• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3805-3809
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• 2014

Background: In Mexico, breast cancer (BCa) is the leading type of cancer in women. Cytochrome P450 (CYP450) is a superfamily of major oxidative enzymes that metabolize carcinogens and many antineoplastic drugs. In addition, these enzymes have influence on tumor development and tumor response to therapy. In this report, we analyzed the protein expression in patients with BCa and in healthy women. Links with some clinic-pathological characteristic were also assessed. Materials and Methods: Immunohistochemical analyses were conducted on 48 sets of human breast tumors and normal breast tissues enrolled in Hospital Militar de Especialidades de la Mujer y Neonatologia and Hospital Central Militar, respectively, during the time period from 2010 to 2011. Informed consent was obtained from all participants. Statistical analysis was performed using ${\chi}^2$ or Fisher exact tests to estimate associations and the Mann Whitney U test for comparison of group means. Results: We found a significant CYP3A4 overexpression in BCa stroma and gland regions in comparison with healthy tissue. A significant association between protein expression with smoking, alcoholism and hormonal contraceptives use was also observed. Additionally, we observed estrogen receptor (ER) and progesterone receptor (PR) positive association in BCa. Conclusions: We suggest that CYP3A4 expression promotes BCa development and can be used in the prediction of tumor response to different treatments. One therapeutic approach may thus be to block CYP3A4 function.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.3
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• pp.307-312
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• 2007

The present study was carried out to investigate differentially expressed chicken muscle proteins using proteomics approach. More than 300 protein spots were investigated for the muscle samples in 2DE gels and the differentially expressed protein spots between pectoralis and peroneus longus muscles from Cornish and White Leghorn breeds were characterized by MALDI-TOF. In pectoralis muscles, PGAM1 protein was detected as differentially expressed between White Leghorn and Cornish breeds. On the other hand, 4 protein spots (SP22, nxf-2, SOD1, TNNI2) were differentially expressed between White Leghorn and Cornish breeds in peroneus longus muscles. These proteins assumed to be related with muscle development, growth, stress, and movements in chicken. In this experimental process, 2D reference map of the chicken muscle proteins was needed and 25 proteins, which were commonly expressed in both pectoralis and peroneus longus muscles in both breeds, were selected and characterized. Upon finishing the exact roles of the differentially expressed proteins, the identified 5 proteins will be used as valuable information for the fundamental mechanisms of muscle biology and underline genetics.

• 한국전산유체공학회:학술대회논문집
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• 1998.05a
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• pp.15-28
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• 1998

As an alternative for solving the incompressible Navier-Stokes equations, we present a vorticity-based integro-differential formulation for vorticity, velocity and pressure variables. One of the most difficult problems encountered in the vorticity-based methods is the introduction of the proper value-value of vorticity or vorticity flux at the solid surface. A practical computational technique toward solving this problem is presented in connection with the coupling between the vorticity and the pressure boundary conditions. Numerical schemes based on an iterative procedure are employed to solve the governing equations with the boundary conditions for the three variables. A finite volume method is implemented to integrate the vorticity transport equation with the dynamic vorticity boundary condition . The velocity field is obtained by using the Biot-Savart integral derived from the mathematical vector identity. Green's scalar identity is used to solve the total pressure in an integral approach similar to the surface panel methods which have been well-established for potential flow analysis. The calculated results with the present mettled for two test problems are compared with data from the literature in order for its validation. The first test problem is one for the two-dimensional square cavity flow driven by shear on the top lid. Two cases are considered here: (i) one driven both by the specified non-uniform shear on the top lid and by the specified body forces acting through the cavity region, for which we find the exact solution, and (ii) one of the classical type (i.e., driven only by uniform shear). Secondly, the present mettled is applied to deal with the early development of the flow around an impulsively started circular cylinder.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.16-25
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• 2010

Objectives: Compliance of herbal medicine is extremely important in Korean oriental medicine, since herbal medicine is main approach to the most of outpatients in Korean pediatrics. The more compliant to the medication, the more effective care is given to children. Thus, we conducted this research to evaluate the compliance of herbal medicine, and factors associated with compliance in children. Methods: 61 children (men 28, women 33) were participated who visited the Korean Oriental Medicine Department in university hospital for two weeks. We used Morisky's self-reported questionnaire which is consisted of four questions. Also, we checked medical records and researched respondent to acquire more factors. We defined as a "full compliant" if answers were 'No' to all of the questions. We analyzed the compliance and associated factors with Pearson's $x^2$-test and Fisher's exact test, and Spearman correlation coefficient. Compliance and associated factors were analyzed with linear regression. Results: Compliance of herbal medicine was not related to respondent, and 34 children (55.7%) were non-compliant. The best compliant type of herbal medicine was granule medication (p=0.046). However, there was no relationship between compliance and age, sex, sibling, purpose of medication, period of disease, frequency of medication, and medication duration. The age, frequency of medication, medication duration, and purpose of medications(period of disease) had correlation(p<0.01). Also, older children tended to forget to take herbal medicine(p=0.004). Conclusions: Over an half of the total subjects (55.7%) were non-compliant, so we should improve compliance of herbal medicine. Since granule form of medication was shown to have the best compliance, we should try to use granule form of medication instead of liquid medications. Also, we can also improve compliance with giving attention to the patients, especially older children in order to improve their compliance.

• Journal of Powder Materials
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• v.12 no.3
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• pp.167-173
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• 2005

Production of weakly agglomerated nanopowders with the characteristic size of about 10 nm and a narrow particle size distribution is still a topical problem especially if the matter is an acceptable output (>50 g/hour), a high purity of the final product, and a low (energy consumption. The available experience and literature data show that the most promising approach to production of such powders is the evaporation-condensation method, which has a set of means for heating of the target. From this viewpoint the use of pulsed electron accelerators for production of nanopowders is preferable since they allow a relatively simple adjustment of the energy, the pulse length, and the pulse repetition rate. The use of a pulsed electron accelerator provides the following opportunities: a high-purity product; only the target and the working gas will interact and their purity can be controlled; evaporation products will be removed from the irradiation zone between pulses; as a result, the electron energy will be used more efficiently; adjustment of the particle size distribution and the characteristic size of particles by changing the pulse energy and the irradiated area. Considering the obtained results, we developed a design and made an installation for production of nanopowders, which is based on a hollow-cathode pulsed gas-filled diode. The use of a hollow-cathode gas-filled diode allows producing and utilizing an electron beam in a single chamber. The emission modulation in the hollow cathode will allow forming an electron beam 5 to 100 ms long. This will ensure an exact selection of the beam energy. By now we have completed the design work, manufactured units, equipped the installation, and began putting the installation into operation. A small amount of nanopowders has been produced.

• Journal of Power System Engineering
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• v.3 no.3
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• pp.60-69
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• 1999

The noise and vibration sources of rotary compressor for room air-conditioner are pressure pulsation of compression process, cavity resonance of inner space, structural radiation noise of shell and impact noise of discharge valve. Among them, pressure pulsation is very important noise and vibration source. Because it transferred various kinds of noise and vibration like as mentioned above. In this reason, muffler and resonator are used in order to absorb and remove these noises. But an analytical prediction using acoustic analysis does not coincident with the experimental result. The difference between analysis and actual state is due to the assumption of analysis. This paper covered with new concept of muffler design based on the turbulence kinetic energy of flow by using CFD. From this analysis, it is possible to decide the best position of discharge port of muffler. Therefore $2{\sim}3dB$ noise reduction effect is acquired in rotary compressor of 5000 BTU grade. Also new approach of resonator design is suggested. From this study, the characteristics of resonator and surge hole (a kind of resonator without pipe length) are identified. The former is useful for pure tone noise (narrow frequency band), and the latter is effective for broad frequency band. This paper shows that it is very available to use 3 dimensional analysis of resonator in order to predict more exact tuning frequency. The result is proved by a lot of experiments. From combination of fluid analysis and acoustic analysis, up stream position is effective location of resonator concerning turbulence motion of fluid.

• Journal of Trauma and Injury
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• v.26 no.3
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• pp.248-251
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• 2013

Introduction: A post-traumatic mesenteric arteriovenous fistula (AVF) is extremely rare. Case Report: A previously healthy 26-year-old male was injured with an abdominal stab wound. Computed tomography (CT) showed liver injury, pancreas injury and a retropancreatic hematoma. We performed the hemostasis of the bleeding due to the liver injury, a distal pancreatectomy with splenectomy and evacuation of the retropancreatic hematoma. On the 5th postoperative day, an abdominal bruit and thrill was detected. CT and angiography showed an AVF between the superior mesenteric artery (SMA) and the inferior mesenteric vein with early enhancement of the portal vein (PV). The point of the AVF was about 4 cm from the SMA's orifice. After an emergent laparotomy and inframesocolic approach, the isolation of the SMA was performed by dissection and ligation of adjacent mesenteric tissues which was about 6 cm length from the nearby SMA orifice, preserving the major side branches of the SMA, because the exact point of the AVF could not be identified despite the shunt flow in the PV being audible during an intraoperative hand-held Doppler-shift measurement. After that, the shunt flow could not be detected by using an intraoperative hand-held Doppler-shift measuring device. CT two and a half months later showed no AVF. There were no major complications during a 19-month follow-up period. Conclusion: Early management of a post-traumatic mesenteric AVF is essential to avoid complications such as hemorrhage, congestive heart failure and portal hypertension.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.26 no.1
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• pp.81-87
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• 1990

In this paper, a new design method in which transient response behavior of a servo~system can be improved, is proposed using a bilinear transformation method which assigns the poles of the closed-loop system in a specified region. The servo-system is a dynamic system which follows the given reference input automatically. In the above meaning, the design of a servo-system is similar to a regulator design problem for the extended system which is resulted from the given system and the reference input by the well known internal moel principle. In the design problem of servo control system, it is supposed that the proposed design method has more practical meaning in comparison to the other design methods, in the views of assigning the characteristic roots of the closed loop system in a specified region satisfying a design specification for the given transient response rather than in the exact positions of the poles. The applicability of the design method proposed in this paper was proved by the simulation results for the angle control problem of an electrical servo mechanism.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.25 no.5
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• pp.427-436
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• 2007

Because the slope made up the construction of any other facilities, has many risks of a collapse, existing inspection methods to collect information for a construction site of slope bring up a long time of inspection period, cost and approach for a measuring instrument and it presents the critical point of collecting materials. For getting images to use zoom lens in any positions this study will use free zoomer constructed values of data classified by the focal length develop Image Loader system to make it load not only camera information but also camera test data values of the focal length took a photograph automatically if it measure to use a variety of cameras or other lens. Also, as it constructs three dimensions spatial image information from images of obtained objects this study presents effective basic materials of slope surveying and inspection and it shows exact surveying methods for dangerous slope not to access.

• Journal of Korean Society of Steel Construction
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• v.16 no.5 s.72
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• pp.671-682
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• 2004

This study investigated the effects of a shear slip on the deflection of steel-concretecomposite beams with partial shear interaction. Under the guidance of various current design codes, this deflection was related to the strength of shear connectors in the composite beams. In this paper, a shear connector stiffness based on exact solutions, regardless of loading conditions, was developed. The equivalent rigidity of composite beams that considered three different loading types was first derived, based on equilibrium and curvature compatibility, from which a general formula accounting for slips was developed. To validate this approach, the predicted maximum deflection under the proposed method was compared against currently used equations to calculate beam effective stiffness (AISC)Nie's equations, which have recently been proposed. For typical beams that were used in practice, shear slips might result in stiffness reduction of up to 18% for short-span beams. For full composite sections, the effective section modulus with the AISC specifications was larger than that of the present study, which meant that the specifications were not conservative. For partial composite sections, the AISC predictions were more conservative than those in the present study.