• Journal of the Korean BIBLIA Society for library and Information Science
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• v.18 no.2
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• pp.203-228
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• 2007

This study was conducted to explore pending issues as an obstacle factor in the library growth and progress through measurement of Korean and Chinese College undergraduates' perception on the library, and suggest its countermeasure to that the study result showed that their perception to the library's social and cultural function was low, so the library's cultural events need to be consolidated to enhance perception, and the Korean student's study zeal was lower than Chinese, and amny students did not go to the library, but an incentive is needed to escalate the strength of course study or the library availability. Also a countermeasure should be established such as a class link project through continuing specialized librarians' training strengthened, users' group education for the satisfaction enhancement and validity of the information service users.

• Anatomy and Cell Biology
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• v.57 no.1
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• pp.105-118
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• 2024

The world has witnessed tremendous advancements in nano-base applications. Zinc oxide nanoparticles (ZON) are widely used in food industry and medicine. Although their application is of important value, they may cause toxicity to body tissues. Peripheral blood mononuclear cells (PBMCs) proved its efficacy in tissue regeneration especially when it is preconditioned by activated platelet supernatant (APS). The aim of this study is to evaluate the effect of ZON on the gastric mucosa and the therapeutic role of the PBMCs preconditioned by APS in rats. Ten rats were donors and fifty rats were recipients. The recipients were divided into; control group, ZON group (10 mg/kg/day orally for five days) and preconditioned PBMCs group (1×10⁷ once intravenously 24 hours after ZON). Gastric specimens were processed for histological, immunohistochemical, biochemical and quantitative real-time polymerase chain reaction studies. ZON group showed marked structural changes in the gastric mucosa. There was desquamation or deep ulceration of the epithelium. Cytoplasmic vacuoles and pyknotic nuclei were in glandular cells. Reduced proliferating cell nuclear antigen and increased tumor necrosis factor-α were in epithelial cells. There were significant elevation in malondialdahyde and reduction in glutathione, superoxide dismutase, and catalase. Enhancement in mRNA expression of nuclear factor kappa-B and cyclooxygenase-2 was detected. The preconditioned PBMCs group showed significant improvement of all parameters. So, ZON had cytotoxic effects on the gastric mucosa and the preconditioned PBMCs had a therapeutic effect on gastric mucosal damage after ZON.

• Journal of Life Science
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• v.26 no.3
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• pp.331-337
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• 2016

Although fibroblast growth factor 23 (FGF23) is exclusively produced in osteoblasts and osteocytes, its main target is the kidney, where it decreases phosphate reabsorption by suppressing Na-phosphate cotransporters. Independently of its action on phosphate homeostasis, FGF23 also inhibits bone formation in vivo. In a calvarial osteoblastic cell model, FGF23 was shown to negatively affect extracellular matrix mineralization. This study investigated whether FGF23 had similar effects on osteoblast maturation, including differentiation and mineralization of bone marrow-derived mesenchymal stem cells (MSCs). D1 MSCs were cultured in an osteogenic medium containing β-glycerophosphate, ascorbic acid, and dexamethazone. Osteoblastic differentiation was evaluated by alkaline phosphatase (Alp) staining, and matrix mineralization was evaluated by alizarin red staining and calcium deposition. The expression of differentiation-stimulating genes Runx2, Alp, and osteocalcin and mineralization-inhibiting genes Enpp1 and Ank was analyzed using semiquantitative RT-PCR. Supraphysiological doses of FGF23 did not stimulate proliferation or osteoblastic differentiation of MSCs. Matrix mineralization 1, 2, and 3 weeks after the FGF23 treatment did not vary between control and FGF23 groups, although time-dependent enhancement of mineralization was obvious. Calcium deposition was also unchanged after the FGF23 treatment. mRNA expression levels of differentiation- and mineralization-related genes were also similar between the groups. Despite these negative findings, FGF23 signaling through FGF receptors seemed to function normally, with phosphorylation of the Erk protein more evident in the FGF23 group than in controls. These findings suggest that unlike calvarial osteoblasts, FGF23 is not likely to affect osteoblastic differentiation and mineralization of MSCs.

• Journal of KIISE:Software and Applications
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• v.37 no.2
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• pp.85-94
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• 2010

This paper introduces a novel way to leverage convolution parse tree kernel to extract the interaction information between two proteins in a sentence without multiple features, clues and complicated kernels. Our approach needs only the parse tree alone of a candidate sentence including pairs of protein names which is potential to have interaction information. The main contribution of this paper is two folds. First, we show that for the PPI, it is imperative to execute parse tree pruning removing unnecessary context information in deciding whether the current sentence imposes interaction information between proteins by comparing with the latest existing approaches' performance. Secondly, this paper presents that tree kernel decay factor can play an pivotal role in improving the extraction performance with the identical learning conditions. Consequently, we could witness that it is not always the case that multiple kernels with multiple parsers perform better than each kernels alone for PPI extraction, which has been argued in the previous research by presenting our out-performed experimental results compared to the two existing methods by 19.8% and 14% respectively.

• Smart Structures and Systems
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• v.3 no.3
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• pp.281-298
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• 2007

The load carrying capacity of a bridge needs to be properly assessed to operate the bridge safely and maintain it efficiently. For the evaluation of load carrying capacity considering the current state of a bridge, static and quasi-static loading tests with weight-controlled heavy trucks have been conventionally utilized. In these tests, the deflection (or strain) of the structural members loaded by the controlled vehicles are measured and analyzed. Using the measured data, deflection (or strain) correction factor and impact correction factor are calculated. These correction factors are used in the enhancement of the load carrying capacity of a bridge, reflecting the real state of a bridge. However, full or partial control of the traffic during the tests and difficulties during the installment of displacement transducers or strain gauges may cause not only inconvenience to the traffic but also the increase of the logistics cost and time. To overcome these difficulties, an alternative method is proposed using an excited response part of full measured ambient acceleration data by ordinary traffic on a bridge without traffic control. Based on the modal properties extracted from the ambient vibration data, the initial finite element (FE) model of a bridge can be updated to represent the current real state of a bridge. Using the updated FE model, the deflection of a bridge akin to the real value can be easily obtained without measuring the real deflection. Impact factors are obtained from pseudo-deflection, which is obtained by double-integration of the acceleration data with removal of the linear components on the acceleration data. For validation, a series of tests were carried out on a steel plategirder bridge of an expressway in Korea in four different seasons, and the evaluated load carrying capacities of the bridge by the proposed method are compared with the result obtained by the conventional load test method.

• Information Systems Review
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• v.15 no.1
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• pp.1-24
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• 2013

This study empirically investigated inter-relationships among the influence factors on the adoption of e-commerce, which are classified as cause factor (i.e., perceived environmental uncertainty and competition), facilitators (i.e., perceived economic benefits, inter-organizational trust, suppliers' pressure and capability and asset specificity) and support factor (i.e., top management's support and organizational resource capability). The results of regression analyses showed that competition, inter-organizational trust, suppliers' pressure and capability, top management's support, and organizational resource capability have a positive impact on the adoption of e-commerce. In the analyses of inter-relationships among the influence factors, it was found that perceived environmental uncertainty positively influences suppliers' pressure and capability and perceived economic benefits, and competition has a positive impact on asset specificity. It was also observed that perceived economic benefits, inter-organizational trust and suppliers' pressure and capability positively affect top management's support, and inter-organizational trust and suppliers' pressure and capability have a positive impact on organizational resource capability. With mediating regression analyses, it was found that competition has an indirect impact on the adoption of e-commerce through the effect on perceived economic benefits, suppliers' pressure and capability, organizational resource capability and top management's support. The results of mediating regression analyses also showed that suppliers' pressure and capability and perceived economic benefits have indirect effects on the adoption of e-commerce through the effects on top management's support and organizational resource capability. From these results, it is concluded that intense competition causes the activation of facilitators, and the facilitators contribute to both the enhancement of top management support and the creation of organizational resource capability, which are directly linked to the adoption of e-commerce.

• Applied Chemistry for Engineering
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• v.23 no.3
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• pp.313-319
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• 2012

In this work, the electroplating of copper was introduced on PAN-based carbon fibers for the enhancement of mechanical interfacial strength of carbon fibers-reinforced composites. The surface properties of carbon fibers were determined by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and contact angle measurements. Its mechanical interfacial properties of the composites were studied by interlaminar shear strength (ILSS) and critical stress intensity factor ($K_{IC}$). From the results, it was found that the mechanical interfacial properties of Cu-plated carbon fibers-reinforced composites (Cu-CFRPs) enhanced with increasing the Cu plating time, Cu content and COOH group up to Cu-CFRP-30. However, the mechanical interfacial properties of the Cu-CFRPs decreased dramatically in the excessively Cu-plated CFRPs sample. In conclusion, the presence of Cu particles on carbon fiber surfaces can be a key factor to determine the mechanical interfacial properties of the Cu-CFRPs, but the excessive Cu content can lead the failure due to the interfacial separation between fibers and matrices in this system.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2384-2389
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• 2007

The 2nd order response surface method (RSM) has been carried out to get optimum thermal design for enhanced heat transfer on square channel with bleed holes. The RSM was used as an optimization technique with Reynolds-averaged navier-stokes equation. Turbulence model for heat transfer analysis used RNG k-epsilon model. The wall function used enhanced wall function. Numerical local heat transfer coefficients were similar to the experimental tendency. Two design variables such as attack angle of rib (${\alpha}$), rib pitch-to-rib height ratio (p/e) were chosen. Operation condition considered bleeding ratio per bleed hole ($BR_{hole}$). A response surface were constructed by the design variables and operation condition. As a result, adjusted $R^2$ was more than 0.9. Optimization results of various objective function were similar to heat transfer in channel with and without bleed flow. But friction factor was lower than channel without bleed flow.

• Korean Journal of Materials Research
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• v.14 no.8
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• pp.542-546
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• 2004

We report a new fabrication process for high performance triode type CNT field emitters and their superior electrical properties. The CNT-based triode-type field emitter structure was fabricated by the conventional semiconductor processes. The keys of the fabrication process are spin-on-glass coating and trim-and-leveling of the carbon nanotubes grown in trench structures by employing a chemical mechanical polishing process. They lead to strong adhesion and a uniform distance from the carbon nanotube tips to the electrode. The measured emission property of the arrays showed a remarkably uniform and high current density. The gate leakage current could be remarkably reduced by coating of thin $SiO_{2}$ insulating layer over the gate metal. The field enhancement factor(${\beta}$) and emission area(${\alpha}$) were calculated from the F-N plot. This process can be applicable to fabrication of high power CNT vacuum transistors with good electrical performance.

• Journal of Korean Academy of Nursing
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• v.39 no.4
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• pp.499-507
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• 2009

Purpose: This study was conducted to identify the factors that influence nurses' organizational citizenship behavior. Methods: A cross-sectional design was used, with a convenience sample of 547 nurses from four university hospitals in Seoul and Gyeonggi province. The data were collected through a questionnaire survey done from September 22 to October 10, 2008. The tools used for this study were scales on organizational citizenship behavior (14 items), self-leadership (14 items), empowerment (10 items), organizational commitment (7 items), job satisfaction (8 items) and transformational transactional leadership (14 items). Cronbach's alpha and factor analysis were examined to test reliability and construct validity of the scale. The data collected were processed using SPSS Window 15.0 Program for actual numbers and percentages, differences in the dependent variable according to general characteristics, and means, standard deviations, correlation coefficients and multiple regression analysis. Results: The factors influencing nurses' organizational citizenship behavior were identified as self-leadership ($\beta=.247$), empowerment ($\beta=.233$), job satisfaction ($\beta=.209$), organizational commitment ($\beta=.158$), and transactional leadership ($\beta=.142$). Five factors explained 42.0% of nurses' organizational citizenship behavior. Conclusion: The results of this study can be used to develop further management strategies for enhancement of nurses' organizational citizenship behavior.