• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.282-291
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• 2023

Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t_1/2 was 0.97 h, T_max was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED₅₀) and ED₉₀ values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89-treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic characteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.

• 전자통신동향분석
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• 제39권4호
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• pp.54-62
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• 2024

The emergence and resurgence of novel respiratory infectious diseases since the turn of the millennium, including SARS, H1N1 flu, MERS, and COVID-19, have posed a significant global health threat. Efforts to combat these threats have involved various approaches, however, continued research and development are crucial to prepare for the possibility of emerging viruses and viral variants. Direct detection methods for viral pathogens include molecular diagnostic techniques and immunodiagnostic methods, while indirect diagnostic methods involve detecting changes in the condition of infected patients through imaging diagnostics, gas analysis, and biosignal measurement. Molecular diagnostic techniques, utilizing advanced technologies such as gene editing, are being developed to enable faster detection than traditional PCR methods, and research is underway to improve the efficiency of diagnostic devices. Diagnostic technologies for infectious diseases continue to evolve, and several key trends are expected to emerge in the future. Automation will facilitate widespread adoption of rapid and accurate diagnostics, portable diagnostic devices will enable immediate on-site diagnosis by healthcare professionals, and advancements in AI-based deep learning diagnostic models will enhance diagnostic accuracy.

• 한국동물위생학회지
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• 제32권2호
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• pp.111-117
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• 2009

Farmed deer could be susceptible carrier to bovine viral infectious disease. But unfortunately, there has not been an overall study over this subject in Korea so far. Therefore, a study was conducted to see serum antibodies to bovine leukosis, food and mouth disease, bovine viral diarrhea and infectious bovine rhinotracheitis in deer using the sera of farmed deer. As a result, two deer in a farms showed positive in bovine leukosis antibodies, using ELISA. For wild water deer, no antibodies were found for those diseases. As a result, it can be assumed that deer were relatively low rate of exposure to highly contagious disease such as viral bovine infectious disease in Korea. As this study was conducted over limited in number of subject and regions, continued study should be carried out in order to prevent and control the interspecies transmission in the future.

• Journal of Preventive Medicine and Public Health
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• 제39권2호
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• pp.110-114
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• 2006

From the start of the residency trainingship in 1963, the residency training programs have been contributed much on the establishment and development of preventive medicine in Korea. But these programs are now have several problems to update the changes in health service needs of the population that were caused by a rapid epidemiologic transition from the acute infectious diseases to chronic diseases in last a few decades. Strengthening in medical practice, not just in knowledge is urgently required. Must have more concentrate on preventive service for the individual, as in clinical preventive medicine. Training residents by the systematic and well scheduled programs, not just 'teacher' assistant' in the academic facilities. Trying the change in the system of Specilty of Preventive Medicine to the well established several subspecialty, so more specific competency can be gained through the training. These approach and reformation may not only contribute for the better future of the preventive medicine, but also improve in disease prevention and health promotion, which required by the society in Korea.

• 대한수의학회지
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• 제43권2호
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• pp.247-253
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• 2003

Actinobacillus pleuropneumoniae causes a highly contagious pleuropneumoniae in swine. The bacterium produces several virulence factors such as exotoxin, LPS, capsular polysaccharide, etc. Among them, the exotoxin, called Apx, has been focused as the major virulence factor, and the toxin consists of 4 gene cluster. apx CABD. apxA is the structural gene of toxin and has four different types, I, II, III, and IV. As the first step of development of a new subunit vaccine, the three different types of apxA gene were amplified from A. pleuropneumoniae isolated from Korea by PCR with primer designed based on the N- and C-terminal of the toxin. The sizes of apxIA, IIA and IIIA were 3,073, 2,971 and 3,159bps, respectively. The comparison of whole DNA sequences of apxIA, IIA and IIIA genes with those of the reference strain demonstrated 98%, 99% and 98% homology, respectively. In addition, the phylogenetic analysis was performed based on the amino acid sequences compared with 12 different RTX toxin family using the neighbor-joining method. ApxA proteins of Korean isolates were identical with reference strains in this study. All ApxA proteins were expressed in E. coli with pQE expression vector and identified using Western blot with polyclonal antibodies against culture supernatants of A. pleuropneumoniae serotype 2 or 5. The sizes of each expressed ApxA protein were about 120, 110, 125 kDa (M.W.), respectively. The results obtained in this study could be used for the future study to develop a new vaccine to porcine pleuropneumoniae.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제29권1호
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• pp.43-51
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• 2023

Purpose: To accommodate the increasing number of patients during the COVID-19 pandemic, numerous portable HEPA filter units (PHUs) were installed in the general wards of existing medical facilities(EMFs) to convert them into emergency conversion facilities (ECFs). The purpose of this study was to build a dataset in preparation for emerging infectious diseases in the post-COVID-19 era by analyzing the construction and operation of ECFs. Methods: Field investigations were conducted during ECF operation periods based on the analysis of heating, ventilation, and air conditioning (HAVC) system design documents for six ECFs across Korea. Interviews were conducted with facility managers during the field investigations. Results: When constructing an ECF within an EMF, the installation status and characteristics of the existing system should be considered. Field investigations and verifications of the operation of HAVC systems must be conducted beforehand for smooth ECF operations. If heating and cooling are required with indoor air circulation type equipment in an ECF zone, the implementation of a heating and cooling method that can satisfy the comfort requirements of the occupants while minimizing cross-contamination is essential. When using PHUs that do not meet the performance standards required by medical equipment, the noise level resulting from such equipment operation must be evaluated and improved. Implications: For EMFs, various guidelines that can be referred to for the construction and operation of ECFs must be developed to prepare for emerging infectious diseases in the future.

• 한국의사학회지
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• 제36권2호
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• pp.99-113
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• 2023

This paper is a study to find the philological basis of Bihoon (鼻熏) therapy. There is no separate philological study of Bihoon therapy to date, and for this reason, there is no clear definition or specific treatment manual. In this study, a related database was created and analyzed by examining literature data related to Bihoon therapy, focusing on Korean traditional medical books. There were about 1,000 data points related to Bihoon therapy in 45 kinds of medical books. They were largely classified into 1. Acute diseases such as insensitivity, 2. Diseases that occur in the upper human body such as nose, head, eyes, and throat, 3. Women's diseases related to childbirth, 4. Treatment of skin diseases and prevention of infectious diseases. In the case of insensitivity treatment, the focus was on awakening the patient's mind, and the treatment of diseases such as the nose, head, eyes, etc. was focused on resolving each symptom. Symptoms related to childbirth were mainly treated for uterine escapism or fainting after childbirth, while skin diseases were mainly treated for diseases that did not heal well, such as amniotic fluid. If a multifaceted approach to non-discipline therapy is added in the future, it is expected that clinical utilization will also be increased.

• 농촌의학ㆍ지역보건
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• 제44권1호
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• pp.39-42
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• 2019

Zoonoses are the diseases that are transmitted to human being from vertebrate animals either from livestock animals or from wildlife. Recently, zoonoses are increasingly common as a result of incremental human-animal contact. Propagative infections in wild animals and livestock are transmitted to human beings who are encountered with them. In general, wild animals can transmit infectious agents to livestock, and then livestock further transmit them to human being is a simple model of on how zoonotic diseases get transmitted to human being. This model emphasizes the importance of early detection of zoonoses by surveillance at its incipient stage. Cooperation between the respective ministries plays an important role in the identification of zoonoses and planning for the formulation of better preventive and control policy and strategy. We will be able to predict the occurrence of zoonotic diseases in human on the basis of disease trends in wildlife and livestock once when we obtain the surveillance data and data generated by respective ministries through sound cooperation and collaboration.

• International journal of advanced smart convergence
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• 제10권2호
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• pp.151-157
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• 2021

Livestock farmers are using animal carcasses to dispose of the carcasses of livestock that have died of natural causes or disease. Most of the existing livestock carcass processors are mechanical in their structure without considering the environment. It has a function of sterilizing dead bodies at high pressure after processing them and causes environmental problems such as carbon monoxide emissions. If livestock carcasses occur, livestock farmers have to purchase their own livestock carcasses or entrust them to the outside world, which is costly. For this reason, the possibility of environmental pollution, infectious diseases, and spread has been increased recently by frequent dumping of dead bodies. The carcass of livestock mixed with manure not only serves as a medium for infectious diseases but also needsto be buried on a large scale as foot-and-mouth disease and avian influenza spread. As a result, the possibility of environmental pollution, such as contamination of groundwater, is increasing, so research is needed to protect and improve the environment. We aim to improve the process of processing livestock carcasses and purify the agricultural environment through development results on the form, structure and function of eco-friendly livestock carcasses. Its shape is applied with naturalshapessuch asstones and seeds. The material used in the dead body processis a brown beggar biocouple and is applied with an eco-friendly industrial animal recycling process. As a result of the study, it is expected to improve odors and the environment, and to be used as data to improve and help the livestock industry in the future.

• 국제초고층학회논문집
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• 제11권1호
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• pp.69-74
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• 2022

- COVID -19 taught us a lot about how to protect our tall buildings from infectious diseases. This paper captures the lessons learned about airflow in indoor spaces when considering furniture and its placement. By applying them we move towards future proofing our buildings both in normal and pandemic times.