• 대한두개안면성형외과학회지
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• 제11권2호
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• pp.85-90
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• 2010

Purpose: The goals of a blow-out fracture reconstruction are to restore the osseous continuity, provide support for the orbital contents and prevent functional and anatomic defects. Over the past several years, a range of autogenous and synthetic implants have been used extensively in orbital reconstructions. None of these implants have any absolute indications or contraindications in certain clinical settings. However, in extensive blow-out fractures, it is difficult to restore support of the orbital contents, which can cause more complications, such as enophthalmos. This study examined the clinical outcomes of extensive or comminuted blow-out fractures that were reconstructed by the simultaneous use of a titanium mesh plate and $Medpor^{(R)}$. Methods: Eighty six patients with extensive orbital fractures, who were admitted between March 1999 and February 2007, were reviewed retrospectively. The patients' chart and CT were inspected for review. Twenty three patients were operated on with both a titanium mesh plate (Matrix MIDFACE pre-formed orbital plate, Synthes, USA) and $Medpor^{(R)}$ (Porex, GA, USA). The patients underwent pre-operative CT scans to evaluate the fracture site and measure the area of the fracture. A transconjunctival approach was used, and titanium mesh plates were inserted subperiosteally with screw fixation. $Medpor^{(R)}$ was inserted above the titanium mesh plate. The patients were evaluated post-operatively for enophthalmos, diplopia, sensory disturbances and eyeball movement for a period of at least 6 months. Results: No implant-related complications were encountered during the follow-up period. Enophthalmos occurred in 1 patient, 1 patient had permanent sensory disturbance, and 3 patients complained of ocular pain and fatigue, which recovered without treatment. Although there were no significance differences between groups, the use of 2 implants had fewer complications. Therefore, it can be an alternative method for treating blow out fractures. Conclusion: The use of both a titanium mesh plate and $Medpor^{(R)}$ simultaneously may be a safe and acceptable technique in the reconstruction of extensive blow-out fractures.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.222-230
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• 2000

Purpose : Resection of the epileptogenic zone in the parietal and occipital lobes may be relevant although only few studies have been reported. Methods : Eight patients with parietal epilepsy and nine patients with occipital epilepsy were included for this study. Preoperatively, all had video-EEG monitoring with extracranial electrodes, MRI, 3D-surface rendering of MRI using Allegro(ISG Technologies Inc., Toronto, Canada), and PET scans. Sixteen patients underwent invasive recording with subdural grid. Eight had parietal resection including the sensory cortex in two. Seven had partial occipital resection. Two underwent total unilateral occipital lobectomy. The extent of the resection was made based mainly on the data of invasive EEG recordings, MRI, and 3D-surface rendering of MRI, not on the intraoperative electrocorticographic findings as usually done. During resection, electrocortical stimulation was performed on the motor cortex and speech area. Results : Out of eight patients with parietal epilepsy, three had sensory aura, two had gustatory aura, and two had visual aura. Six of nine patients with occipital epilepsy had visual auras. All had complex partial seizures with lateralizing signs in 15 patients. Four had quadrantopsia. One had mild right hemiparesis. Abnormality in MRI was noticed in six out of eight parietal epilepsy and in eight out of nine occipital epilepsy. 3D-surface rendering of MRI visualized volumetric abnormality with geometric spatial relationships adjacent to the normal brain, in all of parietal and occipital epilepsy. Surface EEG recording was not reliable in localizing the epileptogenic zone in any patient. The subdural grid electrodes can be implanted on the core of the structural abnormality in 3D-reconstructed brain. Ictal onset zone was localized accurately by subdural grid EEGs in 16 patients. Motor cortex in nine and sensory speech area in two were identified by electrocortical stimulation. Histopathologic findings revealed cortical dysplasia in 10 patients ; tuberous sclerosis was combined in two, hamartoma and ganglioglioma in one each, and subpial gliosis in six. Eleven patients were seizure free at follow-up of 6 months to 37 months(mean 19.7 months) after surgery. Seizures recurred in two and were unchanged in one. Six produced transient sensory loss and one developed hemiparesis and tactile agnosia. One revealed transient apraxia. Two patients with preoperative quadrantopsia developed homonymous hemianopsia. Conclusion : This study suggests that surgical treatment was relevant in parietal and occipital epilepsies with good surgical outcome, without significant neurologic sequelae. Neuroimaging studies including conventional MRI, 3Dsurface rendering of MRI were necessary in identifying the epileptogenic zone. In particular, 3D-surface rendering of MRI was very helpful in presuming the epileptogenic zone in patients with unidentifiable lesion in the conventional MRI, in planning surgical approach to lesions, and also in making a decision of the extent of the epileptogenic zone in patients with identifiable lesion in conventional MRI. Invasive EEG recording with the subdural grid electrodes helped to confirm a core of the epileptogenic zone which was revealed in 3D-surface rendered brain.

• Journal of Korean Neurosurgical Society
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• 제61권1호
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• pp.81-88
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• 2018

Objective : Spondylitis is often chemotherapy resistant and requires long-term treatment. Without adequate chemotherapy, the outcome can be fatal or result in severe neurologic damage. Therefore, differentiating the etiology of spondylitis is very important, particularly in spontaneous cases. As the prevalence of tuberculosis in Korea has decreased in recent years, updated clinical research about spondylitis is warranted. Methods : From April 2010 to March 2016, data from spondylitis patients were collected retrospectively. In total, 69 patients (51 with pyogenic spondylitis and 18 with tuberculous spondylitis) were included. Clinical data, laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level, measurements of Cobb angles at the initial and final follow-up, and radiologic features on magnetic resonance imaging (MRI) scans were evaluated. To test differences between the pyogenic and tuberculous groups, numerical data were compared using the student's t-test and Mann-Whitney U test, and categorical data were compared using the chi-square test and Fisher's exact test. Results : The patients' mean age was 60.0 years. Male sex was slightly predominant (56.5%). There was no difference in mean age and sex between the two groups. The pyogenic group had a relatively higher proportion of immunocompromised patients. The peak CRP value was higher in the pyogenic group than in the tuberculous group (14.08 mg/dL and 8.50 mg/dL, respectively, p=0.009), whereas the ESR was not significantly different between the groups (81.5 mm/h and 75.6 mm/h, respectively, p=0.442). Radiologically, the presence of disc space sparing and vertebral body collapse differed between the groups. In the tuberculous group, the disc was more commonly preserved on contrast-enhanced MRI (50% and 23.5%, respectively, p=0.044), and vertebral body collapse was more common (66.6% and 15.7%, respectively, p<0.001). The mean length of hospitalization was longer in the pyogenic group (56.5 days and 41.2 days, respectively, p=0.001). Four mortality cases were observed only in the pyogenic group. The most commonly isolated microorganism in the pyogenic group was Staphylococcus aureus(S. aureus) (methicillin susceptible S. aureus and methicillin resistant S. aureus [MRSA] in 8 and 4 cases, respectively). Conclusion : The clinical and radiological manifestations of spontaneous spondylitis differ based on the causative organism. Pyogenic spondylitis patients tend to have a higher CRP level and a more severe clinical course, whereas tuberculous spondylitis patients present with destruction of the vertebral body with disc sparing more frequently. The presence of MRSA is increasing in community-acquired spondylitis cases.

• 한국콘텐츠학회논문지
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• 제13권6호
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• pp.331-338
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• 2013

간질환을 주소로 추적검사를 위해 내원한 CT(Computer Tomography, 이하 CT) 검사자를 대상으로 체질량 지수와 관전압 변화에 따른 영상의 화질 및 방사선 피폭선량변화에 대하여 알아보고자 하였다. 2010년 3월부터 2011년 6월까지 부산 P대학병원에 복부 CT 를 검사한 환자 중 체질량지수(Body Mass Index, 이하 BMI)가 25이하인 환자를 대상으로 하였고 대상자는 48명이었다. 영상의 질의 객관적 평가로 신호대 잡음비와 유효선량을 비교하였다. 복부 영상의 화질평가는 영상의학과 의사2명이 한국의료영상품질관리원에서 선정한 임상영상 평가의 기준을 근거로 해 1점에서 20점까지 점수를 매겨 평가하였다. 피폭선량분석에서 CTDIvol값은 관전압이 100kVp일 때 120kVp보다 약44.1%가 감소하였다. 그리고 유효선량은 관전압 100kVp일 때 120kVp보다 약43%가 감소하였다. 영상의 화질 평가는 반복적으로 CT검사를 위해 내원한 총48명의 검사자 영상 중 Good 1명, Excellent 47명으로 평가되었다. 추적검사를 시행하는 환자 중 BMI지수가 25이하인 환자들을 대상으로 저관전압을 적용한 복부 CT검사 시 영상의 질적 저하없이 진단 가치가 있는 영상의 획득과 피폭선량 감소효과를 얻을 수 있다고 사료된다.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.84-91
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• 2017

본 연구는 컴퓨터 단층촬영 영상에서 제거할 수 없는 의료용 고밀도 물질을 Somatom Definition Flash(Siemens, Enlarge, Germany.)와 GE 64-MDCT (Discovery 750 HD, GE HEALTHCARE, Milwaukee, USA.)스캔 후 획득한 팬텀영상 데이터와 이미 촬영된 Raw 데이터영상을 이용하여 IMAR 알고리즘과 MAR 알고리즘 적용 및 재구성한 후 CT 재구성영상의 CT Number 변화율을 정량적으로 분석하였다. 그 결과 팬텀영상의 모든 의료용 고밀도 물질은 IMAR 알고리즘과 MAR 알고리즘 적용 시 CT Number의 변화와 영상의 차이가 있는 것으로 나타났지만(p<0.05). Stainless Steel 재질은 Black streak artifact에서 MAR 또는 IMAR 알고리즘 적용 시 재구성 영상의 변화와 CT Number의 변화차이가 없는 것으로 분석되었다(p>0.05). 또한 이미 촬영된 Raw 데이터영상 분석결과 IMAR 알고리즘 적용 시 적용 전에 비하여 영상 CT Number 변화가 있어, IMAR 알고리즘 적용은 Attenuation deviation에 영향을 미치는 것을 알 수 있었다. 이 결과를 바탕으로 향후 Implant시술 후 추적 CT검사 시 수술부위 및 주변조직의 상태를 관찰하는데 유용할 것으로 사료된다.

• Radiation Oncology Journal
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• 제30권4호
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• pp.189-196
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• 2012

Purpose: To investigate the safety of high dose hypofractionated radiotherapy (RT) in patients with small hepatocellular carcinoma (HCC) in terms of liver volumetric changes and clinical liver function. Materials and Methods: We retrospectively reviewed 16 patients with small HCC who were treated with high dose hypofractionated RT between 2006 and 2009. The serial changes of the liver volumetric parameter were analyzed from pre-RT and follow-up (FU) computed tomography (CT) scans. We estimated linear time trends of whole liver volume using a linear mixed model. The serial changes of the Child-Pugh (CP) scores were also analyzed in relation to the volumetric changes. Results: Mean pre-RT volume of entire liver was 1,192.2 mL (range, 502.6 to 1,310.2 mL) and mean clinical target volume was 14.7 mL (range, 1.56 to 70.07 mL). Fourteen (87.5%) patients had 4 FU CT sets and 2 (12.5%) patients had 3 FU CT sets. Mean interval between FU CT acquisition was 2.5 months. After considering age, gender and the irradiated liver volume as a fixed effects, the mixed model analysis confirmed that the change in liver volume is not significant throughout the time course of FU periods. Majority of patients had a CP score change less than 2 except in 1 patient who had CP score change more than 3. Conclusion: The high dose hypofractionated RT for small HCC is relatively safe and feasible in terms of liver volumetric changes and clinical liver function.

• Radiation Oncology Journal
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• 제30권4호
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• pp.218-225
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• 2012

Purpose: The relationship between treatment outcomes, alteration of the expression of biological markers, and tumor volume response during radiotherapy (RT) in patients with uterine cervical cancer was analyzed. Materials and Methods: Twenty patients with cervical squamous cell carcinoma received definitive RT with (n = 17) or without (n = 3) concurrent chemotherapy. Tumor volumes were measured by three serial magnetic resonance imaging scans at pre-, mid-, and post-RT. Two serial punch biopsies were performed at pre- and mid-RT, and immunohistochemical staining for cyclooxygenase (COX)-2 and epidermal growth factor receptor was performed. The median follow-up duration was 60 months. Results: The median tumor volume response at mid-RT (V2R) was 0.396 (range, 0.136 to 0.983). At mid-RT, an interval increase in the distribution of immunoreactivity for COX-2 was observed in 8 patients, and 6 of them showed poor mid-RT tumor volume response ($V2R{\geq}0.4$). Four (20%) patients experienced disease progression after 10 to 12 months (median, 11 months). All 4 patients had poor mid-RT tumor volume response (p = 0.0867) and 3 of them had an interval increase in COX-2 expression. Overall survival (OS) and progression-free survival (PFS) decreased in patients with $V2R{\geq}0.4$ (p = 0.0291 for both). An interval increase in COX-2 expression at mid-RT was also associated with a decreased survival (p = 0.1878 and 0.1845 for OS and PFS, respectively). Conclusion: Poor tumor volume response and an interval increase in COX-2 expression at mid-RT decreased survival outcomes in patients with uterine cervical cancer.

• 구강회복응용과학지
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• 제28권3호
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• pp.301-307
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• 2012

50세 여자 환자와 남자 환자가 파노라마 방사선사진에서 우연히 발견된 무증상의 하악 구치부의 방사선투과성 병소로 인해 의뢰되었다. 임상검사에서 특이할 만한 소견은 발견되지 않았다. 파노라마 방사선사진에서 각각 우측과 좌측 하악 구치부에서 경계가 비교적 명확하며, 과골성 변연을 수반하지 않는 원형의 방사선투과성 병소가 관찰되었다. 병소 내부는 다방성의 양상이었으며, 또한 병소 부위를 주행하는 하악관의 불연속성 소견이 관찰되었다. 이에 양성 종양을 배제하기 위해서 조영증강 전산화단층사진을 촬영하였다. 전산화단층사진의 축상면에서 불규칙한 경계를 가지는 명확한 설측 함요부가 관찰되었으며, 내부는 지방 및 일부 악하선 조직으로 채워져 있었으나 다른 질환을 의심할 만한 연조직 종괴는 관찰되지 않았다. 최종적으로 비전형적 형태의 발육성 타액선 골결손으로 진단하였으며, 이 중 한 증례에서, 4개월 후의 재검사시 촬영한 파노라마 방사선사진에서 뚜렷한 변화가 관찰되지 않았다. 본 증례들과 같은 비전형적 발육성 타액선 골결손을 다른 질환과 감별하기 위해서는 단면 및 내부 구조물에 대한 보다 정확한 평가가 이루어져야 하므로 일반방사선사진뿐만 아니라 전산화단층영상 또는 자기공명영상이 추가적으로 필요하리라 생각된다.

• Investigative Magnetic Resonance Imaging
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• 제12권2호
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• pp.170-177
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• 2008

목적 : 순차적인 뇌초음파 검사 후 신생아 중환자실을 퇴원하는 고위험 환아에서 시행한 자기 공명 영상의 유용성을 알아보고자 하였다. 대상 및 방법 : 총 121명의 신생아에서 시행한 412 초음파와 121 자기공명 영상을 후향적으로 분석하여 초음파 검사에서 발견된 뇌병변과 자기 공명영상에서 발견된 병변을 비교하였다. 뇌병변은 배아기질 출혈 및 뇌실 내 출혈, 그 밖의 여러 출혈과 뇌실질 손상을 중심으로 비교 분석하였다. 결과 : 총 242개의 측뇌실 중 30뇌실의 배아기질 출혈 (GMH)을 초음파로 진단하였고 자기공명영상으로 7개의 GMH를 추가로 진단할 수 있었으며 46개 뇌실의 출혈 (IVH)을 추가로 진단하였다. 출혈의 1/2/3/4 등급은 초음파에서 각각 24/8/13/0 뇌실에서 진단하였고 자기공명영상에서 3/49/10/2 뇌실에서 진단하였다. 그 외에 자기공명영상에서 대뇌 출혈 (4예), 소뇌 출혈(4예), 경막하 및 지주막하 출혈 (8예), 미만성 백질 신호강도 변화 (72예), 조직손실이 없는 작은 실질 병변 (4예), 뇌연화증 (2예), 그리고 뇌실확장 (5예)이 추가로 발견되었다. 결론 : 자기공명영상은 초음파 검사 후 두개강내 출혈과 뇌실질 손상을 추가적으로 진단하는 유용한 검사였으며 특히 뇌실 출혈과 백질 손상의 진단에 우수한 반면 배아기질 출혈은 초음파 추적검사가 더 유용할 것으로 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2925-2929
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• 2013

Objective: To explore the relationships between primary tumor $^{18}F$-FDG uptake measured as the SUVmax and local extension, and nodal or distant organ metastasis in patients with NSCLC on pretreatment PET-CT. Methods: 93 patients with NSCLC who underwent $^{18}F$-FDG PET-CT scans before the treatment were included in the study. Primary tumor SUVmax was calculated; clinical stages, presence of local extension, nodal and distant organ metastases were recorded. The patients with SUVmax${\geq}2.5$ were divided into low and high SUVmax groups by using the median SUVmax. The low SUVmax group consisted of 45 patients with SUVmax<10.5, the high SUVmax group consisted of 46 patients with SUVmax${\geq}10.5$. Their data were compared statistically. Results: 91 cases with SUVmax${\geq}2.5$ were included for analysis. The mean SUVmax in patients without any metastasis was $7.42{\pm}2.91$ and this was significantly lower than that ($12.18{\pm}4.94$) in patients with nodal and/or distant organ metastasis (P=0.000). In the low SUV group, 19 patients had local extension, 22 had nodal metastasis, and 9 had distant organ metastasis. In the high SUV group, 31 patients had local extension, 37 had nodal metastasis, and 18 had distant organ metastases. There was a significant difference in local extension (P =0.016), distant organ metastasis (P =0.046), and most significant difference in nodal metastasis rate (P =0.002) between the two groups. In addition, there was a moderate correlation between SUVmax and tumor size (r = 0.642, P<0.001), tumor stage (r = 0.546, P<0.001), node stage (r = 0.388, P<0.001), and overall stage (r = 0.445, P= 0.000). Conclusion: Higher primary tumor SUVmax predicts higher extensional or metastatic potential in patients with NSCLC. Patients with higher SUVmax may need a close follow-up and more reasonable individual treatment because of their higher extensional and metastatic potential.