• Molecules and Cells
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• v.21 no.2
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• pp.224-228
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• 2006

Glypican-3 (GPC3) is a member of the glypican family, which encodes cell-surface heparan-sulfate proteoglycans, and is frequently upregulated in hepatocellular carcinoma (HCC). We have recently reported that blocking endogenous GPC3 expression promotes the growth of HCC cell lines, suggesting that GPC3 plays a negative role in HCC cell proliferation. Here, we report that forced expression of GPC3 reduced the growth of HCC cells. We also found that FGF2-mediated cell proliferation was inhibited by GPC3. In addition, we observed that the adhesion of HCC cells to collagen type I and fibronectin was decreased by GPC3, whereas cellular migration and invasiveness were stimulated. Collectively, these results suggest that progression of hepatocellular carcinoma is associated with upregulation of GPC3.

• Current Applied Physics
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• v.18 no.11
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• pp.1368-1374
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• 2018

In this paper, forced vibration was used to regulate the droplet migration, fully recording the transient migration of droplets on a micro-textured substrate under the resonance frequency by a high-speed camera. The influence of resonance frequency and dynamic migration characteristics of droplets on the solid micro-texture surface under lateral vibration were researched. The experiment demonstrates that the driving force is caused by the difference between the left and right contact angles made the droplet oscillate and migrate, and as time t increases, the left and right contact points are periodically shifted and the amplitude of migration increases. Therefore, based on the droplet migration behavior and its force balance mechanism, a spring vibration model of migration behavior of the vibrating droplet micro unit was set up to predict the complete trajectory of its migration on a solid surface. The calculation results show that the theoretical displacement is less than the experimental displacement, and the longer the time, the larger the difference. Affected by the vibration, part of the droplet permeates through the micro-texture, resulting in the droplet losing height and the contact angle becoming smaller as well. While the other part of droplet overcomes the internal surface tension to migrate.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.2
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• pp.4-12
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• 2003

The present study investigated the effect of transverse vibration on the hemorheological characteristics of blood using a newly designed pressure-scanning capillary viscometer. As vibration was applied, aggregated blood cells (rouleaux) were disaggregated. The range of vibration frequency and amplitude are $0{\sim}100\;Hz$ and $0{\sim}0.8\;mm$, respectively for a capillary diameter 0.84 mm. As vibration increased, blood viscosity initially increased and tended to decrease. In order to delineate the unexpected results, the present study proposed two counteracting mechanisms of vibration related with red blood cell (RBC) aggregation affecting hemo-rheological properties. One is the reduction of RBC aggregation due to vibration causing an increase of blood viscosity. The other is forced cell migration due to the transverse vibration, which in turn forms a cell-free layer near the tube wall and causes a decrease of flow resistance.

• Proceedings of the KSME Conference
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• 2001.06c
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• pp.246-250
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• 2001

In resin transfer molding (RTM), resin is forced to flow through the fiber perform of inhomogeneous permeability. This inhomogeneity is responsible for the mismatch of resin velocity within and between the fiber tows. The capillary pressure of the fiber tows exacerbates the spatial variation of the resin velocity. The resulting microscopic perturbations of resin velocity at the flow front allow numerous air voids to form. In this study, a mathematical model was developed to predict the formation and migration of micro-voids during resin transfer molding. A transport equation was employed to account for the migration of voids between fiber tows. Incorporating the proposed model into a resin flow simulator, the volumetric content of micro-voids in the preform could be obtained during the simulation of resin impregnation.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.11a
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• pp.551-554
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• 2006

Java 기반의 이동 에이전트 시스템은 에이전트의 실행 상태를 이주시킬 수 없는 문제점을 가지고 있다. 이러한 문제점을 해결하기 위해 JVM을 수정하거나 이주에 필요한 소스 코드, 혹은 바이트 코드를 삽입하는 메커니즘을 이용한 이동 에이전트 시스템들이 연구되었다. 하지만 이러한 시스템들은 이식성이 떨어지거나 에이전트의 이주부분을 프로그래밍 할 수 없는 단점이 존재한다. 또한 이러한 시스템들은 플랫폼의 요청에 의한 에이전트 이주 기법인 forced migration을 지원하지 않는다. 본 논문에서는 AOP(Aspect Oriented Programming)를 이용한 에이전트의 투명한 이주 기법을 제안한다. 제안 기법에서는 에이전트를 비즈니스 로직, 이동성 코드, 상태 저장 코드로 나누어 개발하고, 이를 직조하여 이동 에이전트를 개발한다. 제안 기법을 사용하면 에이전트 개발자는 이동 에이전트의 비즈니스 로직 개발에 집중할 수 있고 에이전트의 이주 부분을 프로그래밍 함으로써, 유연한 에이전트의 이주 정책을 수립할 수 있다.

• Journal of Korea Water Resources Association
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• v.47 no.1
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• pp.37-47
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• 2014

This study examines the processes and the behaviour characteristics of forcing bars in channels with periodic variable width in the alternate and braided regimes by using a two dimensional numerical model. The wavelength and the migration speed decrease as the amplitude of variable width increases. The forcing effects of the width variation on the alternate bars is stronger than those on the braided bars. The bar migration speed increases as the dimensionless amplitude in the braided regime is 0.25. However, the migration speed is abruptly decreased as the amplitude in it was larger than 0.25. The bar migration speed increases in the alternates bar regime as the dimensionless wavelength increases. However, the migration speed decreases around 1 of the wavelength. As the bar wavelength and the variable width wavelength coincide, the bars don't migrate downstream by the strong forcing effects on the bars due to the suppression by the width variation.

• Journal of the Korean Geographical Society
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• v.51 no.1
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• pp.167-184
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• 2016

This paper investigates the migration process of Korean population in Northeastern China since the 19th century, focusing on the population distribution patterns in different time periods which reflect changes and diffusions of diaspora space. Korean migration into Northeastern China seemed to begin from the late 19th century, and can be classified into four different periods including cross-border refugee period (19th to 1910), political exile period(1911-1931), forced migration period(1932-1945), and economic-driven migration period(after 1946). The Korean migration into Northeastern China was closely related to paddy field rice farming by Korean migrants, which can be interpreted as a process of contagious diffusion starting from border area between Korea and China at the early stage. And then, process of hierarchical diffusion occurred along with urban centers on the railways from the 1930s. At the later stage, Korean migration has extended to coastal urban centers, other big cities in China and other countries including Korea since the 2000s. Recently, ethnic Korean communities in China have experienced changes from rural village based community to urban district based community as well as from single-nuclei ethnic structure around Northeastern China toward multi-nuclei ethnic structure extending to coastal urban areas in China.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6543-6546
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• 2014

MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers, including gastric cancer (GC), but the molecular mechanisms are not well understood. Herein, we investigated the role of miR-124 in GC. We found that its expression was significantly reduced in both GC tissue samples and cell lines. Forced expression of miR-124 suppressed GC cell proliferation, migration, and invasion. Furthermore, the Rho-associated protein kinase (ROCK1) was identified as a direct target of miR-124 in GC cells. Finally, silencing of ROCK1 showed similar effects as miR-124 overexpression, while supplementation of ROCK1 remarkably restored the cell growth and invasion inhibited by miR-124. Together, our data demonstrate that miR-124 acts as a tumor suppressor by targeting ROCK1, and posit miR-124 as a novel strategy for GC treatment.

• Journal of the Korean housing association
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• v.20 no.4
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• pp.103-112
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• 2009

The purpose of this research was to find out the housing history of Sakhalin returnees in Ansan Gohyangmaeul since leaving hometown under the Japanese ruling period, who experienced two international migration for one's life. Face to face interview had been done with 20 returnees in the community center of Ansan Gohyangmaeul during October to December, 2008. The semi-structured questionnaire about housing the respondents lived in major life changes used to guide the individual interview. The results showed that personal life as well as housing histories were differed by the reason to move into Sakhalin, which still influenced the returnee' life up to now. The housing they had lived changed from barracks like a training camp, to Japanese small wooden cottage/row house, and then Russian brick house/ apartment. Housing alteration and addition and rebuilding were common to renew the old existing house. The boundary of residing area was mostly limited to the first residing location under soviet governing system throughout one's life without a long distance move. Housing satisfaction was very high in Gohyangmaeul because of the improvement of housing facilities and residence itself as well as the convenience of housing management, compared to former residence in Sakhalin. Economic and emotional aspects of life satisfaction were also high during about 8 years of living in the apartment. Forced movers still require the compensation on hand to either Korean or Japanese government no matter the amount. Social integration to the Korean community would be one of the main issues to new returnees as well as the already returned. In-depth interviews of case study need to reveal the unique housing experience of the forced mover according to the type of leaving hometown by oneself or by parents, and to returned region and time to motherland.

• Journal of Advanced Marine Engineering and Technology
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• v.21 no.5
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• pp.557-563
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• 1997

The unsteady flow in three-dimensional cubic cavity with narrow channel at upper region is investigated experimentally for three kinds of Reynolds number, 1*10/sup 4/, 3*10/sup 4/ and 5*10/sup 4/ based on the cavity width and cavity inlet mean flow velocity. Instant velocity vectors are obtained simultaneously at whole field by PIV(Particle Image Velocimetry). Wall pressure distributions are estimated using Poisson equation from the velocity data. Results of PIV reveal that severe unsteady flow fluctuation within the cavity are remarkable at all Reynolds numbers and sheared mixing layer phenomena are also found at the region where inlet driving flow is collided with the clock-wise rotating main primary vortex. Instant velocity profiles reveal that deformed forced vortex formation is observed throughout the entire region and spanwise kinetic energy migration is conspicuous.