• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.21 no.2
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• pp.103-109
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• 2011

Object: we investigated some factors which can affect workers' comprehension of chemical hazard information and their actions to protect themselves from the hazard. Method: Comprehension score of chemical hazard information and the rate of wearing personal protective equipment (PPE) was surveyed for the 109 workers from 15 factories who were exposed to N, N-dimethylformamide. Difference of the worker's comprehension score of hazard information was analyzed by education interval, work duration and the way of occupational safety and health management between self-managed or sub-contracted. Result: Mean comprehension score of N, N-dimethylformamide hazard, which was given as a short quiz composed of 10 "true" or "false" problems, was 65%. Mean percentage of wearing PPE was improved as the education program was done within a month but decreased after 6 months. Eighty seven % of workers got the chemical hazard information from the material safety data sheet placed at workplace. Conclusion: Education interval and comprehension score affected the rate of wearing PPE. The way of occupational safety and health management self-managed or sub-contracted did not affect the workers' comprehension score on hazard information nor the rate of wearing PPE.

• Toxicological Research
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• v.25 no.1
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• pp.1-8
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• 2009

Validation specifies and coordinates all relevant activities to ensure compliance with good laboratory practices (GLP) according to suitable international standards. This includes validation activities of past, present and future for the best possible actions to ensure the integrity of non-clinical laboratory data. Recently, validation has become increasingly important, not only in good manufacturing practice (GMP) institutions but also in GLP facilities. In accordance with the guideline for GLP regulations, all equipments used to generate, measure, or assess data should undergo validation to ensure that this equipment is of appropriate design and capacity and that it will consistently function as intended. Therefore, the implantation of validation processes is considered to be an essential step in a global institution. This review describes the procedures and documentations required for validation of GLP. It introduces basic elements such as the validation master plan, risk assessment, gap analysis, design qualification, installation qualification, operational qualification, performance qualification, calibration, traceability, and revalidation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.2
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• pp.187-196
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• 1991

Aging is the progressive accumulation of changes with time associated with responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age. Lipid peroxides easily produced in the membrane system by the chain reaction of free radicals which occurred from various environmental factors. The amount of lipid peroxides produced in biological system increased with aging process, and lipid peroxidation damages involved in aging process and pathological disorders. Although lipid peroxides have such deleterious effects on the organisms, there are numerous substances and mechanisms which prevent the reaction of peroxide formation and protect the subject from its toxicity. This review provides an overview of how does lipid peroxidation of unsaturated lipids take place by free radical, and what is the intervention of lipid peroxides in pathogenesis of some human diseases, and also how does food restriction influences the aging process and various pathological disorders. The major focus of this paper is to review the evidence indicating that food restriction retards the aging process, and possible mechanisms of its actions. Therefore, it discussed the effects of age and food restriction on life-span, membrane yield, lipid peroxidation, fatty acid composition and peroxidizability, cholesterol and triglyceride levels, prostaglasndin and thromboxane synthesis, which may be concerned with blood flow, membrane fluidity, homeostasis and glomerular filtration rate in living body.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.9
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• pp.3444-3457
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• 2021

In the field of anti-jamming based on dynamic spectrum, most methods try to improve the ability to avoid jamming and seldom consider whether the jammer would perceive the user's signal. Although these existing methods work in some anti-jamming scenarios, their long-term performance may be depressed when intelligent jammers can learn user's waveform or decision information from user's historical activities. Hence, we proposed a hidden anti-jamming method to address this problem by reducing the jammer's sense probability. In the proposed method, the action correlation between the user and the jammer is used to evaluate the hiding effect of the user's actions. And a deep reinforcement learning framework, including specific action correlation calculation and iteration learning algorithm, is designed to maximize the hiding and communication performance of the user synchronously. The simulation result shows that the algorithm proposed reduces the jammer's sense probability significantly and improves the user's anti-jamming performance slightly compared to the existing algorithms based on jamming avoidance.

• Molecules and Cells
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• v.45 no.4
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• pp.169-176
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• 2022

A primary cilium, a hair-like protrusion of the plasma membrane, is a pivotal organelle for sensing external environmental signals and transducing intracellular signaling. An interesting linkage between cilia and obesity has been revealed by studies of the human genetic ciliopathies Bardet-Biedl syndrome and Alström syndrome, in which obesity is a principal manifestation. Mouse models of cell type-specific cilia dysgenesis have subsequently demonstrated that ciliary defects restricted to specific hypothalamic neurons are sufficient to induce obesity and hyperphagia. A potential mechanism underlying hypothalamic neuron cilia-related obesity is impaired ciliary localization of G protein-coupled receptors involved in the regulation of appetite and energy metabolism. A well-studied example of this is melanocortin 4 receptor (MC4R), mutations in which are the most common cause of human monogenic obesity. In the paraventricular hypothalamus neurons, a blockade of ciliary trafficking of MC4R as well as its downstream ciliary signaling leads to hyperphagia and weight gain. Another potential mechanism is reduced leptin signaling in hypothalamic neurons with defective cilia. Leptin receptors traffic to the periciliary area upon leptin stimulation. Moreover, defects in cilia formation hamper leptin signaling and actions in both developing and differentiated hypothalamic neurons. The list of obesity-linked ciliary proteins is expending and this supports a tight association between cilia and obesity. This article provides a brief review on the mechanism of how ciliary defects in hypothalamic neurons facilitate obesity.

• The Journal of Industrial Distribution & Business
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• v.13 no.10
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• pp.23-30
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• 2022

Purpose: The advantages of corporate social responsibility (CSR) include stronger recognition and reputation, which lead to a company's good public image, increased customer loyalty, operational cost saving, and employee retention. The purpose of the present research is to take a close look at the association between CSR and organization's value. Research design, data and methodology: The authors tried to obtain the high-quality textual data from mostly peer-reviewed journals using a PRISMA ((Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The authors was to figure out adequate solutions from limited range of the current literature (only peer-reviewed research) regarding CSR and corporate value. Results: Our investigation indicates that CSR is essential to all businesses as it ensures they keep in touch with society, retaining top personnel, and achieving top financial success. Companies and organizations can engage in four corporate social responsibility initiatives to increase value, including environmental projects, charitable work, honest labor practices, and volunteer activity. Conclusions: An organizations should be involved in the community and consider how its actions affect the environment and society. Small or large businesses are expected to lead in developing a progressive CSR program that benefits people and the environment and continuously changes depending on the social and economic environment.

• Journal of information and communication convergence engineering
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• v.20 no.3
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• pp.181-188
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• 2022

An intelligent distributed multi-agent system (IDMS) using reinforcement learning (RL) is a challenging and intricate problem in which single or multiple agent(s) aim to achieve their specific goals (sub-goal and final goal), where they move their states in a complex and cluttered environment. The environment provided by the IDMS provides a cumulative optimal reward for each action based on the policy of the learning process. Most actions involve interacting with a given IDMS environment; therefore, it can provide the following elements: a starting agent state, multiple obstacles, agent goals, and a cluttered index. The reward in the environment is also reflected by RL-based agents, in which agents can move randomly or intelligently to reach their respective goals, to improve the agent learning performance. We extend different cases of intelligent multi-agent systems from our previous works: (a) a proposed environment-clutter-based-index for agent sub-goal selection and analysis of its effect, and (b) a newly proposed RL reward scheme based on the environmental clutter-index to identify and analyze the prerequisites and conditions for improving the overall system.

• Clinical Endoscopy
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• v.56 no.3
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• pp.263-267
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• 2023

Climate change is a global emergency. Consequently, current global targets to combat the climate crisis include reaching net-zero carbon emissions by 2050 and keeping global temperature increases below 1.5 ℃. In 2014, the healthcare carbon footprint was 5.5% of the total national footprint. Gastrointestinal endoscopy (GIE) has a large carbon footprint compared to other procedures performed in healthcare facilities. GIE was identified as the third largest generator of medical waste in healthcare facilities for the following reasons: (1) GIE is associated with high case volumes, (2) GIE patients and relatives travel frequently, (3) GIE involves the use of many nonrenewable wastes, (4) single-use devices are used during GIE, and (5) GIE is frequently reprocessed. Immediate actions to reduce the environmental impact of GIE include: (1) adhering to guidelines, (2) implementing audit strategies to determine the appropriateness of GIE, (3) avoiding unnecessary procedures, (4) using medication rationally, (4) digitalization, (5) telemedicine, (6) critical pathways, (7) outpatient procedures, (8) adequate waste management, and (9) minimizing single-use devices. In addition, sustainable infrastructure for endoscopy units, using renewable energy, and 3R (reduce, reuse, and recycle) programs are necessary to reduce the impact of GIE on the climate crisis. Consequently, healthcare providers need to work together to achieve a more sustainable future. Therefore, strategies must be implemented to achieve net-zero carbon emissions in the healthcare field, especially from GIE, by 2050.

• Advances in environmental research
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• v.12 no.2
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• pp.113-122
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• 2023

Biometric authentication has become an essential part of modern-day security systems, especially in financial institutions like banks. A face recognition-based ATM is a biometric authentication system, that uses facial recognition technology to verify the identity of bank account holders during ATM transactions. This technology offers a secure and convenient alternative to traditional ATM transactions that rely on PIN numbers for verification. The proposed system captures users' pictures and compares it with the stored image in the bank's database to authenticate the transaction. The technology also offers additional benefits such as reducing the risk of fraud and theft, as well as speeding up the transaction process. However, privacy and data security concerns remain, and it is important for the banking sector to instrument solid security actions to protect customers' personal information. The proposed system consists of two stages: the first stage captures the user's facial image using a camera and performs pre-processing, including face detection and alignment. In the second stage, machine learning algorithms compare the pre-processed image with the stored image in the database. The results demonstrate the feasibility and effectiveness of using face recognition for ATM authentication, which can enhance the security of ATMs and reduce the risk of fraud.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.47 no.3
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• pp.217-227
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• 2024

This study investigated the effects of social responsibility activities on consumer attitudes, product evaluation, corporate support, and corporate trust through structural equations and path analysis. Corporate social responsibility activities were divided into five areas: consumer and environmental protection, social contribution, cultural business, and economic responsibility, and the relative impact on consumer attitudes was considered. The results and strategic implications of this study are as follows. The same results as in previous studies confirmed that the performance of corporate social responsibility activities induces positive attitudes and behaviors of consumers. It proved that the performance of corporate social responsibility activities leads consumers to form a positive attitude, which can eventually be transferred to products and corporate images by a halo effect, leading to product evaluation, corporate support and trust. In addition, the composition dimension and measurement items of corporate social responsibility activities were re-verified, and from a consumer point of view, it was confirmed that social responsibility activities include not only economic activities, but also activities that contribute positively, such as social contribution, support for local and cultural projects, and actions that do not harm society as a whole, such as protecting consumer rights and protecting the environment.