better understanding of how the wound healing process is regulated by the hypoxic microenvironment and HIF-1 signaling pathway will provide insight into the development of a novel therapeutic strategy for impaired wound healing conditions such as diabetic wound and fibrosis. In this review, we will discuss recent studies illuminating the roles of HIF-1 in physiologic and pathologic wound repair and further, the therapeutic potentials of HIF-1 stabilization or inhibition.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.95-112
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• 2021

This study analyzed the effects of healing agriculture program types on program satisfaction by using functional image and emotional image of the program as mediators for the participants of healing agriculture program. The sub-variables of the healing agriculture program were classified into horticultural healing, animal healing, food healing, and forest healing. 328 questionnaires collected from the participants of healing agriculture program in the whole country were used for empirical analysis, which used SPSS v22.0 and PROCESS macro v3.4 to analyze the parallel multiple mediation model. First, Among the types of healing agriculture programs, animal healing, food healing, and forest healing had a positive (+) effect on functional image. Second, all types of healing agriculture program had a positive (+) effect on emotional image. Third, both functional and emotional images had a significant positive effect on satisfaction. Fourth, among the types of healing agriculture program, horticultural healing, animal healing, and forest healing had a significant effect on satisfaction, while food healing did not maintain the significant effect on satisfaction. Fifth, functional image mediated between healing agriculture program and satisfaction. Sixth, emotional image mediated between healing agriculture program type and satisfaction. In the next study, it is necessary to study for the adjustment of mediators other than the mediators introduced in this study or the controlled mediated analysis through the conditional process model in which the moderator variable is introduced.

• Applied Microscopy
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• v.29 no.3
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• pp.315-321
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• 1999

Vitamin D is one of important factors involved in the regulation of bone metabolism. In osteoporosis, the therapeutic effect of vitamin D on the healing process of fracture has still been controversial. These studies were designed to understand the healing process of normal fibular fracture and the therapeutic effects of $1\alpha$, 25 dihydroxycholecalciferol on the osteoporotic fracture in rats. The simple transverse fractures of rat fibulae were produced with a rotating diamond saw. The histological and ultrastructural changes of rats were observed. The histological and ultrastructural studies revealed the healing of the fibular fracture in the 5th week after simple transverse fracture. The osteoporosis impaired more the healing of osteoporotic fibular fracture than normal non-osteoporotic fibular fracture. The healing process of osteoporotic fracture was facilitated by the treatment with $1\alpha$, 25 dihydroxycholecalciferol, however, was delayed more than the healing process of normal fracture. These results suggest that $1\alpha$, 25 dihydroxycholecalciferol was effective for reducing the deleterious effects of osteoporosis in fracture healing.

• Journal of Society of Preventive Korean Medicine
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• v.14 no.1
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• pp.97-110
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• 2010

The wound healing process can be categorized as follows : inflammation, fibroplasia, neovascularization, collagen deposition, epithelialization, and wound contraction. During the healing process, various growth factors are secreted to accelerate wound healing. Previous studies have demonstrated that endogenous growth factors, such as vascular endothelial growth factor(VEGF) are the important regulatory polypeptides for coordinating the healing process. They are released from macrophages, fibroblasts, and keratinocytes at the site of injury and participate in the regulation of reepithelization, granulation tissue formation, collagen synthesis and neovascularization. Onchung-Um has been used clinically to treat various skin diseases. In addition, Onchung-Um has been also used for congestive inflammations. In the present study, we evaluated the effects of Onchung-Um on wound healing process and wound size reduction in rats. Full-thickness skin wounds ($15mm\;{\times}\;15mm$) were created on the back of rats. Rats were then divided into 2 groups : The Onchung-Um treated group that was orally administered with a dose of 193.9mg/100g of Onchung-Um extract per day for 15 days and Control group without Onchung-Um administration. Moreover, the histological changes and VEGF immunoexpressions of two groups were estimated. In results, wound closures were significantly accelerated by oral administration of Onchung-Um extract. Furthermore, in Onchung-Um treated group, there were significant increases in fibroblast migration, epithelialization compared with the Control group. VEGF expressions were also increased in Onchung-Um treated group. This study has therefore demonstrated the Onchung-Um can significantly improve the quality of wound healing and scar formation and the oral administration of Onchung-Um extract may increase early tissue angiogenesis in the incisional wound of an experimental animal model.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.1
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• pp.116-123
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• 2003

In children, they were presented pain and discomfort after surgical procedure. Some study has been suggested that Soft Laser promote healing process. So, the aim of the present study was to examine the effect of low power generating semiconductor laser on healing process after surgical procedure. DENS-BIO Laser applied to the wounds created by mesiodens extraction and lingual frenectomy. DENS-BIO Laser was irradiated on the wound with pulse 8(1000Hz) and 2mW, for 4 minutes. And then, healing process of surgical site was observed. The results from the present study can be summarized as follows : 1. In the irradiated wound, the healing process is more faster than not irradiation group. 2. Pain is less than not irradiation group.

• Journal of Biomedical Engineering Research
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• v.39 no.1
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• pp.1-9
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• 2018

This study was carried out to evaluate the effect of micro-current therapy on muscle atrophy and delayed wound healing process caused by traumatic peripheral nerve injury. For this, twenty-five 5-week-old Sprague Dawley rat were used and assigned to five groups including the normal group (NOR, n=5), the wound group (WD, n=5), the wounded and treated with micro-current electrical therapy group (WD+MET, n=5), the sciatic nerve denervated and wounded group (WD+DN, n=5), and the sciatic nerve denervated, wounded and treated with micro-current electrical therapy group (WD+DN+MET, n=5). In order to assess the changes in length of incisional wound for 12 days and the muscle volume for 2 weeks, the ImageJ analysis of macroscopic analysis and micro-CT data were obtained and analyzed. As a result, significant delay in the process in wound healing were observed and micro-current therapy suppress the postponement of healing process. Furthermore, there were significant changes in muscle volume between electrically treated group and non-treated group. These result shows that electrical stimulation may improve the delayed healing process and muscle atrophy at once.