• Journal of Life Science
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• v.28 no.5
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• pp.532-539
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• 2018

Hair graying is processed by loss of melanin production caused by the decrease of activity and number of melanocyte and the accumulation of hydrogen peroxide ($H_2O_2$) in the hair follicle with increase of age. The purpose of this study was to investigate the effect the Black oryzasativa ethanolic extract (BLEE) on the melanin production. In this study BLEE at $8{\mu}g/ml$ or more showed a significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity and reduction power. BLEE at $16{\mu}g/ml$ or more showed promoted tyrosinase activity and melanin production. In addition BLEE scavenged intracellular $H_2O_2$ in 2',7'-dichlorodihydrofluorescein (DCF) fluorescence assay in B16F1 cells. However, Western blot analyses displayed that BLEE decreased the expression level of catalase, but no effect on the expression level of tyrosinase, tyrosinase associated protein-1 (TRP-1), tyrosinase associated protein-2 (TRP-2) and microphthalmia-associated transcription factor (MITF) transcription factor involved in melanogenesis. Thus, the promotive effect of BLEE on melanin production is attributed to the increase of tyrosinase activity and the reduction of intracellular $H_2O_2$ level. In conclusion, BLEE played a key role in in promoting melanin production, which suggests that the BLEE could be applied as a potential functional material in the development of hair care cosmetics related to the promotion of melanin production for the growth of black hair.

• The Journal of the Korea Contents Association
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• v.12 no.9
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• pp.357-368
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• 2012

The purpose of this study is to empirically examine the impact of enterprise R&D investment on international trade in Korea under the new Normal Era. In order to test whether the time series data of trade variables are stationary or not, we put in operation unit root test and cointegration test. Based on VECM (Vector Error Correction Model), we also apply impulse response functions and variance decomposition to estimate the dynamic effects in the short-run and long-run. The results show that the relationship between enterprise R&D investment and international trade (export and import) exists in the long-run as well as in the short-run. The results of applying impulse response functions and variance decomposition also indicate that the impact of enterprise R&D investment on international trade is positive, and a significant portion of fluctuations in the trade variable is explained by enterprise R&D investment. Therefore, enterprise R&D investment must be continuously increased to improve economic growth with promoting trading competition power in Korea under the new Normal Era.

• Journal of Periodontal and Implant Science
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• v.50 no.3
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• pp.159-170
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• 2020

Purpose: Immunization with Porphyromonas gingivalis heat shock protein 60 (PgHSP60) may have an immunoregulatory effect on atherogenesis. The aim of this study was to determine whether nasal immunization with a PgHSP60 peptide could reduce atherosclerotic plaque formation in apolipoprotein E knockout (ApoE KO) mice. Methods: Seven-week-old male ApoE KO mice were assigned to receive a normal diet, a Western diet, a Western diet and challenge with PgHSP60-derived peptide 14 (Pep14) or peptide 19 (Pep19), or a Western diet and immunization with Pep14 or Pep19 before challenge with Pep14 or Pep19. Results: Atherosclerotic plaques were significantly smaller in mice that received a Western diet with Pep14 nasal immunization than in mice that received a Western diet and no Pep14 immunization with or without Pep14 challenge. An immunoblot profile failed to detect serum reactivity to Pep14 in any of the study groups. Stimulation by either Pep14 or Pep19 strongly promoted the induction of CD4⁺CD25⁺ forkhead box P3 (FoxP3)⁺ human regulatory T cells (Tregs) in vitro. However, the expression of mouse splenic CD4⁺CD25⁺FoxP3⁺ Tregs was lower in the Pep14-immunized mice than in the Pep14-challenged or Pep19-immunized mice. Levels of serum interferon gamma (IFN-γ) and transforming growth factor beta were higher and levels of interleukin (IL) 10 were lower in the Pep14-immunized mice than in the other groups. Induction of CD25^- IL-17⁺ T helper 17 (Th17) cells was attenuated in the Pep14-immunized mice. Conclusions: Nasal immunization with Pep14 may be a mechanism for attenuating atherogenesis by promoting the secretion of IFN-γ and/or suppressing Th17-mediated immunity.

• Journal of Distribution Science
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• v.15 no.3
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• pp.73-80
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• 2017

Purpose - Since Korean distribution market was opened, the domestic environment in department stores has been changed by the pattern of consumption and consumer need based on income classes. As multilateral Free Trade Agreement (FTA) accelerates opening markets, the scale of circulating capital has become bigger. Large-scale commercial facilities have developed quickly as a form of a large shopping center, thus, the matter of choice and securing market area became an important valuable in this trend. Moreover, multi-complex space has been proposed as the goal of successful business with promoting the public benefit. Research design, data, and methodology - This research studied consumer behavior using data about the life style and sales of consumers, not statistical data or survey as previous studies. This research tried to find the differentiation in complex cultural space with consumption behavior of department store. Results - As the structure of society and culture was getting diverse and complex, economic growth and development with such diversity and complexity improved consumers' quality of life. The changes of consumer life style are quite natural like human instinct. Department stores have activated retail business with the products of accumulated technology. Moreover, they have created the space of consumption and culture. Because of these social and environmental changes, department stores are being developed as Multi-functional spaces as well as sale places considering the strategies of department and the changes of consumers' purchasing behaviors. Conclusions - Urban culture complex is a landmark standing for the culture era of 21st century. It has provided an opportunity for consumers to enjoy culture, and has been an important factor to improve company images. Based on these roles and needs, expectancy effects are related with consumer preference and space preference, and the attitude toward companies. Moreover, the expectancy effects from those relationships are getting bigger and bigger. We should respect nature, a characteristic of Korean architecture, maintain visual continuity that harmonies with nature in the development of the complex space of the domestic department stores, and should take significance in the development of the complex cultural space in the direction of feeling the hierarchy of the space to obtain the visual pleasure with the artificial structure.

• Journal of the Economic Geographical Society of Korea
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• v.17 no.4
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• pp.632-645
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• 2014

This paper criticized the recent Korean 'creative economy policies' focused on regional developmental implications. Even though the policies targeted to promote ICT new startups and build virtuous circle of ICT industrial ecosystem in Korea as a whole, the outside regions of the Seoul-Busan industrial axis where the bases of ICT industries are very weak would suffer from systematic exclusion in ICT investments and deepening regional disparities. Second, ICT-centered policies would selectively affect or operate commensurate with the size of regions in this low-growth, after-financial crisis age. Third, the possibilities of regional insularity and lock-in in these low levels of 'related variety' regions would worsen the industrial competitiveness. Lastly, the policies should be reoriented to fortify region-based creative economic ecosystem based upon triple helix learning region.

• The Journal of the Korea Contents Association
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• v.12 no.6
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• pp.518-529
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• 2012

Integration of Europe was started when European Union Treaty was concluded at Maastricht for the first time on December, 1991. Europe which may be called as a cradle of modern national state has realized a single Europe not only in the socio-economic integration field but also in the political field. Under this background, it is considered that life-long education policy for developing a new integrated growth engine of EU requires educational response that may get ready for socio-economic environmental transformation more than anything else. In particular, this policy is faced with an important task of having to achieve harmony of efficiency through diversity and mutual coordination in pursuing cooperation and integrated development of life-long education field. However, notwithstanding their efforts, since 2008, some countries of EU were faced with economic crisis due to economic recession and this situation starts to drive the whole Europe even to the point of their financial crisis at last. This crisis is currently shaking socio-economic integration of EU. This study intends to observe a status of establishing life-long education system and promoting a policy for socio-economic integration of EU and to analyze as to what kind of relevance adult participation rate of life-long learning among the countries belonged to EU has with per capita income and to explore as whether socio-economic integration among member countries could be sustained based on problems of integrative life-long education system under the economic crisis of EU. In addition, through this study, an implication required for presenting a new paradigm conversion, policy establishment and development direction for the life-long education of our country is intended to be deduced.

• Cartoon and Animation Studies
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• s.41
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• pp.187-222
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• 2015

The quantitave increase and qualitative development in the game industry leads to bitter competition and makes game companies struggle to find better ways promoting their own games. The game trailer is one of the critical ways to publicize diverse games by showing visual images directly. There are three reasons why the game trailer comes into the spotlight these days; the rapid growth of the Internet speed handling the large size of files, the remarkable development of visual image quality just like digital movies, and the advent of video websites such as You Tube that shows huge amount of videos regardless of the type and size. However, there are not enough amount of research on the game trailer because using game trailers as the marketing source is still at an early stage. Therefore, this research focuses on providing characteristics of game trailers that are available for practical market analysis. First, this research shows that game trailers can be divided by the category of display, style, and contents type. Second, this research provides the component parts of game trailers that are divided into contents factors such as characters, backgrounds, events and promotional factors such as title, production company name, distribution company name. Third, this research explores research frames that would be needed to analyze marketing strategies, effects of game trailers, production pipelines and so on. These categorizations would be useful for producing game trailers efficiently and utilizing them effectively.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.5
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• pp.187-193
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• 2020

The purpose of this study is to study the methodology of deriving a policy that activates artificial intelligence from the governmental perspective in order to induce corporate growth by effectively grafting artificial intelligence technology into society and thereby improve individual and national competitiveness by creating new jobs. In order to derive activation plans, 1) detailed investigation of the domestic environment, 2) discovery of priority support fields and models that can be applied to artificial intelligence, 3) preparation of guidelines for activation and introduction, 4) specific methods for promoting and activating artificial intelligence Should be presented. The proposed artificial intelligence activation method performs a procedure to verify and confirm the effectiveness of artificial intelligence nurturing through a multi-faceted approach. The multi-faceted analysis approach includes business ecosystem aspects, industry-specific aspects including companies, technology fields, policy aspects, public and non-public services aspects, government-led and private-led aspects. Therefore, it can be reviewed as a method of inducing activation in various forms. In the future research field, it is necessary to prove the effectiveness of the proposed activation plan based on empirical data on artificial intelligence-based services. The expected effect of this study is to contribute to support the development of artificial intelligence technology and to establish related policies.

• Korean Business Review
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• v.18 no.1
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• pp.59-79
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• 2005

recently, world is progressing large quantity consumption with continuous Innovation and economic growth and pollution is accelerated at these process. Increase of industry activity and service that is point of corporation activity is discharging environmental pollutants at whole process to manufacture of end product and exhaust process from acquisition of raw material for accompanied product production hereupon. At the same time, being promoting resources consumption by that use much raw material, As a result, is becoming obstacle factors in sustainable development. So, corporation's responsibility for environmental protection is emphasized. Corporation which must prepare in green round or environmental problems should consider environmental effects that is happened over whole life of products that include waste treatment after raw material acquisition and use as well as selling end product simply. A Life Cycle Assessment techniques is normalized and standardized in International Standard Organization for technical committee 207(TC 207) world widely, and effort to apply in corporation's activity because mastering LCA techniques in domestic several corporations is undergone actively. Coming into effect of Kyoto's Protocol and International Organization for Standard 14000 series revision are presenting new survival principle in competition between country or corporation. LCA technique may become very useful means to corporation which wish to attempt environment management in real condition that awareness for environment is important. Also, An LCA to each product is going to cause big effects in corporation's whole image as well as competitive power raising for single product. Therefore, this research wishes to examine some instances for the future competitive product development at the estimation of environmental friendliness using LCA techniques and more theoretical considerations of the LCA techniques that can dominate corporation's fate.

• Korean Journal of Social Welfare
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• v.69 no.3
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• pp.121-140
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• 2017

The purpose of this study was to use the Korea Health Panel to determine how the mother's characteristic and household characteristic variables were associated with dental clinic use of children in childhood and adolescence. The logistic regression analysis found that mother's education level was statistically significantly positively correlated with underage child's dental clinic use and children in single-parent family were less likely to use a dental clinic than those in two-parent family. As for dental clinic use by diseases, the higher level of mother's education, the more likely to use a dental clinic due to dental caries and children in single-parent family were less likely to use a dental clinic due to dental caries than those in two-parent family. No difference in dental clinic use due to tooth extraction was found by any of mother's characteristics or household characteristics, probably because age has an absolute impact during the period between milk teeth and permanent teeth. Lastly, mother's education level and household income were significantly positively correlated with dental clinic use due to orthodontics. On the basis of these results, it is necessary to develop a customized strategy reflecting children's growth stages and household characteristics in making a plan for promoting oral health of children and adolescents.