• Asian Pacific Journal of Cancer Prevention
• /
• 제15권19호
• /
• pp.8035-8040
• /
• 2014

Gastric cancer is the second after lung cause of cancer-related mortality in the world. Early detection and treatment can lead to a long survival time. Recently microarrays and next generation sequencing (NGS) have become very useful tools of comprehensive research into gastric cancer, facilitating the identification of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discovery to practical clinical benefits. Although there are many biomarkers and target agents, only a minority of patients are tested and treated accordingly. Microarray technology with maturity was established more than 10 years ago, and has been widely used in the study of functional genomics, systems biology, and genomes in medicine. Second generation sequencing technology is more recent, but development is very fast, and it has been applied to the genome, including sequencing and epigenetics and many aspects of functional genomics. Here we review insights gained from these studies regarding the technology of microarray and NGS, how to elucidate the molecular basis of gastric cancer and identify potential therapeutic targets, and how to analyse candidate genes. We also discuss the challenges and future directions of such efforts.

• 벤처창업연구
• /
• 제13권2호
• /
• pp.39-50
• /
• 2018

본 연구는 아산나눔재산의 AER사례를 중심으로 스타트업의 성공요인을 ERIS모델을 기반으로 창업단계, 상업화단계, 정착단계로 구분하여 분석하고 결과를 도출하였다. 사례분석 결과, 스타트업의 ERIS모델별 성공요인으로 창업단계에는 창업가의 창업 이력 및 경력, 분야경험 및 전문지식, 신속한 판단력과 문제해결이며, 구성원의 역량 및 팀웍, 네트워크, 정부의 창업지원 등이다. 상업화단계에는 사업화 및 투자자금 확보, 타이밍, 차별화전략, 해외진출, 고객의견 수용 등이며, 성장(성숙)단계에는 신제품 출시 및 다각화, 조직문화의 수립 등이었다. 본 연구는 이러한 분석결과를 바탕으로 각 단계별 성공요인 및 시사점을 도출하고 향후 연구방향을 모색하였다.

• 한국작물학회지
• /
• 제30권4호
• /
• pp.381-387
• /
• 1985

밀의 등숙에 따른 종실의 품질과 제분특성에 대하여 검토하였다. 천립중과 용적중은 등숙이 진행됨에 따라 그리고 수분함량이 감소함에 따라 증가하였으며 출수후 40일이 성숙기로 추정되었다. 종실의 수분함량과 천립중 및 용적중은 각각 -0.877＊＊ 및 -0.761＊＊의 부의 상관이 있었으며, Pearling index와는 0.915＊＊의 정의 상관이 있었다. 제분특성과 관련된 배유는 등숙초기에도 종실의 많은 부분을 차지하고 있었으나 제분평점은 출수후 40일이 되어서야 일정수준에 도달하였다. Break-Reduction flour ratio는 품종에 따라 큰 차이가 있었으며, 특히 조광은 높은 Break-Reduction flour ratio를 보였다. 천립중과 제분율, 회분함량 및 제분평점과는 0.603＊＊, -0.958＊＊ 및 0.956＊＊의 고도의 상관이 있었다.

• 한국잠사곤충학회지
• /
• 제13권2호
• /
• pp.135-139
• /
• 1971

1. Ecdysterone의 숙화 촉진작용은 5령 성식기이후에 유효하다. 2. Ecdysterone은 누에의 숙화를 촉진하고 또 초숙잠과 종숙잠간의 시차폭을 축소시킨다. 3. Ecdysterone의 숙화 촉진작용은 Ecdysterone의 식하량과 비례한다. 4. Dodecyl alcohol 주제의 DAT는 등족작용을 촉진한다. 5. Ecdysterone과 Dodecyl alcohol의 병용은 숙화와 등족을 촉진하여 자연상족을 가능케 하며 상족기술 개량에 공헌할 줄 믿는다.

• 여성건강간호학회지
• /
• 제2권1호
• /
• pp.40-52
• /
• 1996

This study sought to investigate the spousal role expectation of married childbearing women in the social milieu. The purpose of this study was to determine the spouse's role expectation which influences marital quality and marital satisfaction, thereby contributing to married women's psychological well-being and family health. Data collection was done in the prenatal care center of 212 early adult, married, middle class women living in the urban area by interview. Using content analysis, 701 answers were recoded by 12 categories of role expectation as family integration, health maintenance, father role taking, personal maturity, communication and respect, social confidence, division of domestic labor, relationship with extended family, recreation and hobby, social support for wife's self actualization, faith in sexual relationship, and security in economic status. The influence of the altered gender role in modern society, women's expectation is derived from somewhat masculinity and feminity in role expectation. The results are discussed in relation to prototype of gender role and relationships. These finding will assist nurse in the understanding and intervening the marital problem and women's health.

• Journal of Periodontal and Implant Science
• /
• 제34권2호
• /
• pp.411-424
• /
• 2004

This study was performed to evaluate bone formation in the calvaria of rabbit by the concept of guided bone regeneration with titanium mesh membrane. Two different titanium meshes with varying number (353, 565) of pore were utilized in the study. Two surgical sites(T353, T565) were evaluated about whether or not the number of pore may have effect on the bone formation. The animal was sacrificed at 10days, 3 weeks, 6weeks, and 8 weeks after the surgery. Non-decalcified specimens were processed for histologic analysis. 1. Titanium mesh was biocompatible and capable of maintaining the spacemaking. 2. At 3 weeks, 6 weeks, and 8 weeks after GBR procedure, bone formation was more in the T353 site than in the T565 site. 3. Soft tissue layer above the regenerated bone was better developed in the T565 site. 4. There was no difference between two membranes in bone maturity with time. Within the above results, titanium mesh with lesser pore in number might be recommended for the early bone formation.

• Journal of Forest and Environmental Science
• /
• 제31권3호
• /
• pp.149-163
• /
• 2015

The aim of the present study was to assess the variation in species composition and diversity of woody species at different altitudes (900 to 2600 m asl) in Kedarnath Wildlife Sanctuary (KWLS) and its adjoining areas in Garhwal Himalaya, India. A total of 94 woody plant species (including 44 tree and 50 shrub species) belonging to 72 genera and 44 families were reported. Density varied from $235{\pm}9$ to $505{\pm}21trees\;ha^{-1}$ and $4,730{\pm}474$ to $9,530{\pm}700shrubs\;ha^{-1}$. Total basal cover varied from $10.49{\pm}0.66$ to $42.92{\pm}2.57m^2ha^{-1}$ (trees) and $0.36{\pm}0.024$ to $0.62{\pm}0.047m^2ha^{-1}$ (shrubs). Shannon-Wiener Index fluctuated between 2.30 to 3.53 (trees) and 2.74 to 3.78 (shrubs). Analysis of variance (ANOVA) indicated that altitude and aspect had significant effect on the distribution of woody species. Taxonomically, Rosaceae with 15 species emerged as the dominant family. Low value of maturity index and contiguous distribution of species denoted the early successional status of the studied forests. The conservation assessment based on altitudinal regimes and the information on species structure and function can provide baseline information for monitoring and sustaining the biodiversity.

• 한국도로학회논문집
• /
• 제19권3호
• /
• pp.1-10
• /
• 2017

PURPOSES : This paper focuses on strength development according to the mix design with cement type and mineral admixture from laboratory and field tests in cool weather. METHODS : Two methods evaluated the mix design of concrete pavement in cool weather. Firstly, laboratory tests including slump, air contents, setting time, strength, maturity, and freezing-thawing test were conducted. Three alternatives were selected based on the tests. Secondly, a field test was conducted and the optimum mix design in cool weather was suggested. RESULTS : It is an evident from the laboratory test that a mix with type III cement showed better performance than the one with type I cement. There was a delay in strength development of a mix with mineral admixture compared to mix design without any mineral admixture. In the field test, type III cement+flyash 20% mix design proved the best performance. CONCLUSIONS : For concrete pavement in cool weather, mix design using type III cement could overcome the strength delay due to mineral admixture. Moreover, it is possible to make sure of durability of pavement. Therefore, strength and durability problems due to cool weather would decrease.

• Child Health Nursing Research
• /
• 제12권2호
• /
• pp.260-267
• /
• 2006

Purpose: This pilot study was to develop Korean version of CDI(The Child Development Inventory) and assess the validation and reliability on K-CDI. Method: The K-CDI is assessed by parent-report method that has designed to screen children developmental functioning on 12 months to 6.5 years of age /or older children who are judged to be functioning in the one to six-year range. The inventory assesses areas of child development in the social, self-help, motor, language, letter and number skills. also, it includes various symptoms and behavior problems that young children may have. Participants were 130 children and their mothers who has lived in Seoul or Gyounggi-Do. Data was analyzed on the ratio of item response, Pearson's correlation, and Cronbach alpha. Results: 270 items with 8 sub-developmental realms were confirmed the reliabilities and validity on Korean children. Total 300 items were selected for restandardization. There was a significant correlation between the score of Social Maturity Scale and K-CDI. The corrlation coefficient alpha was .98. Conclusion: This study indicated that CDI is applicable in the clinical and early childhood educational setting for developmental assessment in Korea.

• 부모자녀건강학회지
• /
• 제16권1호
• /
• pp.27-36
• /
• 2013

Purpose: The purpose of this study was to develop a nocturnal emission and menstruation education program using CAI for Korean elementary school children. Methods: The research design was methodological study a ISD model 4 fields into sub contents in each field of the nocturnal emission and menstruation by CD titles. And to verify the effect of the education program, performance evaluation of the educational program for structured questionnaire was conducted on 120 late school-age children on June, 2010. Results: The results of this study were as follows; Through this, developed program was proved its effectiveness in enhancing knowledge level on nocturnal emission and menstruation in late school-age children(t=14.03, p<.001, t=11.52, p<.001). Conclusion : Accordingly, this program is expected to be an educational program to be used in various educational institutes, communities, and home as well as self-study that allows children themselves to study repeatedly, choosing the contents they want, whenever they hope as an educational program on nocturnal emission and menstruation in school-age children. In addition, it is suggested that various fields of programs should develop in consideration of early sexual maturity.