• 한국산학기술학회논문지
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• 제15권2호
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• pp.902-913
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• 2014

이 논문은 2005년부터 2009년까지 농식품부에서 지원하는 지역농업클러스터 사업을 수행한 농업생산자 단체인 푸른들 영농조합법인의 신내생적 발전과정을 분석한 것이다. 신내생적 발전론은 기존의 외생적/내생적 발전론처럼 발전을 지리적인 내부와 외부로 구분하는 것은 실제 농촌발전과정에서 나타나는 현상을 제대로 설명하지 못한다고 비판하고, 발전의 초기에는 내부와 외부의 자원을 동시에 활용하는 신내생적 발전이 나타나며 실질적으로 발전에 도움이 되는 자원들을 조절할 수 있는 능력이 가장 핵심적인 요소라고 주장한다. 유럽에서 시작된 이 개념을 우리나라 지역농업 클러스터 사업에 적용해서 살펴봄으로써 지역농업클러스터 사업을 지역에서 실행하면서 나타나는 사업주체와 행정기관 간의 갈등은 단순히 내생적/외생적인 논란으로는 그 실체를 파악하기 어렵고 신내생적 발전의 개념을 적용해야 그 장기적인 변화방향을 파악할 수 있다는 것이다. 결론적으로 이 연구에서는 아산의 사례를 통해서 농민단체가 발전을 주도할 수 있는 능력이 있다면 이들이 시행하는 것은 내생적 발전으로 진화하는 과도기 단계의 신내생적 발전이라고 평가할 수 있다는 것이다.

• 한국발생생물학회지:발생과생식
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• 제22권3호
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• pp.213-223
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• 2018

Ultrastructural studies on oocyte differentiation and vitellogenesis in the oocytes of female Kareius bicoloratus were investigated by transmission electron microscopy. The Golgi complex in the cytoplasm is involved in the formation of yolk vesicles that contain yolk carbohydrates in the yolk vesicle of oocytes in the early vitellogenic phase. In this phase, many pinocytotic vesicles (PVs), which are formed by pinocytosis, contain yolk precursors (exogenous substances). These substances are associated with exogenous heterosynthetic vitellogenesis. In yolked oocytes in the late vitellogenic phase, two morphologically different bodies, which formed by modified mitochondria, appear in oocytes. One is a multivesicular body (synthesized by autosynthetic vitellogenesis), and the other is a yolk precursor (an exogenous substance formed by heterosynthetic vitellogenesis). The multivesicular bodies (MVB) are taken into the yolk precursors (YP) and are transformed into primary yolk globules. However, after the YP mix with exogenous PVs near the zona pellucida, they are transformed into primary yolk globules. Vitellogenesis of this species occurs via endogenous autosynthesis and exogenous heterogenesis. Vitellogenesis occurs through endogenous autosynthesis, which involves the combined activity of the Golgi complex, mitochondria and MVB formed by modified mitochondria. However, heterosynthesis involves pinocytotic incorporation of extraovarian precursors (such as vitellogenin in the liver) into the zona pellucida (via granulosa cells and thecal cells) of the yolked oocyte.

• 한국유기농업학회지
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• 제28권1호
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• pp.69-93
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• 2020

The paper is to compare two villages in Songak-myeon, Asan, Cnungnam Province in Korea. It tries to show how the joint village project, which began with the support of the same external organization, produces different results depending on the internal conditions and circumstances of the village. From the end of the 1990s, Pyeongchon-ri and Sugok-ri started developing villages under the influence of the environmentally friendly farming movement. And subsequent supports were provided by local organizations for the development of the village. However, the village project in Sugok-ri, which focused on economic performance, later turned out to be a failure, and the residents changed to pursue activities for their own economic interests individually. On the other hand, In Pyeongchon-ri, the cooperation among villagers was strengthened in implementing support projects by similar external agencies. In addition, community ties and identity have been strengthened as problems have been solved through cooperation among residents in the process of promoting the village project. Nevertheless, projects undertaken in Pyeongchon-ri for the purpose of increasing economic performance was all failed. Through these findings, the paper asserts that the neo-endogenous development approach utilizing external support on the basis of internal cooperative network among villagers must be a very useful method for rural development in contemporary societies.

• 한국발생생물학회지:발생과생식
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• 제20권2호
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• pp.127-133
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• 2016

Purine metabolism is known factor for nuclear maturation of oocytes through both follicle cells and oocyte itself. However, it is largely unknown the roles of purine metabolism in the oocyte competence for fertilization and early development. In this study, the effects of adenosine in oocyte competence for development were examined using adenosine and its synthetic inhibitors. Adenosine treatment from GV intact stage for 18 hr (fGV) caused of decrease the fertilization rate but of increase the cleavage rate compared from the other stage treatment groups. Hadacidin did not effect on fertilization rate but increased cleavage rate without stage specificity. Adenosine did not block the effects of hadacidin with the exception of fGV group. Inhibition of purine synthetic pathways the fertilization rate was decreased in the fGV and fGVB groups but increased in the fMII group. Exogenous adenosine caused of decrease fertilization rate in the fGVB group but increase in the fMII group. Cleavage rate was dramatically increased in the adenosine treatment with synthetic inhibitors. It means that the metabolism of purine has stage specific effects on fertilization and cleavage. Exogenous adenosine had only can improve oocyte developmental competence when it treated at GV intact stage. On the other hand, endogenous synthesis in all maturation stage cause of increase the cleavage rate without effects on fertilization. These data suggest that adenosine at GV stage as a paracrine fashion and inhibitions of endogenous adenosine in all stage improve oocyte developmental competence.

• 생명과학회지
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• 제25권4호
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• pp.481-485
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• 2015

수백만 년 전부터 인간의 유전체에는 retrovirus의 유전자들이 삽입되기 시작하였다. 이러한 retrovirus의 유전자들은 결실 혹은 nonsense mutation등 여러 영향으로 지금은 더 이상 활동성 있는 바이러스로서의 역할을 못하는 흔적으로만 남아 있는 형태로 존재하며 이러한 내생(endogenous) retrovirus를 human endogenous retrovirus (HERV)라 부른다. HERV의 각 유전자들은 완성된 활동성을 지닌 바이러스를 만들어 내지는 못하지만 여전히 부분적으로 발현이 가능하고 심지어는 바이러스 particle 까지 만들어지는 것이 관찰되었다. 이러한 내성 retrovirus 에 반해 실질적으로 감염되고 활동하여 질병을 야기하는 외인성(exogenous) retrovirus들이 있는데 이 중 human immunodeficiency virus (HIV)는 인간의 생명을 위협하는 대표적 바이러스로 가장 많이 연구되고 있는 바이러스중의 하나이다. 최근 흔적으로만 존재하는 것으로 보고된 HERV가 실질적으로 활성화된 바이러스인 HIV의 감염에 의해 활성화되고 발현이 증가할 뿐 아니라 HIV 감염의 여러 과정에 관여하고 있다는 연구 결과가 보고되고 있다. 또한 이러한 현상을 이용하여 HIV의 백신 및 치료 방법으로 HERV를 이용하고자 하는 시도가 활발히 이루어지고 있다. 이 리뷰에서는 HIV 감염에 의한 HERV의 활성화 및 관련 상호 기작에 관한 연구를 소개하고 HERV를 이용한 HIV의 백신 및 치료제 개발을 위한 시도들을 함께 소개하고자 한다.

• 자원ㆍ환경경제연구
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• 제15권5호
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• pp.885-919
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• 2006

본 연구는 환경 비시장가치 평가에서 일반적으로 통용되는 두 가지 '믿음'을 재조명하고 그 단점과 해결책을 고찰한다. 이 믿음은 (1) 지불의사액(WTP)이 비시장 선호도의 타당한 추정치라는 것과, (2) WTP를 설명함에 있어 외생변수(exogenous variables)의 기여도는 인정하면서도 내생변수(endogenous variables)는 무시할 수 있다는 것이다. 하지만, 심리행동학과 후생경제학의 최근 관련 문헌조사를 통해서 평가해 볼 때 두 가지 믿음으로부터의 이탈현상이 두드러지게 발견된다, 결론적으로, 이 같은 현상의 주요 원인으로 알려져 있는 응답자 이질성(heterogeneity)에 효과적으로 대처하기 위해서는 소비자의 선택행동을 설명하는 확률효용모델의 구성에 사회경제 변수와 심리태도 변수를 함께 고려하여야 한다. 특히, 측정의 번거로움을 이유로 후자가 무시될 경우 기존 문헌에서 제기된 다양한 편중(bias)에 노출됨으로써 추정치의 신뢰도가 낮아질 수 있다.

• 한국발생생물학회지:발생과생식
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• 제16권2호
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• pp.107-112
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• 2012

Early growth, the rate of yolk sac absorption, and nucleus size in liver parenchymal cells were correlated with the nutritional status of first feeding larval haddock, Melanogrammus aeglefinus. Larvae that successfully began exogenous feeding maintained high growth rates, delayed yolk sac resorption, and had larger hepatocyte nuclear sizes than starved larvae. At 10 days post hatch (DPH) the cumulative mortality in the starved larval haddock group was 100%. The area of the hepatocyte nuclei in starved larvae gradually decreased, reaching its lowest value by 9 DPH. Our results support the current practice of providing the first food supply at 3 DPH. Hepatocyte nuclear size can be used to assess larval haddock nutrition status, and may be a good criterion for assessing the success of transition from endogenous to exogenous feeding.

• 한국조경학회지
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• 제18권4호
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• pp.127-140
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• 1991

The Primary purpose of this study is to investigate factors and variables which have significant effects on user satisfaction with recreational facilities in Taejong-Dae recreational complex, thereby establishing indices of planning and development of urban parks and open space. To test the causal models of this research, the date were gathered by self-administered questionnaires from 967 households in Pusan City which were selected by the multi-stage probability sampling methood. The analysis of the multi-stage primarily consists of two phase : The first analysis dealt exploratory factor analysis which identified major factors involved in satisfaction with recreational activities and facilities in Taejong-Dae recreational complex and the second analysis tested the fit of the causal models of this research by employing LISREL methodology. There are three advantages of using LISREL over other multivariate analysis methods : First, measurement error is allowed and calculated in LISREL, otherwise there is a risk of seriously misleading estimates of coefficients ; Second, LISREL deals with latent variables or unmeasured variables ; Third, it enables to test causal relations among variables. The factors analysis identified that five factors are involved in satisfaction with recreational facilities. The five factors of satisfaction with recreational facilities are space for repose and relaxation, active recreation facilities such as pool and zoo, physical exercise facility, convenience and maintenance facility, and linear facility, and linear facility for walking. The second phase analysis tested the fit of the causal models for satisfaction with recreational facilities to the data and identified statistically significant causal linkage among overall satisfaction with Taejong-Dae recreational complex, other endogenous factors and exogenous variables. Overall fits of both causal models were very good. Among endogenous factors, facility for repose and relaxation. linear facility for walking, active recreation facility, facility for convenience and maintenance were identified as having significant effects on overall satisfaction. Exogenous variables which have significant effects on endogenous variables wer also identified. These significant relationships indicate important factors and variables that should be considered in planning and development of the recreational complex. On the basis of these significant causal relationships, implications for planning and the delovepment of Taejong-Dae recreational complex were suggested.

• 한국조경학회지
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• 제20권1호
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• pp.29-38
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• 1992

The primary objective of this study is to investigate factors and variables which have significant effects on user satisfaction with recreational facilities in Children's Grand Park in Pusan City, theregby to establish the developmental way of urban park and open space. To test the causal models of this research, the data were gathered by self-administered questionnaires from 1085 households in Pusan City which were selected by the multi-stage probability sampling method. The analysis of the data primarily consists of two phase : The fist analysis dealt exploratory factor analysis which identified major factors involved in satisfaction with recreational facilities in Children's Grand Park and the second analysis tested the fit of the causal models of this research by employing LISREL methodology. The factor analysis identified that five factors are involved in satisfaction with recreational facilities. The five factors of satisfaction with recreational facilities are convenience and maintanance facilities, learnded recreational facilities, spaces for repose and relaxation, spaces for active recreation failities, and facilities for health and physical facilities. The second phase analysis tested the fit of the causal models for satisfaction with recreational facilities to the data and identified statistically significant causal linkage among overall satisfaction with Children's Grand Park, other endogenous factors and exogenous variables. Overall fits of both causal models were very good. Among endogenous factors, facilities for repose and relaxation, facilities for convenience and maintenance, learnded recreational facilities were identified as having significant effects on overall satisfaction. Exogenous variables which have significant effects on endogenous variables were also identified. These significant relationships indicate important factors and variables that should be considered in planning and development of urban park and open space. On the basis of these significant causal relationships, way for delovepment of urban park and open space were suggested.

• 미생물학회지
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• 제43권4호
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• pp.237-242
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• 2007

레트로바이러스(Retrovirus; RV)의 독특한 특징 중 하나는 프로바이러스의 상태로 숙주세포의 염색체에 삽입되어 숙주세포 유전자의 일부분으로서 다른 숙주세포 유전자들과 함께 다음세대로 유전된다는 것이다. 이러한 독특한 형태의 RV를 내인성 RV (endogenous RV; ERV)라고 하는데, 여러 종류의 내 외적신호에 의해 그자신의 유전자뿐만 아니라 인근한 숙주유전자의 발현에 변화가 일어난다. 사람과 쥐에서는 각각 HERV (Human ERV)와 MuERV (Murine ERV)가 세포 속에 존재하여 이들의 발현 변화가 숙주 생물체에 주로 해롭게 작용하여 질병을 일으키게 된다. 이들 ERV는 생체분자, 세포물질들이 관여하는 기작을 통해 암과 자가면역 반응과 같은 질병을 일으키는데, 이에 수반하여 많은 병리생리적 변화를 가져온다. HERV와 관련된 질병을 앓고 있는 환자들을 위해서는 이러한 질병을 이해하고, 이를 바탕으로 치료요법을 개발하기 위해 여러 단계의 대책들이 고려되어야 한다.